AVIAN REOVIRUS: VIRULENCE FACTORS AND NEW THERAPEUTIC TARGETS (Q3195190)
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Project Q3195190 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | AVIAN REOVIRUS: VIRULENCE FACTORS AND NEW THERAPEUTIC TARGETS |
Project Q3195190 in Spain |
Statements
118,592.1 Euro
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217,800.0 Euro
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54.45 percent
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1 January 2014
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30 June 2018
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UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
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15872
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LOS BROTES RECIENTES E INESPERADOS DE DIFERENTES VIRUS EN TODO EL MUNDO, ILUSTRAN LA NECESIDAD DE COMPRENDER MEJOR LOS MECANISMOS POR LOS QUE LOS VIRUS MODIFICAN SU RANGO DE HUESPEDES Y/O SU PATOGENICIDAD. TAMBIEN ES NECESARIO EL DESARROLLO DE NUEVOS METODOS PARA COMBATIR LAS INFECCIONES VIRICAS. NUESTRO GRUPO Y OTROS GRUPOS DE INVESTIGACION, HEMOS DETECTADO UNA SERIE DE DIFERENCIAS MOLECULARES ENTRE LOS REOVIRUS FUSOGENICOS Y LOS NO FUSOGENICOS. ESTOS DOS GRUPOS DE REOVIRUS SON EXTREMADAMENTE SIMILARES EN SUS ESTRUCTURAS Y CICLOS DE REPLICACION, PERO MUY DIFERENTES EN SU CAPACIDAD PATOGENICA. ASI, MIENTRAS QUE LOS VIRUS NO FUSOGENICOS SON VIRUS UBICUOS QUE NO ESTAN DIRECTAMENTE ASOCIADOS CON ENFERMEDADES, LA MAYORIA (SI NO TODOS) LOS REOVIRUS FUSOGENICOS SON PATOGENOS IMPORTANTES DE AVES, MAMIFEROS Y REPTILES. NUESTRO OBJETIVO ES DETERMINAR SI LAS DIFERENCIAS MOLECULARES EXISTENTES ENTRE LOS REOVIRUS FUSOGENICOS Y NO FUSOGENICOS SE CORRELACIONAN CON LAS DIFERENCIAS EN SU PATOGENICIDAD._x000D_ POR LO TANTO, PRIMERO DESARROLLAREMOS UN METODO DE GENETICA INVERSA PARA LOS REOVIRUS AVIARES, COMO REPRESENTANTES DEL GRUPO DE REOVIRUS FUSOGENICOS. PARA ELLO NOS APOYAREMOS EN LAS DIFERENTES ESTRATEGIAS QUE SE HAN DESARROLLADO RECIENTEMENTE PARA LOS REOVIRUS DE MAMIFERO (MRV) Y EL VIRUS DE LA LENGUA AZUL (BTV) DEL GENERO ORBIVIRUS, QUE TAMBIEN PERTENECE A LA FAMILIA REOVIRIDAE._x000D_ USANDO GENETICA INVERSA CREAREMOS MUTANTES DEL REOVIRUS AVIAR (ARV ) PARA ESTUDIAR LA POSIBLE INFLUENCIA QUE LAS DIFERENCIAS MOLECULARES OBSERVADAS ENTRE LOS VIRUS FUSOGENICOS Y NO FUSOGENICOS TIENEN SOBRE LA REPLICACION VIRAL Y LA PATOGENESIS IN VITRO Y EN ANIMALES SUSCEPTIBLES ._x000D_ ADICIONALMENTE HAREMOS USO DE NUESTRO CONOCIMIENTO PROFUNDO SOBRE LA PROTEINA MUNS DE ARV PARA: I) OBTENER IMPORTANTE INFORMACION SOBRE EL PROCESO DE FORMACION DE LAS FABRICAS DE VIRUS QUE SE PRODUCEN DURANTE LA INFECCION POR ARV; II) TRATAR DE DESARROLLAR UN NUEVO CONCEPTO DE MOLECULAS ANTIVIRALES (QUE PUEDA APLICARSE A OTROS VIRUS), Y III) TRATAR DE DETERMINAR LA ESTRUCTURA TRIDIMENSIONAL DE LA PROTEINA MUNS. LA FORMACION DE LAS FABRICAS DE VIRUS O VIROPLASMAS DENTRO DE LAS CELULAS INFECTADAS ES UN PUNTO ESENCIAL DEL CICLO DE REPLICACION DE MUCHOS VIRUS Y UNA DIANA CLAVE PARA INTERFERIR CON LA REPLICACION VIRICA._x000D_ CON TODA LA INFORMACION QUE OBTENGAMOS, TAMBIEN ESPERAMOS COMPRENDER MEJOR LOS SUTILES DETALLES DE LA INTERACCION VIRUS-CELULA QUE DICTAN LA PERMISIVIDAD DE UNA LINEA CELULAR (O ESPECIE) HACIA UN VIRUS EN PARTICULAR. EL COMPRENDER ESOS DETALLES JUEGA UN PAPEL IMPORTANTE EN LA LUCHA CONTRA LAS INFECCIONES POR VIRUS Y LA PROPAGACION ENTRE ESPECIES. (Spanish)
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RECENT AND UNEXPECTED OUTBREAKS OF DIFFERENT VIRUSES AROUND THE WORLD ILLUSTRATE THE NEED TO BETTER UNDERSTAND THE MECHANISMS BY WHICH VIRUSES CHANGE THEIR HOST RANGE AND/OR THEIR PATHOGENICITY. IT IS ALSO NECESSARY TO DEVELOP NEW METHODS TO COMBAT VIRIC INFECTIONS. OUR GROUP AND OTHER RESEARCH GROUPS HAVE DETECTED A NUMBER OF MOLECULAR DIFFERENCES BETWEEN FUSOGENICAL AND NON-FUSOGENICAL REOVIRUSES. THESE TWO GROUPS OF REOVIRUSES ARE EXTREMELY SIMILAR IN THEIR REPLICATION STRUCTURES AND CYCLES, BUT VERY DIFFERENT IN THEIR PATHOGENIC CAPACITY. THUS, WHILE NON-FUSOGENICOS VIRUSES ARE UBIQUITOUS VIRUSES THAT ARE NOT DIRECTLY ASSOCIATED WITH DISEASES, MOST (IF NOT ALL) REOVIRUSES ARE IMPORTANT PATHOGENS OF BIRDS, MAMMALS AND REPTILES. Our OBJECTIVE IS to Determine Whether the Existing Molecular Differentiaries BETWEEN THE FUSOGENICAL REOVIRUS AND NON-FUSOGENICOS are correlated with the Differents in their PATOGENICITY._x000D_ FOR THE FUSOGENICAL REOVIRUS GROUP we will develop an INVESTIVE GENETIC METHOD FOR AVIARY REOVIRUS, AS REPRESENTANTS OF THE FUSOGENICAL REOVIRUS GROUP. For it we will support the different strategies that have been re-developed for mamiferous (MRV) and the blue language (BTV) VIRUS of ORBIVIRUS GENERO ORBIVIRUS, which also pertains to the REOVIRIDAE FAMILY._x000D_ USANDO GENETICA INVERSA CREAREM MUTANTS OF REOVIRUS AVIAR (ARV) TO STUDY THE POSSIBLE INFLUENCE THAT the observed MOLECULAR DIFFERENCES BETWEEN FUSOGENICAL AND NON-FUSOGENIC VIRUS VIRUS VIRUS VIRUS VIRUS AND NON-FUSOGENICAL VIRUS VIRUS VIRAL REPLICATIONS AND PHOTOGENCIALS IN VITRO AND SUSCEPTIBLE ANIMALS._x000D_ ADDITIONLY HAREMOS use OF OUR PROTEIN PROTEIN OF ARV PROTEIN PROTEIN PROTEIN PROTEIN PROFUND FOR: I) OBTAIN IMPORTANT INFORMATION ON THE FORMATION PROCESS OF THE VIRUS FACTORIES THAT OCCUR DURING ARV INFECTION; II) TRY TO DEVELOP A NEW CONCEPT OF ANTIVIRAL MOLECULES (WHICH MAY BE APPLIED TO OTHER VIRUSES), AND III) TRY TO DETERMINE THE THREE-DIMENSIONAL STRUCTURE OF THE MUNS PROTEIN. The FORMATION OF VIRUS FABRICS or viroplasms within the INFECTATED CELLS is a central point of the VIRUS REPLICATION CICLE AND A KEY DAILED DIANA for interfering with the VIRIC REPLICATION._x000D_ with all the information we obtain, we also hope to buy better the SUTILES DETAILS OF THE VIRUS-CELULA INTERACTION that dictates the perMISIVITY of a hairline (or SPECIE) DOES A VIRUS IN PARTICULAR. UNDERSTANDING THESE DETAILS PLAYS AN IMPORTANT ROLE IN THE FIGHT AGAINST VIRUS INFECTIONS AND SPREAD AMONG SPECIES. (English)
13 October 2021
0.6662540827705311
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DES ÉCLOSIONS RÉCENTES ET INATTENDUES DE DIFFÉRENTS VIRUS À TRAVERS LE MONDE ILLUSTRENT LA NÉCESSITÉ DE MIEUX COMPRENDRE LES MÉCANISMES PAR LESQUELS LES VIRUS CHANGENT LEUR AIRE D’ACCUEIL ET/OU LEUR PATHOGÉNICITÉ. IL EST ÉGALEMENT NÉCESSAIRE DE DÉVELOPPER DE NOUVELLES MÉTHODES DE LUTTE CONTRE LES INFECTIONS VIRALES. NOTRE GROUPE ET D’AUTRES GROUPES DE RECHERCHE ONT DÉTECTÉ UN CERTAIN NOMBRE DE DIFFÉRENCES MOLÉCULAIRES ENTRE LES REOVIRUS FUSOGENICAL ET NON-FUSOGENICAL. CES DEUX GROUPES DE RÉOVIRUS SONT EXTRÊMEMENT SIMILAIRES DANS LEURS STRUCTURES ET CYCLES DE RÉPLICATION, MAIS LEUR CAPACITÉ PATHOGÈNE EST TRÈS DIFFÉRENTE. AINSI, ALORS QUE LES VIRUS NON-FUSOGENICOS SONT DES VIRUS OMNIPRÉSENTS QUI NE SONT PAS DIRECTEMENT ASSOCIÉS À DES MALADIES, LA PLUPART (SI CE N’EST TOUS) LES RÉOVIRUS SONT DES AGENTS PATHOGÈNES IMPORTANTS DES OISEAUX, DES MAMMIFÈRES ET DES REPTILES. Notre OBJECTIF est de déterminer si les différenciations moléculaires existantes entre le reovirus FUSOGENICAL et les NON-FUSOGENICOS sont corrélées avec les Différents dans leur PATOGENICITY._x000D_ Pour le groupe de reovirus FUSOGENICAL, nous développerons une MÉTHODE GENETIQUE investive pour le reovirus AVIAIRE, en tant que représentants du GROUPE FUSOGENICAL de reovirus. Pour cela, nous soutiendrons les différentes stratégies qui ont été re-développées pour le mamiferous (MRV) et le langage bleu (BTV) VIRUS de l’Orbivirus GENERO Orbivirus, qui concerne également les Reoviridae FAMILY._x000D_ USANDO GENETICA inversa MUTANTS CREAREM de l’aviar réovirus (ARV) pour STUDY L’INFLUENCE POSSIBLE QUE les DIFFÉRENCES MOLECULAIRES observées enTRE VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS et NON-FUSOGENICAL VIRUS VIRUS REPLICATIONS ET PHOTOGENCIALS VIRUS VIRUS VIRUS ET NON-FUSOGENICAL VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS ET NON-FUSOGENICAL VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS ET NON-FUSOGENIQUE VIRUS VIRUS REPLICATIONS VIRAUX VIRUS ET PHOTOGENCIAUX DE VIRUS VIRUS ET NON-FUSOGÉNIQUE VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS ET NON-FUSOGÉNIQUE VIRUS REPLICATIONS VIRAUX VIRUS VIRUS VIRUS ET VIRUS VIRUS VIRUS VIRUS VIRUS ET NON-FUSCÉNIQUE VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS ET NON-fusogène VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS ET NON-F I) OBTENIR DES INFORMATIONS IMPORTANTES SUR LE PROCESSUS DE FORMATION DES USINES VIRALES QUI SE PRODUISENT AU COURS DE L’INFECTION À ARV; II) ESSAYER DE DÉVELOPPER UN NOUVEAU CONCEPT DE MOLÉCULES ANTIVIRALES (QUI PEUVENT ÊTRE APPLIQUÉES À D’AUTRES VIRUS), ET III) ESSAYER DE DÉTERMINER LA STRUCTURE TRIDIMENSIONNELLE DE LA PROTÉINE MUNS. La FORMATION DES FABRIQUES VIRUS ou viroplasmes à l’intérieur des VILLES INFECTÉES est un point central de la REPLICATION VIRUS CICLE ET UN CEY DIANA pour interférer avec la REPLICATION Virique._x000D_ avec toutes les informations que nous obtenons, nous espérons également acheter mieux les DÉTAILS SUTILES DE L’INTERACTION VIRUS-Célula qui dictent la perMISIVITÉ d’une ligne de cheveux (ou SPECIE) A VIRUS EN PARTICULIER. LA COMPRÉHENSION DE CES DÉTAILS JOUE UN RÔLE IMPORTANT DANS LA LUTTE CONTRE LES INFECTIONS VIRALES ET LA PROPAGATION PARMI LES ESPÈCES. (French)
4 December 2021
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JÜNGSTE UND UNERWARTETE AUSBRÜCHE VERSCHIEDENER VIREN AUF DER GANZEN WELT VERANSCHAULICHEN DIE NOTWENDIGKEIT, DIE MECHANISMEN, MIT DENEN VIREN IHREN WIRTSREICHTUM UND/ODER IHRE PATHOGENITÄT VERÄNDERN, BESSER ZU VERSTEHEN. ES IST AUCH NOTWENDIG, NEUE METHODEN ZUR BEKÄMPFUNG VIRISCHER INFEKTIONEN ZU ENTWICKELN. UNSERE GRUPPE UND ANDERE FORSCHUNGSGRUPPEN HABEN EINE REIHE MOLEKULARER UNTERSCHIEDE ZWISCHEN FUSOGENICAL UND NICHT-FUSOGENICAL-REOVIREN ENTDECKT. DIESE BEIDEN GRUPPEN VON REOVIREN SIND IN IHREN REPLIKATIONSSTRUKTUREN UND -ZYKLEN ÄUSSERST ÄHNLICH, ABER SEHR UNTERSCHIEDLICH IN IHRER PATHOGENEN KAPAZITÄT. SO, WÄHREND NICHT-FUSOGENICOS VIREN SIND ALLGEGENWÄRTIGE VIREN, DIE NICHT DIREKT MIT KRANKHEITEN VERBUNDEN SIND, DIE MEISTEN (WENN NICHT ALLE) REOVIREN SIND WICHTIGE KRANKHEITSERREGER VON VÖGELN, SÄUGETIEREN UND REPTILIEN. Unser OBJECTIVE IST zu bestimmen, ob die bestehenden molekularen Differenzien das FUSOGENICAL Reovirus UND NON-FUSOGENICOS mit den Unterschieden in ihrer PATOGENICITY korrelieren._x000D_ Für die FUSOGENICAL-Reovirus-GRUPPE werden wir ein investierendes GENETIC METHOD für AVIARY Reovirus entwickeln, AS Vertreter der FUSOGENICAL Reovirus GROUP. Dafür werden wir die verschiedenen Strategien unterstützen, die für mamiferous (MRV) und die blaue Sprache (BTV) VIRUS von Orbivirus GENERO Orbivirus neu entwickelt wurden, die sich auch auf die Reoviridae FAMILY bezieht._x000D_ USANDO GENETICA inversa CREAREM MUTANTS OF Reovirus aviar (ARV) ZU STUDIE DIE POSSIBLE INFLUENCE DAS beobachtete MOLECULAR DIFFERENZEN FUSOGENISCHE UND NON-fusogenic VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS UND NON-FUSOGENICAL VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS UND NON-FUSOGENICAL VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS und NON-FUSOGENICAL VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS I) WICHTIGE INFORMATIONEN ÜBER DEN ENTSTEHUNGSPROZESS DER VIRUSFABRIKEN ERHALTEN, DIE WÄHREND DER ARV-INFEKTION AUFTRETEN; II) VERSUCHEN, EIN NEUES KONZEPT DER ANTIVIRALEN MOLEKÜLE (DIE AUF ANDERE VIREN ANGEWENDET WERDEN KÖNNEN) ZU ENTWICKELN, UND III) VERSUCHEN, DIE DREIDIMENSIONALE STRUKTUR DES MUNS PROTEINS ZU BESTIMMEN. Die Formation von VIRUS FABRICS oder Viroplasmen innerhalb der INFECTATED CELLS ist ein zentraler Punkt des VIRUS REPLICATIONCICLE UND A KEY dailed DIANA für die Einmischung in die Viric REPLICATION._x000D_ mit allen Informationen, die wir erhalten, hoffen wir auch, die SUTILES DETAILS DER VIRUS-Zellula INTERACTION, die die PerMISIVity einer Haarlinie (oder SPECIE) DOES A VIRUS IN PARTICULAR diktiert, besser zu kaufen. DAS VERSTÄNDNIS DIESER DETAILS SPIELT EINE WICHTIGE ROLLE BEI DER BEKÄMPFUNG VON VIRUSINFEKTIONEN UND DER VERBREITUNG VON VIRUSARTEN. (German)
9 December 2021
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RECENTE EN ONVERWACHTE UITBRAKEN VAN VERSCHILLENDE VIRUSSEN OVER DE HELE WERELD ILLUSTREREN DE NOODZAAK OM BETER INZICHT TE KRIJGEN IN DE MECHANISMEN WAARMEE VIRUSSEN HUN GASTHEERBEREIK EN/OF HUN PATHOGENITEIT VERANDEREN. HET IS OOK NOODZAKELIJK OM NIEUWE METHODEN TE ONTWIKKELEN OM VIRIC INFECTIES TE BESTRIJDEN. ONZE GROEP EN ANDERE ONDERZOEKSGROEPEN HEBBEN EEN AANTAL MOLECULAIRE VERSCHILLEN TUSSEN FUSOGENICAL EN NIET-FUSOGENICAL REOVIRUSSEN ONTDEKT. DEZE TWEE GROEPEN REOVIRUSSEN ZIJN ZEER VERGELIJKBAAR IN HUN REPLICATIESTRUCTUREN EN CYCLI, MAAR ZEER VERSCHILLEND IN HUN PATHOGENE CAPACITEIT. HOEWEL NIET-FUSOGENICOS VIRUSSEN ALOMTEGENWOORDIGE VIRUSSEN ZIJN DIE NIET DIRECT GEASSOCIEERD ZIJN MET ZIEKTEN, ZIJN DE MEESTE (ZO NIET ALLE) REOVIRUSSEN BELANGRIJKE ZIEKTEVERWEKKERS VAN VOGELS, ZOOGDIEREN EN REPTIELEN. Onze OBJECTIVE IS om te bepalen of de bestaande moleculaire Differentiaries BETWEEN DE FUSOGENICAL reovirus EN NON-FUSOGENICOS zijn gecorreleerd met de Verschillen in hun PATOGENICITY._x000D_ VOOR DE FUSOGENICAL reovirus GROUP zullen we een investerende GENETIC METHOD voor AVIARY reovirus, AS vertegenwoordigers van de FUSOGENICAL reovirus GROUP ontwikkelen. Daarvoor zullen we de verschillende strategieën ondersteunen die zijn herontwikkeld voor mamifere (MRV) en de blauwe taal (BTV) VIRUS van Orbivirus GENERO Orbivirus, die ook betrekking heeft op de Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS OF reovirus aviar (ARV) TO STUDY THE POSSIBLE INFLUENCE DAT de waargenomen MOLECULAR DIFFERENCES BETWEEN FUSOGENICAL EN NON-fusogene VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS en NON-FUSOGENICAL VIRUS VIRUS VIRAL REPLICATIES EN PHOTOGENCIAL IN VITRO EN SUSCEPTIBLE ANIMALS._x000D_ extra haremos gebruik van onze PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEGEN VOOR: I) BELANGRIJKE INFORMATIE TE VERKRIJGEN OVER HET VORMINGSPROCES VAN DE VIRUSFABRIEKEN DIE TIJDENS DE ARV-INFECTIE OPTREDEN; II) PROBEREN EEN NIEUW CONCEPT VAN ANTIVIRALE MOLECULEN TE ONTWIKKELEN (DIE OP ANDERE VIRUSSEN KUNNEN WORDEN TOEGEPAST), EN III) PROBEREN DE DRIEDIMENSIONALE STRUCTUUR VAN HET MUNS-EIWIT TE BEPALEN. De FORMATION VAN VIRUS FABRICS of viroplasma’s binnen de INFECTATED CELLS is een centraal punt van de VIRUS REPLICATION CICLE EN A KEY dailed DIANA voor interferentie met de Viric REPLICATION._x000D_ met alle informatie die we verkrijgen, we hopen ook beter de SUTILES DETAILS van de VIRUS-celula INTERACTION te kopen die de perMISIVITY van een haarlijn (of SPECIE) vereist. HET BEGRIJPEN VAN DEZE DETAILS SPEELT EEN BELANGRIJKE ROL IN DE STRIJD TEGEN VIRUSINFECTIES EN VERSPREIDING ONDER SOORTEN. (Dutch)
17 December 2021
