role of miRNA in host-intestinal microbiome interaction in metformin therapy against a background of metabolic disorders (Q3056421)
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Project Q3056421 in Latvia
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | role of miRNA in host-intestinal microbiome interaction in metformin therapy against a background of metabolic disorders |
Project Q3056421 in Latvia |
Statements
374,918.54 Euro
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648,648.0 Euro
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57.8 percent
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1 April 2019
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31 March 2022
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Atvasināta publiska persona "Latvijas Biomedicīnas pētījumu un studiju centrs"
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56°58'59.81"N, 24°1'53.44"E
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Izmaiņas zarnu mikrobioma pamata kompozīcijā ir saistītas ar dažādu slimību attīstību. Līdz šim nav izskaidroti šo noviržu pamatā esošie mehānismi. Ir pierādīts, ka saimniekorganisma miRNS ir iesaistītas saimniekorganisma un tā zarnu mikrobioma mijiedarbībā. Ir nepieciešama šīs mijiedarbības tālāka izpēte ar zarnu mikrobiomu saistītu slimību, piemēram, 2. tipa cukura diabēta (T2D) kontekstā, jo tai ir potenciāls radīt pilnīgi jaunas terapijas stratēģijas.Projekta mērķis ir izpētīt saimniekorganisma miRNS nozīmi metformīna izraisītās zarnu mikrobioma kompozīcijas un funkciju izmaiņās T2D kontekstā un identificēt miRNS paneli, kuru varētu izmantot turpmākos klīniskos pētījumos.Mēs izmantosim ievērojamus paraugu resursus, kas ir ievākti jau notiekoša peļu eksperimenta ietvaros. Mēs ar nākamās paaudzes sekvenēšanas palīdzību iegūsim zarnu metagenoma un miRNS kompozīciju datus un novērtēsim korelāciju starp miRNS un zarnu mikrobioma profiliem peļu modelī, kas saņem diētu ar paaugstinātu tauku saturu un T2D pacientos.Šis projekts radīs plašas zināšanas par saimniekorganisma miRNS un zarnu mikrobioma mijiedarbību T2D un sniegs jaunu informāciju personalizētas T2D terapijas pieeju attīstīšanai vai esošo stratēģiju uzlabošanai.Projekts ir saskaņā ar RIS3 tautsaimniecības transformācijas virzienu “nozares ar nozīmīgu horizontālo ietekmi un ieguldījumu tautsaimniecības transformācijā” un viedās specializācijas jomu “biomedicīna, medicīnas tehnoloģijas, biofarmācija un biotehnoloģijas”, un saimniecisko darbību statistiskās klasifikācijas kods ir 72.11.Projekts atbilst rūpniecisko pētījumu kategorijai ar tehnoloģiju gatavības līmeni 2: formulēta tehnoloģijas praktiskā lietojuma koncepcija un nav saistīts ar saimniecisko darbību. Šis starpdisciplinārais pētījums pēc OECD klasifikācijas atbilst sekojošām zinātnes nozarēm: bioloģijas zinātnes (1.6.), datoru un informācijas zinātnes (1.2.) un bāzes medicīna (3.1.).Projekts tiks īstenots, sadarbojoties Latvijas Biomedicīnas pētījumu un studiju centram un SIA “GenEra”. Vairāk nekā 25% no projektā iesaistītajiem ir studenti, un mēs nodrošināsim >25% jaunu zinātniskā personāla pozīciju.Projekta ilgums ir 36 mēneši, sākot no 01.04.2019.līdz 31.03.2022. Kopējais projekta finansējums ir 648 648 EUR, tai skaitā no ERAF 374 918,54 EUR.Atslēgvārdi: saimniekorganisma miRNS; zarnu mikrobioms; 2. tipa cukura diabēts; metformīns, peļu modeļi (Latvian)
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Changes in the basic composition of the intestinal microbiome are related to the development of various diseases. The mechanisms underlying these deviations have not been explained so far. The host miRNA has been shown to be involved in the interaction between the host and its intestinal microbiome. Further investigation of this interaction is necessary in the context of diseases related to intestinal microbiome, e.g. type 2 diabetes (T2D), because it has the potential to create completely new therapeutic strategies.The aim of the project is to explore the role of the host miRNA in the intestinal microbiome composition and function changes of metformin in the context of T2D and to identify a miRNA panel that could be used in future clinical studies.We will use significant sample resources that have been collected within the framework of ongoing mouse experiments. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. This interdisciplinary study according to OECD classification corresponds to the following fields of science: Biological sciences (1.6), computer and information sciences (1.2) and basic medicine (3.1).The project will be implemented by cooperation of Latvian Biomedical Research and Study Centre and SIA GenEra. More than 25 % of the participants in the project are students, and we will provide >25 % of the new position of scientific staff.The duration of the project is 36 months, from 01.04.2019 to 31.03.2022. The total project funding is EUR 648648, including ERDF EUR 374918,54. MiRNA of host; Intestinal microbiome Type 2 diabetes mellitus Metformin, mouse models (English)
15 July 2021
0.6340554300586457
