Q3176886 (Q3176886): Difference between revisions
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(Created claim: summary (P836): Retinal degeneration is the most frequent cause of legal blindness in the western world without yet available curative treatment. Our objective is to evaluate the protective action of melatonin and epigalocatechin gallate (EGCG) for its antioxidant action against retinal degeneration in an animal model of Pigmentary Retinosis (RP) and one of Age-Associated Macular Degeneration (AMD). Antioxidant treatment is an important option in these diseases...) |
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Retinal degeneration is the most frequent cause of legal blindness in the western world without yet available curative treatment. Our objective is to evaluate the protective action of melatonin and epigalocatechin gallate (EGCG) for its antioxidant action against retinal degeneration in an animal model of Pigmentary Retinosis (RP) and one of Age-Associated Macular Degeneration (AMD). Antioxidant treatment is an important option in these diseases where oxidative stress is fundamental in their ethiopathogeny. The animal models will be the P23H line 1 pigmented heterozygote rat, autosomal dominant RP model and the mouse knowdown for superoxide decreasetase 2 (Sod2KD), model of DMAE. Oral treatment will be performed with melatonin or epigalocatechin gallate (ECGC). Visual function (electroretinography and visual acuity using Optomotor), non-visual retinal functions (telemetry for the study of circadian rhythms) and anatomical titration will be performed using spectral domain and immunocytochemical optical coherence tomography. Oxidative stress parameters, inflammatory and antioxidant defenses will be evaluated. The use of antioxidants, individually or associatedly, is one of the future therapeutic pillars in human pathology related to degeneration and aging. Like our group is developing a Clinical Trial in PR patients with melatonin based on previous results in animal models, this preclinical study aims to be the basis for the evaluation of melatonin and EGCG in DMAE or RP for the further development of clinical trials in these patients. (English) | |||||||||||||||
| Property / summary: Retinal degeneration is the most frequent cause of legal blindness in the western world without yet available curative treatment. Our objective is to evaluate the protective action of melatonin and epigalocatechin gallate (EGCG) for its antioxidant action against retinal degeneration in an animal model of Pigmentary Retinosis (RP) and one of Age-Associated Macular Degeneration (AMD). Antioxidant treatment is an important option in these diseases where oxidative stress is fundamental in their ethiopathogeny. The animal models will be the P23H line 1 pigmented heterozygote rat, autosomal dominant RP model and the mouse knowdown for superoxide decreasetase 2 (Sod2KD), model of DMAE. Oral treatment will be performed with melatonin or epigalocatechin gallate (ECGC). Visual function (electroretinography and visual acuity using Optomotor), non-visual retinal functions (telemetry for the study of circadian rhythms) and anatomical titration will be performed using spectral domain and immunocytochemical optical coherence tomography. Oxidative stress parameters, inflammatory and antioxidant defenses will be evaluated. The use of antioxidants, individually or associatedly, is one of the future therapeutic pillars in human pathology related to degeneration and aging. Like our group is developing a Clinical Trial in PR patients with melatonin based on previous results in animal models, this preclinical study aims to be the basis for the evaluation of melatonin and EGCG in DMAE or RP for the further development of clinical trials in these patients. (English) / rank | |||||||||||||||
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| Property / summary: Retinal degeneration is the most frequent cause of legal blindness in the western world without yet available curative treatment. Our objective is to evaluate the protective action of melatonin and epigalocatechin gallate (EGCG) for its antioxidant action against retinal degeneration in an animal model of Pigmentary Retinosis (RP) and one of Age-Associated Macular Degeneration (AMD). Antioxidant treatment is an important option in these diseases where oxidative stress is fundamental in their ethiopathogeny. The animal models will be the P23H line 1 pigmented heterozygote rat, autosomal dominant RP model and the mouse knowdown for superoxide decreasetase 2 (Sod2KD), model of DMAE. Oral treatment will be performed with melatonin or epigalocatechin gallate (ECGC). Visual function (electroretinography and visual acuity using Optomotor), non-visual retinal functions (telemetry for the study of circadian rhythms) and anatomical titration will be performed using spectral domain and immunocytochemical optical coherence tomography. Oxidative stress parameters, inflammatory and antioxidant defenses will be evaluated. The use of antioxidants, individually or associatedly, is one of the future therapeutic pillars in human pathology related to degeneration and aging. Like our group is developing a Clinical Trial in PR patients with melatonin based on previous results in animal models, this preclinical study aims to be the basis for the evaluation of melatonin and EGCG in DMAE or RP for the further development of clinical trials in these patients. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 18:42, 12 October 2021