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FOCOLAI RECENTI E IMPREVISTI DI DIVERSI VIRUS IN TUTTO IL MONDO ILLUSTRANO LA NECESSITÀ DI COMPRENDERE MEGLIO I MECCANISMI ATTRAVERSO I QUALI I VIRUS CAMBIANO LA LORO GAMMA OSPITE E/O LA LORO PATOGENICITÀ. È INOLTRE NECESSARIO SVILUPPARE NUOVI METODI PER COMBATTERE LE INFEZIONI VIRICHE. IL NOSTRO GRUPPO E ALTRI GRUPPI DI RICERCA HANNO RILEVATO UNA SERIE DI DIFFERENZE MOLECOLARI TRA REOVIRUS FUSOGENICAL E NON-FUSOGENICAL. QUESTI DUE GRUPPI DI REOVIRUS SONO ESTREMAMENTE SIMILI NELLE LORO STRUTTURE E CICLI DI REPLICAZIONE, MA MOLTO DIVERSI NELLA LORO CAPACITÀ PATOGENA. COSÌ, MENTRE I VIRUS NON-FUSOGENICOS SONO VIRUS ONNIPRESENTI CHE NON SONO DIRETTAMENTE ASSOCIATI A MALATTIE, LA MAGGIOR PARTE (SE NON TUTTI) I REOVIRUS SONO IMPORTANTI PATOGENI DI UCCELLI, MAMMIFERI E RETTILI. Il nostro OBIETTIVO È determinare se i Differenziari Molecolari esistenti tra il Reovirus FUSOGENICAL E NON FUSOGENICOS sono correlati con i Diversi nella loro PATOGENICITÀ._x000D_Per il GRUPPO FUSOGENICAL Reovirus svilupperemo un metodo GENETICO Investivo per il reovirus AVIARY, come rappresentanti del gruppo di reovirus FUSOGENICAL. Per questo sosterremo le diverse strategie che sono state ri-sviluppate per mamiferous (MRV) e il linguaggio blu (BTV) VIRUS di Orbivirus GENERO Orbivirus, che riguarda anche il Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS OF reovirus aviar (ARV) per STUDARE L'INFLUENZA POSSIBILE CHE le DIFFERENZE MOLECULARI osservate tra FUSOGENICA e non-fusogenica VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIR I) OTTENERE INFORMAZIONI IMPORTANTI SUL PROCESSO DI FORMAZIONE DELLE FABBRICHE DI VIRUS CHE SI VERIFICANO DURANTE L'INFEZIONE DA ARV; II) CERCARE DI SVILUPPARE UN NUOVO CONCETTO DI MOLECOLE ANTIVIRALI (CHE POSSONO ESSERE APPLICATE AD ALTRI VIRUS), E III) CERCARE DI DETERMINARE LA STRUTTURA TRIDIMENSIONALE DELLA PROTEINA MUNS. La FORMAZIONE DI FABRICI VIRUS o viroplasmi all'interno delle CELLE INFECTATED è un punto centrale del VIRUS REPLICATION CICLE E A KEY Dailed DIANA per interferire con la REPLICAZIONE VIRUS-celula._x000D_ con tutte le informazioni che otteniamo, speriamo anche di acquistare meglio i DETAILS SUTILES DELLA VIRUS-celula INTERACTION che detta la perMISIVITÀ di una linea di capelli (o SPECIE) DOES A VIRUS IN PARTICOLARE. LA COMPRENSIONE DI QUESTI DETTAGLI SVOLGE UN RUOLO IMPORTANTE NELLA LOTTA CONTRO LE INFEZIONI DA VIRUS E NELLA DIFFUSIONE TRA LE SPECIE. (Italian)
16 January 2022
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ΠΡΌΣΦΑΤΕΣ ΚΑΙ ΑΠΡΟΣΔΌΚΗΤΕΣ ΕΣΤΊΕΣ ΔΙΑΦΌΡΩΝ ΙΏΝ ΣΕ ΌΛΟ ΤΟΝ ΚΌΣΜΟ ΚΑΤΑΔΕΙΚΝΎΟΥΝ ΤΗΝ ΑΝΆΓΚΗ ΚΑΛΎΤΕΡΗΣ ΚΑΤΑΝΌΗΣΗΣ ΤΩΝ ΜΗΧΑΝΙΣΜΏΝ ΜΈΣΩ ΤΩΝ ΟΠΟΊΩΝ ΟΙ ΙΟΊ ΑΛΛΆΖΟΥΝ ΤΟ ΦΆΣΜΑ ΤΩΝ ΞΕΝΙΣΤΏΝ ΤΟΥΣ Ή/ΚΑΙ ΤΗΝ ΠΑΘΟΓΈΝΕΙΆ ΤΟΥΣ. ΕΊΝΑΙ ΕΠΊΣΗΣ ΑΠΑΡΑΊΤΗΤΟ ΝΑ ΑΝΑΠΤΥΧΘΟΎΝ ΝΈΕΣ ΜΈΘΟΔΟΙ ΓΙΑ ΤΗΝ ΚΑΤΑΠΟΛΈΜΗΣΗ ΤΩΝ ΛΟΙΜΏΞΕΩΝ ΤΟΥ VIRIC. Η ΟΜΆΔΑ ΜΑΣ ΚΑΙ ΆΛΛΕΣ ΕΡΕΥΝΗΤΙΚΈΣ ΟΜΆΔΕΣ ΈΧΟΥΝ ΕΝΤΟΠΊΣΕΙ ΜΙΑ ΣΕΙΡΆ ΑΠΌ ΜΟΡΙΑΚΈΣ ΔΙΑΦΟΡΈΣ ΜΕΤΑΞΎ FUSOGENICAL ΚΑΙ ΜΗ-FUSOGENICAL REOVIRUSES. ΑΥΤΈΣ ΟΙ ΔΎΟ ΟΜΆΔΕΣ REOVIRUS ΕΊΝΑΙ ΕΞΑΙΡΕΤΙΚΆ ΠΑΡΌΜΟΙΕΣ ΣΤΙΣ ΔΟΜΈΣ ΑΝΤΙΓΡΑΦΉΣ ΚΑΙ ΤΟΥΣ ΚΎΚΛΟΥΣ ΤΟΥΣ, ΑΛΛΆ ΠΟΛΎ ΔΙΑΦΟΡΕΤΙΚΈΣ ΩΣ ΠΡΟΣ ΤΗΝ ΠΑΘΟΓΌΝΟ ΙΚΑΝΌΤΗΤΆ ΤΟΥΣ. ΈΤΣΙ, ΕΝΏ ΟΙ ΜΗ FUSOGENICOS ΙΟΊ ΕΊΝΑΙ ΠΑΝΤΑΧΟΎ ΠΑΡΌΝΤΕΣ ΙΟΊ ΠΟΥ ΔΕΝ ΣΥΝΔΈΟΝΤΑΙ ΆΜΕΣΑ ΜΕ ΑΣΘΈΝΕΙΕΣ, ΟΙ ΠΕΡΙΣΣΌΤΕΡΟΙ (ΑΝ ΌΧΙ ΌΛΟΙ) REOVIRUS ΕΊΝΑΙ ΣΗΜΑΝΤΙΚΆ ΠΑΘΟΓΌΝΑ ΤΩΝ ΠΤΗΝΏΝ, ΤΩΝ ΘΗΛΑΣΤΙΚΏΝ ΚΑΙ ΤΩΝ ΕΡΠΕΤΏΝ. Ο ΣΤΟΧΟΣ μας είναι να καθορίσουμε αν οι Υπάρχουσες Μοριακές Διαφορετικές Μεταξύ του FUSOGENICAL reovirus και του NON-FUSOGENICOS συσχετίζονται με τους Διαφορείς στην ΠΑΤΟΓΕΝΙΚΟΤΗΤΑ τους._x000D_ ΓΙΑ ΤΗΝ ΟΜΑΔΑ FUSOGENICAL reovirus θα αναπτύξουμε μια επενδυτική ΓΕΝΙΚΗ ΜΕΘΟΔΟΣ για τον AVIARY reovirus, ως εκπροσώπους της ΟΜΑΔΑΣ ΑΣΦΑΛΕΙΑΣ. Για αυτό θα στηρίξουμε τις διάφορες στρατηγικές που έχουν αναπτυχθεί εκ νέου για το mamiferous (MRV) και το μπλε γλώσσα (BTV) VIRUS του Orbivirus GENERO Orbivirus, το οποίο αφορά επίσης την ΟΙΚΟΓΕΝΕΙΑ Reoviridae._x000D_ USANDO GENETICA inversa CREAREM MUTANTS OF reovirus aviar (ARV) ΝΑ ΒΕΛΤΙΖΕΙ ΤΗΝ ΠΟΛΥΠΟΙΗΤΙΚΗ ΔΙΕΥΘΥΝΣΗ ΒΙRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VUSGEN-EN-NON FUSOGENIC VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIR I) ΝΑ ΛΑΜΒΆΝΟΥΝ ΣΗΜΑΝΤΙΚΈΣ ΠΛΗΡΟΦΟΡΊΕΣ ΣΧΕΤΙΚΆ ΜΕ ΤΗ ΔΙΑΔΙΚΑΣΊΑ ΣΧΗΜΑΤΙΣΜΟΎ ΤΩΝ ΕΡΓΟΣΤΑΣΊΩΝ ΤΟΥ ΙΟΎ ΠΟΥ ΕΜΦΑΝΊΖΟΝΤΑΙ ΚΑΤΆ ΤΗ ΔΙΆΡΚΕΙΑ ΤΗΣ ΛΟΊΜΩΞΗΣ ΑΠΌ ARV· II) ΠΡΟΣΠΑΘΟΎΝ ΝΑ ΑΝΑΠΤΎΞΟΥΝ ΜΙΑ ΝΈΑ ΈΝΝΟΙΑ ΤΩΝ ΑΝΤΙΙΙΚΏΝ ΜΟΡΊΩΝ (ΠΟΥ ΜΠΟΡΕΊ ΝΑ ΕΦΑΡΜΟΣΤΕΊ ΣΕ ΆΛΛΟΥΣ ΙΟΎΣ), ΚΑΙ III) ΠΡΟΣΠΑΘΟΎΝ ΝΑ ΚΑΘΟΡΊΣΟΥΝ ΤΗΝ ΤΡΙΣΔΙΆΣΤΑΤΗ ΔΟΜΉ ΤΗΣ ΠΡΩΤΕΪ́ΝΗΣ MUNS. Η ΔΗΛΩΣΗ ΒΙRUS FABRICS ή viroplasms στο πλαίσιο των ΠΛΗΡΟΦΟΡΙΩΝ είναι ένα κεντρικό σημείο του VIRUS REPLICATION CICLE AND A KEY dailed DIANA για την παρεμβολή του Viric REPLICATION._x000D_ με όλες τις πληροφορίες που λαμβάνουμε, ελπίζουμε επίσης να αγοράσουμε καλύτερα τα SUTILES ΛΕΠΤΟΜΕΡΕΙΕΣ ΤΗΣ VIRUS-celula INTERACTION που υπαγορεύουν την perMISIVITY ενός hairline (ή SPECIE) DOES A VIRUS IN PARTICULAR. Η ΚΑΤΑΝΌΗΣΗ ΑΥΤΏΝ ΤΩΝ ΛΕΠΤΟΜΕΡΕΙΏΝ ΔΙΑΔΡΑΜΑΤΊΖΕΙ ΣΗΜΑΝΤΙΚΌ ΡΌΛΟ ΣΤΗΝ ΚΑΤΑΠΟΛΈΜΗΣΗ ΤΩΝ ΛΟΙΜΏΞΕΩΝ ΑΠΌ ΙΟΎΣ ΚΑΙ ΣΤΗΝ ΕΞΆΠΛΩΣΗ ΜΕΤΑΞΎ ΤΩΝ ΕΙΔΏΝ. (Greek)
18 August 2022
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NYLIGE OG UVENTEDE UDBRUD AF FORSKELLIGE VIRA RUNDT OM I VERDEN ILLUSTRERER BEHOVET FOR BEDRE AT FORSTÅ DE MEKANISMER, HVORMED VIRA ÆNDRER DERES VÆRTSSORTIMENT OG/ELLER DERES PATOGENICITET. DET ER OGSÅ NØDVENDIGT AT UDVIKLE NYE METODER TIL BEKÆMPELSE AF VIRUSINFEKTIONER. VORES GRUPPE OG ANDRE FORSKERGRUPPER HAR OPDAGET EN RÆKKE MOLEKYLÆRE FORSKELLE MELLEM FUSOGENICAL OG IKKE-FUSOGENIKAL REOVIRUS. DISSE TO GRUPPER AF REOVIRUS ER MEGET ENS I DERES REPLIKATIONSSTRUKTURER OG -CYKLUSSER, MEN MEGET FORSKELLIGE I DERES PATOGENE KAPACITET. MENS IKKE-FUSOGENICOS VIRUS ER ALLESTEDSNÆRVÆRENDE VIRA, DER IKKE ER DIREKTE FORBUNDET MED SYGDOMME, ER DE FLESTE (HVIS IKKE ALLE) REOVIRUS VIGTIGE PATOGENER HOS FUGLE, PATTEDYR OG KRYBDYR. Vores OBJEKTIV er at afgøre, om de eksisterende Molekylære Differentiarer BETWEEN DET FUSOGENICAL reovirus OG NON-FUSOGENICOS er korreleret med de forskellige i deres PATOGENICITY._x000D_ FOR FUSOGENICAL reovirus GROUP vil vi udvikle en investeringsiv GENETIC METHOD TIL AVIARY reovirus, som repræsentanter for den FUSOGENICAL reovirus GROUP. For det vil vi støtte de forskellige strategier, der er blevet re-udviklet for mamiferous (MRV) og det blå sprog (BTV) VIRUS af Orbivirus GENERO Orbivirus, som også vedrører Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS OF Reovirus aviar (ARV) TIL STUDY THE POSSIBLE INFLUENCE TEDTADE MOLECULAR DIFFERENCES BETWEEN FUSOGENISKE OG NON-fusogenic VIRUS VIRUS VIRUS VIRUS VIRUS OG NON-FUSOGENICAL VIRUS VIRUS VIRAL REPLIKATIONER OG PHOTOGENCIALER I VITRO- OG SUSCEPTIBLE ANIMALS._x000D_ derudover haremos brug af vores PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROFUND TIL: I) INDHENTE VIGTIGE OPLYSNINGER OM DANNELSEN AF VIRUSFABRIKKER, DER FOREKOMMER UNDER ARV-INFEKTION; II) FORSØGE AT UDVIKLE ET NYT BEGREB FOR ANTIVIRALE MOLEKYLER (SOM KAN ANVENDES PÅ ANDRE VIRA), OG III) FORSØGE AT BESTEMME DEN TREDIMENSIONALE STRUKTUR AF MUNS PROTEIN. Den FORMATION AF VIRUS FABRICS eller viroplasmer inden for INFECTATED CELLS er et centralt punkt i VIRUS REPLICATION CICLE OG en KEY duiled DIANA for at forstyrre den Viric REPLICATION._x000D_ med alle de oplysninger, vi får, håber vi også at købe bedre SUTILES DETAILS AF VIRUS-celula INTERACTION, der dikterer perMISIVITY af en hårlinje (eller SPECIE) gør en VIRUS I PARTICULAR. FORSTÅELSE AF DISSE DETALJER SPILLER EN VIGTIG ROLLE I KAMPEN MOD VIRUSINFEKTIONER OG SPREDNING BLANDT ARTER. (Danish)
18 August 2022
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ERI VIRUSTEN VIIMEAIKAISET JA ODOTTAMATTOMAT TAUDINPURKAUKSET ERI PUOLILLA MAAILMAA OSOITTAVAT, ETTÄ ON TARPEEN YMMÄRTÄÄ PAREMMIN MEKANISMEJA, JOILLA VIRUKSET MUUTTAVAT ISÄNTÄALUEENSA JA/TAI PATOGEENISYYTENSÄ. ON MYÖS TARPEEN KEHITTÄÄ UUSIA MENETELMIÄ VIRUSINFEKTIOIDEN TORJUMISEKSI. RYHMÄMME JA MUUT TUTKIMUSRYHMÄT OVAT HAVAINNEET USEITA MOLEKYYLIEROJA FUSOGENICAL JA EI-FUSOGENICAL REOVIRUS. NÄMÄ KAKSI REOVIRUSRYHMÄÄ OVAT HYVIN SAMANKALTAISIA REPLIKAATIORAKENTEISSA JA -SYKLEISSÄÄN, MUTTA PATOGEENISESSÄ KAPASITEETISSAAN HYVIN ERILAISIA. VAIKKA FUSOGENICOS-VIRUKSET OVAT KAIKKIALLA ESIINTYVIÄ VIRUKSIA, JOTKA EIVÄT LIITY SUORAAN SAIRAUKSIIN, USEIMMAT (ELLEIVÄT KAIKKI) REOVIRUKSET OVAT TÄRKEITÄ LINTUJEN, NISÄKKÄIDEN JA MATELIJOIDEN PATOGEENEJÄ. Tavoitteemme on määrittää, ovatko olemassa olevat molekyylierot kasvaneet FUSOGENICAL reovirus ja NON-FUSOGENICOS korreloivat eri osapuolten kanssa niiden PATOGENICITY._x000D_ FUSOGENICAL reovirus GROUP me kehitämme investoiva GENETIC METHOD AVIARY reovirus, jotka edustavat FUSOGENICAL reovirus GROUP. Sen vuoksi tuemme erilaisia strategioita, jotka on kehitetty uudelleen mamiferous (MRV) ja sininen kieli (BTV) VIRUS Orbivirus GENERO Orbivirus, joka koskee myös Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS OF reovirus aviaari (ARV) STUDY THE POSSIBLE INFLUENCE OTTAA havaitun MOLECULAR DIFFERENTIAL VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUSVIRUS VIRUKSET JA NÄTÄÄNTÄMYKSET JA NÄIVÄT VIRUS-VIRUSVIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS I) SAADA TÄRKEÄÄ TIETOA ARV-INFEKTION AIKANA ESIINTYVIEN VIRUSTEHTAIDEN MUODOSTUMISPROSESSISTA; II) YRITTÄÄ KEHITTÄÄ UUSI KÄSITE ANTIVIRAALISIA MOLEKYYLEJÄ (JOTA VOIDAAN SOVELTAA MUIHIN VIRUKSIIN), JA III) YRITTÄÄ MÄÄRITTÄÄ KOLMIULOTTEINEN RAKENNE MUNS PROTEIINI. VIRUS FABRICS tai viroplasmat sisällä INFECTATED CELLS on keskeinen kohta VIRUS REPLICATION CICLE JA KEY dailed DIANA puuttua Viric REPLICATION._x000D_ kanssa kaikki tiedot saamme, toivomme myös ostaa paremmin SUTILES DETAILS VIRUS-celula INTERACTION, joka sanelee perMISIVITY hiusrajan (tai SPECIE) ODOES VIRUS IN PARTICULAR. NÄIDEN YKSITYISKOHTIEN YMMÄRTÄMISELLÄ ON TÄRKEÄ MERKITYS VIRUSTARTUNTOJEN TORJUNNASSA JA LAJIEN KESKUUDESSA LEVIÄMISESSÄ. (Finnish)
