Modification of signaling pathways of Canne Th17 lymcytes SUBSET to improve Infections for humanans (Q84267)
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Project in Poland financed by DG Regio
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Modification of signaling pathways of Canne Th17 lymcytes SUBSET to improve Infections for humanans |
Project in Poland financed by DG Regio |
Statements
1,999,750.0 zloty
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1,999,750.0 zloty
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100.0 percent
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1 November 2017
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31 October 2020
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SZKOŁA GŁÓWNA GOSPODARSTWA WIEJSKIEGO W WARSZAWIE
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Adoptive cell transfer (ACT) immunotherapy is considered the most promising treatment of cancer; however it is still limited by the use of short-lived and exhausted T cells. Recently, IL-17 producing CD4+ T lymphocytes (Th17 cells) have been shown to be superior in eradication of melanoma in mouse compared to Th1 cells. We propose to determine the expanding ex vivo protocol of Th17 cells from domestic dog in order to support comparative oncology research and improve the ACT-based immunotherapy for humans. We hypothesized that pharmacological manipulation of signaling pathways of canine Th17 cells will enhance their antitumor activity and increase the efficacy of tumor immunotherapy. We plan to evaluate the results on the tumor infiltrating lymphocytes from melanoma-bearing dogs (patients of Veterinary Clinic). The outcomes of the project will provide the rationale for designing next-generation clinical trials for human cancer patients and facilitate development of cell-based drugs. (Polish)
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(ACT) immunotherapie is recognised the most Promisised treatment of cancer;h it is still limited by the use of short and open T cells.Recentric, IL-17 producing CD4 + T lympcytes (Th17 celels) have been shown to be superimor in operation of molasses in mouse comed to Th1 cells.To justify this determine the exating ex vivo protocol of Th17 cells from domestic provision in order to support comparative therapeutic research and improvements to the ACT-based immunosorbent assay for humanans.Hypotassised that pharmacotoxicological manipulation of signaling patterns of Canne Th17 cells cells.To evaluate the results on the counts of Veterinary Clinic.The outcomes of the project will provide the relevant development of focused drugs. (English)
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Identifiers
POIR.04.04.00-00-3EE9/17
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