Q3143447 (Q3143447): Difference between revisions
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(Created claim: summary (P836): Objectives: To evaluate the usefulness of the criteria of the “Porto proposal” (PP), as well as the participation of hormonal receptors and the BRAF gene in the aggressiveness and progression of papillary microcarcinoma (mCP) of thyroid by: clinical-pathological study of 100 mCP and 100 microtumors (MTP) classified according to PP criteria. b) Study of the expression of hormone receptors of alpha (REa) and beta (Reb), progesterone (RP) and andro...) |
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Objectives: To evaluate the usefulness of the criteria of the “Porto proposal” (PP), as well as the participation of hormonal receptors and the BRAF gene in the aggressiveness and progression of papillary microcarcinoma (mCP) of thyroid by: clinical-pathological study of 100 mCP and 100 microtumors (MTP) classified according to PP criteria. b) Study of the expression of hormone receptors of alpha (REa) and beta (Reb), progesterone (RP) and androgens (RA) in these neoplasms. Study of prevalence, anatomical distribution, BRAF status and expression of hormonal receptors in MCP and solid cell nests (SCNs) in 100 thyroid glands from the autopsy of subjects without clinical thyroid pathology. Methodology: 3-year unicentric study of paraffin-included samples from total hemithyroidectomy and thyroidectomy (retrospective) and autopsy thyroid glands (prospective). Clinical data (age, gender, distant and nodal metastases, associated thyroid pathology and follow-up) and pathological data (size, type and subtype tumor, presence of capsule, extrathyroid extension, multifocality, lymphovascular invasion and presence of high cells, column cells or clove cells) will be evaluated. Immunohistochemical analysis will be in complete sections with antibodies for REa, Reb, RP, RA, thyroglobulin, and calcitonin. The expression of the receptors will be evaluated by the Allred method. BRAF will be studied by PCR in real time from samples of laser microdissection. A planimetry system shall be used for the anatomical distribution of the MCP and NCS. The statistical analysis will verify the correlation between the different parameters. (English) | |||||||||||||||
| Property / summary: Objectives: To evaluate the usefulness of the criteria of the “Porto proposal” (PP), as well as the participation of hormonal receptors and the BRAF gene in the aggressiveness and progression of papillary microcarcinoma (mCP) of thyroid by: clinical-pathological study of 100 mCP and 100 microtumors (MTP) classified according to PP criteria. b) Study of the expression of hormone receptors of alpha (REa) and beta (Reb), progesterone (RP) and androgens (RA) in these neoplasms. Study of prevalence, anatomical distribution, BRAF status and expression of hormonal receptors in MCP and solid cell nests (SCNs) in 100 thyroid glands from the autopsy of subjects without clinical thyroid pathology. Methodology: 3-year unicentric study of paraffin-included samples from total hemithyroidectomy and thyroidectomy (retrospective) and autopsy thyroid glands (prospective). Clinical data (age, gender, distant and nodal metastases, associated thyroid pathology and follow-up) and pathological data (size, type and subtype tumor, presence of capsule, extrathyroid extension, multifocality, lymphovascular invasion and presence of high cells, column cells or clove cells) will be evaluated. Immunohistochemical analysis will be in complete sections with antibodies for REa, Reb, RP, RA, thyroglobulin, and calcitonin. The expression of the receptors will be evaluated by the Allred method. BRAF will be studied by PCR in real time from samples of laser microdissection. A planimetry system shall be used for the anatomical distribution of the MCP and NCS. The statistical analysis will verify the correlation between the different parameters. (English) / rank | |||||||||||||||
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| Property / summary: Objectives: To evaluate the usefulness of the criteria of the “Porto proposal” (PP), as well as the participation of hormonal receptors and the BRAF gene in the aggressiveness and progression of papillary microcarcinoma (mCP) of thyroid by: clinical-pathological study of 100 mCP and 100 microtumors (MTP) classified according to PP criteria. b) Study of the expression of hormone receptors of alpha (REa) and beta (Reb), progesterone (RP) and androgens (RA) in these neoplasms. Study of prevalence, anatomical distribution, BRAF status and expression of hormonal receptors in MCP and solid cell nests (SCNs) in 100 thyroid glands from the autopsy of subjects without clinical thyroid pathology. Methodology: 3-year unicentric study of paraffin-included samples from total hemithyroidectomy and thyroidectomy (retrospective) and autopsy thyroid glands (prospective). Clinical data (age, gender, distant and nodal metastases, associated thyroid pathology and follow-up) and pathological data (size, type and subtype tumor, presence of capsule, extrathyroid extension, multifocality, lymphovascular invasion and presence of high cells, column cells or clove cells) will be evaluated. Immunohistochemical analysis will be in complete sections with antibodies for REa, Reb, RP, RA, thyroglobulin, and calcitonin. The expression of the receptors will be evaluated by the Allred method. BRAF will be studied by PCR in real time from samples of laser microdissection. A planimetry system shall be used for the anatomical distribution of the MCP and NCS. The statistical analysis will verify the correlation between the different parameters. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 13:19, 12 October 2021