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Les changements dans la composition de base du microbiome intestinal sont associés au développement de diverses maladies. Jusqu’à présent, les mécanismes sous-jacents à ces écarts n’ont pas été expliqués. Il a été démontré que le miRNA hôte est impliqué dans l’interaction entre l’hôte et son microbiome intestinal. D’autres recherches sur cette interaction sont nécessaires dans le contexte de maladies liées au microbiome intestinal, telles que le diabète de type 2 (T2D), car elle a le potentiel de créer de nouvelles stratégies thérapeutiques.Le projet a pour but d’explorer le rôle du miRNA hôte dans les changements dans la composition et la fonction du microbiome intestinal dans le contexte du T2D et d’identifier un panel d’ARNmi qui pourrait être utilisé dans d’autres essais cliniques.Nous utiliserons d’importantes ressources d’échantillons recueillies dans le cadre d’une expérience de souris en cours. Avec l’aide du séquençage de prochaine génération, nous obtiendrons des données sur les compositions de métagénome intestinal et de Myrna et évaluerons la corrélation entre Myrna et les profils de microbiome intestinal dans le modèle de souris recevant des régimes riches en graisses et des patients atteints de T2D. Ce projet permettra d’obtenir une connaissance approfondie de l’interaction du miRNA hôte et du microbiome intestinal T2D et fournira de nouvelles informations pour le développement de thérapies T2D personnalisées ou pour l’amélioration des stratégies existantes. le concept d’utilisation pratique de la technologie a été formulé et n’est pas lié à l’activité économique. Cette étude interdisciplinaire selon la classification de l’OCDE correspond aux disciplines suivantes: sciences biologiques (1.6), informatique et informatique (1.2) et médecine fondamentale (3.1). Le projet sera mis en œuvre en coopération entre le Centre letton de recherche et d’études biomédicales et les genres SIA. Plus de 25 % des personnes impliquées dans le projet sont des étudiants, et nous fournirons >25 % des nouveaux postes de personnel scientifique. La durée du projet est de 36 mois, à partir du 01.04.2019 au 31.03.2022. Le financement total du projet s’élève à 648 648 EUR, y compris au titre du FEDER 374 918,54 EUR. Myrna de l’hôte; microbiome intestinal; Diabète sucré de type 2; metformine, modèles de souris (French)
25 November 2021
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Veränderungen in der Grundzusammensetzung des Darmmikrobioms sind mit der Entwicklung verschiedener Krankheiten verbunden. Die Mechanismen, die diesen Abweichungen zugrunde liegen, wurden bisher nicht erläutert. Der Wirt miRNA hat gezeigt, dass er an der Interaktion zwischen dem Wirt und seinem Darmmikrobiom beteiligt ist. Weitere Untersuchungen zu dieser Wechselwirkung sind im Zusammenhang mit Erkrankungen im Zusammenhang mit Darmmikrobiom erforderlich, wie z. B. Typ-2-Diabetes (T2D), da es das Potenzial hat, völlig neue therapeutische Strategien zu entwickeln.Ziel des Projekts ist es, die Rolle des Wirts miRNA bei Veränderungen der Darm-Mikrobiomzusammensetzung und -funktion im T2D-Kontext zu untersuchen und ein miRNA-Panel zu identifizieren, das in weiteren klinischen Studien eingesetzt werden könnte.Wir werden signifikante Probenressourcen nutzen, die im Rahmen eines laufenden Mausexperiments gesammelt wurden. Mit Hilfe der Sequenzierung der nächsten Generation erhalten wir Daten über Darm-Metagenom und Myrna-Kompositionen und bewerten die Korrelation zwischen Myrna und Darm-Mikrobiom-Profilen im Mausmodell, die hohe Fettdiäten und T2D-Patienten erhalten. Dieses Projekt wird umfassende Kenntnisse über die Interaktion des Wirts miRNA und des Darmmikrobiom T2D generieren und neue Informationen für die Entwicklung personalisierter T2D Therapieansätze oder zur Verbesserung bestehender Strategien liefern. das Konzept des praktischen Einsatzes der Technologie wurde formuliert und steht nicht im Zusammenhang mit der Wirtschaftstätigkeit. Diese interdisziplinäre Studie nach OECD-Klassifikation entspricht folgenden Disziplinen: Biowissenschaften (1,6), Informatik und Informationswissenschaften (1.2) und Grundmedizin (3.1). Das Projekt wird in Zusammenarbeit zwischen dem lettischen Biomedizinischen Forschungs- und Studienzentrum und dem SIA-Genra durchgeführt. Mehr als 25 % der Projektbeteiligten sind Studierende, und wir stellen >25 % der neuen wissenschaftlichen Mitarbeiterpositionen zur Verfügung. Die Projektlaufzeit beträgt 36 Monate, beginnend vom 01.04.2019 bis zum 31.03.2022. Die Projektförderung beläuft sich insgesamt auf 648 648 EUR, einschließlich EFRE 374 918,54 EUR. Myrna des Wirts; intestinales Mikrobiom; Typ-2-Diabetes mellitus; Metformin, Mausmodelle (German)
28 November 2021
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Veranderingen in de basissamenstelling van het darmmicrobioom worden geassocieerd met de ontwikkeling van verschillende ziekten. Tot dusver zijn de mechanismen die aan deze afwijkingen ten grondslag liggen, niet toegelicht. De gastheer miRNA is getoond om betrokken te zijn bij de interactie tussen de gastheer en zijn darmmicrobiome. Verder onderzoek naar deze interactie is vereist in de context van ziekten gerelateerd aan intestinale microbiome, zoals type 2 diabetes (T2D), omdat het de potentie heeft om volledig nieuwe therapeutische strategieën te creëren.Het doel van het project is om de rol van gastheer miRNA in veranderingen in de samenstelling en functie van de darmmicrobiome in de T2D-context te onderzoeken en een miRNA-panel te identificeren dat in verdere klinische proeven zou kunnen worden gebruikt.We zullen significante monsterbronnen gebruiken die worden verzameld als onderdeel van een doorlopend muizenexperiment. Met behulp van de volgende generatie sequencing, zullen we gegevens over intestinale metagenoom en Myrna samenstellingen te verkrijgen en zal de correlatie tussen Myrna en intestinale microbiome profielen in het muismodel die hoge vette diëten en T2D-patiënten ontvangen. Dit project zal uitgebreide kennis van de interactie van de gastheer miRNA en intestinale microbiome T2D en zal nieuwe informatie verstrekken voor de ontwikkeling van gepersonaliseerde T2D therapieën benaderingen of voor de verbetering van bestaande strategieën. Het project is in overeenstemming met de RIS3 economische transformatie onderdeel „sectoren met een aanzienlijke horizontale impact en bijdrage aan de economische transformatie” en het gebied van slimme specialisatie „biocinegeneeskunde, medische technologieën, biofarmaceutische technologieën en biofarmacea” het begrip „praktisch gebruik van de technologie” is geformuleerd en houdt geen verband met de economische activiteit. Deze interdisciplinaire studie volgens de OESO-classificatie komt overeen met de volgende disciplines: biologische wetenschappen (1.6), computer- en informatiewetenschappen (1.2) en basisgeneeskunde (3.1). Het project zal worden uitgevoerd in samenwerking tussen het Letse Biomedisch Onderzoeks- en Studiecentrum en SIA genera. Meer dan 25 % van degenen die betrokken zijn bij het project zijn studenten, en we zullen >25 % van de nieuwe wetenschappelijke staffuncties leveren. De duur van het project is 36 maanden, vanaf 01.04.2019 tot 31.03.2022. De totale projectfinanciering bedraagt 648 648 EUR, inclusief uit het EFRO 374 918,54 EUR. Myrna van de gastheer; intestinale microbioom; Type 2 diabetes mellitus; metformine, muismodellen (Dutch)
