Q3712207 (Q3712207): Difference between revisions

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(‎Changed label, description and/or aliases in en: Setting new description)
(‎Created claim: summary (P836): The objective of the EpiRNA project is to study the molecular mechanisms involved in RNA modifications by analysing the relationship between structure and function of ribonucleoproteic complexes (RNP complexes) in relation to several RNAs on which genetic translation mechanics (rRNA, tRNA, snoRNA) or regulatory RNA depend. An analysis of the dynamics and recognition properties of RNPs that involve, inter alia, transient interactions will be one...)
Property / summary
 
The objective of the EpiRNA project is to study the molecular mechanisms involved in RNA modifications by analysing the relationship between structure and function of ribonucleoproteic complexes (RNP complexes) in relation to several RNAs on which genetic translation mechanics (rRNA, tRNA, snoRNA) or regulatory RNA depend. An analysis of the dynamics and recognition properties of RNPs that involve, inter alia, transient interactions will be one of the challenges to be addressed. For this reason, the project requires a multidisciplinary approach (biochemistry, biophysics, genetics, structural biology, etc.) and the development of high-throughput extraction techniques (epitranscriptomic analysis, purification of RNPs), hence the need to invest in the appropriate equipment and to establish a strong synergy between internationally recognised laboratories at the forefront in this field (IBMC/IBMP in Strasbourg, CBI/IGBMC and LBP in Illkirch, IMOPA and Ngere in Nancy and LNIO in Troyes). The equipment acquired under the project is: an electron microscope to be installed in the IBMC/IBMP premises (to enable cryo-EM analyses under optimal experimental conditions); — a latest generation Gatan K3 high-sensitivity camera that will be an improvement of CBI cryo-EM equipment, which already hosts the Frisbi and Instruct infrastructures. (English)
Property / summary: The objective of the EpiRNA project is to study the molecular mechanisms involved in RNA modifications by analysing the relationship between structure and function of ribonucleoproteic complexes (RNP complexes) in relation to several RNAs on which genetic translation mechanics (rRNA, tRNA, snoRNA) or regulatory RNA depend. An analysis of the dynamics and recognition properties of RNPs that involve, inter alia, transient interactions will be one of the challenges to be addressed. For this reason, the project requires a multidisciplinary approach (biochemistry, biophysics, genetics, structural biology, etc.) and the development of high-throughput extraction techniques (epitranscriptomic analysis, purification of RNPs), hence the need to invest in the appropriate equipment and to establish a strong synergy between internationally recognised laboratories at the forefront in this field (IBMC/IBMP in Strasbourg, CBI/IGBMC and LBP in Illkirch, IMOPA and Ngere in Nancy and LNIO in Troyes). The equipment acquired under the project is: an electron microscope to be installed in the IBMC/IBMP premises (to enable cryo-EM analyses under optimal experimental conditions); — a latest generation Gatan K3 high-sensitivity camera that will be an improvement of CBI cryo-EM equipment, which already hosts the Frisbi and Instruct infrastructures. (English) / rank
 
Normal rank
Property / summary: The objective of the EpiRNA project is to study the molecular mechanisms involved in RNA modifications by analysing the relationship between structure and function of ribonucleoproteic complexes (RNP complexes) in relation to several RNAs on which genetic translation mechanics (rRNA, tRNA, snoRNA) or regulatory RNA depend. An analysis of the dynamics and recognition properties of RNPs that involve, inter alia, transient interactions will be one of the challenges to be addressed. For this reason, the project requires a multidisciplinary approach (biochemistry, biophysics, genetics, structural biology, etc.) and the development of high-throughput extraction techniques (epitranscriptomic analysis, purification of RNPs), hence the need to invest in the appropriate equipment and to establish a strong synergy between internationally recognised laboratories at the forefront in this field (IBMC/IBMP in Strasbourg, CBI/IGBMC and LBP in Illkirch, IMOPA and Ngere in Nancy and LNIO in Troyes). The equipment acquired under the project is: an electron microscope to be installed in the IBMC/IBMP premises (to enable cryo-EM analyses under optimal experimental conditions); — a latest generation Gatan K3 high-sensitivity camera that will be an improvement of CBI cryo-EM equipment, which already hosts the Frisbi and Instruct infrastructures. (English) / qualifier
 
point in time: 22 November 2021
Timestamp+2021-11-22T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0

Revision as of 14:00, 22 November 2021

Project Q3712207 in France
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English
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Project Q3712207 in France

    Statements

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    320,000.0 Euro
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    800,000.0 Euro
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    40.0 percent
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    1 January 2019
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    31 December 2021
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    Centre National de la Recherche Scientifique
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    L'objectif du projet EpiARN est d'étudier les mécanismes moléculaires impliqués dans les modifications d'ARN en analysant la relation entre structure et fonction de complexes ribonucléoprotéiques (complexes RNP) en lien avec plusieurs ARN dont dépendent les mécanique de traduction génétique (rRNA, tRNA, snoRNA) ou les ARN régulateurs. L'analyse des dynamiques et des propriétés de reconnaissance des RNP qui impliquent notamment des interactions transitoires constituera l'un des défis à relever. Pour cette raison, le projet nécessite une approche pluridisciplinaire (biochimie, biophysique, génétique, biologie structurelle, etc.) et le développement de technique d'extraction à haut débit (analyse épitranscriptomique, purification des RNP), d'où la nécessité d'investir dans les équipements appropriés et de mettre en place une synergie forte entre les laboratoire, reconnus sur le plan international, à la pointe dans ce domaine (IBMC/IBMP à Strasbourg, CBI/IGBMC et LBP à Illkirch, IMoPA et NGERE à Nancy et LNIO à Troyes). Les équipements acquis dans le cadre du projet sont : - un microscope électronique qui sera installé dans les locaux de l'IBMC/IBMP (pour permettre d'effectuer les analyses cryo-EM dans des conditions expérimentales optimales) ; - une caméra haute-sensibilité de dernière génération GATAN K3 qui constituera une amélioration du matériel cryo-EM du CBI, qui accueille déjà les infrastructures FRISBI et Instruct. (French)
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    The objective of the EpiRNA project is to study the molecular mechanisms involved in RNA modifications by analysing the relationship between structure and function of ribonucleoproteic complexes (RNP complexes) in relation to several RNAs on which genetic translation mechanics (rRNA, tRNA, snoRNA) or regulatory RNA depend. An analysis of the dynamics and recognition properties of RNPs that involve, inter alia, transient interactions will be one of the challenges to be addressed. For this reason, the project requires a multidisciplinary approach (biochemistry, biophysics, genetics, structural biology, etc.) and the development of high-throughput extraction techniques (epitranscriptomic analysis, purification of RNPs), hence the need to invest in the appropriate equipment and to establish a strong synergy between internationally recognised laboratories at the forefront in this field (IBMC/IBMP in Strasbourg, CBI/IGBMC and LBP in Illkirch, IMOPA and Ngere in Nancy and LNIO in Troyes). The equipment acquired under the project is: an electron microscope to be installed in the IBMC/IBMP premises (to enable cryo-EM analyses under optimal experimental conditions); — a latest generation Gatan K3 high-sensitivity camera that will be an improvement of CBI cryo-EM equipment, which already hosts the Frisbi and Instruct infrastructures. (English)
    22 November 2021
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    Identifiers

    AL0024408
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