Determinants of resistance, virulence and population structure of invasive and non-invasive uropathogen E. coli and relation to the clinical-epidemiological characteristics of urinary infection (Q3161685): Difference between revisions
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(Removed claim: summary (P836): Escherichia coli (Ec) is the most common causal agent of urinary tract infection (UTI). Our participation in a multicenter study promoted by the Hospital Infection Study Group of the Spanish Society of Infectious Diseases and Clinical Microbiology, and in the European project of the 7th Framework Programme R-GNOSIS (HEALTH-F3-2011-282512) has enabled us to obtain a collection of more than 500 isolates of uropathogenic bacteria that cause urina...) |
(Created claim: summary (P836): Escherichia coli (Ec) is the most common causal agent of urinary tract infection (UTI). Our participation in a multicenter study promoted by the Hospital Infection Study Group of the Spanish Society of Infectious Diseases and Clinical Microbiology, and in the European project of the 7th Framework Programme R-GNOSIS (HEALTH-F3-2011-282512) has enabled us to obtain a collection of more than 500 isolates of uropathogenic bacteria that cause urinary...) |
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Escherichia coli (Ec) is the most common causal agent of urinary tract infection (UTI). Our participation in a multicenter study promoted by the Hospital Infection Study Group of the Spanish Society of Infectious Diseases and Clinical Microbiology, and in the European project of the 7th Framework Programme R-GNOSIS (HEALTH-F3-2011-282512) has enabled us to obtain a collection of more than 500 isolates of uropathogenic bacteria that cause urinary bacteremias (invasive hemoculture isolates) and ITU uncomplicated in the community (non-invasive urocultural isolations) from different areas and associated with epidemiological variables and well studied clinics. The objective of the project is to characterise this collection microbiologically, describing the resistance rates and their genetic bases, the determinants of virulence and their expression, and the presence of multi-resistant high-risk clones (CAR) with high epidemic potential, using state-of-the-art molecular microbiology techniques and bioinformatics tools. The analysis of the microbiological results in relation to epidemiological and clinical variables will allow the identification of patients with the highest risk of developing CAR UTIs and the definition of the associated severity prognosis. This proposal is an example of translational research through the application of knowledge of population genetics, antibiotic resistance and virulence to a frequent infectious entity in the health field such as UTI. The results will help to design strategies that optimise and improve clinical management and empirical therapy of UTI in Spain. Finally, two already consolidated projects converge synergistically in this proposal, allowing the continuity of this line of research. (English) | |||||||||||||||
| Property / summary: Escherichia coli (Ec) is the most common causal agent of urinary tract infection (UTI). Our participation in a multicenter study promoted by the Hospital Infection Study Group of the Spanish Society of Infectious Diseases and Clinical Microbiology, and in the European project of the 7th Framework Programme R-GNOSIS (HEALTH-F3-2011-282512) has enabled us to obtain a collection of more than 500 isolates of uropathogenic bacteria that cause urinary bacteremias (invasive hemoculture isolates) and ITU uncomplicated in the community (non-invasive urocultural isolations) from different areas and associated with epidemiological variables and well studied clinics. The objective of the project is to characterise this collection microbiologically, describing the resistance rates and their genetic bases, the determinants of virulence and their expression, and the presence of multi-resistant high-risk clones (CAR) with high epidemic potential, using state-of-the-art molecular microbiology techniques and bioinformatics tools. The analysis of the microbiological results in relation to epidemiological and clinical variables will allow the identification of patients with the highest risk of developing CAR UTIs and the definition of the associated severity prognosis. This proposal is an example of translational research through the application of knowledge of population genetics, antibiotic resistance and virulence to a frequent infectious entity in the health field such as UTI. The results will help to design strategies that optimise and improve clinical management and empirical therapy of UTI in Spain. Finally, two already consolidated projects converge synergistically in this proposal, allowing the continuity of this line of research. (English) / rank | |||||||||||||||
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| Property / summary: Escherichia coli (Ec) is the most common causal agent of urinary tract infection (UTI). Our participation in a multicenter study promoted by the Hospital Infection Study Group of the Spanish Society of Infectious Diseases and Clinical Microbiology, and in the European project of the 7th Framework Programme R-GNOSIS (HEALTH-F3-2011-282512) has enabled us to obtain a collection of more than 500 isolates of uropathogenic bacteria that cause urinary bacteremias (invasive hemoculture isolates) and ITU uncomplicated in the community (non-invasive urocultural isolations) from different areas and associated with epidemiological variables and well studied clinics. The objective of the project is to characterise this collection microbiologically, describing the resistance rates and their genetic