Q3143769 (Q3143769): Difference between revisions
Jump to navigation
Jump to search
(Changed an Item: Edited by the materialized bot - inferring region from the coordinates) |
(Created claim: summary (P836): Objectives: knowing the role of residential radon, tobacco use, exposure to environmental tobacco smoke in childhood and adult life, occupation (including leisure activities), diet (including alcohol consumption), and polymorphisms in susceptility genes and DNA-repairing genes in the development of small cell lung cancer (the most lethal histological type of lung cancer, with 15-20 % lung cancer). Methodology: study of multicenter cases and cont...) |
||||||||||||||
| Property / summary | |||||||||||||||
Objectives: knowing the role of residential radon, tobacco use, exposure to environmental tobacco smoke in childhood and adult life, occupation (including leisure activities), diet (including alcohol consumption), and polymorphisms in susceptility genes and DNA-repairing genes in the development of small cell lung cancer (the most lethal histological type of lung cancer, with 15-20 % lung cancer). Methodology: study of multicenter cases and controls in 9 hospitals in 3 Autonomous Communities. Case: subject diagnosed with small cell lung cancer (incident cases). Control: subjects intervened by non-complex non-tobacco-related surgery. Inclusion criteria: subjects with no neoplastic history older than 30 years at the time of diagnosis or surgery. The cases will be recruited consecutively at the participating centers for 30 months. The controls will be selected in the same hospitals as the cases with a sampling by sex and age frequency. Cases and controls will be extracted 3 ml of total blood, radon will be measured at home and trained staff will interview them. Genetic polymorphisms will be determined in the National Genotyping Center and residential radon in the Radón Laboratory of Galicia. The results will be analysed with multivariate logistic regression. Sample size estimate: taking into account lung cancer mortality, the expected percentage of small cell cancer and the mortality-incidence ratio in lung cancer, and estimating case losses in 25 %, 537 cases will be recruited. The necessary controls, ratio 1:1.5 to the cases, will be 806, with a total of 1,343 participants. (English) | |||||||||||||||
| Property / summary: Objectives: knowing the role of residential radon, tobacco use, exposure to environmental tobacco smoke in childhood and adult life, occupation (including leisure activities), diet (including alcohol consumption), and polymorphisms in susceptility genes and DNA-repairing genes in the development of small cell lung cancer (the most lethal histological type of lung cancer, with 15-20 % lung cancer). Methodology: study of multicenter cases and controls in 9 hospitals in 3 Autonomous Communities. Case: subject diagnosed with small cell lung cancer (incident cases). Control: subjects intervened by non-complex non-tobacco-related surgery. Inclusion criteria: subjects with no neoplastic history older than 30 years at the time of diagnosis or surgery. The cases will be recruited consecutively at the participating centers for 30 months. The controls will be selected in the same hospitals as the cases with a sampling by sex and age frequency. Cases and controls will be extracted 3 ml of total blood, radon will be measured at home and trained staff will interview them. Genetic polymorphisms will be determined in the National Genotyping Center and residential radon in the Radón Laboratory of Galicia. The results will be analysed with multivariate logistic regression. Sample size estimate: taking into account lung cancer mortality, the expected percentage of small cell cancer and the mortality-incidence ratio in lung cancer, and estimating case losses in 25 %, 537 cases will be recruited. The necessary controls, ratio 1:1.5 to the cases, will be 806, with a total of 1,343 participants. (English) / rank | |||||||||||||||
Normal rank | |||||||||||||||
| Property / summary: Objectives: knowing the role of residential radon, tobacco use, exposure to environmental tobacco smoke in childhood and adult life, occupation (including leisure activities), diet (including alcohol consumption), and polymorphisms in susceptility genes and DNA-repairing genes in the development of small cell lung cancer (the most lethal histological type of lung cancer, with 15-20 % lung cancer). Methodology: study of multicenter cases and controls in 9 hospitals in 3 Autonomous Communities. Case: subject diagnosed with small cell lung cancer (incident cases). Control: subjects intervened by non-complex non-tobacco-related surgery. Inclusion criteria: subjects with no neoplastic history older than 30 years at the time of diagnosis or