28 November 2021
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I cambiamenti nella composizione di base del microbioma intestinale sono associati con lo sviluppo di varie malattie. Finora non sono stati spiegati i meccanismi alla base di tali deviazioni. Il miRNA ospite ha dimostrato di essere coinvolto nell'interazione tra l'ospite e il suo microbioma intestinale. Ulteriori ricerche su questa interazione sono necessarie nel contesto di malattie legate al microbioma intestinale, come il diabete di tipo 2 (T2D), in quanto ha il potenziale per creare strategie terapeutiche completamente nuove.L'obiettivo del progetto è quello di esplorare il ruolo del miRNA ospite nei cambiamenti nella composizione e nella funzione del microbioma intestinale nel contesto T2D e di identificare un pannello miRNA che potrebbe essere utilizzato in ulteriori sperimentazioni cliniche. Con l'aiuto del sequenziamento di prossima generazione, otterremo dati sul metagenoma intestinale e sulle composizioni di Myrna e valuteremo la correlazione tra i profili Myrna e microbiome intestinali nel modello di topo ricevendo diete ad alto contenuto di grassi e pazienti T2D. Questo progetto genererà una vasta conoscenza dell'interazione tra il miRNA ospite e il microbiome intestinale T2D T2D e fornirà nuove informazioni per lo sviluppo di approcci personalizzati di terapie T2D o per il miglioramento delle strategie esistenti. Il progetto è in linea con il polo di trasformazione economica RIS3 e le strategie biofarmaceutiche esistenti. il concetto di uso pratico della tecnologia è stato formulato e non è collegato all'attività economica. Questo studio interdisciplinare secondo la classificazione OCSE corrisponde alle seguenti discipline: scienze biologiche (1.6), informatica e informatica (1.2) e medicina di base (3.1). Il progetto sarà attuato in collaborazione tra il Centro di ricerca e studio biomedico lettone e i generi SIA. Più del 25 % di coloro che partecipano al progetto sono studenti, e forniremo >25 % di nuovi posti di personale scientifico. La durata del progetto è di 36 mesi, a partire dal 01.04.2019 al 31.03.2022. Il finanziamento totale dei progetti ammonta a 648 648 EUR, anche a titolo del FESR 374 918,54 EUR. Myrna dell'esercito; microbioma intestinale; Diabete mellito di tipo 2; metformina, modelli del mouse (Italian)
11 January 2022
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Los cambios en la composición básica del microbioma intestinal se asocian con el desarrollo de diversas enfermedades. Hasta ahora, no se han explicado los mecanismos subyacentes a estas desviaciones. Se ha demostrado que el miRNA huésped está involucrado en la interacción entre el huésped y su microbioma intestinal. Es necesario seguir investigando esta interacción en el contexto de enfermedades relacionadas con el microbioma intestinal, como la diabetes tipo 2 (T2D), ya que tiene el potencial de crear estrategias terapéuticas completamente nuevas.El objetivo del proyecto es explorar el papel del miRNA huésped en los cambios en la composición y función del microbioma intestinal en el contexto T2D e identificar un panel de miRNA que podría utilizarse en otros ensayos clínicos. Con la ayuda de la próxima generación de secuenciación, obtendremos datos sobre el metagenoma intestinal y las composiciones de Myrna y valoraremos la correlación entre los perfiles de Myrna y microbioma intestinal en el modelo ratón que reciben dietas altas en grasas y pacientes con T2D. Este proyecto generará un amplio conocimiento de la interacción del miRNA huésped y el microbioma intestinal T2D y proporcionará nueva información para el desarrollo de enfoques personalizados de terapias T2D o para la mejora de las estrategias existentes. El proyecto está en línea con el capítulo de transformación económica RIS3 y la transformación económica «sectores con impacto horizontal significativo y contribución a la transformación económica» y el campo de especialización inteligente «biomedicina, tecnologías médicas, biofarmacéuticas y biofarmacéuticas existentes». el concepto de uso práctico de la tecnología se ha formulado y no está relacionado con la actividad económica. Este estudio interdisciplinario según la clasificación de la OCDE corresponde a las siguientes disciplinas: las ciencias biológicas (1.6), las ciencias de la informática y la información (1.2) y la medicina básica (3.1) El proyecto se ejecutará en cooperación entre el Centro de Investigación y Estudios Biomédicos de Letonia y los géneros SIA. Más del 25 % de los participantes en el proyecto son estudiantes, y proporcionaremos >25 % de nuevos puestos de personal científico. La duración del proyecto es de 36 meses, a partir del 01.04.2019 al 31.03.2022. La financiación total del proyecto asciende a 648 648 EUR, incluidos 374 918,54 EUR del FEDER. Myrna del anfitrión; microbioma intestinal; Diabetes mellitus tipo 2; metformina, modelos de ratón (Spanish)
12 January 2022
