No label defined (Q84343)
Jump to navigation
Jump to search
Project in Poland financed by DG Regio
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project in Poland financed by DG Regio |
Statements
1,995,510.0 zloty
0 references
1,995,510.0 zloty
0 references
100.0 percent
0 references
1 February 2019
0 references
31 January 2022
0 references
UNIWERSYTET WARSZAWSKI
0 references
The goal of the project is to infer a detailed evolutionary history of the Rossmann fold, which is one of the most prominent protein folds and by far the most functionally diverse one, with >300 different functions. To this end, we will perform a comprehensive bioinformatics analysis, with the aim of integrating data from different sources to obtain a reliable phylogenetic tree that encompasses all the major Rossmann enzymes classes (NAD(P)-dependent dehydrogenases; SAM-dependent methyltransferases; and NTP-utilizing enzymes). Unraveling the natural history of the Rossmann enzymes will have a significant impact on our understanding of protein fold evolution. Also, it will open the possibility (i) to reveal the principles that governed the divergence of cofactor specificity of Rossmann enzymes, (ii) use these principles to re-engineer Rossmann enzymes, and (iii) to identify the rudimentary Rossmann fold, and thereby design a functional minimal Rossman. (Polish)
0 references
Identifiers
POIR.04.04.00-00-5CF1/18
0 references