Project Q3176886 in Spain
| Language | Label | Description | Also known as |
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| English | No label defined |
Project Q3176886 in Spain |
Statements
19,000.0 Euro
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38,000.0 Euro
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50.0 percent
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1 January 2014
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30 September 2018
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INSTITUTO ARAGONES DE CIENCIAS DE LA SALUD
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41°39'7.67"N, 0°52'51.38"W
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50297
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Las degeneraciones retinianas constituyen la causa más frecuente de ceguera legal en el mundo occidental sin existir todavía un tratamiento curativo disponible. Nuestro objetivo es evaluar la acción protectora de melatonina y galato de epigalocatequina (EGCG) por su acción antioxidante frente a la degeneración retiniana en un modelo animal de Retinosis Pigmentaria (RP) y uno de Degeneración Macular Asociada a la Edad (DMAE). El tratamiento antioxidante es una importante opción en estas enfermedades donde el estrés oxidativo es fundamental en su etiopatogenia. Los modelos de animales serán la rata P23H línea 1 heterocigota pigmentada, modelo autosómico dominante de RP y el ratón knowdown para la superóxido disminutasa 2 (Sod2KD), modelo de DMAE. El tratamiento oral se realizará con melatonina y/o galato de epigalocatequina (ECGC). Se realizará valoración de la función visual (electrorretinografía y agudeza visual mediante Optomotor), las funciones retinianas no visuales (telemetría para estudio de ritmos circadianos) y valoración anatómica mediante tomografía de coherencia óptica de dominio espectral e inmunocitoquímica. Se evaluarán parámetros de estrés oxidativo, inflamatorio y defensas antioxidantes. El uso de antioxidantes, de modo individual o asociado, es uno de los futuros pilares terapéuticos en la patología humana relacionada con la degeneración y el envejecimiento. Al igual que nuestro grupo está desarrollando un Ensayo Clínico en pacientes de RP con melatonina basado en resultados previos en modelos animales, este estudio preclínico pretende ser la base de evaluación de melatonina y EGCG en DMAE o RP para el posterior desarrollo de Ensayos Clínicos en estos enfermos. (Spanish)
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Retinal degeneration is the most frequent cause of legal blindness in the western world without yet available curative treatment. Our objective is to evaluate the protective action of melatonin and epigalocatechin gallate (EGCG) for its antioxidant action against retinal degeneration in an animal model of Pigmentary Retinosis (RP) and one of Age-Associated Macular Degeneration (AMD). Antioxidant treatment is an important option in these diseases where oxidative stress is fundamental in their ethiopathogeny. The animal models will be the P23H line 1 pigmented heterozygote rat, autosomal dominant RP model and the mouse knowdown for superoxide decreasetase 2 (Sod2KD), model of DMAE. Oral treatment will be performed with melatonin or epigalocatechin gallate (ECGC). Visual function (electroretinography and visual acuity using Optomotor), non-visual retinal functions (telemetry for the study of circadian rhythms) and anatomical titration will be performed using spectral domain and immunocytochemical optical coherence tomography. Oxidative stress parameters, inflammatory and antioxidant defenses will be evaluated. The use of antioxidants, individually or associatedly, is one of the future therapeutic pillars in human pathology related to degeneration and aging. Like our group is developing a Clinical Trial in PR patients with melatonin based on previous results in animal models, this preclinical study aims to be the basis for the evaluation of melatonin and EGCG in DMAE or RP for the further development of clinical trials in these patients. (English)
12 October 2021
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Zaragoza
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Identifiers
PI13_01124
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