18 August 2022
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TIFQIGĦAT RIĊENTI U MHUX MISTENNIJA TA’ VIRUSES DIFFERENTI MADWAR ID-DINJA JURU L-ĦTIEĠA LI WIEĦED JIFHEM AĦJAR IL-MEKKANIŻMI LI BIHOM IL-VIRUSES JIBDLU L-FIRXA OSPITANTI TAGĦHOM U/JEW IL-PATOĠENIĊITÀ TAGĦHOM. HUWA WKOLL MEĦTIEĠ LI JIĠU ŻVILUPPATI METODI ĠODDA GĦALL-ĠLIEDA KONTRA L-INFEZZJONIJIET VIRIC. GRUPP TAGĦNA U GRUPPI OĦRA TA ‘RIĊERKA SABU NUMRU TA’ DIFFERENZI MOLEKULARI BEJN REOVIRUSES FUSOGENICAL U NON-FUSOGENICAL. DAWN IŻ-ŻEWĠ GRUPPI TA’ REOVIRUSES HUMA SIMILI ĦAFNA FL-ISTRUTTURI U Ċ-ĊIKLI TA’ REPLIKAZZJONI TAGĦHOM, IŻDA HUMA DIFFERENTI ĦAFNA FIL-KAPAĊITÀ PATOĠENIKA TAGĦHOM. GĦALHEKK, FILWAQT LI L-VAJRUSIS LI MHUMIEX FUSOGENICOS HUMA VAJRUSIS LI JINSABU KULLIMKIEN LI MHUMIEX ASSOĊJATI DIRETTAMENT MAL-MARD, IL-BIĊĊA L-KBIRA TAR-REOVIRUSES (JEKK MHUX KOLLHA) HUMA PATOĠENI IMPORTANTI TAL-GĦASAFAR, IL-MAMMIFERI U R-RETTILI. Objettiv tagħna IS li Determinazzjoni Jekk il-Differenza Molekulari Eżistenti QABEL-reovirus FUSOGENICAL U MHUX FUSOGENICOS humiex korrelatati mal-Differenti fil-PATOGENICITÀ tagħhom._x000D_ GĦALL-GROUP reovirus FUSOGENICAL aħna se tiżviluppa investive GENETICAL METHOD GĦAL reovirus AVIARY, AS rappreżentattivi tal-GROUP reovirus FUSOGENICAL. Għal dan se nappoġġaw l-istrateġiji differenti li ġew żviluppati mill-ġdid għall-mamferu (MRV) u l-VIRUS tal-Orbivirus GENERO Orbivirus (MRV) u l-lingwa blu (BTV) tal-Orbivirus Orbivirus, li jappartjeni wkoll għar-Reoviridae FAMILY._x000D_ USANDO GENETICA INversa CREAREM MUTANTS OF reovirus aviar (ARV) LI STUDJU L-INFLUZZJONI TAL-PARTIBBLI LI DIFFERENZA MOLECULAR osservata BETWEEN FUSGENICAL u VIRUS VIRUS mhux fenoġeniċi VIRUS VIRUS VIRUS u VIRUS FUSOĠIĊI MHUX VIRUS RIPLIKAZZJONI VIRALI U FOTOĠENZJALI FIL-VITRO U L-ANNIMALI SUSCEPTIBLE._x000D_ użu ta’ haremos b’mod addizzjonali ta’ PROTEINA PROTEINA TA’ PROTEINA ARV PROTEINA PROTEIN PROTEINA PROTEINA PROTEINA PROTEINA għal: I) JIKSBU INFORMAZZJONI IMPORTANTI DWAR IL-PROĊESS TA’ FORMAZZJONI TAL-FABBRIKI TAL-VIRUS LI JSEĦĦU WAQT L-INFEZZJONI ARV; II) TIPPROVA TIŻVILUPPA KUNĊETT ĠDID TA ‘MOLEKULI ANTIVIRALI (LI JISTGĦU JIĠU APPLIKATI GĦAL VIRUSES OĦRA), U III) JIPPRUVAW JIDDETERMINAW L-ISTRUTTURA TRIDIMENSJONALI TAL-PROTEINA MUNS. Il-FORMAZZJONI TAL-FABRICS VIRUS jew il-viroplażmi fi ħdan il-KELLs INFECTATED hija punt ċentrali taċ-Ċiklju tar-REPLIKAZZJONI VIRUS U A DIANA dailed għall jinterferixxu mal-RIPLIKAZZJONI Viric._x000D_ bl-informazzjoni kollha li niksbu, nittamaw ukoll li jixtru aħjar id-DETTALJI SUTILI TAL-INTERACTION VIRUS-celula li tiddetta l-perMISIVITÀ ta’ linja tax-xagħar (jew SPECIE) DOES A VIRUS INARTICULICAR. IL-FEHIM TA’ DAWN ID-DETTALJI GĦANDU RWOL IMPORTANTI FIL-ĠLIEDA KONTRA L-INFEZZJONIJIET TAL-VIRUS U T-TIXRID FOST L-ISPEĊIJIET. (Maltese)
18 August 2022
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NESENIE UN NEGAIDĪTIE DAŽĀDU VĪRUSU UZLIESMOJUMI VISĀ PASAULĒ LIECINA PAR NEPIECIEŠAMĪBU LABĀK IZPRAST MEHĀNISMUS, AR KURIEM VĪRUSI MAINA SAIMNIEKORGANISMA DIAPAZONU UN/VAI PATOGENITĀTI. IR NEPIECIEŠAMS ARĪ IZSTRĀDĀT JAUNAS METODES, LAI APKAROTU VĪRUSU INFEKCIJAS. MŪSU GRUPA UN CITAS PĒTNIECĪBAS GRUPAS IR KONSTATĒJUŠAS VAIRĀKAS MOLEKULĀRĀS ATŠĶIRĪBAS STARP FUSOGENICAL UN NE-FUSOGENICAL REOVĪRUSIEM. ŠĪS DIVAS REOVĪRUSU GRUPAS IR ĻOTI LĪDZĪGAS REPLIKĀCIJAS STRUKTŪRĀS UN CIKLOS, BET ĻOTI ATŠĶIRĪGAS PĒC TO PATOGĒNĀS KAPACITĀTES. TĀDĒJĀDI, LAI GAN NE-FUSOGENICOS VĪRUSI IR VISURESOŠI VĪRUSI, KAS NAV TIEŠI SAISTĪTI AR SLIMĪBĀM, LIELĀKĀ DAĻA (JA NE VISI) REOVĪRUSI IR SVARĪGI PUTNU, ZĪDĪTĀJU UN RĀPUĻU PATOGĒNI. Mūsu MĒRĶIS ir noteikt, vai esošie molekulārās diferenciācijas BETWEEN FUSOGENICAL reovirus AND NON-FUSOGENICOS ir saistīti ar diferentiem to PATOGENICITY._x000D_ For The FUSOGENICAL reovirus GROUP mēs izstrādāsim ieguldījumu GENETIC METHOD AVIARY reovirus, kas pārstāv FUSOGENICAL reovirus GROUP. Par to mēs atbalstīsim dažādas stratēģijas, kas ir atkārtoti izstrādātas mamiferous (MRV) un zilās valodas (BTV) VIRUS Orbivirus GENERO Orbivirus, kas attiecas arī uz Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS of reovirus aviar (ARV) lai STUDY POSSIBLE INFLUENCE, ka novērotās MOLECULAR DIFFERENCES BETWEEN FUSOGENICAL UN NON-fuzogēnās VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRAL REPLIKĀCIJAS UN FOTOGENCIALS VITRO UN SUSCEPTIBLE ANIMALS._x000D_ papildus haremos lietošana mūsu PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROFUND: I) IEGŪT SVARĪGU INFORMĀCIJU PAR VĪRUSA RŪPNĪCU VEIDOŠANĀS PROCESU ARV INFEKCIJAS LAIKĀ; II) MĒĢINĀT IZSTRĀDĀT JAUNU KONCEPCIJU PRETVĪRUSU MOLEKULAS (KAS VAR PIEMĒROT CITIEM VĪRUSIEM), UN III) MĒĢINĀT NOTEIKT TRĪSDIMENSIJU STRUKTŪRU MUNS PROTEĪNU. VIRUS FABRICS jeb viroplasms FORMATION ietvaros INFECTATED CELLS ir centrālais punkts VIRUS REPLICATION CICLE UN KEY dailed DIANA, lai traucētu Viric REPLICATION._x000D_ ar visu informāciju, ko mēs iegūstam, mēs arī ceram labāk iegādāties VIRUS-celula INTERACTION SUTILES DETAILS, kas diktē matu līnijas (vai SPECIE) perMISIVITY DOES A VIRUS PARTIKULĀ. ŠO DETAĻU IZPRATNEI IR SVARĪGA NOZĪME CĪŅĀ PRET VĪRUSU INFEKCIJĀM UN IZPLATĪŠANOS STARP SUGĀM. (Latvian)
18 August 2022
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NEDÁVNE A NEOČAKÁVANÉ PREPUKNUTIA RÔZNYCH VÍRUSOV NA CELOM SVETE ILUSTRUJÚ POTREBU LEPŠIE POCHOPIŤ MECHANIZMY, KTORÝMI VÍRUSY MENIA ROZSAH ICH HOSTITEĽOV A/ALEBO ICH PATOGENITU. JE TIEŽ POTREBNÉ VYVINÚŤ NOVÉ METÓDY NA BOJ PROTI VÍRUSOVÝM INFEKCIÁM. NAŠA SKUPINA A ĎALŠIE VÝSKUMNÉ SKUPINY ZISTILI MNOŽSTVO MOLEKULÁRNYCH ROZDIELOV MEDZI FUSOGENICAL A NON-FUSOGENICAL REOVÍRUSMI. TIETO DVE SKUPINY REOVÍRUSOV SÚ VEĽMI PODOBNÉ VO SVOJICH REPLIKAČNÝCH ŠTRUKTÚRACH A CYKLOCH, ALE VEĽMI ODLIŠNÉ VO SVOJEJ PATOGÉNNEJ KAPACITE. ZATIAĽ ČO VÍRUSY NON-FUSOGENICOS SÚ VŠADEPRÍTOMNÉ VÍRUSY, KTORÉ NIE SÚ PRIAMO SPOJENÉ S CHOROBAMI, VÄČŠINA (AK NIE VŠETKY) REOVÍRUSY SÚ DÔLEŽITÝMI PATOGÉNMI VTÁKOV, CICAVCOV A PLAZOV. Náš OBJECTÍM je určiť, či existujúce molekulové rozdiely BETWEEN FUSOGENICAL reovirus a NON-FUSOGENICOS sú korelované s rôznymi v ich PATOGENICITY._x000D_ pre FUSOGENICAL reovirus GROUP budeme vyvíjať investive GENETICKÉ METHOD pre AVIARY reovírus, ako zástupcovia FUSOGENICAL reovirus GROUP. Za to budeme podporovať rôzne stratégie, ktoré boli znovu vyvinuté pre mamiferous (MRV) a modrý jazyk (BTV) VIRUS Orbivirus GENERO Orbivirus, ktorý sa vzťahuje aj na Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS of reovirus aviar (ARV) ŠTUDY POSSIBLE INFLUENCE, že pozorované MOLECULARAR DIFFERENCES BETWEEN FUSGENICAL A NON-fusogénne VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS A NON-FUSGENICAL VIRUS VIRUS VIRUS VIRUS VIRAL REPLIKÁCIE A FOTOGENCIALS VITRO A PUSCEPTIBLE ANIMALS._x000D_ okrem toho použitie nášho PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROFUND FOR: I) ZÍSKAŤ DÔLEŽITÉ INFORMÁCIE O PROCESE TVORBY VÍRUSOVÝCH TOVÁRNÍ, KTORÉ SA VYSKYTUJÚ POČAS INFEKCIE ARV; II) POKÚSIŤ SA VYVINÚŤ NOVÚ KONCEPCIU ANTIVÍRUSOVÝCH MOLEKÚL (KTORÉ MÔŽU BYŤ APLIKOVANÉ NA INÉ VÍRUSY) A III) POKÚSIŤ SA URČIŤ TROJROZMERNÚ ŠTRUKTÚRU MUNS PROTEÍNU. FORMATION OF VIRUS FABRICS alebo viroplazmy v rámci INFECTATED CELLS je ústredným bodom VIRUS REPLICATION CICLE A KEY dailed DIANA pre zasahovanie do Viric REPLICATION._x000D_ so všetkými informáciami, ktoré získame, tiež dúfame, že lepšie nakupujeme SUTILES DETAILS OF THE VIRUS-celula INTERACTION, ktorá diktuje perMISIVITY vlasovej čiary (alebo SPECIE) VIRUS-Celula INTERACTION, ktorá diktuje perMISIVITY vlasovej línie (alebo SPECIE) VIRUS IN PARTICULÁLNE. POCHOPENIE TÝCHTO DETAILOV ZOHRÁVA DÔLEŽITÚ ÚLOHU V BOJI PROTI VÍRUSOVÝM INFEKCIÁM A ŠÍRENIU MEDZI DRUHMI. (Slovak)
