Integrated cardiac rehabilitation programs with physical exercise in the prevention of cardiovascular toxicity mediated by anthracyclines or anti-HER-2 antibodies. Study ONCORE (Q3140721)
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Project Q3140721 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Integrated cardiac rehabilitation programs with physical exercise in the prevention of cardiovascular toxicity mediated by anthracyclines or anti-HER-2 antibodies. Study ONCORE |
Project Q3140721 in Spain |
Statements
51,400.0 Euro
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64,250.0 Euro
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80.0 percent
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1 January 2018
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31 March 2021
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FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA
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42°52'49.51"N, 8°32'45.10"W
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15078
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La toxicidad cardiovascular (TCV) por quimioterapia es la principal causa de muerte de los pacientes que sobreviven a un cáncer. El ejercicio físico durante el tratamiento con quimioterapia ha demostrado mejorar la calidad de vida y disminuir el riesgo de muerte. El objetivo de este proyecto es conocer si una intervención mediante un programa integrado de rehabilitación cardiaca que incluya ejercicio físico supervisado es capaz de prevenir la TCV durante el tratamiento con antraciclinas y/o tratamiento con anticuerpos anti-HER-2 en mujeres con cáncer de mama. Para ello se pretende realizar un estudio prospectivo observacional de cohortes en pacientes manejadas bajo el mismo protocolo de prevención de la TCV (seguimiento clínico, analítico y ecocardiográfico) a las que se ofrece la participación en un programa multidisciplinar de rehabilitación cardiaca con ejercicio físico supervisado. El hecho de que la principal variable que determina la participación o el rechazo de un programa de rehabilitación sea la accesibilidad (distancia al centro del domicilio) nos permitirá el ajuste correcto por variables potencialmente confusoras (edad y comorbilidades). Como hipótesis del estudio planteamos que un programa de rehabilitación cardíaca podría limitar la TCV en mujeres con cáncer de mama y mejorar el remodelado cardiaco y su perfil de riesgo cardiovascular global. (Spanish)
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Cardiovascular toxicity (CVT) from chemotherapy is the leading cause of death in patients who survive cancer. Physical exercise during chemotherapy treatment has been shown to improve quality of life and decrease the risk of death. The aim of this project is to know whether an intervention through an integrated cardiac rehabilitation program that includes supervised physical exercise is able to prevent VCT during treatment with anthracyclines or treatment with anti-HER-2 antibodies in women with breast cancer. For this purpose, it is intended to carry out a prospective observational study of cohorts in patients managed under the same protocol for the prevention of CVT (clinical, analytical and echocardiographic monitoring) to whom participation in a multidisciplinary cardiac rehabilitation program with supervised physical exercise is offered. The fact that the main variable that determines the participation or rejection of a rehabilitation program is accessibility (distance to the home) will allow us to adjust correctly for potentially confusing variables (age and comorbidities). As a hypothesis of the study, we suggested that a cardiac rehabilitation program could limit VCT in women with breast cancer and improve cardiac remodeling and their overall cardiovascular risk profile. (English)
12 October 2021
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Santiago de Compostela
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Identifiers
PI17_01687
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