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Soole mikrobioomi põhikoostise muutused on seotud erinevate haiguste arenguga. Nende kõrvalekallete aluseks olevaid mehhanisme ei ole seni selgitatud. On tõestatud, et peremeesorganismi miRNA osaleb peremeesorganismi ja selle soole mikrobioomi koostoimes. Selle koostoime edasine uurimine on vajalik soolestiku mikrobioomiga seotud haiguste, nt II tüüpi diabeedi (T2D) kontekstis, sest see võib luua täiesti uusi ravistrateegiaid. Projekti eesmärk on uurida peremeesorganismi miRNA rolli metformiini soolestiku mikrobioomi koostises ja funktsioonimuutustes T2D kontekstis ning teha kindlaks miRNA paneel, mida saaks kasutada tulevastes kliinilistes uuringutes.Me kasutame märkimisväärseid prooviressursse, mis on kogutud käimasolevate hiire eksperimentide raames. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. OECD klassifikatsioonile vastav interdistsiplinaarne uuring vastab järgmistele teadusvaldkondadele: Bioteadused (1.6), arvuti- ja infoteadused (1.2) ja põhimeditsiin (3.1). Projekti viiakse ellu koostöös Läti biomeditsiiniliste uuringute ja õppekeskuse ning SIA perekondadega. Üle 25 % projektis osalejatest on üliõpilased ja pakume >25 % teadustöötajate uuest positsioonist. Projekti kestus on 36 kuud, 01.04.2019–31.03.2022. Projektide rahastamise kogusumma on 648648 eurot, sealhulgas ERFi 374918,54 eurot. Võõrustaja Mirna; Soole mikrobioom tüüp 2 diabeet Metformin, hiire mudelid (Estonian)
3 August 2022
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Žarnyno mikrobiomo pagrindinės sudėties pokyčiai yra susiję su įvairių ligų vystymusi. Mechanizmai, kuriais grindžiami šie nukrypimai, iki šiol nebuvo paaiškinti. Nustatyta, kad priimantysis miRNR dalyvauja šeimininko ir jo žarnyno mikrobiomo sąveikoje. Tolesnis šios sąveikos tyrimas yra būtinas ligų, susijusių su žarnyno mikrobiomu, pvz., 2 tipo cukriniu diabetu (T2D), kontekste, nes jis gali sukurti visiškai naujas terapines strategijas. Projekto tikslas – ištirti šeimininko miRNR vaidmenį žarnyno mikrobiomų sudėtyje ir metformino funkcijos pokyčius T2D kontekste ir nustatyti miRNR skydelį, kuris galėtų būti naudojamas būsimuose klinikiniuose tyrimuose.Mes naudosime didelius mėginio išteklius, kurie buvo surinkti vykdomų pelių eksperimentų metu. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Šis tarpdisciplininis tyrimas pagal EBPO klasifikaciją atitinka šias mokslo sritis: Biologiniai mokslai (1.6), kompiuterių ir informatikos mokslai (1.2) ir bazinė medicina (3.1). Projektas bus įgyvendinamas bendradarbiaujant Latvijos biomedicininių tyrimų ir studijų centrui ir SIA gentims. Daugiau nei 25 % projekto dalyvių yra studentai, ir mes suteiksime >25 % naujos mokslo darbuotojų pozicijos. Projekto trukmė yra 36 mėnesiai, nuo 01.04.2019 iki 31.03.2022. Bendras projektų finansavimas yra 648 648 EUR, įskaitant ERPF 374 918,54 EUR. Priimančiosios Mirna; 2 tipo žarnyno mikrobiomas cukrinis diabetas Metforminas, pelės modeliai (Lithuanian)
3 August 2022
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Promjene u osnovnom sastavu crijevnog mikrobioma odnose se na razvoj različitih bolesti. Mehanizmi na kojima se temelje ta odstupanja dosad nisu objašnjeni. Pokazalo se da je domaćin miRNA uključen u interakciju domaćina i njegovog crijevnog mikrobioma. Daljnje istraživanje ove interakcije potrebno je u kontekstu bolesti povezanih s crijevnim mikrobiomom, npr. dijabetesom tipa 2 (T2D), jer ima potencijal za stvaranje potpuno novih terapijskih strategija. Cilj projekta je istražiti ulogu domaćina miRNA u sastavu crijevnog mikrobioma i promjenama funkcije metformina u kontekstu T2D i identificirati miRNA ploču koja bi se mogla koristiti u budućim kliničkim studijama. Koristit ćemo značajne resurse uzoraka koji su prikupljeni u okviru tekućih pokusa na miševima. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Ova interdisciplinarna studija prema klasifikaciji OECD-a odgovara sljedećim područjima znanosti: Biološke znanosti (1.6.), računalne i informacijske znanosti (1.2) i osnovna medicina (3.1).Projekt će se provoditi u suradnji s Latvijskim biomedicinskim istraživačkim i studijskim centrom i rodovima SIA. Više od 25 % sudionika projekta su studenti, a mi ćemo osigurati > 25 % nove pozicije znanstvenog osoblja.Trajanje projekta je 36 mjeseci, od 01.04.2019 do 31.03.2022. Ukupno financiranje projekta iznosi 648 648 EUR, uključujući EFRR 374 918,54 EUR. Mirna domaćina; Crijevni mikrobiom Tip 2 dijabetes melitus Metformin, miš modeli (Croatian)
3 August 2022
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Οι αλλαγές στη βασική σύνθεση του εντερικού μικροβιώματος σχετίζονται με την ανάπτυξη διαφόρων ασθενειών. Οι μηχανισμοί στους οποίους βασίζονται οι αποκλίσεις αυτές δεν έχουν εξηγηθεί μέχρι στιγμής. Το miRNA ξενιστή έχει αποδειχθεί ότι εμπλέκεται στην αλληλεπίδραση μεταξύ του ξενιστή και του εντερικού μικροβιώματος του. Η περαιτέρω διερεύνηση αυτής της αλληλεπίδρασης είναι απαραίτητη στο πλαίσιο ασθενειών που σχετίζονται με το εντερικό μικροβιομέτρο, π.χ. διαβήτη τύπου 2 (T2D), επειδή έχει τη δυνατότητα να δημιουργήσει εντελώς νέες θεραπευτικές στρατηγικές. Σκοπός του έργου είναι να διερευνήσει το ρόλο του ξενιστή miRNA στην εντερική σύνθεση μικροβιώματος και τις αλλαγές λειτουργίας της μετφορμίνης στο πλαίσιο του T2D και να εντοπίσει μια ομάδα miRNA που θα μπορούσε να χρησιμοποιηθεί σε μελλοντικές κλινικές μελέτες. Θα χρησιμοποιήσουμε σημαντικούς πόρους δείγματος που έχουν συλλεχθεί στο πλαίσιο συνεχιζόμενων πειραμάτων ποντικιών. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Αυτή η διεπιστημονική μελέτη σύμφωνα με την ταξινόμηση του ΟΟΣΑ αντιστοιχεί στα ακόλουθα επιστημονικά πεδία: Βιολογικές επιστήμες (1.6), επιστήμες πληροφορικής και πληροφοριών (1.2) και βασική ιατρική (3.1).Το έργο θα υλοποιηθεί με τη συνεργασία του Λετονικού Κέντρου Βιοϊατρικής Έρευνας και Μελέτης και των γενών SIA. Πάνω από το 25 % των συμμετεχόντων στο έργο είναι φοιτητές και θα παρέχουμε >25 % της νέας θέσης του επιστημονικού προσωπικού.Η διάρκεια του έργου είναι 36 μήνες, από 01.04.2019 έως 31.03.2022. Η συνολική χρηματοδότηση του έργου ανέρχεται σε 648 648 EUR, συμπεριλαμβανομένου του ΕΤΠΑ 374 918,54 EUR. Mirna του ξενιστή· Εντερικό μικροβιομέτρο τύπου 2 σακχαρώδης διαβήτης Metformin, μοντέλα ποντικιών (Greek)
