Investigation of the role of N-acetylase Naa40 in colon cancer (Q2720789): Difference between revisions
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(Created claim: summary (P836): Modifying histone enzymes and catalysing modifications are one of the main epigenetic mechanisms through which the cell regulates gene expression. Cancer often develops because the effect of these enzymes is deregulated, leading to incorrect gene expression, which then promotes carcinogenicity. Therefore, modifying histone enzymes consider promising therapeutic goals, and some such enzymes are already currently targeted at medicinal therapies. H...) |
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Modifying histone enzymes and catalysing modifications are one of the main epigenetic mechanisms through which the cell regulates gene expression. Cancer often develops because the effect of these enzymes is deregulated, leading to incorrect gene expression, which then promotes carcinogenicity. Therefore, modifying histone enzymes consider promising therapeutic goals, and some such enzymes are already currently targeted at medicinal therapies. However, the molecular function of many modifying histone enzymes remains unknown. One such epigenetic enzyme is the abundant and evolutionarily conserved N-alpha acetyltransferase 40 (Naa40), which remained unexplored for several decades because it was thought to catalyse a minor histonic modification. However, recent studies have highlighted Naa40 and N-terminal acetylation that catalyses as important regulators of gene expression and cell growth. We have also found that elimination of Naa40 in human cancer cells of the colon causes strong cell death. The latter findings involve Naa40 and N-final acetylation of H4 tissue in carcinogenicity and suggest that this epigenetic enzyme should be further investigated as a potential therapeutic target. Therefore, the main objective of this research project is to decipher Naa40's molecular role in the development of colon cancer and to assess its prospect as a therapeutic goal. To achieve this goal, a combination of modern genomics, proteomics, biochemistry and molecular biology will be used. The proposed project will provide new scientific knowledge that will serve as an example for the operation of other N-final protein modifications and, most importantly, define a new therapeutic target for cancer. (English) | |||||||||||||||
| Property / summary: Modifying histone enzymes and catalysing modifications are one of the main epigenetic mechanisms through which the cell regulates gene expression. Cancer often develops because the effect of these enzymes is deregulated, leading to incorrect gene expression, which then promotes carcinogenicity. Therefore, modifying histone enzymes consider promising therapeutic goals, and some such enzymes are already currently targeted at medicinal therapies. However, the molecular function of many modifying histone enzymes remains unknown. One such epigenetic enzyme is the abundant and evolutionarily conserved N-alpha acetyltransferase 40 (Naa40), which remained unexplored for several decades because it was thought to catalyse a minor histonic modification. However, recent studies have highlighted Naa40 and N-terminal acetylation that catalyses as important regulators of gene expression and cell growth. We have also found that elimination of Naa40 in human cancer cells of the colon causes strong cell death. The latter findings involve Naa40 and N-final acetylation of H4 tissue in carcinogenicity and suggest that this epigenetic enzyme should be further investigated as a potential therapeutic target. Therefore, the main objective of this research project is to decipher Naa40's molecular role in the development of colon cancer and to assess its prospect as a therapeutic goal. To achieve this goal, a combination of modern genomics, proteomics, biochemistry and molecular biology will be used. The proposed project will provide new scientific knowledge that will serve as an example for the operation of other N-final protein modifications and, most importantly, define a new therapeutic target for cancer. (English) / rank | |||||||||||||||
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| Property / summary: Modifying histone enzymes and catalysing modifications are one of the main epigenetic mechanisms through which the cell regulates gene expression. Cancer often develops because the effect of these enzymes is deregulated, leading to incorrect gene expression, which then promotes carcinogenicity. Therefore, modifying histone enzymes consider promising therapeutic goals, and some such enzymes are already currently targeted at medicinal therapies. However, the molecular function of many modifying histone enzymes remains unknown. One such epigenetic enzyme is the abundant and evolutionarily conserved N-alpha acetyltransferase 40 (Naa40), which remained unexplored for several decades because it was thought to catalyse a minor histonic modification. However, recent studies have highlighted Naa40 and N-terminal acetylation that catalyses as important regulators of gene expression and cell growth. We have also found that elimination of Naa40 in human cancer cells of the colon causes strong cell death. The latter findings involve Naa40 and N-final acetylation of H4 tissue in carcinogenicity and suggest that this epigenetic enzyme should be further investigated as a potential therapeutic target. Therefore, the main objective of this research project is to decipher Naa40's molecular role in the development of colon cancer and to assess its prospect as a therapeutic goal. To achieve this goal, a combination of modern genomics, proteomics, biochemistry and molecular biology will be used. The proposed project will provide new scientific knowledge that will serve as an example for the operation of other N-final protein modifications and, most importantly, define a new therapeutic target for cancer. (English) / qualifier | |||||||||||||||