18 August 2022
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LÉIRÍONN RÁIGEANNA LE DÉANAÍ AGUS GAN CHOINNE VÍRIS ÉAGSÚLA AR FUD AN DOMHAIN AN GÁ ATÁ LE TUISCINT NÍOS FEARR AR NA MEICNÍOCHTAÍ TRÍNA N-ATHRAÍONN VÍRIS A RAON ÓSTACH AGUS/NÓ A BPATAIGINEACHT. IS GÁ FREISIN MODHANNA NUA A FHORBAIRT CHUN IONFHABHTUITHE VIRIC A CHOMHRAC. TÁ ROINNT DIFRÍOCHTAÍ MÓILÍNEACHA AIMSITHE AG ÁR NGRÚPA AGUS AG GRÚPAÍ TAIGHDE EILE IDIR FUSOGENICAL AGUS REOVIRUSES NEAMH-FUSOGENICAL. TÁ AN DÁ GHRÚPA ATHVÍREAS SEO AN-CHOSÚIL LENA STRUCHTÚIR MACASAMHLAITHE AGUS LENA DTIMTHRIALLTA, ACH TÁ SIAD AN-DIFRIÚIL INA GCÁIL PHATAIGINEACH. DÁ BHRÍ SIN, CÉ GUR VÍRIS UILELÁITHREACHA IAD VÍRIS NEAMH-FUSOGENICOS NACH MBAINEANN GO DÍREACH LE GALAIR, IS PATAIGINÍ TÁBHACHTACHA D’ÉIN, DE MHAMAIGH AGUS DE REIPTÍLÍ IAD FORMHÓR NA N-ATHVÍREAS (MURA BHFUIL SIAD GO LÉIR). Is é ár OBJECTIVE a chinneadh Cibé an bhfuil na difríochtaí móilíneacha atá ann faoi láthair BETWEENENENENENEN An bhfuil an t-athvíreas FUSOGENICAL AGUS NON-FUSOGENICOS comhghaolaithe leis na difríochtaí ina PATOGENICITY._x000D_ le haghaidh GROUP FUSOGENICAL reovirus forbrófar METHOD INVESTIVE GENETIC le haghaidh athvíreas éanúil, chomh maith le hionadaithe de chuid GROUP Úslaivíreas FUSOGENICAL. Chun é beidh muid ag tacú leis na straitéisí éagsúla a ath-fhorbairt le haghaidh mamiferous (MRV) agus an teanga gorm (BTV) VIRUS de Orbivirus Genero Orbivirus Orbivirus, a bhaineann chomh maith leis an Reoviridae FAMILY._x000D_ usando Géiniteacha inversa CREAREM MUTANTS OF reovirus AVIAR (ARV) LE STUDY AN INFLUENCE POSSIBLE GO bhfuil an MOLECULAR DIFERERENCE BETWENCE BETWEENS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS agus VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VRUSICUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUSENUS VIRUS VIRUS VIRUS VIRUS agus NON-FUSIGIÚIL VIRUS VIRUS VIRUS VIRUS VIRUS VRUSIGIÚIL VIRUS agus NON-fusigineach VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VRUSRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS agus NON-FUSIGIÚNACH VIRUS VIRUS VIRUS VIRUS VIRUS agus NEAMHNEAÍOCHTA VIRUS VIRUS VIRUS VIRUS VIRUS VIRUSAS VIRUS VIRUS agus NON-FUSIGIÚILIÚILIÚILIÚILIÚILIÚILIÚILIÚIL AGUS NEAMHDÚSANTAÍOCHTAÍ VIRUSeachtaithe VIRUSÍOCHTAÍ VIRUSÍOCHTAÍ VIRUSÍOCHTA agus NEASAÍOCHTAÍ VIR I) FAISNÉIS THÁBHACHTACH A FHÁIL MAIDIR LE PRÓISEAS FOIRMITHE NA MONARCHANA VÍREAS A THARLAÍONN LE LINN IONFHABHTÚ ARV; II) IARRACHT A FHORBAIRT COINCHEAP NUA MÓILÍNÍ ANTIVIRAL (A FHÉADFAR A CHUR I BHFEIDHM AR VÍRIS EILE), AGUS III) IARRACHT A CHINNEADH AN STRUCHTÚR TRÍTHOISEACH AN PRÓITÉIN MUNS. Is é an FORMATION FABRICS VIRUS nó viroplasms laistigh de na CELLS INFECTATED pointe lárnach de na CICLE REPLICATION VIRUS AGUS A DIANA DAILED EOCHAIR chun cur isteach ar an REPLICATION VIRIC._x000D_ leis an fhaisnéis go léir a fháil againn, tá súil againn freisin a cheannach níos fearr ar an Déileálann SUTILES AN VIRUS-Celula INTERACTION a dictates an perMISIVITY de hairline (nó SPECIE) DOES A VIRUS IN CÚRSAÍ. TÁ RÓL TÁBHACHTACH AG TUISCINT NA SONRAÍ SEO SA CHOMHRAC I GCOINNE IONFHABHTUITHE VÍREAS AGUS LEATHADH I MEASC SPEICEAS. (Irish)
18 August 2022
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NEDÁVNÁ A NEOČEKÁVANÁ OHNISKA RŮZNÝCH VIRŮ NA CELÉM SVĚTĚ UKAZUJÍ, ŽE JE TŘEBA LÉPE POROZUMĚT MECHANISMŮM, JIMIŽ VIRY MĚNÍ JEJICH ROZSAH A/NEBO PATOGENITU. JE TAKÉ NUTNÉ VYVINOUT NOVÉ METODY BOJE PROTI VIROVÝM INFEKCÍM. NAŠE SKUPINA A DALŠÍ VÝZKUMNÉ SKUPINY ZJISTILY ŘADU MOLEKULÁRNÍCH ROZDÍLŮ MEZI FUSOGENICAL A NON-FUSOGENICAL REOVIRUSY. TYTO DVĚ SKUPINY REOVIRŮ JSOU VELMI PODOBNÉ V JEJICH REPLIKAČNÍCH STRUKTURÁCH A CYKLECH, ALE VELMI ODLIŠNÉ, POKUD JDE O JEJICH PATOGENNÍ KAPACITU. TAKŽE ZATÍMCO JINÉ NEŽ FUSOGENICOS VIRY JSOU VŠUDYPŘÍTOMNÉ VIRY, KTERÉ NEJSOU PŘÍMO SPOJENY S CHOROBAMI, VĚTŠINA (POKUD NE VŠECHNY) REOVIRY JSOU DŮLEŽITÝMI PATOGENY PTÁKŮ, SAVCŮ A PLAZŮ. Náš OBJEKTIVE je určit, zda stávající molekulární diferenciály BETWEEN THE FUSOGENICAL reovirus A NON-FUSOGENICOS jsou korelovány s rozdílnými v jejich PATOGENICITY._x000D_ Pro FUSOGENICKÝ reovirus GROUP vyvineme investující GENETICKOU METHOD pro AVIARY reovirus, AS reprezentanty FUSOGENICAL reovirus GROUP. Pro to budeme podporovat různé strategie, které byly nově vyvinuty pro mamiferous (MRV) a modrý jazyk (BTV) VIRUS orbivirus GENERO Orbivirus, který se týká také Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS OF reovirus aviar (ARV) STUDY POSSIBLE INFLUENCE, že pozorované MOLECULAR DIFFERENCES VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS I) ZÍSKAT DŮLEŽITÉ INFORMACE O PROCESU TVORBY VIROVÝCH TOVÁREN, KTERÉ SE VYSKYTUJÍ BĚHEM INFEKCE ARV; II) POKUSIT SE VYVINOUT NOVÝ KONCEPT ANTIVIROVÝCH MOLEKUL (KTERÉ MOHOU BÝT APLIKOVÁNY NA JINÉ VIRY), A III) POKUSIT SE URČIT TROJROZMĚRNOU STRUKTURU PROTEINU MUNS. Formace VIRUS FABRICS nebo viroplazmů v rámci INFECTATED CELLS je ústředním bodem VIRUS REPLICATION CICLE A KEY kvetená DIANA pro zasahování do Viric REPLICATION._x000D_ se všemi informacemi, které získáme, také doufáme, že koupit lépe SUTILES DETAILS VIRUS-celula INTERACTION, který diktuje perMISIVITY vlasové linky (nebo SPECIE) dělá VIRUS-celula INTERACTION, která diktuje perMISIVITY vlasové linky (nebo SPECIE) dělá VIRUS VARTICULAR. POCHOPENÍ TĚCHTO DETAILŮ HRAJE DŮLEŽITOU ROLI V BOJI PROTI VIROVÝM INFEKCÍM A ŠÍŘENÍ MEZI DRUHY. (Czech)
18 August 2022
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RECENTES E NÃO EXPECIDAS RESULTADOS DE DIFERENTES VÍRUS EM TODO O MUNDO ILUSTRAM A NECESSIDADE DE COMPREENDER MELHOR OS MECANISMOS PELOS QUAIS OS VÍRUS ALTERAM A SUA GANHA DE Acolhimento E/OU A SUA PATOGENICIDADE. É igualmente necessário desenvolver novos métodos para combater as infecções víricas. O NOSSO GRUPO E OUTROS GRUPOS DE INVESTIGAÇÃO DETETARAM UM NÚMERO DE DIFERENÇAS MOLECULARES ENTRE REOVÍRIOS FUSOGENICOS E NÃO FUSOGENICOS. Estes dois grupos de repetições são muito semelhantes nas suas estruturas e nos seus ciclos de replicação, mas muito diferentes na sua capacidade patogénica. Assim, embora os vírus não fusogenicos sejam vírus ubíquos que não estão diretamente associados a doenças, a maioria (se não todos) dos surtos são importantes para as aves, os mamíferos e os reprodutores. O nosso OBJETIVO é determinar se os Diferenças Moleculares Existentes ENTRE O REOVÍRIO FUSOGENICO E O NÃO-FUSOGENICO estão correlacionados com os Diferentes na sua PATOGENICIDADE._x000D_ Para o GRUPO REOVÍRIO FUSOGENICO, desenvolveremos um MÉTODO GENÉTICO INVESTIVO PARA O REOVÍRIO AVIÁRIO, como REPRESENTANTES DO GRUPO REOVÍRIO FUSOGENICO. Para isso, apoiaremos as diferentes estratégias que foram re-desenvolvidas para o vírus mamífero (MRV) e o vírus da língua azul (BTV) do ORBIVIRUS GENERO ORBIVIRUS, que também pertence à família REOVIRIDAE._x000D_ USANDO GENETICA INVERSA CREAREM MUTANTES DO AVIAR REOVIRUS (ARV) para estudar a possível influência que as diferenças moleculares observadas entre as diferenças entre o Vírus Vírus FUSOGENICAL e não-FUSOGENIC VIRUS VIRUS VIRUS e o Vírus Vírus não-FUSOGENICO VIRUS VIRUS VIRUS VIRUS VIRUS PROPLICAÇÕES E PROFINTE PHOTOGENCIALS EM ANIMALS VITROS E SUSCEPTÍVEIS._x000D_ ADDITION HOSEMLY UTILIZAÇÃO DO PROFITO VIRINTE: I) OBTER INFORMAÇÕES IMPORTANTES SOBRE O PROCESSO DE FORMAÇÃO DAS FACTORIAS DE VÍRUS QUE REALIZAM DURANTE A INFEÇÃO ARV; II) Tentar desenvolver um novo conceito de moléculas antivirais (que podem ser aplicadas a outros vírus), e III) tentar determinar a estrutura tridimensional da proteína das mulheres. A FORMAÇÃO DE TECIDOS VÍRUS ou viroplasmas dentro das CÉLULAS INFECTADAS é um ponto central do CICLO DE REPLICAÇÃO VÍRUS E UM DIANA DIÁLIDO-CHAVE por interferir com a REPLICAÇÃO VÍRICA._x000D_ com todas as informações que obtemos, também esperamos comprar melhor os SUTILES DETALHES DA INTERACÇÃO VÍRUS-CELULA que dita a perMISIVIDADE de um hairline (ou ESPECIE) FAZ UM VÍRUS EM PARTICULAR. Compreender estes detalhes joga um papel importante na luta contra as infecções por vírus e espalhou-se entre as espécies. (Portuguese)
