Technological development and clinical validation of an adaptive radiation therapy strategy in lung cancer (Q3146647): Difference between revisions
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(Created claim: summary (P836): The respiratory movement of tumors in the lung limits the dose prescribed by the oncologist, increases the uncertainty in the absorbed dose, compromises the probability of local disease control, and increases the risk of toxicity. This project addresses this problem with the aim of developing and validating a strategy to adapt lung treatments to ensure correct tumor coverage, less dosimetric uncertainty, and to subsequently propose dose escalati...) |
(Changed label, description and/or aliases in fr: translated_label) |
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| label / fr | label / fr | ||
Développement technologique et validation clinique d’une stratégie de radiothérapie adaptative pour le cancer du poumon | |||
Revision as of 15:31, 2 December 2021
Project Q3146647 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Technological development and clinical validation of an adaptive radiation therapy strategy in lung cancer |
Project Q3146647 in Spain |
Statements
30,750.0 Euro
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61,500.0 Euro
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50.0 percent
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1 January 2017
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31 March 2020
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FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE NAVARRA
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42°49'6.42"N, 1°38'39.34"W
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31201
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El movimiento respiratorio que sufren los tumores en el pulmón limita la dosis que puede prescribir el oncólogo, aumenta la incertidumbre en la dosis absorbida, compromete la probabilidad de control local de la enfermedad, y aumenta el riesgo de toxicidad. Este proyecto aborda este problema con el objetivo de desarrollar y validar una estrategia de adaptación de tratamientos en pulmón que asegure una correcta cobertura tumoral, una menor incertidumbre dosimétrica, y permita plantear posteriormente la escalada de dosis. En primer lugar desarrollaremos herramientas para evaluar las incertidumbres globales en la dosis absorbida en tumores de pulmón tratados con radioterapia estereotáctica guiada por imagen. En segundo lugar, aplicaremos las herramientas en una cohorte de pacientes, para establecer una estrategia clínicamente práctica de radioterapia adaptativa, que validaremos evaluando el acuerdo entre las dosis planificada y reconstruida. En esta investigación se introducen las siguientes novedades metodológicas para alcanzar los objetivos: 1) el uso y validación del registro deformable de imágenes entre conjuntos de TAC (planificación) y CBCT 4D adquirido justo antes del tratamiento, y de registro CBCT - CBCT; 2) la voxelización del tumor y el empleo del campo de vectores de desplazamiento para acumular y reconstruir la dosis global; 3) el uso del método de Monte Carlo para calcular la dosis en cada fracción de tratamiento sobre imágenes de CBCT 4D; 4) el estudio del efecto interplay en tratamientos con hipofraccionamiento y VMAT en pulmón, y, sobre todo; 5) la aplicación clínica de la radioterapia adaptativa en el pulmón, área en la que actualmente hay muy poca bibliografía. (Spanish)
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The respiratory movement of tumors in the lung limits the dose prescribed by the oncologist, increases the uncertainty in the absorbed dose, compromises the probability of local disease control, and increases the risk of toxicity. This project addresses this problem with the aim of developing and validating a strategy to adapt lung treatments to ensure correct tumor coverage, less dosimetric uncertainty, and to subsequently propose dose escalation. First, we will develop tools to assess global uncertainties in the absorbed dose in lung tumors treated with image-guided stereotactic radiation therapy. Secondly, we will apply the tools in a cohort of patients, to establish a clinically practical strategy of adaptive radiation therapy, which we will validate by evaluating the agreement between planned and reconstructed doses. This research introduces the following methodological innovations to achieve the objectives: 1) the use and validation of the deformable imaging record between sets of TACs (planning) and CBCT 4D acquired just before treatment, and of CBCT — CBCT registry; 2) the voxelisation of the tumor and the use of the field of displacement vectors to accumulate and reconstruct the global dose; 3) the use of the Monte Carlo method to calculate the dose in each 4D CBCT imaging fraction; 4) the study of the interplay effect in treatments with hypofractionation and VMAT in the lung, and above all; 5) The clinical application of adaptive radiation therapy in the lung, an area in which there is currently very little bibliography. (English)
12 October 2021
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Pamplona/Iruña
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Identifiers
PI16_00899
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