bases, the determinants of virulence and their expression, and the presence of multi-resistant high-risk clones (CAR) with high epidemic potential, using state-of-the-art molecular microbiology techniques and bioinformatics tools. The analysis of the microbiological results in relation to epidemiological and clinical variables will allow the identification of patients with the highest risk of developing CAR UTIs and the definition of the associated severity prognosis. This proposal is an example of translational research through the application of knowledge of population genetics, antibiotic resistance and virulence to a frequent infectious entity in the health field such as UTI. The results will help to design strategies that optimise and improve clinical management and empirical therapy of UTI in Spain. Finally, two already consolidated projects converge synergistically in this proposal, allowing the continuity of this line of research. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 18:23, 12 October 2021
Project Q3161685 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Determinants of resistance, virulence and population structure of invasive and non-invasive uropathogen E. coli and relation to the clinical-epidemiological characteristics of urinary infection |
Project Q3161685 in Spain |
Statements
24,875.0 Euro
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49,750.0 Euro
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50.0 percent
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1 January 2014
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30 September 2018
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FUNDACION INVESTIGACION BIOMEDICA HOSPITAL RAMON Y CAJAL
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40°25'0.12"N, 3°42'12.89"W
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28079
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Escherichia coli (Ec) es el agente causal más frecuente de infección del tracto urinario (ITU). Nuestras participación en un estudio multicéntrico promovido por el Grupo de Estudio de Infección Hospitalaria de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica, y en el proyecto europeo del 7º Programa Marco R-GNOSIS (HEALTH-F3-2011-282512) nos ha permitido conseguir una colección de más de 500 aislados de Ec uropatógeno causantes de bacteriemias de origen urinario (aislados invasivos de hemocultivos) e ITU no complicadas en la comunidad (aislados no invasivos de urocultivos) procedentes de diferentes áreas y asociados con variables epidemiológicas y clínicas bien estudiadas. El objetivo del proyecto es caracterizar microbiológicamente esta colección, describiendo las tasas de resistencia y sus bases genéticas, los determinantes de virulencia y su expresión, y la presencia de clones de alto riesgo (CAR) multirresistentes con alto potencial epidémico, empleando técnicas de microbiología molecular de última generación y herramientas bioinformáticas. El análisis de los resultados microbiológicos en relación con variables epidemiológicas y clínicas permitirá identificar los pacientes con mayor riesgo de presentar ITU por CAR y definir el pronóstico de gravedad asociado. Esta propuesta constituye un ejemplo de investigación traslacional mediante la aplicación de conocimientos de genética poblacional, resistencias a los antibióticos y virulencia a una entidad infecciosa frecuente en el ámbito sanitario como es la ITU. Los resultados ayudarán a diseñar estrategias que optimicen y mejoren el manejo clínico y la terapia empírica de la ITU en España. Finalmente, dos proyectos ya consolidados convergen de forma sinérgica en esta propuesta, permitiendo la continuidad de esta línea de investigación. (Spanish)
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Escherichia coli (Ec) is the most common causal agent of urinary tract infection (UTI). Our participation in a multicenter study promoted by the Hospital Infection Study Group of the Spanish Society of Infectious Diseases and Clinical Microbiology, and in the European project of the 7th Framework Programme R-GNOSIS (HEALTH-F3-2011-282512) has enabled us to obtain a collection of more than 500 isolates of uropathogenic bacteria that cause urinary bacteremias (invasive hemoculture isolates) and ITU uncomplicated in the community (non-invasive urocultural isolations) from different areas and associated with epidemiological variables and well studied clinics. The objective of the project is to characterise this collection microbiologically, describing the resistance rates and their genetic bases, the determinants of virulence and their expression, and the presence of multi-resistant high-risk clones (CAR) with high epidemic potential, using state-of-the-art molecular microbiology techniques and bioinformatics tools. The analysis of the microbiological results in relation to epidemiological and clinical variables will allow the identification of patients with the highest risk of developing CAR UTIs and the definition of the associated severity prognosis. This proposal is an example of translational research through the application of knowledge of population genetics, antibiotic resistance and virulence to a frequent infectious entity in the health field such as UTI. The results will help to design strategies that optimise and improve clinical management and empirical therapy of UTI in Spain. Finally, two already consolidated projects converge synergistically in this proposal, allowing the continuity of this line of research. (English)
12 October 2021
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Madrid
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Identifiers
PI13_02092
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