Q3161185 (Q3161185): Difference between revisions
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(Created claim: summary (P836): BACKGROUND: Spinal cord injury (LM) has a devastating effect on sensory motor function and impacts directly on its quality of life. Approximately half of the subjects with ML are diagnosed as incomplete (MIL), but their motor recovery is limited. The identification of new neurophysiological biomarkers, which have diagnostic and prognostic value, and are sensitive to changes caused by combined strategies of intensive pedaling and spinal stimulati...) |
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BACKGROUND: Spinal cord injury (LM) has a devastating effect on sensory motor function and impacts directly on its quality of life. Approximately half of the subjects with ML are diagnosed as incomplete (MIL), but their motor recovery is limited. The identification of new neurophysiological biomarkers, which have diagnostic and prognostic value, and are sensitive to changes caused by combined strategies of intensive pedaling and spinal stimulation, is required in order to measure the neuroplastic changes produced that may have long-term clinical impact. OBJECTIVES: 1) Analyse the contribution of descending motor control systems related to motor spinal excitability after LMI with neurophysiological techniques that measure the skin conditioning of the H reflex (sensitivomotor medullary excitability) and muscle coherence, 2) Characterising the medulla-sensitive motor excitability related to the muscle strength of the lower limbs induced by non-invasive spinal stimulation combined with the motion of pedaling after LMI, 3) Assess the prognostic value of sensory medullary excitability induced by non-invasive spinal stimulation and pedaling in the acute phase. METHODOLOGY: Rehabilitators, physiotherapists and research staff will recruit patients from the National Paraplegic Hospital. Subjects: IML (AIS C-D) D1-L1, 2-9 months after injury. Design: Objective 1 (cross-sectional study), Objective 2 (randomised clinical trial) and Objective 3 (longitudinal study between early and late subacute phase). Intervention (Objectives 2 and 3): Non-invasive spinal stimulation combined with a hybrid ergometer without and with spinal stimulation. Variables: Clinical, biomechanical and neurophysiological measures. Estimated spinal excitability at rest and the muscle coherence quantified during walking and controlled movement. (English) | |||||||||||||||
| Property / summary: BACKGROUND: Spinal cord injury (LM) has a devastating effect on sensory motor function and impacts directly on its quality of life. Approximately half of the subjects with ML are diagnosed as incomplete (MIL), but their motor recovery is limited. The identification of new neurophysiological biomarkers, which have diagnostic and prognostic value, and are sensitive to changes caused by combined strategies of intensive pedaling and spinal stimulation, is required in order to measure the neuroplastic changes produced that may have long-term clinical impact. OBJECTIVES: 1) Analyse the contribution of descending motor control systems related to motor spinal excitability after LMI with neurophysiological techniques that measure the skin conditioning of the H reflex (sensitivomotor medullary excitability) and muscle coherence, 2) Characterising the medulla-sensitive motor excitability related to the muscle strength of the lower limbs induced by non-invasive spinal stimulation combined with the motion of pedaling after LMI, 3) Assess the prognostic value of sensory medullary excitability induced by non-invasive spinal stimulation and pedaling in the acute phase. METHODOLOGY: Rehabilitators, physiotherapists and research staff will recruit patients from the National Paraplegic Hospital. Subjects: IML (AIS C-D) D1-L1, 2-9 months after injury. Design: Objective 1 (cross-sectional study), Objective 2 (randomised clinical trial) and Objective 3 (longitudinal study between early and late subacute phase). Intervention (Objectives 2 and 3): Non-invasive spinal stimulation combined with a hybrid ergometer without and with spinal stimulation. Variables: Clinical, biomechanical and neurophysiological measures. Estimated spinal excitability at rest and the muscle coherence quantified during walking and controlled movement. (English) / rank | |||||||||||||||
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| Property / summary: BACKGROUND: Spinal cord injury (LM) has a devastating effect on sensory motor function and impacts directly on its quality of life. Approximately half of the subjects with ML are diagnosed as incomplete (MIL), but their motor recovery is limited. The identification of new neurophysiological biomarkers, which have diagnostic and prognostic value, and are sensitive to changes caused by combined strategies of intensive pedaling and spinal stimulation, is required in order to measure the neuroplastic changes produced that may have long-term clinical impact. OBJECTIVES: 1) Analyse the contribution of descending motor control systems related to motor spinal excitability after LMI with neurophysiological techniques that measure the skin conditioning of the H reflex (sensitivomotor medullary excitability) and muscle coherence, 2) Characterising the medulla-sensitive motor excitability related to the muscle strength of the lower limbs induced by non-invasive spinal stimulation combined with the motion of pedaling after LMI, 3) Assess the prognostic value of sensory medullary excitability induced by non-invasive spinal stimulation and pedaling in the acute phase. METHODOLOGY: Rehabilitators, physiotherapists and research staff will recruit patients from the National Paraplegic Hospital. Subjects: IML (AIS C-D) D1-L1, 2-9 months after injury. Design: Objective 1 (cross-sectional study), Objective 2 (randomised clinical trial) and Objective 3 (longitudinal study between early and late subacute phase). Intervention (Objectives 2 and 3): Non-invasive spinal stimulation combined with a hybrid ergometer without and with spinal stimulation. Variables: Clinical, biomechanical and neurophysiological measures. Estimated spinal excitability at rest and the muscle coherence quantified during walking and controlled movement. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 16:44, 12 October 2021
