Q3175526 (Q3175526): Difference between revisions
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(Created claim: summary (P836): Metalloprotease (MMPs) participate in the progression of atherosclerotic plaque, thrombosis, fibrinolysis ischemic damage and tissue repair. MMP-10 is associated with subclinical and clinical atherosclerosis, as well as brain damage and worse functional prognosis in ischemic stroke. However, MMP-10 also plays an important profibrinolytic function and is necessary for tissue repair processes after lower extremity ischemia, after liver and skeleta...) |
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Metalloprotease (MMPs) participate in the progression of atherosclerotic plaque, thrombosis, fibrinolysis ischemic damage and tissue repair. MMP-10 is associated with subclinical and clinical atherosclerosis, as well as brain damage and worse functional prognosis in ischemic stroke. However, MMP-10 also plays an important profibrinolytic function and is necessary for tissue repair processes after lower extremity ischemia, after liver and skeletal muscle damage. With the hypothesis that MMP-10 can have a dual function, we propose: 1. Determine the circulating levels of MMP-10 after acute myocardial infarction, analyse its vehiculisation in microparticles, association with acute clinical parameters and prognostic value. 2. Study the functional relevance of MMP-10 in the repair and remodeling processes after myocardial infarction, using an experimental model for permanent coronary occlusion in mice MMP-10 KO. 3. Define in which cell types MMP-10 originates, performing this model in mice with conditional MMP-10 deficiency in endothelium and mice MMP-10 KO with wild type bone marrow. 4. Identify, by means of genomics and proteomics, new molecular pathways and MMP-10 substrates involved in the repair after myocardial ischemia. The results of this project will make it possible to assess the usefulness of the MMP-10 as a marker in AMI. Knowledge of the role of MMP-10 in repair and remodeling processes, as well as the cellular types and mechanisms involved, will facilitate the discovery of new therapeutic targets in tissue regeneration after ischemia. (English) | |||||||||||||||
| Property / summary: Metalloprotease (MMPs) participate in the progression of atherosclerotic plaque, thrombosis, fibrinolysis ischemic damage and tissue repair. MMP-10 is associated with subclinical and clinical atherosclerosis, as well as brain damage and worse functional prognosis in ischemic stroke. However, MMP-10 also plays an important profibrinolytic function and is necessary for tissue repair processes after lower extremity ischemia, after liver and skeletal muscle damage. With the hypothesis that MMP-10 can have a dual function, we propose: 1. Determine the circulating levels of MMP-10 after acute myocardial infarction, analyse its vehiculisation in microparticles, association with acute clinical parameters and prognostic value. 2. Study the functional relevance of MMP-10 in the repair and remodeling processes after myocardial infarction, using an experimental model for permanent coronary occlusion in mice MMP-10 KO. 3. Define in which cell types MMP-10 originates, performing this model in mice with conditional MMP-10 deficiency in endothelium and mice MMP-10 KO with wild type bone marrow. 4. Identify, by means of genomics and proteomics, new molecular pathways and MMP-10 substrates involved in the repair after myocardial ischemia. The results of this project will make it possible to assess the usefulness of the MMP-10 as a marker in AMI. Knowledge of the role of MMP-10 in repair and remodeling processes, as well as the cellular types and mechanisms involved, will facilitate the discovery of new therapeutic targets in tissue regeneration after ischemia. (English) / rank | |||||||||||||||
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| Property / summary: Metalloprotease (MMPs) participate in the progression of atherosclerotic plaque, thrombosis, fibrinolysis ischemic damage and tissue repair. MMP-10 is associated with subclinical and clinical atherosclerosis, as well as brain damage and worse functional prognosis in ischemic stroke. However, MMP-10 also plays an important profibrinolytic function and is necessary for tissue repair processes after lower extremity ischemia, after liver and skeletal muscle damage. With the hypothesis that MMP-10 can have a dual function, we propose: 1. Determine the circulating levels of MMP-10 after acute myocardial infarction, analyse its vehiculisation in microparticles, association with acute clinical parameters and prognostic value. 2. Study the functional relevance of MMP-10 in the repair and remodeling processes after myocardial infarction, using an experimental model for permanent coronary occlusion in mice MMP-10 KO. 3. Define in which cell types MMP-10 originates, performing this model in mice with conditional MMP-10 deficiency in endothelium and mice MMP-10 KO with wild type bone marrow. 4. Identify, by means of genomics and proteomics, new molecular pathways and MMP-10 substrates involved in the repair after myocardial ischemia. The results of this project will make it possible to assess the usefulness of the MMP-10 as a marker in AMI. Knowledge of the role of MMP-10 in repair and remodeling processes, as well as the cellular types and mechanisms involved, will facilitate the discovery of new therapeutic targets in tissue regeneration after ischemia. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 18:16, 12 October 2021