18 August 2022
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HILJUTISED JA OOTAMATUD ERI VIIRUSTE PUHANGUD KOGU MAAILMAS NÄITAVAD VAJADUST PAREMINI MÕISTA MEHHANISME, MILLE ABIL VIIRUSED MUUDAVAD OMA PEREMEESORGANISMI LEVIALA JA/VÕI PATOGEENSUST. SAMUTI ON VAJA VÄLJA TÖÖTADA UUED MEETODID VIRIC’I INFEKTSIOONIDE VASTU VÕITLEMISEKS. MEIE GRUPP JA TEISED UURIMISRÜHMAD ON AVASTANUD MITMEID MOLEKULAARSEID ERINEVUSI FUSOGENICAL JA MITTE-FUSOGENICAL REOVIIRUSTE VAHEL. NEED KAKS REOVIIRUSTE RÜHMA ON REPLIKATSIOONISTRUKTUURIDES JA -TSÜKLITES ÄÄRMISELT SARNASED, KUID PATOGEENSETE VÕIMETE POOLEST VÄGA ERINEVAD. SEEGA, KUIGI FUSOGENICOSE VIIRUSED ON ÜLDLEVINUD VIIRUSED, MIS EI OLE OTSESELT SEOTUD HAIGUSTEGA, ON ENAMIK (KUI MITTE KÕIK) REOVIIRUSI OLULISED LINDUDE, IMETAJATE JA ROOMAJATE PATOGEENID. Meie OBJEKTIIV on kindlaks teha, kas olemasolevad molekulaardiferentsiaalid BETWEEN the FUSOGENICAL reoviirus JA NON-FUSOGENICOS on korrelatsioonis nende PATOGENICITY._x000D_ FOR the FUSOGENICAL reovirus GROUP’iga. Me töötame välja investeeriva GENETICIC METHOD AVIARY reoviirus, AS esindavad FUSOGENICAL reoviirus GROUP. Me toetame erinevaid strateegiaid, mis on uuesti välja töötatud mamiferous (MRV) ja sinine keel (BTV) VIRUS Orbivirus GENERO Orbivirus, mis puudutab ka Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS of reovirus aviar (ARV) STUDYLE INFLUENCE, et täheldatud MOLECULAR DIFFERENCES BETWEEN FUSOGENICAL JA NON-fusogeensed VIRUS VIRUS VIRUS VIRUSVIRUS JA NON-FUSOGENICALALID VIRUS VIRUS VIRELIKATSIOONID JA HOTOGENCIALID VITRO JA SUSCEPTIBLE ANIMALS._x000D_ lisaks haremoseerib oma PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROFUND PROFUND: I) SAADA OLULIST TEAVET VIIRUSVABRIKUTE TEKKEPROTSESSI KOHTA ARV-INFEKTSIOONI AJAL; II) PROOVIGE VÄLJA TÖÖTADA VIIRUSEVASTASTE MOLEKULIDE UUS KONTSEPTSIOON (MIDA VÕIB RAKENDADA KA TEISTELE VIIRUSTELE) JA III) PROOVIGE MÄÄRATA MUNI VALGU KOLMEMÕÕTMELIST STRUKTUURI. VIRUS FABRICS-ide või viroplasmade vorm INFECTATED CELLS-is on VIRUS REPLIKATSIOONI JA KEY dailed DIANA keskne punkt sekkumiseks Viric REPLICATION._x000D_ kogu informatsiooniga, mida me saame, loodame ka osta paremini VIRUS-celula INTERACTION’i SUTILES DETAILS, mis dikteerib juukseliini (või SPECIE) perMISIVITY, mis dikteerib juukseliini (või SPECIE) PARTICULAR’i VIRUSED. NENDE ÜKSIKASJADE MÕISTMINE MÄNGIB OLULIST ROLLI VÕITLUSES VIIRUSNAKKUSTE JA LIIKIDE VAHEL LEVIMISE VASTU. (Estonian)
18 August 2022
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A VILÁG KÜLÖNBÖZŐ VÍRUSAINAK KÖZELMÚLTBELI ÉS VÁRATLAN KITÖRÉSEI JÓL ILLUSZTRÁLJÁK ANNAK SZÜKSÉGESSÉGÉT, HOGY JOBBAN MEGÉRTSÜK AZOKAT A MECHANIZMUSOKAT, AMELYEKKEL A VÍRUSOK MEGVÁLTOZTATJÁK GAZDATEST-TARTOMÁNYUKAT ÉS/VAGY PATOGENITÁSUKAT. ÚJ MÓDSZEREKET KELL KIDOLGOZNI A VIRIC FERTŐZÉSEK LEKÜZDÉSÉRE IS. CSOPORTUNK ÉS MÁS KUTATÓCSOPORTOK SZÁMOS MOLEKULÁRIS ELTÉRÉST ÉSZLELTEK A FUSOGENICAL ÉS A NEM FUSOGENICAL REOVÍRUSOK KÖZÖTT. A REOVÍRUSOK E KÉT CSOPORTJA RENDKÍVÜL HASONLÓ REPLIKÁCIÓS STRUKTÚRÁIKBAN ÉS CIKLUSAIKBAN, DE PATOGÉN KÉPESSÉGÜKBEN NAGYON ELTÉRŐ. ÍGY MÍG A NEM FUSOGENICOS VÍRUSOK MINDENÜTT JELEN LÉVŐ VÍRUSOK, AMELYEK NEM KAPCSOLÓDNAK KÖZVETLENÜL A BETEGSÉGEKHEZ, A LEGTÖBB (HA NEM AZ ÖSSZES) REOVÍRUS A MADARAK, EMLŐSÖK ÉS HÜLLŐK FONTOS KÓROKOZÓI. Célunk annak meghatározása, hogy a létező molekuláris különbségek a FUSOGENICAL reovírus és a NON-FUSOGENICOS között korrelálnak-e a különbözőekkel a PATOGENICITY-ben._x000D_ A FUSOGENICAL reovírus csoport számára egy befektetéses GENETIC Módszert fejlesztünk ki az AVIARY reovírus számára, mint a FUSOGENICAL reovirus csoport reprezentánsait. Ehhez támogatjuk azokat a különböző stratégiákat, amelyeket a mamiferous (MRV) és az Orbivirus GENERO Orbivirus kéknyelvű (BTV) VIRUSa számára fejlesztettek ki, amely a Reoviridae FAMILY-ra is vonatkozik._x000D_ USANDO GENETICA inversa CREAREM MUTANTS OF reovirus aviar (ARV) A POSSIBLE INFLUENCE-hez, amely a megfigyelt MOLECULAR DIFFERENCES-hez is kapcsolódik. BETWEEN FUSOGENICAL ÉS NON-fuzogén VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS ÉS NON FUSOGENIKAI VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS I) FONTOS INFORMÁCIÓKAT SZEREZ AZ ARV-FERTŐZÉS SORÁN ELŐFORDULÓ VÍRUSGYÁRAK KÉPZŐDÉSI FOLYAMATÁRÓL; II) PRÓBÁLJA KIFEJLESZTENI EGY ÚJ KONCEPCIÓ ANTIVIRÁLIS MOLEKULÁK (AMI ALKALMAZHATÓ MÁS VÍRUSOK), ÉS III) PRÓBÁLJA MEGHATÁROZNI A HÁROMDIMENZIÓS SZERKEZETE A MUNS FEHÉRJE. A VIRUS FABRICS vagy a viroplasmák FORMÁJA az INFECTATED CELLS-en belül a VIRUS REPLICATION CICLE és a KEY dailed DIANA központi pontja a Viric REPLICATION._x000D_ minden megszerzett információval, azt is reméljük, hogy jobban megvásároljuk a VIRUS-celula INTERACTION SUTILES DETAILS-t, amely diktálja a hajvonal (vagy SPECIE) perMISIVITY-ját a VIRUS-celulában. E RÉSZLETEK MEGÉRTÉSE FONTOS SZEREPET JÁTSZIK A VÍRUSFERTŐZÉSEK ELLENI KÜZDELEMBEN ÉS A FAJOK KÖZÖTTI TERJEDÉSBEN. (Hungarian)
18 August 2022
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НЕОТДАВНАШНИТЕ И НЕОЧАКВАНИ ОГНИЩА НА РАЗЛИЧНИ ВИРУСИ ПО СВЕТА ИЛЮСТРИРАТ НЕОБХОДИМОСТТА ОТ ПО-ДОБРО РАЗБИРАНЕ НА МЕХАНИЗМИТЕ, ЧРЕЗ КОИТО ВИРУСИТЕ ПРОМЕНЯТ ОБХВАТА СИ И/ИЛИ ПАТОГЕННОСТТА СИ. НЕОБХОДИМО Е СЪЩО ТАКА ДА СЕ РАЗРАБОТЯТ НОВИ МЕТОДИ ЗА БОРБА С ВИРУСНИТЕ ИНФЕКЦИИ. НАШАТА ГРУПА И ДРУГИ ИЗСЛЕДОВАТЕЛСКИ ГРУПИ СА ОТКРИЛИ РЕДИЦА МОЛЕКУЛЯРНИ РАЗЛИКИ МЕЖДУ FUSOGENICAL И НЕ-FUSOGENICAL REOVIRUSES. ТЕЗИ ДВЕ ГРУПИ РЕОВИРУСИ СА ИЗКЛЮЧИТЕЛНО СХОДНИ В ТЕХНИТЕ РЕПЛИКАЦИОННИ СТРУКТУРИ И ЦИКЛИ, НО МНОГО РАЗЛИЧНИ ПО СВОЯ ПАТОГЕНЕН КАПАЦИТЕТ. ПО ТОЗИ НАЧИН, ДОКАТО НЕ-FUSOGENICOS ВИРУСИ СА ПОВСЕМЕСТНИ ВИРУСИ, КОИТО НЕ СА ПРЯКО СВЪРЗАНИ СЪС ЗАБОЛЯВАНИЯ, ПОВЕЧЕТО (АКО НЕ ВСИЧКИ) РЕОВИРУСИ СА ВАЖНИ ПАТОГЕНИ НА ПТИЦИ, БОЗАЙНИЦИ И ВЛЕЧУГИ. Нашата OBJECTIVE е да се определи дали съществуващите молекулярни диференциали МЕЖДУ ФУСОГЕНИКАЛЕН реовирус И NON-FUSOGENICOS са свързани с различните в тяхната PATOGENICITY._x000D_ За ФУСОГЕНИКАЛНИЯ реовирус ГРУП ние ще разработим инвестиционен GENETIC METHOD FOR AVIARY reovirus, като представители на FUSOGENIC Reovirus GROUP. За него ще подкрепим различните стратегии, които са били разработени повторно за бозайниците (MRV) и синия език (BTV) VIRUS на Orbivirus GENERO Orbivirus, който също се отнася до Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS OF reovirus aviar (ARV), за да устои на POSSIBLE INFLUENCE, че наблюдаваните MOLECULAR DIFFERENCES BETWEEN FUSOGENICAL И NON-fusogenic VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS И NON-FUSOGENICAL VIRUS VIRUS VIRAL REPLICATIONS AND PHOTOGENCIALS IN VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIR И) ПОЛУЧАВАНЕ НА ВАЖНА ИНФОРМАЦИЯ ЗА ПРОЦЕСА НА ОБРАЗУВАНЕ НА ЗАВОДИТЕ ЗА ВИРУСИ, КОИТО ВЪЗНИКВАТ ПО ВРЕМЕ НА ИНФЕКЦИЯТА С АРВ; II) СЕ ОПИТВАТ ДА РАЗРАБОТЯТ НОВА КОНЦЕПЦИЯ ЗА АНТИВИРУСНИ МОЛЕКУЛИ (КОИТО МОГАТ ДА СЕ ПРИЛАГАТ КЪМ ДРУГИ ВИРУСИ), И III) СЕ ОПИТВАТ ДА ОПРЕДЕЛЯТ ТРИИЗМЕРНАТА СТРУКТУРА НА ПРОТЕИНА НА MUNS. ФОРМАЦИЯ НА VIRUS FABRICS или вироплазми в рамките на INFECTATED CELLS е централна точка на VIRUS REPLICATION CICLE AND A KEY dailed DIANA за намеса в Viric REPLICATION._x000D_ с цялата информация, която получаваме, ние също се надяваме да купим по-добре СЛУЖБИТЕ НА ВИРУС-целула ИНТЕРАКЦИЯ, която диктува perMISIVITY на линия за коса (или SPECIE) Прави VIRUS в PARTICULAR. РАЗБИРАНЕТО НА ТЕЗИ ПОДРОБНОСТИ ИГРАЕ ВАЖНА РОЛЯ В БОРБАТА СРЕЩУ ВИРУСНИТЕ ИНФЕКЦИИ И СЕ РАЗПРОСТРАНЯВА СРЕД ВИДОВЕТЕ. (Bulgarian)