3 August 2022
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Zmeny v základnom zložení črevného mikrobiómu súvisia s vývojom rôznych chorôb. Mechanizmy, na ktorých sa tieto odchýlky zakladajú, zatiaľ neboli vysvetlené. Preukázalo sa, že hostiteľ miRNA sa podieľa na interakcii medzi hostiteľom a jeho črevným mikrobiómom. Ďalšie skúmanie tejto interakcie je potrebné v kontexte ochorení súvisiacich s črevným mikrobiómom, napr. diabetes typu 2 (T2D), pretože má potenciál vytvoriť úplne nové terapeutické stratégie. Cieľom projektu je preskúmať úlohu hostiteľskej miRNA v zložení črevného mikrobiómu a zmeny funkcie metformínu v kontexte T2D a identifikovať panel miRNA, ktorý by sa mohol použiť v budúcich klinických štúdiách. Využijeme významné zdroje vzoriek, ktoré boli zozbierané v rámci prebiehajúcich experimentov s myšou. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Táto interdisciplinárna štúdia podľa klasifikácie OECD zodpovedá týmto oblastiam vedy: Biologické vedy (1.6), počítačové a informačné vedy (1.2) a základná medicína (3.1).Projekt sa bude realizovať spoluprácou lotyšského biomedicínskeho výskumného a študijného centra a rodov SIA. Viac ako 25 % účastníkov projektu sú študenti a zabezpečíme >25 % novej pozície vedeckých pracovníkov. Trvanie projektu je 36 mesiacov, od 01.04.2019 do 31.03.2022. Celkové financovanie projektov je 648 648 EUR vrátane EFRR 374 918,54 EUR. Mirna hostiteľa; Črevný mikrobióm typu 2 diabetes mellitus Metformin, myš modely (Slovak)
3 August 2022
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Muutokset suoliston mikrobiomin peruskoostumuksessa liittyvät erilaisten sairauksien kehittymiseen. Näiden poikkeamien taustalla olevia mekanismeja ei ole toistaiseksi selitetty. Isäntä miRNA:n on osoitettu osallistuvan isännän ja sen suoliston mikrobiomin väliseen vuorovaikutukseen. Tämän vuorovaikutuksen lisätutkimus on tarpeen suoliston mikrobiomeihin liittyvien sairauksien, kuten tyypin 2 diabeteksen (T2D), yhteydessä, koska sillä on potentiaalia luoda täysin uusia hoitostrategioita. Hankkeen tavoitteena on tutkia isäntä miRNA:n roolia suoliston mikrobiomin koostumuksessa ja metformiinin toimintojen muutoksissa T2D:n yhteydessä ja tunnistaa miRNA-paneeli, jota voitaisiin käyttää tulevissa kliinisissä tutkimuksissa. Käytämme merkittäviä näyteresursseja, jotka on kerätty meneillään olevien hiirikokeiden yhteydessä. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Tämä OECD:n luokituksen mukainen monitieteinen tutkimus vastaa seuraavia tieteenaloja: Biotieteet (1.6), tietokone- ja informaatiotieteet (1.2) ja peruslääketiede (3.1). Hanke toteutetaan Latvian biolääketieteen tutkimus- ja tutkimuskeskuksen ja SIA-sukujen yhteistyön avulla. Yli 25 % hankkeen osallistujista on opiskelijoita, ja tarjoamme yli 25 % tieteellisen henkilöstön uudesta tehtävästä. Hankkeen kesto on 36 kuukautta 1.4.2019–31.3.2022. Hankkeen kokonaisrahoitus on 648648 euroa, mukaan lukien EAKR 374918,54 euroa. Isäntämaan Mirna; Suoliston mikrobiomi Tyypin 2 diabetes mellitus Metformin, hiirimallit (Finnish)
3 August 2022
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Zmiany w podstawowym składzie mikrobiomu jelitowego są związane z rozwojem różnych chorób. Mechanizmy leżące u podstaw tych odstępstw nie zostały dotychczas wyjaśnione. Wykazano, że miRNA gospodarza uczestniczy w interakcji między gospodarzem a jego mikrobiomem jelitowym. Dalsze badanie tej interakcji jest konieczne w kontekście chorób związanych z mikrobiomem jelitowym, np. cukrzycy typu 2 (T2D), ponieważ ma potencjał tworzenia zupełnie nowych strategii terapeutycznych.Celem projektu jest zbadanie roli miRNA gospodarza w składzie mikrobiomów jelitowych i zmianach funkcji metforminy w kontekście T2D oraz zidentyfikowanie panelu miRNA, który mógłby zostać wykorzystany w przyszłych badaniach klinicznych.Będziemy wykorzystywać znaczne zasoby próbki, które zostały zebrane w ramach trwających eksperymentów na myszach. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. To interdyscyplinarne badanie według klasyfikacji OECD odpowiada następującym dziedzinom nauki: Nauki biologiczne (1.6), informatyka i informatyka (1.2) oraz medycyna podstawowa (3.1). Projekt będzie realizowany poprzez współpracę Łotewskiego Centrum Badań i Badań Biomedycznych oraz rodzajów SIA. Ponad 25 % uczestników projektu to studenci, a my zapewnimy >25 % nowej pozycji kadry naukowej. Czas trwania projektu wynosi 36 miesięcy, od 01.04.2019 do 31.03.2022. Całkowite finansowanie projektów wynosi 648 648 EUR, w tym z EFRR 374 918,54 EUR. Mirna gospodarza; Mikrobiom jelitowy typu 2 cukrzyca Metformina, modele myszy (Polish)
3 August 2022
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A bél mikrobióm alapvető összetételének változásai különböző betegségek kialakulásához kapcsolódnak. Az eltérések mögött meghúzódó mechanizmusokat eddig nem fejtették ki. Kimutatták, hogy a gazdaszervezet miRNS részt vesz a gazdaszervezet és a bél mikrobiómja közötti kölcsönhatásban. Ennek a kölcsönhatásnak a további vizsgálata szükséges a bél mikrobiómával kapcsolatos betegségek, például a 2-es típusú cukorbetegség (T2D) összefüggésében, mivel teljesen új terápiás stratégiákat hozhat létre.A projekt célja, hogy feltárja a gazda miRNS szerepét a metformin bél mikrobióm összetételében és funkcióváltozásaiban a T2D összefüggésében, és azonosítson egy miRNS panelt, amely felhasználható a jövőbeli klinikai vizsgálatokban. Jelentős mintaforrásokat fogunk felhasználni, amelyeket a folyamatban lévő egérkísérletek keretében gyűjtöttünk. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Ez az OECD-osztályozás szerinti interdiszciplináris tanulmány a következő tudományterületeknek felel meg: Biológiai tudományok (1.6.), számítástechnika és informatika (1.2) és alapgyógyászat (3.1).A projekt a lett Biomedical Research and Study Centre és a SIA nemzetségek együttműködésével valósul meg. A projekt résztvevőinek több mint 25%-a diák, és a tudományos munkatársak új pozíciójának >25%-át biztosítjuk.A projekt időtartama 36 hónap, 2019.04.01-től 2022.03.31-ig. A projekt teljes finanszírozása 648 648 EUR, beleértve az ERFA 374 918,54 EUR-t. A vendéglátó Mirna; Bél mikrobiome 2-es típusú diabetes mellitus Metformin, egér modellek (Hungarian)