surgery. The cases will be recruited consecutively at the participating centers for 30 months. The controls will be selected in the same hospitals as the cases with a sampling by sex and age frequency. Cases and controls will be extracted 3 ml of total blood, radon will be measured at home and trained staff will interview them. Genetic polymorphisms will be determined in the National Genotyping Center and residential radon in the Radón Laboratory of Galicia. The results will be analysed with multivariate logistic regression. Sample size estimate: taking into account lung cancer mortality, the expected percentage of small cell cancer and the mortality-incidence ratio in lung cancer, and estimating case losses in 25 %, 537 cases will be recruited. The necessary controls, ratio 1:1.5 to the cases, will be 806, with a total of 1,343 participants. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
| |||||||||||||||
Revision as of 13:42, 12 October 2021
Project Q3143769 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3143769 in Spain |
Statements
73,200.0 Euro
0 references
91,500.0 Euro
0 references
80.0 percent
0 references
1 January 2016
0 references
31 March 2020
0 references
FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA
0 references
42°52'49.51"N, 8°32'45.10"W
0 references
15078
0 references
Objetivos: conocer el papel del radón residencial, consumo de tabaco, exposición a humo de tabaco ambiental en la infancia y en la vida adulta, ocupación (incluyendo actividades de tiempo libre), dieta (incluyendo consumo de alcohol) y polimorfismos en genes de susceptilidad y genes reparadores de DNA en el desarrollo de cáncer de pulmón de células pequeñas (tipo histológico más letal del cáncer pulmonar, con un 15-20% de cánceres pulmonares). Metodología: estudio de casos y controles multicéntrico en 9 hospitales de 3 CCAA. Caso: sujeto diagnosticado de cáncer de pulmón de célula pequeña (casos incidentes). Control: sujetos intervenidos por cirugía no compleja no relacionada con el tabaco. Criterios de inclusión: sujetos sin antecedentes neoplásicos mayores de 30 años en el momento del diagnóstico o de la cirugía. Los casos serán reclutados consecutivamente en los centros participantes durante 30 meses. Los controles se seleccionarán en los mismos hospitales que los casos con un muestreo por frecuencia de sexo y edad. A casos y a controles se les extraerán 3 ml de sangre total, se medirá radón en su domicilio y personal entrenado les hará una entrevista. Los polimorfismos genéticos se determinarán en el Centro Nacional de Genotipado y el radón residencial en el Laboratorio de Radón de Galicia. Los resultados se analizarán con regresión logística multivariante. Estimación de tamaño muestral: teniendo en cuenta la mortalidad del cáncer de pulmón, el porcentaje esperado de cáncer de células pequeñas y la relación mortalidad-incidencia en cáncer de pulmón y estimando las pérdidas de casos en el 25% se reclutarán 537 casos. Los controles necesarios, relación 1:1,5 con los casos, serán 806, con un total de 1.343 participantes. (Spanish)
0 references
Objectives: knowing the role of residential radon, tobacco use, exposure to environmental tobacco smoke in childhood and adult life, occupation (including leisure activities), diet (including alcohol consumption), and polymorphisms in susceptility genes and DNA-repairing genes in the development of small cell lung cancer (the most lethal histological type of lung cancer, with 15-20 % lung cancer). Methodology: study of multicenter cases and controls in 9 hospitals in 3 Autonomous Communities. Case: subject diagnosed with small cell lung cancer (incident cases). Control: subjects intervened by non-complex non-tobacco-related surgery. Inclusion criteria: subjects with no neoplastic history older than 30 years at the time of diagnosis or surgery. The cases will be recruited consecutively at the participating centers for 30 months. The controls will be selected in the same hospitals as the cases with a sampling by sex and age frequency. Cases and controls will be extracted 3 ml of total blood, radon will be measured at home and trained staff will interview them. Genetic polymorphisms will be determined in the National Genotyping Center and residential radon in the Radón Laboratory of Galicia. The results will be analysed with multivariate logistic regression. Sample size estimate: taking into account lung cancer mortality, the expected percentage of small cell cancer and the mortality-incidence ratio in lung cancer, and estimating case losses in 25 %, 537 cases will be recruited. The necessary controls, ratio 1:1.5 to the cases, will be 806, with a total of 1,343 participants. (English)
12 October 2021
0 references
Santiago de Compostela
0 references
Identifiers
PI15_01211
0 references