18 August 2022
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NESENI IR NETIKĖTI ĮVAIRIŲ VIRUSŲ PROTRŪKIAI VISAME PASAULYJE RODO, KAD REIKIA GERIAU SUPRASTI MECHANIZMUS, KURIAIS VIRUSAI KEIČIA VIRUSO ŠEIMININKO DIAPAZONĄ IR (ARBA) PATOGENIŠKUMĄ. TAIP PAT BŪTINA SUKURTI NAUJUS KOVOS SU VIRUSINĖMIS INFEKCIJOMIS METODUS. MŪSŲ GRUPĖ IR KITOS MOKSLINIŲ TYRIMŲ GRUPĖS APTIKO KELETĄ MOLEKULINIŲ SKIRTUMŲ TARP FUSOGENICAL IR NE FUSOGENICAL REOVIRUSŲ. ŠIOS DVI REOVIRUSŲ GRUPĖS YRA LABAI PANAŠIOS SAVO REPLIKACIJOS STRUKTŪROSE IR CIKLUOSE, TAČIAU LABAI SKIRIASI JŲ PATOGENINIU PAJĖGUMU. TAIGI, NORS NE FUSOGENICOS VIRUSAI YRA VISUR ESANTYS VIRUSAI, KURIE NĖRA TIESIOGIAI SUSIJĘ SU LIGOMIS, DAUGUMA (JEI NE VISI) REOVIRUSŲ YRA SVARBŪS PAUKŠČIŲ, ŽINDUOLIŲ IR ROPLIŲ PATOGENAI. Mūsų TIKSLAS yra nustatyti, ar egzistuojantys molekuliniai skirtumai yra susiję su FUSOGENICAL reovirusas ir NON-FUSOGENICOS yra susiję su skirtingais jų PATOGENICITY._x000D_ FUSOGENICAL reovirus GROUP, mes sukursime investicinį GENETINĖS METODĄ AVIARY reovirusui, kaip FUSOGENICAL reoviruso grupės atstovai. Už tai mes remsime įvairias strategijas, kurios buvo perkurtos mamiferous (MRV) ir mėlynosios kalbos (BTV) Orbivirus GENERO Orbivirus VIRUS, kuris taip pat yra susijęs su Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS REOvirus AVIAR (ARV) SUTIKITI POSSIBLE INFLUENCE, KAD pastebėtas MOLECULAR DIFFERENCES VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUSOGENINĖS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIR I) GAUTI SVARBIOS INFORMACIJOS APIE VIRUSO GAMYKLŲ SUSIDARYMO PROCESĄ ARV INFEKCIJOS METU; II) PABANDYKITE SUKURTI NAUJĄ ANTIVIRUSINIŲ MOLEKULIŲ KONCEPCIJĄ (KURIOS GALI BŪTI TAIKOMOS KITIEMS VIRUSAMS) IR III) PABANDYTI NUSTATYTI TRIMATĘ MUNO BALTYMO STRUKTŪRĄ. VIRUS FABRICS ar viroplazmų FORMACIJA INFECTATED CELLS yra pagrindinis VIRUS REPLIKACIJOS IR KEY prakeiktos DIAnos taškas, trukdantis virusinei REPLIKACIJAi._x000D_ su visa gauta informacija, mes taip pat tikimės geriau nusipirkti VIRUS-celulos INTERACTION SUTILES DETAILS, kuri diktuoja plaukų linijos (arba SPECIE) perMISIVITYJĄ. ŠIŲ DETALIŲ SUPRATIMAS ATLIEKA SVARBŲ VAIDMENĮ KOVOJANT SU VIRUSINĖMIS INFEKCIJOMIS IR PLINTA TARP RŪŠIŲ. (Lithuanian)
18 August 2022
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NEDAVNA I NEOČEKIVANA IZBIJANJA RAZLIČITIH VIRUSA DILJEM SVIJETA POKAZUJU POTREBU ZA BOLJIM RAZUMIJEVANJEM MEHANIZAMA POMOĆU KOJIH VIRUSI MIJENJAJU RASPON I/ILI PATOGENOST VIRUSA. TAKOĐER JE POTREBNO RAZVITI NOVE METODE ZA BORBU PROTIV VIRIČKIH INFEKCIJA. NAŠA GRUPA I DRUGE ISTRAŽIVAČKE SKUPINE OTKRILI SU NIZ MOLEKULARNIH RAZLIKA IZMEĐU FUSOGENICAL I NE-FUSOGENICAL REOVIRUSA. OVE DVIJE SKUPINE REOVIRUSA SU VRLO SLIČNE U NJIHOVIM REPLIKACIJSKIM STRUKTURAMA I CIKLUSIMA, ALI VRLO RAZLIČITE U NJIHOVOM PATOGENOM KAPACITETU. STOGA, IAKO SU NE-FUSOGENICOS VIRUSI SVEPRISUTNI VIRUSI KOJI NISU IZRAVNO POVEZANI S BOLESTIMA, VEĆINA (AKO NE I SVI) REOVIRUSI VAŽNI SU PATOGENI PTICA, SISAVACA I GMAZOVA. Naš CILJ je utvrditi jesu li postojeći molekularni diferencijanci BETWE S FUSOGENICALnim reovirusom i NON-FUSOGENICOS povezani s različitima u svojim PATOGENICITY._x000D_Za FUSOGENICAL reovirus GROUP ćemo razviti investicijski GENETIC METHOD za AVIARY reovirus, kao zastupnici FUSOGENICAL reovirus GROUP. Za to ćemo podržati različite strategije koje su ponovno razvijene za mamiferous (MRV) i plavi jezik (BTV) VIRUS od Orbivirusa GENERO Orbivirus, koji se također odnosi na Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS of Reovirus aviar (ARV) kako bi se uvjerili da je uočena MOLECULAR DIFFERENCES BETWEEN FUSOGENICAL I NON-fusogenic VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRAL REPLICATIONS I PHOTOGENCIALS u VITRO I SUSCEPTIBLE ANIMALS._x000D_ dodatno haremos korištenje naših PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTE I) DOBITI VAŽNE INFORMACIJE O PROCESU FORMIRANJA VIRUSNIH TVORNICA KOJE SE JAVLJAJU TIJEKOM ARV INFEKCIJE; II) POKUŠATI RAZVITI NOVI KONCEPT ANTIVIRUSNIH MOLEKULA (KOJI SE MOGU PRIMIJENITI NA DRUGE VIRUSE), I III) POKUŠATI ODREDITI TRODIMENZIONALNU STRUKTURU PROTEINA MUNS. FORMACIJA VIRUS FABRICS ili viroplasms unutar INFECTATED CELLS je središnja točka VIRUS REPLICATION CICLE I KEY ugušen DIANA za ometanje Viric REPLICATION._x000D_ sa svim informacijama koje dobijemo, također se nadamo da ćemo bolje kupiti SUTILES DETAILS VIRUS-celula INTERACTION koji diktira perMISIVITY kose (ili SPECIE) DOE VIRUS U PARTICULARU. RAZUMIJEVANJE TIH DETALJA IGRA VAŽNU ULOGU U BORBI PROTIV VIRUSNIH INFEKCIJA I ŠIRENJA MEĐU VRSTAMA. (Croatian)
18 August 2022
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NYLIGEN INTRÄFFADE OCH OVÄNTADE UTBROTT AV OLIKA VIRUS RUNT OM I VÄRLDEN ILLUSTRERAR BEHOVET AV ATT BÄTTRE FÖRSTÅ DE MEKANISMER GENOM VILKA VIRUS ÄNDRAR SITT VÄRDOMRÅDE OCH/ELLER DERAS PATOGENICITET. DET ÄR OCKSÅ NÖDVÄNDIGT ATT UTVECKLA NYA METODER FÖR ATT BEKÄMPA VIRUSINFEKTIONER. VÅR GRUPP OCH ANDRA FORSKARGRUPPER HAR UPPTÄCKT ETT ANTAL MOLEKYLÄRA SKILLNADER MELLAN FUSOGENICAL OCH ICKE-FUSOGENICAL REOVIRUS. DESSA TVÅ GRUPPER AV REOVIRUS ÄR EXTREMT LIKA I SINA REPLIKERINGSSTRUKTURER OCH CYKLER, MEN MYCKET OLIKA I SIN PATOGENA KAPACITET. ÄVEN OM ICKE-FUSOGENICOS-VIRUS ÄR ALLMÄNT FÖREKOMMANDE VIRUS SOM INTE ÄR DIREKT FÖRKNIPPADE MED SJUKDOMAR, ÄR DE FLESTA (OM INTE ALLA) REOVIRUS VIKTIGA PATOGENER HOS FÅGLAR, DÄGGDJUR OCH REPTILER. Vårt OBJEKTIV är att fastställa om de befintliga molekylära skillnaderna BETWEEN THE FUSOGENICAL reovirus OCH NON-FUSOGENICOS är korrelerade med skillnaderna i deras PATOGENICITY._x000D_ FÖR FUSOGENICAL reovirus GROUP vi kommer att utveckla en investeringsiv GENETIC METHOD FÖR AVIARY reovirus, AS representants of the FUSOGENICAL reovirus GROUP. För det kommer vi att stödja de olika strategier som har utvecklats för mamiferous (MRV) och blå språk (BTV) VIRUS av Orbivirus GENERO Orbivirus, som också gäller Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS OF reovirus aviar (ARV) för att STUDY THE POSSIBLE INFLUENCE DHAT de observerade MOLECULAR DIFFERENCES BETWEEN FUSOGENICAL och icke-fusogena VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRAL REPLICATIONER OCH FOTOGENCIALS I VITRO OCH SUSCEPTIBLE ANIMALS._x000D_ Dessutom haremos användning av vårt PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROFUND FÖR: I) INHÄMTA VIKTIG INFORMATION OM HUR VIRUSFABRIKERNA BILDAS UNDER INFEKTION MED ARV, II) FÖRSÖKA UTVECKLA ETT NYTT KONCEPT AV ANTIVIRALA MOLEKYLER (SOM KAN APPLICERAS PÅ ANDRA VIRUS), OCH III) FÖRSÖKA BESTÄMMA DEN TREDIMENSIONELLA STRUKTUREN AV MUNS PROTEIN. Den FORMATION AV VIRUS FABRIKER eller viroplasmer inom INFEKTATED CELLS är en central punkt i VIRUS REPLICATION CICLE OCH en nyckel dailed DIANA för att störa den Viric REPLICATION._x000D_ med all information vi får, hoppas vi också att köpa bättre SUTILES DETAILS AV VIRUS-celula INTERACTION som dikterar perMISIVITY av en hårlinje (eller SPECIE) gör en VIRUS i PARTICULAR. ATT FÖRSTÅ DESSA DETALJER SPELAR EN VIKTIG ROLL I KAMPEN MOT VIRUSINFEKTIONER OCH SPRIDNING BLAND ARTER. (Swedish)
18 August 2022