3 August 2022
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Změny v základním složení střevního mikrobiomu souvisejí s vývojem různých onemocnění. Mechanismy, z nichž tyto odchylky vycházejí, dosud nebyly vysvětleny. Bylo prokázáno, že hostitelská miRNA je zapojena do interakce mezi hostitelem a jeho střevním mikrobiomem. Další zkoumání této interakce je nezbytné v souvislosti s nemocemi souvisejícími s střevním mikrobiomem, např. diabetes 2. typu (T2D), protože má potenciál vytvořit zcela nové léčebné strategie.Cílem projektu je prozkoumat úlohu hostitelského miRNA ve střevním složení mikrobiomu a funkčních změnách metforminu v rámci T2D a identifikovat panel miRNA, který by mohl být použit v budoucích klinických studiích. Využijeme významné zdroje vzorků, které byly shromážděny v rámci probíhajících experimentů na myších. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Tato interdisciplinární studie podle klasifikace OECD odpovídá následujícím oblastem vědy: Biologické vědy (1.6), počítačové a informační vědy (1.2) a základní medicína (3.1). Projekt bude realizován ve spolupráci lotyšského biomedicínského výzkumného a studijního centra a rodů SIA. Více než 25 % účastníků projektu jsou studenti a my poskytneme >25 % nové pozice vědeckých pracovníků. Doba trvání projektu je 36 měsíců, od 01.04.2019 do 31.03.2022. Celkové financování projektů činí 648 648 EUR, včetně EFRR 374 918,54 EUR. Mirna hostitele; Střevní mikrobiom 2. typ diabetes mellitus Metformin, modely myší (Czech)
3 August 2022
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Baineann athruithe i gcomhdhéanamh bunúsach an mhiocrób intestinal le galair éagsúla a fhorbairt. Níor míníodh go dtí seo na sásraí is bun leis na diallais sin. Léiríodh go bhfuil baint ag an óstach miRNA leis an idirghníomhaíocht idir an t-óstach agus an micribhithóm stéigeach atá aige. Is gá imscrúdú breise a dhéanamh ar an idirghníomhaíocht sin i gcomhthéacs galair a bhaineann le micribhithm stéigeach, e.g. diaibéiteas de chineál 2 (T2D), toisc go bhfuil sé d’acmhainn aige straitéisí teiripeacha nua go hiomlán a chruthú.Is é aidhm an tionscadail iniúchadh a dhéanamh ar ról an óstaigh miRNA i gcomhdhéanamh miocróbach stéigeach agus in athruithe feidhme meiteaisnéise i gcomhthéacs T2D agus painéal miRNA a shainaithint a d’fhéadfaí a úsáid i staidéir chliniciúla amach anseo. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Freagraíonn an staidéar idirdhisciplíneach seo de réir aicmiú ECFE do na réimsí eolaíochta seo a leanas: Eolaíochtaí bitheolaíocha (1.6), eolaíocht ríomhaireachta agus faisnéise (1.2) agus leigheas bunúsach (3.1). Cuirfear an tionscadal chun feidhme trí chomhar idir Ionad Taighde agus Staidéir Bithleighis na Laitvia agus SIA GenEra. Is mic léinn iad níos mó ná 25 % de rannpháirtithe an tionscadail, agus cuirfimid > 25 % de phost nua na foirne eolaíochta ar fáil.Is é 36 mhí ré an tionscadail, ón 01.04.2019 go dtí an 31.03.2022. Is é EUR 648648 maoiniú iomlán an tionscadail, lena n-áirítear CFRE EUR 374918,54. Mirna ina hóstach; Microbiome intestinal Cineál 2 diaibéiteas mellitus Metformin, samhlacha luch (Irish)
3 August 2022
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Spremembe v osnovni sestavi črevesnega mikrobioma so povezane z razvojem različnih bolezni. Mehanizmi, na katerih temeljijo ta odstopanja, do zdaj niso bili pojasnjeni. Izkazalo se je, da je miRNA gostitelja vključena v interakcijo med gostiteljem in njegovim črevesnim mikrobiomom. Nadaljnja preiskava te interakcije je potrebna v okviru bolezni, povezanih s črevesnim mikrobiomom, npr. sladkorna bolezen tipa 2 (T2D), ker ima potencial za ustvarjanje popolnoma novih terapevtskih strategij.Namen projekta je raziskati vlogo miRNA gostitelja v črevesni sestavi mikrobioma in spremembah delovanja metformina v okviru T2D ter določiti ploščo miRNA, ki bi se lahko uporabila v prihodnjih kliničnih študijah.Uporabili bomo pomembne vzorčne vire, ki so bili zbrani v okviru tekočih poskusov na miših. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Ta interdisciplinarna študija v skladu s klasifikacijo OECD ustreza naslednjim področjem znanosti: Biološka znanost (1.6), računalniška in informacijska znanost (1.2) ter osnovna medicina (3.1).Projekt se bo izvajal s sodelovanjem Latvijskega biomedicinskega raziskovalnega in študijskega centra in SIA genera. Več kot 25 % udeležencev projekta je študentov, mi pa bomo zagotovili >25 % novega položaja znanstvenega osebja. Trajanje projekta je 36 mesecev, od 01.04.2019 do 31.3.2022. Skupno financiranje projektov znaša 648 648 EUR, vključno z ESRR 374 918,54 EUR. Mirna gostitelja; Črevesni mikrobiom tipa 2 diabetes mellitus Metformin, modeli miške (Slovenian)
3 August 2022