Project Q3175526 in Spain
| Language | Label | Description | Also known as |
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| English | No label defined |
Project Q3175526 in Spain |
Statements
57,750.0 Euro
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115,500.0 Euro
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50.0 percent
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1 January 2015
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31 March 2018
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FUNDACION PARA LA INVESTIGACION MEDICA APLICADA
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42°49'6.42"N, 1°38'39.34"W
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31201
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Las metaloproteasas (MMPs) participan en la progresión de la placa aterosclerótica, trombosis, fibrinolisis daño isquémico y reparación tisular. La MMP-10 se asocia con la aterosclerosis subclínica y clínica, así como con el daño cerebral y peor pronóstico funcional en el ictus isquémico. Sin embargo, la MMP-10 también desempeña una relevante función profibrinolítica y es necesaria para los procesos de reparación tisular tras isquemia de extremidades inferiores, tras daño hepático y del músculo esquelético. Con la hipótesis de que la MMP-10 puede tener una función dual, nos proponemos: 1. Determinar los niveles circulantes de MMP-10 tras infarto agudo de miocardio, analizar su vehiculización en micropartículas, asociación con parámetros clínicos agudos y valor pronóstico. 2. Estudiar la relevancia funcional de la MMP-10 en los procesos de reparación y remodelado tras infarto de miocardio, utilizando un modelo experimental por oclusión coronaria permanente en ratones MMP-10 KO. 3. Definir en qué tipos celulares se origina la MMP-10, realizando este modelo en ratones con deficiencia condicional de MMP-10 en endotelio y ratones MMP-10 KO con médula ósea de wild type. 4. Identificar, mediante genómica y proteómica, nuevas vías moleculares y sustratos de MMP-10 implicados en la reparación tras isquemia miocárdica. Los resultados de este proyecto permitirán valorar la utilidad de la MMP-10 como marcador en IAM. El conocimiento de la función de la MMP-10 en los procesos de reparación y remodelado, así como los tipos celulares y mecanismos implicadas, facilitará el hallazgo de nuevas dianas terapéuticas en la regeneración tisular tras isquemia. (Spanish)
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Metalloprotease (MMPs) participate in the progression of atherosclerotic plaque, thrombosis, fibrinolysis ischemic damage and tissue repair. MMP-10 is associated with subclinical and clinical atherosclerosis, as well as brain damage and worse functional prognosis in ischemic stroke. However, MMP-10 also plays an important profibrinolytic function and is necessary for tissue repair processes after lower extremity ischemia, after liver and skeletal muscle damage. With the hypothesis that MMP-10 can have a dual function, we propose: 1. Determine the circulating levels of MMP-10 after acute myocardial infarction, analyse its vehiculisation in microparticles, association with acute clinical parameters and prognostic value. 2. Study the functional relevance of MMP-10 in the repair and remodeling processes after myocardial infarction, using an experimental model for permanent coronary occlusion in mice MMP-10 KO. 3. Define in which cell types MMP-10 originates, performing this model in mice with conditional MMP-10 deficiency in endothelium and mice MMP-10 KO with wild type bone marrow. 4. Identify, by means of genomics and proteomics, new molecular pathways and MMP-10 substrates involved in the repair after myocardial ischemia. The results of this project will make it possible to assess the usefulness of the MMP-10 as a marker in AMI. Knowledge of the role of MMP-10 in repair and remodeling processes, as well as the cellular types and mechanisms involved, will facilitate the discovery of new therapeutic targets in tissue regeneration after ischemia. (English)
12 October 2021
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Pamplona/Iruña
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Identifiers
PI14_01152
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