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FOCARELE RECENTE ȘI NEAȘTEPTATE DE DIFERITE VIRUSURI DIN ÎNTREAGA LUME ILUSTREAZĂ NECESITATEA DE A ÎNȚELEGE MAI BINE MECANISMELE PRIN CARE VIRUȘII ÎȘI SCHIMBĂ GAMA GAZDĂ ȘI/SAU PATOGENITATEA. DE ASEMENEA, ESTE NECESAR SĂ SE DEZVOLTE NOI METODE DE COMBATERE A INFECȚIILOR VIRALE. GRUPUL NOSTRU ȘI ALTE GRUPURI DE CERCETARE AU DETECTAT O SERIE DE DIFERENȚE MOLECULARE ÎNTRE REOVIRUSURILE FUSOGENICALE ȘI NON-FUSOGENICALE. ACESTE DOUĂ GRUPE DE REOVIRUSURI SUNT EXTREM DE ASEMĂNĂTOARE ÎN STRUCTURILE ȘI CICLURILE LOR DE REPLICARE, DAR FOARTE DIFERITE ÎN CEEA CE PRIVEȘTE CAPACITATEA LOR PATOGENĂ. ASTFEL, ÎN TIMP CE VIRUSURILE NON-FUSOGENICOS SUNT VIRUSURI OMNIPREZENTE CARE NU SUNT DIRECT ASOCIATE CU BOLI, CELE MAI MULTE (DACĂ NU TOATE) REOVIRUSURILE SUNT AGENȚI PATOGENI IMPORTANȚI AI PĂSĂRILOR, MAMIFERELOR ȘI REPTILELOR. Obiectivul nostru este de a determina dacă diferențele moleculare existente BETWEEN reovirusul FUSOGENIC ȘI NON-FUSOGENICOS sunt corelate cu diferențele din PATOGENICY._x000D_ PENTRU GROUPul reovirusului FUSOGENIC, vom dezvolta o METODĂ GENETICĂ pentru reovirus AVIARY, ca reprezentanți ai GROUP-ului reovirus FUSOGENIC. Pentru aceasta vom sprijini diferitele strategii care au fost re-dezvoltate pentru mamiferous (MRV) și limbajul albastru (BTV) VIRUS de Orbivirus GENERO Orbivirus, care, de asemenea, se referă la Reoviridae FAMILY._x000D_ USANDO GENETICA inversa MUTANTS CREAREM DE aviar reovirus (ARV) pentru a STUDY INFLUENȚA POSSIBLE CĂ DIFFERERI MOLECULAR observate BETWEEN VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS ȘI VIRUS VIRUS VIRUS FUSOGENIC ȘI NON-fusogenice VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS ȘI VIRUS VIRUS NON-FUSOGENICALE VIRUS VIRUS ȘI REPLICAȚII VIRĂRILOR VIRALE ȘI FON-fuzogenice VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS ȘI SUSCEPTIBIL._x000D_ suplimentar utilizare haremos a PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROTEIN PROteic PROTEIN PROTEIN PROteic PROTEIN PROTEIN PROTEIN PROTEIN PROTEUND PENTRU: I) OBȚINE INFORMAȚII IMPORTANTE CU PRIVIRE LA PROCESUL DE FORMARE A FABRICILOR DE VIRUS CARE APAR ÎN TIMPUL INFECȚIEI CU ARV; II) ÎNCERCAȚI SĂ DEZVOLTAȚI UN NOU CONCEPT DE MOLECULE ANTIVIRALE (CARE POT FI APLICATE ALTOR VIRUSURI) ȘI III) ÎNCERCAȚI SĂ DETERMINAȚI STRUCTURA TRIDIMENSIONALĂ A PROTEINEI MUNS. Forma FABRICULUI VIRUS sau a viroplasmelor din cadrul CELLS INFECTATE este un punct central al CICLULUI DE REPLICARE VIRĂ ȘI O DIANA KEY pentru interferența cu REPLICAREA Virică._x000D_ cu toate informațiile pe care le obținem, sperăm, de asemenea, să cumpărăm mai bine DATELE SUTILESLOR INTERACȚIONALE VIRUS-celula care dictează perMISIVITATEA unei linii de păr (sau SPECIE) face o VIRĂ ÎN PARTICUL. ÎNȚELEGEREA ACESTOR DETALII JOACĂ UN ROL IMPORTANT ÎN LUPTA ÎMPOTRIVA INFECȚIILOR VIRALE ȘI RĂSPÂNDIREA LA SPECII. (Romanian)
18 August 2022
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NEDAVNI IN NEPRIČAKOVANI IZBRUHI RAZLIČNIH VIRUSOV PO VSEM SVETU KAŽEJO, DA JE TREBA BOLJE RAZUMETI MEHANIZME, S KATERIMI VIRUSI SPREMINJAJO SVOJ GOSTITELJSKI RAZPON IN/ALI PATOGENOST. PRAV TAKO JE TREBA RAZVITI NOVE METODE ZA BOJ PROTI OKUŽBAM Z VIRUSI. NAŠA SKUPINA IN DRUGE RAZISKOVALNE SKUPINE SO ODKRILE ŠTEVILNE MOLEKULARNE RAZLIKE MED FUSOGENICAL IN NE-FUSOGENICAL REOVIRUSI. TI DVE SKUPINI REOVIRUSOV STA SI ZELO PODOBNI V SVOJIH REPLIKACIJSKIH STRUKTURAH IN CIKLIH, VENDAR SE ZELO RAZLIKUJETA PO SVOJI PATOGENI ZMOGLJIVOSTI. MEDTEM KO SO NE-FUSOGENICOS VIRUSI VSEPRISOTNI VIRUSI, KI NISO NEPOSREDNO POVEZANI Z BOLEZNIMI, JE VEČINA (ČE NE VSEH) REOVIRUSOV POMEMBNIH PATOGENOV PTIC, SESALCEV IN PLAZILCEV. Naša OBJEKTIVA je ugotoviti, ali so obstoječi molekularni diferencialci BETWEEN THE FUSOGENICAL reovirus IN NON-FUSOGENICOS povezani z različnimi v njihovih PATOGENICITY._x000D_ ZA FUSOGENICAL reovirus GROUP bomo razvili vložni GENETIC METHOD ZA AVIARY reovirus, kot zastopniki FUSOGENICAL reovirus GROUP. Za to bomo podprli različne strategije, ki so bile ponovno razvite za mavrice (MRV) in modri jezik (BTV) VIRUS Orbivirus GENERO Orbivirus, ki se nanaša tudi na Reoviridae DRUŽINA._x000D_ USANDO GENETICA inversa CREAREM MUTANTS of reovirus aviar (ARV) STUDY POSLOVNA INFLUENCE, da se opazovane MOLECULARNE DIFFERENCE BETWEEN FUSOGENIKAL IN NON-fuzogenic VIRUS VIRUS VIRUS VIRUS VIRUS IN NON-FUSOGENICAL VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS IN SUSCEPTIBLE ANIMALSKI VIRUS IN NON-FUSOGENIKAL VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUSNIH VIRUSOV IN NON-FUSOGENIČNI VIRANJE VIRANJE VIRANJE IN VIRANJE VIRUSNIH VIRUSOV IN VIRUSNIH VIRUSOV IN NON-FUSOGENIČNIH VIRUS VIRUSNIH VIRUSOV IN VIRUSNIH VIRUSNIH VIRUSNIH VIRUSNIH VIRUSI VIRUS VIRUS VIRUS VIRUS IN VIRUSI IN NON-FUSOGENSKA VIRANJE VIRUSOV IN VIRUSNIKEGA VIRUSA VIRUSNIH VIRUSNI VIRUS VIRUSI IN VIRUSNI VIRUSI IN NON-FUSOGENJEVALNI VIRANJE VIRANJE VIRUSNIH VIRUSI IN VIRUSNIH VIRUS IN VIRUS VIRUS VIRUS VIR I) PRIDOBITI POMEMBNE INFORMACIJE O PROCESU NASTAJANJA TOVARN VIRUSA, KI SE POJAVIJO MED OKUŽBO Z ARV; II) POSKUSITE RAZVITI NOV KONCEPT PROTIVIRUSNIH MOLEKUL (KI SE LAHKO NANAŠAJO NA DRUGE VIRUSE) IN III) POSKUŠAJO DOLOČITI TRIDIMENZIONALNO STRUKTURO BELJAKOVINE MUNS. FORMATION OF VIRUS FABRICS ali Viroplazme znotraj INFECTATED CELLS je osrednja točka VIRUS REPLICATION CICLE IN TIPKO Dailed DIANA za vmešavanje v Viric REPLICATION._x000D_ z vsemi informacijami, ki jih pridobimo, upamo tudi, da bomo bolje kupili SUTILES DETAILS THE VIRUS-celula INTERACTION, ki narekuje perMISIVITY lasišča (ali SPECIE) VIRUS V PARTICULARJU. RAZUMEVANJE TEH PODROBNOSTI IMA POMEMBNO VLOGO V BOJU PROTI OKUŽBAM Z VIRUSOM IN ŠIRJENJU MED VRSTAMI. (Slovenian)
18 August 2022
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NIEDAWNE I NIEOCZEKIWANE OGNISKA RÓŻNYCH WIRUSÓW NA CAŁYM ŚWIECIE POKAZUJĄ POTRZEBĘ LEPSZEGO ZROZUMIENIA MECHANIZMÓW, ZA POMOCĄ KTÓRYCH WIRUSY ZMIENIAJĄ ZASIĘG ŻYWICIELI I/LUB ICH CHOROBOTWÓRCZOŚĆ. KONIECZNE JEST RÓWNIEŻ OPRACOWANIE NOWYCH METOD ZWALCZANIA ZAKAŻEŃ WIRUSEM VIRIC. NASZA GRUPA I INNE GRUPY BADAWCZE WYKRYŁY SZEREG RÓŻNIC MOLEKULARNYCH MIĘDZY REOWIRUSAMI FUSOGENICAL I NIE-FUSOGENICAL. TE DWIE GRUPY REOWIRUSÓW SĄ BARDZO PODOBNE W SWOICH STRUKTURACH REPLIKACJI I CYKLACH, ALE BARDZO RÓŻNIĄ SIĘ POD WZGLĘDEM ZDOLNOŚCI PATOGENNYCH. TAK WIĘC, CHOCIAŻ WIRUSY INNE NIŻ FUSOGENICOS SĄ WSZECHOBECNYMI WIRUSAMI, KTÓRE NIE SĄ BEZPOŚREDNIO ZWIĄZANE Z CHOROBAMI, WIĘKSZOŚĆ (JEŚLI NIE WSZYSTKIE) REOWIWIRUSÓW SĄ WAŻNYMI PATOGENAMI PTAKÓW, SSAKÓW I GADÓW. Naszym celem jest określenie, czy istniejące różnice molekularne BETWEEN THE FUSOGENICAL reowirus I NON-FUSOGENICOS są skorelowane z różnymi w ich PATOGENICITY._x000D_ Dla FUSOGENICAL Reovirus GROUP opracujemy inwestycyjny METOD GENETIC FOR AVIARY reowirus, jako przedstawiciele grupy reowirusów FUSOGENICAL. W tym celu będziemy wspierać różne strategie, które zostały ponownie opracowane dla mamiferous (MRV) i niebieskiego języka (BTV) VIRUS Orbivirus GENERO Orbivirus, które odnoszą się również do Reoviridae FAMILY._x000D_ USANDO GENETICA inversa CREAREM MUTANTS of reovirus aviar (ARV) TO STUDY THE POSSIBLE INFLUENCE DIFFERENCES BETWEEN FUSOGENICAL I NON-fuzogen VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRICATIONS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIRUS VIR I) UZYSKAĆ WAŻNE INFORMACJE NA TEMAT PROCESU POWSTAWANIA FABRYK WIRUSÓW, KTÓRE WYSTĘPUJĄ PODCZAS ZAKAŻENIA ARV; II) SPRÓBUJ OPRACOWAĆ NOWĄ KONCEPCJĘ CZĄSTECZEK PRZECIWWIRUSOWYCH (KTÓRE MOGĄ BYĆ STOSOWANE DO INNYCH WIRUSÓW) I III) SPRÓBOWAĆ OKREŚLIĆ TRÓJWYMIAROWĄ STRUKTURĘ BIAŁKA MUNS. Forma VIRUS FABRICS lub viroplasms w ramach INFECTATED CELLS jest centralnym punktem VIRUS REPLICATION CICLE I A KEY dailed DIANA za ingerowanie w Viric REPLICATION._x000D_ ze wszystkimi informacjami, które otrzymujemy, mamy również nadzieję, że kupimy lepiej SUTILES DETAILS OF THE VIRUS-celula INTERACTION, która dyktuje perMISIVITY linii włosów (lub SPECIE) DOŚWIADCZENIA WARTOŚCI. ZROZUMIENIE TYCH SZCZEGÓŁÓW ODGRYWA WAŻNĄ ROLĘ W WALCE Z ZAKAŻENIAMI WIRUSAMI I ROZPRZESTRZENIA SIĘ WŚRÓD GATUNKÓW. (Polish)
18 August 2022
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Santiago de Compostela
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20 December 2023
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Identifiers
BFU2013-43513-R
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