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Промените в основния състав на чревния микробиом са свързани с развитието на различни заболявания. Механизмите, които са в основата на тези отклонения, до момента не са обяснени. Установено е, че miRNA гостоприемникът участва във взаимодействието между гостоприемника и чревния микробиом. По-нататъшно изследване на това взаимодействие е необходимо в контекста на заболявания, свързани с чревния микробиом, например диабет тип 2 (T2D), тъй като има потенциала да създаде напълно нови терапевтични стратегии.Целта на проекта е да проучи ролята на miRNA гостоприемника в състава на чревния микробиом и функционалните промени на метформин в контекста на T2D и да идентифицира панел с miRNA, който може да се използва в бъдещи клинични проучвания.Ще използваме значителни ресурси от проби, събрани в рамките на текущите експерименти с мишки. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Това интердисциплинарно проучване съгласно класификацията на ОИСР съответства на следните области на науката: Биологични науки (1.6), компютърни и информационни науки (1.2) и основна медицина (3.1).Проектът ще бъде реализиран чрез сътрудничеството на латвийския център за биомедицински изследвания и проучвания и SIA родовете. Повече от 25 % от участниците в проекта са студенти и ще осигурим >25 % от новата позиция на научния персонал. Продължителността на проекта е 36 месеца, от 01.04.2019 г. до 31.03.2022 г. Общото финансиране на проекти е 648 648 EUR, включително ЕФРР 374 918,54 EUR. Мирна на гостоприемника; Чревен микробиом Тип 2 захарен диабет Метформин, модели на мишки (Bulgarian)
3 August 2022
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Bidliet fil-kompożizzjoni bażika tal-mikrobijoma intestinali huma relatati mal-iżvilupp ta’ diversi mardiet. Il-mekkaniżmi li fuqhom huma bbażati dawn id-devjazzjonijiet s’issa għadhom ma ġewx spjegati. Intwera li l-miRNA ospitanti hija involuta fl-interazzjoni bejn l-ospitant u l-mikrobi intestinali tiegħu. Investigazzjoni ulterjuri ta’ din l-interazzjoni hija meħtieġa fil-kuntest ta’ mard relatat mal-mikrobijoma intestinali, eż. dijabete tat-tip 2 (T2D), minħabba li għandha l-potenzjal li toħloq strateġiji terapewtiċi kompletament ġodda.L-għan tal-proġett huwa li jesplora r-rwol tal-miRNA ospitanti fil-kompożizzjoni tal-mikrobi intestinali u bidliet fil-funzjoni tal-metformina fil-kuntest tat-T2D u li jidentifika panel tal-miRNA li jista’ jintuża fi studji kliniċi futuri. Aħna se nużaw riżorsi sinifikanti ta’ kampjuni li nġabru fil-qafas ta’ esperimenti li jkunu għaddejjin fuq il-ġrieden. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Dan l-istudju interdixxiplinarju skont il-klassifikazzjoni tal-OECD jikkorrispondi għall-oqsma tax-xjenza li ġejjin: Ix-xjenzi bijoloġiċi (1.6), ix-xjenzi tal-kompjuter u tal-informazzjoni (1.2) u l-mediċina bażika (3.1).Il-proġett se jiġi implimentat permezz tal-kooperazzjoni taċ-Ċentru Latvjan għar-Riċerka u l-Istudju Bijomediku u l-ġeneri tal-SIA. Aktar minn 25 % tal-parteċipanti fil-proġett huma studenti, u aħna se nipprovdu >25 % tal-pożizzjoni l-ġdida tal-persunal xjentifiku.It-tul tal-proġett huwa ta’ 36 xahar, mill-01.04.2019 sa 31.03.2022. Il-finanzjament totali tal-proġett huwa ta’ EUR 648648, inklużi EUR 374918,54 tal-FEŻR. Mirna tal-ospitant; Dijabete mellitus ta’ mikrobi intestinali ta’ Tip 2 Metformin, mudelli ta’ ġurdien (Maltese)
3 August 2022
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Alterações na composição básica do microbioma intestinal estão relacionadas ao desenvolvimento de várias doenças. Os mecanismos subjacentes a estes desvios ainda não foram explicados. O miRNA do hospedeiro demonstrou estar envolvido na interação entre o hospedeiro e o seu microbioma intestinal. Uma investigação mais aprofundada dessa interação é necessária no contexto de doenças relacionadas ao microbioma intestinal, por exemplo, diabetes tipo 2 (T2D), pois tem potencial para criar estratégias terapêuticas completamente novas.O objetivo do projeto é explorar o papel do miRNA hospedeiro na composição do microbioma intestinal e alterações de função da metformina no contexto do T2D e identificar um painel miRNA que poderia ser usado em estudos clínicos futuros.Nós usaremos recursos de amostra significativos que foram coletados no âmbito de experimentos em curso com ratinhos. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Este estudo interdisciplinar de acordo com a classificação da OCDE corresponde aos seguintes campos da ciência: As ciências biológicas (1.6), as ciências da informática e da informação (1.2) e a medicina básica (3.1).O projeto será executado através da cooperação do Centro de Estudos e Investigação Biomédica da Letónia e dos géneros SIA. Mais de 25 % dos participantes no projeto são estudantes, e forneceremos >25 % da nova posição da equipa científica.A duração do projeto é de 36 meses, de 01.04.2019 a 31.03.2022. O financiamento total do projeto é de 648 648 EUR, incluindo 374 918,54 EUR do FEDER. Mirna do anfitrião; Microbioma intestinal Tipo 2 diabetes mellitus Metformina, modelos de ratinho (Portuguese)
3 August 2022
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Ændringer i den grundlæggende sammensætning af tarmmikrobiomet er relateret til udviklingen af forskellige sygdomme. De mekanismer, der ligger til grund for disse afvigelser, er endnu ikke blevet forklaret. Værten miRNA har vist sig at være involveret i interaktionen mellem værten og dets tarmmikrobiom. Yderligere undersøgelse af denne interaktion er nødvendig i forbindelse med sygdomme relateret til tarmmikrobiom, f.eks. type 2-diabetes (T2D), fordi det har potentiale til at skabe helt nye terapeutiske strategier.Formålet med projektet er at undersøge den rolle, som værten miRNA spiller i tarmens mikrobiomesammensætning og funktionsændringer af metformin i forbindelse med T2D og at identificere et miRNA-panel, der kan anvendes i fremtidige kliniske undersøgelser.Vi vil bruge betydelige prøveressourcer, der er indsamlet inden for rammerne af igangværende museforsøg. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Denne tværfaglige undersøgelse i henhold til OECD-klassifikationen svarer til følgende videnskabelige områder: Biologiske videnskaber (1.6), computer- og informationsvidenskab (1.2) og grundmedicin (3.1). Projektet vil blive gennemført i samarbejde med lettiske biomedicinske forsknings- og undersøgelsescenter og SIA-slægter. Mere end 25 % af deltagerne i projektet er studerende, og vi vil levere >25 % af den nye stilling for videnskabeligt personale. Projektets varighed er 36 måneder, fra 1.4.2019 til 31.03.2022. Den samlede projektfinansiering er på 648 648 EUR, inklusive EFRU 374 918,54 EUR. Mirna af vært; Intestinal mikrobiome Type 2 diabetes mellitus Metformin, musemodeller (Danish)
