Q3198389 (Q3198389): Difference between revisions
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(Created claim: summary (P836): Uveitis is the third cause of legal blindness in Spain, which carries a significant socio-economic burden.The most common cause of loss of visual acuity in patients with non-infectious uveitis is macular oedema (MA).A better understanding of the causes and risk factors predicting visual prognosis in these patients would allow the use of more selective and efficient pharmacological therapies that would improve long-term visual prognosis. The main...) |
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Uveitis is the third cause of legal blindness in Spain, which carries a significant socio-economic burden.The most common cause of loss of visual acuity in patients with non-infectious uveitis is macular oedema (MA).A better understanding of the causes and risk factors predicting visual prognosis in these patients would allow the use of more selective and efficient pharmacological therapies that would improve long-term visual prognosis. The main objective is to identify predictors of loss of visual acuity in patients with non-infectious uveitic MS. This will be done in patients with uveitic MS: 1) Analysis of clinical and demographic factors 2) Factors oftalmológicos:principalmente of image dependent on structural modifications measured by optical coherence tomography (OCT) 3) Biomarkers: by determining the plasma levels of TNFa, IL1ß, IL6, IL8, IL10, IL17, somatostatin and VEGF as well as the circulating levels of regulatory T lymphocytes. In all three groups of factors their relationship with loss of visual acuity will be studied. Methodology: An analytical multicenter cohort observational study with a minimum follow-up of 12 months shall be conducted, including a group of patients with MS secondary to non-infectious uveitis. The study population shall comprise two populations: patients with non-infectious uveitis secondary to posterior uveitis, panuveitis or intermediate uveitis and patients with MS secondary to anterior uveitis. (English) | |||||||||||||||
| Property / summary: Uveitis is the third cause of legal blindness in Spain, which carries a significant socio-economic burden.The most common cause of loss of visual acuity in patients with non-infectious uveitis is macular oedema (MA).A better understanding of the causes and risk factors predicting visual prognosis in these patients would allow the use of more selective and efficient pharmacological therapies that would improve long-term visual prognosis. The main objective is to identify predictors of loss of visual acuity in patients with non-infectious uveitic MS. This will be done in patients with uveitic MS: 1) Analysis of clinical and demographic factors 2) Factors oftalmológicos:principalmente of image dependent on structural modifications measured by optical coherence tomography (OCT) 3) Biomarkers: by determining the plasma levels of TNFa, IL1ß, IL6, IL8, IL10, IL17, somatostatin and VEGF as well as the circulating levels of regulatory T lymphocytes. In all three groups of factors their relationship with loss of visual acuity will be studied. Methodology: An analytical multicenter cohort observational study with a minimum follow-up of 12 months shall be conducted, including a group of patients with MS secondary to non-infectious uveitis. The study population shall comprise two populations: patients with non-infectious uveitis secondary to posterior uveitis, panuveitis or intermediate uveitis and patients with MS secondary to anterior uveitis. (English) / rank | |||||||||||||||
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| Property / summary: Uveitis is the third cause of legal blindness in Spain, which carries a significant socio-economic burden.The most common cause of loss of visual acuity in patients with non-infectious uveitis is macular oedema (MA).A better understanding of the causes and risk factors predicting visual prognosis in these patients would allow the use of more selective and efficient pharmacological therapies that would improve long-term visual prognosis. The main objective is to identify predictors of loss of visual acuity in patients with non-infectious uveitic MS. This will be done in patients with uveitic MS: 1) Analysis of clinical and demographic factors 2) Factors oftalmológicos:principalmente of image dependent on structural modifications measured by optical coherence tomography (OCT) 3) Biomarkers: by determining the plasma levels of TNFa, IL1ß, IL6, IL8, IL10, IL17, somatostatin and VEGF as well as the circulating levels of regulatory T lymphocytes. In all three groups of factors their relationship with loss of visual acuity will be studied. Methodology: An analytical multicenter cohort observational study with a minimum follow-up of 12 months shall be conducted, including a group of patients with MS secondary to non-infectious uveitis. The study population shall comprise two populations: patients with non-infectious uveitis secondary to posterior uveitis, panuveitis or intermediate uveitis and patients with MS secondary to anterior uveitis. (English) / qualifier | |||||||||||||||
point in time: 13 October 2021
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Revision as of 00:17, 13 October 2021
Project Q3198389 in Spain
| Language | Label | Description | Also known as |
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| English | No label defined |
Project Q3198389 in Spain |
Statements
4,670.0 Euro
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9,340.0 Euro
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50.0 percent
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1 January 2014
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31 March 2017
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INSTITUTO ARAGONES DE CIENCIAS DE LA SALUD
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41°39'7.67"N, 0°52'51.38"W
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50297
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Las uveitis son la tercera causa de ceguera legal en España lo que conlleva una importante carga socioeconómica .La causa de pérdida de agudeza visual más frecuente en pacientes con uveítis no infecciosa es el edema macular (EM).Un mejor conocimiento de las causas y factores de riesgo predictores del pronóstico visual en estos pacientes permitiría utilizar terapias farmacológicas más selectivas y eficientes que mejorarían el pronóstico visual a largo plazo. El objetivo principal es identificar factores de riesgo predictores de pérdida de agudeza visual en pacientes con EM uveítico no infeccioso. Para ello se realizará en pacientes afectos de EM uveitico : 1) Análisis de factores clínicos y demográficos 2) Factores oftalmológicos :principalmente de imagen dependientes de las modificaciones estructurales medidas por tomografía de coherencia óptica (OCT) 3) Biomarcadores: mediante determinación de los niveles plasmáticos de TNFa,, IL1ß, IL6, IL8, IL10, IL17, somatostatina y VEGF así como de los niveles circulantes de linfocitos T reguladores.En los tres grupos de factores se estudiará su relación con la pérdida de agudeza visual. Metodología: Se realizará un estudio multicéntrico observacional analítico de cohortes con un seguimiento mínimo de 12 meses, que incluirá un grupo de pacientes con EM secundario a uveitis no infecciosa. La población de estudio comprenderá dos poblaciones: pacientes con EM uveítico no infeccioso secundario a uveitís posteriores, panuveitis ó uveítis intermedia y pacientes con EM secundario a uveitis anterior. (Spanish)
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Uveitis is the third cause of legal blindness in Spain, which carries a significant socio-economic burden.The most common cause of loss of visual acuity in patients with non-infectious uveitis is macular oedema (MA).A better understanding of the causes and risk factors predicting visual prognosis in these patients would allow the use of more selective and efficient pharmacological therapies that would improve long-term visual prognosis. The main objective is to identify predictors of loss of visual acuity in patients with non-infectious uveitic MS. This will be done in patients with uveitic MS: 1) Analysis of clinical and demographic factors 2) Factors oftalmológicos:principalmente of image dependent on structural modifications measured by optical coherence tomography (OCT) 3) Biomarkers: by determining the plasma levels of TNFa, IL1ß, IL6, IL8, IL10, IL17, somatostatin and VEGF as well as the circulating levels of regulatory T lymphocytes. In all three groups of factors their relationship with loss of visual acuity will be studied. Methodology: An analytical multicenter cohort observational study with a minimum follow-up of 12 months shall be conducted, including a group of patients with MS secondary to non-infectious uveitis. The study population shall comprise two populations: patients with non-infectious uveitis secondary to posterior uveitis, panuveitis or intermediate uveitis and patients with MS secondary to anterior uveitis. (English)
13 October 2021
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Zaragoza
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Identifiers
PI13_00321
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