Project Q3143447 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3143447 in Spain |
Statements
49,200.0 Euro
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61,500.0 Euro
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80.0 percent
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1 January 2016
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30 September 2019
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FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA
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42°52'49.51"N, 8°32'45.10"W
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15078
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Objetivos: Evaluar la utilidad de los criterios de la “propuesta de Porto” (PP), así como la participación de los receptores hormonales y del gen BRAF en la agresividad y progresión del microcarcinoma papilar (mCP) de tiroides mediante: a) Estudio clínico-patológico de 100 mCP y de 100 microtumores (mTP) clasificados según los criterios de la PP. b) Estudio de la expresión de receptores hormonales de estrógenos alfa (REa) y beta (REb), progesterona (RP) y andrógenos (RA) en dichas neoplasias. c) Estudio de la prevalencia de las mutaciones del gen BRAF en dichas series. d). Estudio de la prevalencia, distribución anatómica, estado de BRAF y expresión de receptores de los hormonales en los mCP y nidos celulares sólidos (NCS) en 100 glándulas tiroideas procedentes de la autopsia de sujetos sin patología tiroidea clínica. Metodología: Estudio unicéntrico, a 3 años, sobre muestras incluidas en parafina procedentes de hemitiroidectomía y tiroidectomía total (retrospectivo) y de glándulas tiroides de autopsia (prospectivo). Se evaluarán datos clínicos (edad, género, metástasis ganglionares y a distancia, patología tiroidea asociada y seguimiento) y patológicos (tamaño, tipo y subtipo tumoral, presencia de cápsula, extensión extratiroidea, multifocalidad, invasión linfovascular y presencia de células altas, células columnares o células en clavo). El análisis inmunohistoquímico será en secciones completas con anticuerpos para REa, REb, RP, RA, tiroglobulina y calcitonina. La expresión de los receptores se evaluará por el método de Allred. BRAF se estudiará por PCR en tiempo real a partir de muestras de microdisección láser. Se utilizará un sistema de planimetría para la distribución anatómica de los mCP y NCS. El análisis estadístico verificará la correlación entre los diferentes parámetros. (Spanish)
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Objectives: To evaluate the usefulness of the criteria of the “Porto proposal” (PP), as well as the participation of hormonal receptors and the BRAF gene in the aggressiveness and progression of papillary microcarcinoma (mCP) of thyroid by: clinical-pathological study of 100 mCP and 100 microtumors (MTP) classified according to PP criteria. b) Study of the expression of hormone receptors of alpha (REa) and beta (Reb), progesterone (RP) and androgens (RA) in these neoplasms. Study of prevalence, anatomical distribution, BRAF status and expression of hormonal receptors in MCP and solid cell nests (SCNs) in 100 thyroid glands from the autopsy of subjects without clinical thyroid pathology. Methodology: 3-year unicentric study of paraffin-included samples from total hemithyroidectomy and thyroidectomy (retrospective) and autopsy thyroid glands (prospective). Clinical data (age, gender, distant and nodal metastases, associated thyroid pathology and follow-up) and pathological data (size, type and subtype tumor, presence of capsule, extrathyroid extension, multifocality, lymphovascular invasion and presence of high cells, column cells or clove cells) will be evaluated. Immunohistochemical analysis will be in complete sections with antibodies for REa, Reb, RP, RA, thyroglobulin, and calcitonin. The expression of the receptors will be evaluated by the Allred method. BRAF will be studied by PCR in real time from samples of laser microdissection. A planimetry system shall be used for the anatomical distribution of the MCP and NCS. The statistical analysis will verify the correlation between the different parameters. (English)
12 October 2021
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Santiago de Compostela
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Identifiers
PI15_01501
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