3 August 2022
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Modificările în compoziția de bază a microbiomului intestinal sunt legate de dezvoltarea diferitelor boli. Mecanismele care stau la baza acestor abateri nu au fost explicate până în prezent. MiARN gazdă s-a dovedit a fi implicat în interacțiunea dintre gazdă și microbiomul intestinal. Investigarea în continuare a acestei interacțiuni este necesară în contextul bolilor legate de microbiomul intestinal, de exemplu diabetul de tip 2 (T2D), deoarece are potențialul de a crea strategii terapeutice complet noi. Scopul proiectului este de a explora rolul miARN-ului gazdă în compoziția microbiomului intestinal și modificările funcționale ale metforminei în contextul T2D și de a identifica un panou miARN care ar putea fi utilizat în viitoarele studii clinice. Vom utiliza resurse semnificative de probă care au fost colectate în cadrul experimentelor de șoarece în curs de desfășurare. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Acest studiu interdisciplinar conform clasificării OCDE corespunde următoarelor domenii științifice: Științe biologice (1.6), informatică și informatică (1.2) și medicină de bază (3.1). Proiectul va fi pus în aplicare prin cooperarea Centrului de Cercetare și Studiu Biomedical din Letonia și a genurilor SIA. Peste 25 % dintre participanții la proiect sunt studenți, iar noi vom oferi >25 % din noua funcție de personal științific. Durata proiectului este de 36 luni, de la 01.04.2019 până la 31.03.2022. Finanțarea totală a proiectului este de 648 648 EUR, inclusiv FEDR 374 918,54 EUR. Mirna gazdei; Microbiom intestinal tip 2 diabet zaharat Metformin, modele de șoarece (Romanian)
3 August 2022
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Förändringar i den grundläggande sammansättningen av tarmmikrobiomen är relaterade till utvecklingen av olika sjukdomar. De mekanismer som ligger till grund för dessa avvikelser har hittills inte förklarats. Värd miRNA har visat sig vara involverad i interaktionen mellan värden och dess tarmmikrobiom. Ytterligare undersökning av denna interaktion är nödvändig i samband med sjukdomar relaterade till tarmmikrobiom, t.ex. typ 2-diabetes (T2D), eftersom det har potential att skapa helt nya terapeutiska strategier.Syftet med projektet är att utforska den roll som värd miRNA spelar i tarmmikrobiomens sammansättning och funktionsförändringar av metformin i samband med T2D och att identifiera en miRNA-panel som kan användas i framtida kliniska studier.Vi kommer att använda betydande provresurser som har samlats in inom ramen för pågående musexperiment. With next generation sequencing we will get data from intestinal metagenoma and miRNA compositions and evaluate correlation between miRNA and intestinal microbiome profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge of host microbial microbiome profiles in muRNAs and intestinal microbiome profiles in mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interactions in a mouse model, which will provide new information for the development of personalised T2D treatment approaches or for improvement of existing strategies.The project will generate extensive knowledge about the host miRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host organism’s myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and in T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge of the host microbial myRNA and intestinal microbiome interaction in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism miRNA and intestinal microbiome interactions T2D and provide new information for the development of personalised T2D treatment approaches or improvement of existing strategies.This project will generate extensive knowledge about the host organism miRNAs and the interaction of the host microbiome in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interaction profiles in a mouse model that receives a high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA and intestinal microbiome interactions in a mouse model that receives high fat diet and T2D patients.This project will generate extensive knowledge about the host organism’s miRNA The concept of the practical application of the technology is formulated and is not linked to economic activity. Denna tvärvetenskapliga studie enligt OECD:s klassificering motsvarar följande vetenskapsområden: Biologiska vetenskaper (1.6), data- och informationsvetenskap (1.2) och grundläggande medicin (3.1). Projektet kommer att genomföras genom samarbete mellan Lettlands biomedicinska forsknings- och studiecenter och SIA- släktena. Mer än 25 % av deltagarna i projektet är studenter, och vi kommer att stå för >25 % av den nya befattningen som vetenskaplig personal.Projektets varaktighet är 36 månader, från 1.4.2019 till 31.03.2022. Den totala projektfinansieringen uppgår till 648 648 EUR, inklusive Eruf 374 918,54 EUR. Mirna av värd, Tarmmikrobiom Typ 2 diabetes mellitus Metformin, musmodeller (Swedish)
3 August 2022
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Rātsupītes iela 1 k-1, Rīga, LV-1067
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Rātsupītes iela 1 k-1, Rīga, LV-1067
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Identifiers
1.1.1.1/18/A/092
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