Project Q3161185 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3161185 in Spain |
Statements
5,200.0 Euro
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6,500.0 Euro
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80.0 percent
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1 January 2018
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31 March 2021
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UNIVERSIDAD DE CASTILLA-LA MANCHA
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39°51'21.85"N, 4°1'26.26"W
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45168
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ANTECEDENTES: La lesión medular (LM) tiene un efecto devastador sobre la función sensitivomotora e impacta directamente sobre su calidad de vida. Aproximadamente la mitad de los sujetos con LM son diagnosticados como incompletos (LMi), pero su recuperación motriz es limitada. Se requiere la identificación de nuevos biomarcadores neurofisiológicos, que tengan valor diagnóstico y pronóstico, y sean sensibles a los cambios producidos por estrategias combinadas de pedaleo intensivo y estimulación espinal, con el fin de medir los cambios neuroplásticos producidos que puedan tener repercusión clínica a largo plazo. OBJETIVOS: 1) Analizar la contribución de sistemas descendentes de control motor relacionados con la excitabilidad medular motora tras LMi con técnicas neurofisiológicas que midan el condicionamiento cutáneo del reflejo H (excitabilidad medular sensitivomotora) y coherencia muscular, 2) Caracterizar la excitabilidad medular sensitivomotora relacionada con la fuerza muscular de los miembros inferiores inducida mediante la estimulación espinal no-invasiva combinada con el movimiento de pedaleo tras la LMi, 3) Evaluar el valor pronóstico de la excitabilidad medular sensitivomotora inducida mediante estimulación espinal no-invasiva y pedaleo en la fase aguda de la LMi, como biomarcador de recuperación motriz. METODOLOGÍA: Rehabilitadores, fisioterapeutas y personal investigador reclutarán pacientes del Hospital Nacional de Parapléjicos. Sujetos: LMi (AIS C-D) D1-L1, 2-9 meses tras lesión. Diseño: Objetivo 1 (estudio transversal), Objetivo 2 (Ensayo clínico aleatorizado) y Objetivo 3 (estudio longitudinal entre fase subaguda temprana y tardía). Intervención (Objetivos 2 y 3): Estimulación espinal no-invasiva combinada con un ergómetro híbrido sin y con estimulación medular. Variables: Medidas clínicas, biomecánicas y neurofisiológicas. Excitabilidad medular estimada en reposo y la coherencia muscular cuantificada durante la marcha y el movimiento controlado. (Spanish)
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BACKGROUND: Spinal cord injury (LM) has a devastating effect on sensory motor function and impacts directly on its quality of life. Approximately half of the subjects with ML are diagnosed as incomplete (MIL), but their motor recovery is limited. The identification of new neurophysiological biomarkers, which have diagnostic and prognostic value, and are sensitive to changes caused by combined strategies of intensive pedaling and spinal stimulation, is required in order to measure the neuroplastic changes produced that may have long-term clinical impact. OBJECTIVES: 1) Analyse the contribution of descending motor control systems related to motor spinal excitability after LMI with neurophysiological techniques that measure the skin conditioning of the H reflex (sensitivomotor medullary excitability) and muscle coherence, 2) Characterising the medulla-sensitive motor excitability related to the muscle strength of the lower limbs induced by non-invasive spinal stimulation combined with the motion of pedaling after LMI, 3) Assess the prognostic value of sensory medullary excitability induced by non-invasive spinal stimulation and pedaling in the acute phase. METHODOLOGY: Rehabilitators, physiotherapists and research staff will recruit patients from the National Paraplegic Hospital. Subjects: IML (AIS C-D) D1-L1, 2-9 months after injury. Design: Objective 1 (cross-sectional study), Objective 2 (randomised clinical trial) and Objective 3 (longitudinal study between early and late subacute phase). Intervention (Objectives 2 and 3): Non-invasive spinal stimulation combined with a hybrid ergometer without and with spinal stimulation. Variables: Clinical, biomechanical and neurophysiological measures. Estimated spinal excitability at rest and the muscle coherence quantified during walking and controlled movement. (English)
12 October 2021
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Toledo
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Identifiers
PI17_00581
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