point in time: 31 May 2021
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Revision as of 19:26, 31 May 2021
Project Q2720789 in Cyprus
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Investigation of the role of N-acetylase Naa40 in colon cancer |
Project Q2720789 in Cyprus |
Statements
212,500.01 Euro
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250,000.01 Euro
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85.0 percent
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10 March 2017
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28 February 2022
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University of Cyprus
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Τα τροποποιητικά ένζυμα ιστονών και οι τροποποιήσεις που καταλύουν αποτελούν ένα από τους κύριους επιγενετικούς μηχανισμούς μέσω του οποίου το κύτταρο ρυθμίζει την γονιδιακή έκφραση. Ο καρκίνος αναπτύσσεται συχνά επειδή η δράση αυτών των ενζύμων είναι απορρυθμισμένη οδηγώντας έτσι στην λανθασμένη έκφραση γονιδίων η οποία στη συνέχεια προωθεί την καρκινογένεση. Ως εκ τούτου, τα τροποποιητικά ένζυμα ιστονών θεωρούντε υποσχόμενη θεραπευτικοί στόχοι και μερικά τέτοια ένζυμα ήδη στοχεύονται σήμερα σε φαρμακευτικές θεραπείες. Παρόλο αυτά, η μοριακή λειτουργία πολλών τροποποιητικών ενζύμων ιστονών εξακολουθεί να παραμένει άγνωστη. Ένα τέτοιο επιγενετικό ένζυμο είναι η άφθονη και εξελικτικά συντηρημένη Ν-άλφα ακετυλοτρανσφεράση 40 (Naa40), η οποία έμεινε ανεξερεύνητη για αρκετές δεκαετίες, επειδή θεωρήθηκε ότι καταλύει μια ασήμαντη ιστονική τροποποίηση. Ωστόσο, πρόσφατες μελέτες μας, ανέδειξαν την Naa40 και την Ν-τερματική ακετυλίωση που καταλύει ως σημαντικούς ρυθμιστές της γονιδιακής έκφρασης και της κυτταρικής ανάπτυξης. Επίσης έχουμε διαπιστώσει ότι απαλοιφή της Naa40 σε ανθρώπινα καρκινικά κύτταρα του παχέος εντέρου προκαλεί ισχυρό κυτταρικό θανάτο. Τα τελευταία αυτά ευρήματα εμπλέκουν την Naa40 και την Ν-τελική ακετυλίωση της ιστόνης Η4 στην καρκινογένεση και προτείνουν ότι αυτό το επιγενετικό ενζύμο θα πρέπει να διερευνηθεί περαιτέρω ως πιθανός θεραπευτικός στόχος. Ως εκ τούτου, ο κύριος στόχος του ερευνητικού αυτού έργου είναι να αποκρυπτογραφήσει το μοριακό ρόλο της Naa40 στην ανάπτυξη καρκίνου του παχέος εντέρου και να αξιολογήσει την προοπτική του ως θεραπευτικού στόχου. Για την επίτευξη αυτού του σκοπού θα χρησιμοποιηθεί ένας συνδυασμός σύγχρονων μεθόδων γονιδιωματικής, πρωτεομικής, βιοχημείας και μοριακής βιολογίας. Το προτεινόμενο έργο θα προσφέρει νέα επιστημονική γνώση η οποία θα αποτελέσει παράδειγμα για την λειτουργία άλλων Ν-τελικών τροποποιήσεων πρωτεϊνών και, το σημαντικότερο, θα προσδιορίσει ένα νέο θεραπευτικό στόχο για τον καρκίνο. (Greek)
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Modifying histone enzymes and catalysing modifications are one of the main epigenetic mechanisms through which the cell regulates gene expression. Cancer often develops because the effect of these enzymes is deregulated, leading to incorrect gene expression, which then promotes carcinogenicity. Therefore, modifying histone enzymes consider promising therapeutic goals, and some such enzymes are already currently targeted at medicinal therapies. However, the molecular function of many modifying histone enzymes remains unknown. One such epigenetic enzyme is the abundant and evolutionarily conserved N-alpha acetyltransferase 40 (Naa40), which remained unexplored for several decades because it was thought to catalyse a minor histonic modification. However, recent studies have highlighted Naa40 and N-terminal acetylation that catalyses as important regulators of gene expression and cell growth. We have also found that elimination of Naa40 in human cancer cells of the colon causes strong cell death. The latter findings involve Naa40 and N-final acetylation of H4 tissue in carcinogenicity and suggest that this epigenetic enzyme should be further investigated as a potential therapeutic target. Therefore, the main objective of this research project is to decipher Naa40's molecular role in the development of colon cancer and to assess its prospect as a therapeutic goal. To achieve this goal, a combination of modern genomics, proteomics, biochemistry and molecular biology will be used. The proposed project will provide new scientific knowledge that will serve as an example for the operation of other N-final protein modifications and, most importantly, define a new therapeutic target for cancer. (English)
31 May 2021
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*Δεν έχει γεωγραφική διάσταση*
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Identifiers
34481
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