Revision history of "Development of selective malaria treonyl-tRNA inhibitors" (Q3056430)

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23 March 2024

12 June 2023

3 August 2022

  • curprev 20:0620:06, 3 August 2022DG Regio talk contribs 111,606 bytes +75,443 Changed label, description and/or aliases in et, lt, hr, el, sk, fi, pl, hu, cs, ga, sl, bg, mt, pt, da, ro, sv, nl, fr, de, it, lv, es, and other parts: Adding translations: et, lt, hr, el, sk, fi, pl, hu, cs, ga, sl, bg, mt, pt, da, ro, sv,

12 January 2022

11 January 2022

28 November 2021

  • curprev 18:0018:00, 28 November 2021DG Regio talk contribs 27,765 bytes +4,058 Created claim: summary (P836): Geplande industriële studie. Het project heeft tot doel treonyl-tRNA (ThrRS)-remmers te ontwikkelen als toonaangevende verbindingen voor antimalariële drugdetectie. Remming van ThrRS verstoort eiwitbiosynthese en kan worden bereikt door remmers die zich binden aan het katalytische centrum van het enzym of aan de bindplaats van borelidine. Borelidine is een natuurlijke stof die een actieve remmer van ThrRS is en een zeer hoge antimalariële activi...
  • curprev 18:0018:00, 28 November 2021DG Regio talk contribs 23,707 bytes +115 Changed label, description and/or aliases in nl: translated_label
  • curprev 09:2509:25, 28 November 2021DG Regio talk contribs 23,592 bytes +4,018 Created claim: summary (P836): Geplante Industriestudie. Das Projekt zielt darauf ab, Treonyl-tRNA-Inhibitoren (ThrRS) als führende Verbindungen für den Antimalariatnachweis zu entwickeln. Die Hemmung von ThrRS stört die Proteinbiosynthese und kann durch Inhibitoren erreicht werden, die an das katalytische Zentrum des Enzyms oder an die Boredlidin-Bindungsstelle binden. Borelidin ist ein natürlicher Stoff, der ein aktiver Inhibitor von ThrRS ist und eine sehr hohe antimalaria...
  • curprev 09:2509:25, 28 November 2021DG Regio talk contribs 19,574 bytes +114 Changed label, description and/or aliases in de: translated_label

25 November 2021

  • curprev 19:3419:34, 25 November 2021DG Regio talk contribs 19,460 bytes +4,263 Created claim: summary (P836): Étude industrielle prévue. Le projet vise à développer des inhibiteurs du tréonyl-tRNA (ThrRS) comme principaux composés pour la détection des médicaments antipaludiques. L’inhibition de ThrRS perturbe la biosynthèse des protéines et peut être obtenue par des inhibiteurs qui se lient au centre catalytique de l’enzyme ou au site de liaison de la borelide. La Borelidine est une substance naturelle qui est un inhibiteur actif de ThrRS et présente u...
  • curprev 19:3419:34, 25 November 2021DG Regio talk contribs 15,197 bytes +133 Changed label, description and/or aliases in fr: translated_label

27 September 2021

10 September 2021

15 July 2021

  • curprev 12:3412:34, 15 July 2021DG Regio talk contribs 14,644 bytes +115 Changed label, description and/or aliases in en: translated_label
  • curprev 12:3412:34, 15 July 2021DG Regio talk contribs 14,529 bytes +3,749 Created claim: summary (P836): An industrial study is planned. The aim of the project is to develop treonil-tRNA (ThrRS) inhibitors as leading compounds for the detection of antimalarial drugs. Inhibition of ThrRS disrupts protein biosynthesis and can be achieved by inhibitors that bind to the catalytic centre of the enzyme or to the site of borelidine binding. Borelidine is a natural substance that is an active inhibitor of ThrRS and exhibits very high antimalarial activity....

14 July 2021

13 July 2021