Development and implementation of diagnostic criteria with high specificity for the identification of the viral etiology of acquired pneumonia in the community (Q3136785)
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Project Q3136785 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Development and implementation of diagnostic criteria with high specificity for the identification of the viral etiology of acquired pneumonia in the community |
Project Q3136785 in Spain |
Statements
76,800.0 Euro
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96,000.0 Euro
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80.0 percent
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1 January 2018
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31 March 2021
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FUNDACION PUBLICA ANDALUZA PARA LA GESTION DE LA INVESTIGACION EN SALUD DE SEVILLA
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37°23'19.07"N, 5°59'43.22"W
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41091
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A pesar de los avances tecnológicos y los métodos de diagnóstico molecular, la identificación de la etiología de la neumonía adquirida en la comunidad (NAC) sigue siendo un reto; así, solo en aproximadamente el 50% de las NAC se alcanza un diagnóstico etiológico definitivo. Entre los agentes virales, los más frecuentemente identificados son, por orden de incidencia de mayor a menor, en niños y adultos: rinovirus, virus respiratorio sincitial, virus influenza, virus parainfluenza, metapneumovirus, coronavirus, adenovirus y bocavirus. El papel de las infecciones víricas como agentes causales de las NAC es actualmente un tema controvertido, dado que la identificación de un agente viral en las vías respiratorias altas no es garantía suficiente para asignarle el papel de agente causal de la NAC y, segundo, porque en muchas ocasiones coexisten diferentes patógenos, ya sean bacteria/virus, bacteria/bacteria o virus/virus, lo cual dificulta la identificación del verdadero agente causal, además de suponer un reto la valoración de la especificidad diagnóstica de cada uno de estos patógenos en cada NAC concreta, así como en la valoración pronóstica.El objetivo principal de este proyecto es evaluar la etiología viral en el desarrollo de la NAC, desarrollando criterios diagnósticos con elevada especificidad mediante el análisis de la carga viral en sangre y esputo, y de la presencia de virus en vías respiratorias en un estudio de cohortes, prospectivo, de intervención diagnóstica, de pacientes adultos con NAC (Spanish)
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Despite technological advances and molecular diagnostic methods, the identification of community-acquired pneumonia etiology (CAP) remains a challenge; thus, only about 50 % of CAHs have a definitive etiological diagnosis. Among the viral agents, the most frequently identified are, in order of incidence from highest to lowest, in children and adults: rhinovirus, respiratory syncytial virus, influenza virus, parainfluenza virus, metapneumovirus, coronavirus, adenovirus and bocavirus. The role of viral infections as causative agents of CCS is currently a controversial issue, given that the identification of a viral agent in the upper respiratory tract is not a sufficient guarantee to assign it the role of causative agent of CCS and, secondly, because in many cases different pathogens coexist, be they bacteria/viruses, bacteria/bacteria or viruses/viruses, which makes it difficult to identify the true causal agent, in addition to challenging the assessment of the diagnostic specificity of each of these pathogens in each specific CCN, as well as in the prognostic assessment.The main objective of this project is to evaluate the viral etiology in the development of CRN, developing diagnostic criteria with high specificity through the analysis of viral load in blood and sputum, and of the presence of viruses in the respiratory tract in a prospective, prospective, diagnostic intervention study of adult patients with CCS (English)
12 October 2021
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Sevilla
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Identifiers
PI17_01055
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