Q3137408 (Q3137408): Difference between revisions
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(Changed an Item: Edited by the materialized bot - inferring region from the coordinates) |
(Created claim: summary (P836): SPAIN IS THE SECOND EUROPEAN COUNTRY (AFTER GREECE) WITH THE HIGHEST CAPRINE CENSUS, BEING MAINLY SPECIALISED IN THE PRODUCTION OF MILK AND CHEESE. THE MURCIANO-GRENADINE BREED IS UNDOUBTEDLY THE MAIN SPANISH DAIRY GOAT BREED, PRESENTING AVERAGE PRODUCTIONS OF 530 KG OF MILK PER LACTATION AND BEING EXPORTED TO VARIOUS COUNTRIES SUCH AS MEXICO, ROMANIA AND MOROCCO. IN THIS PROJECT IT IS PROPOSED TO ADDRESS THE STUDY OF THE GENOMIC ARCHITECTURE OF...) |
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SPAIN IS THE SECOND EUROPEAN COUNTRY (AFTER GREECE) WITH THE HIGHEST CAPRINE CENSUS, BEING MAINLY SPECIALISED IN THE PRODUCTION OF MILK AND CHEESE. THE MURCIANO-GRENADINE BREED IS UNDOUBTEDLY THE MAIN SPANISH DAIRY GOAT BREED, PRESENTING AVERAGE PRODUCTIONS OF 530 KG OF MILK PER LACTATION AND BEING EXPORTED TO VARIOUS COUNTRIES SUCH AS MEXICO, ROMANIA AND MOROCCO. IN THIS PROJECT IT IS PROPOSED TO ADDRESS THE STUDY OF THE GENOMIC ARCHITECTURE OF THE MILK CHARACTERS IN THE MURCIA-GRENADINE BREED WITH THE AIM OF EVALUATING THEIR POSSIBLE INCORPORATION, AS A SOURCE OF INFORMATION, IN THE PROGRAM OF GENETIC IMPROVEMENT OF THIS BREED. FIRST, AN EXPERIMENT BASED ON RNA-SEQ TECHNOLOGY WILL BE CARRIED OUT IN WHICH THE BREAST EXPRESSION OF GENES ENCODING MESSENGER RNA AND RNA REGULATORS WERE COMPARED IN FOUR PRODUCTIVE STAGES (BEFORE LACTATION, AND ONSET, HALF AND END OF IT). THIS EXPERIMENT WILL IDENTIFY GENES WHOSE EXPRESSION, IN THE MAMMARY GLAND, IS ACTIVATED AS A RESULT OF THE ESTABLISHMENT AND MAINTENANCE OF LACTATION. IN PARALLEL, THE GENOTYPING OF 1200 GOATS WILL BE CARRIED OUT WITH PRODUCTIVE RECORDS FOR THE PRODUCTION AND COMPOSITION OF MILK AND THE CHARACTERISTICS OF BODY AND UDDER FORMATION. GENOTYPING WILL BE CARRIED OUT WITH A 50K SNPS CHIP, SO THAT VARIATION CAN BE CHARACTERISED ON A GENOMIC SCALE. BY COMBINING THE GWAS AND RNASEQ APPROACHES, THE GENOMIC REGIONS ASSOCIATED SIGNIFICANTLY WITH THE DAIRY AND BODY-FORMING CHARACTERS WILL BE IDENTIFIED. ON THE OTHER HAND, CHARACTERS RELATED TO THE VIABILITY OF THE INDIVIDUAL WILL BE ANALYSED THROUGH A DUAL STRATEGY. FIRST, A BAYESIAN METHOD WILL BE USED TO DETECT REGIONS OF THE CAPRINE GENOME IN WHICH THERE IS A DISTORTION IN THE TRANSMISSION OF ALLELES TO THE OFFSPRING (I.E., THAT THEY DIVIDE INTO NON-MENDELIAN PROPORTIONS). IN ADDITION, GENOMIC CONSANGUINITY COEFFICIENTS WILL BE ESTIMATED AND GENOMIC REGIONS IDENTIFIED WHERE THERE IS CONSANGUINOUS DEPRESSION FOR SOME OF THE CHARACTERS UNDER STUDY. THE INFORMATION GENERATED IN THE PROJECT MAY BE USED TO IDENTIFY MUTATIONS WITH CAUSAL EFFECTS ON THE STUDIED CHARACTERS THAT CAN BE USED AS GENE-ASSISTED SELECTION CRITERIA. LIKEWISE, THE USEFULNESS OF THE GENOMIC INFORMATION IN PREDICTING THE GENETIC POTENTIAL OF THE CANDIDATES FOR BREEDING WILL BE EVALUATED. (English) | |||||||||||||||
| Property / summary: SPAIN IS THE SECOND EUROPEAN COUNTRY (AFTER GREECE) WITH THE HIGHEST CAPRINE CENSUS, BEING MAINLY SPECIALISED IN THE PRODUCTION OF MILK AND CHEESE. THE MURCIANO-GRENADINE BREED IS UNDOUBTEDLY THE MAIN SPANISH DAIRY GOAT BREED, PRESENTING AVERAGE PRODUCTIONS OF 530 KG OF MILK PER LACTATION AND BEING EXPORTED TO VARIOUS COUNTRIES SUCH AS MEXICO, ROMANIA AND MOROCCO. IN THIS PROJECT IT IS PROPOSED TO ADDRESS THE STUDY OF THE GENOMIC ARCHITECTURE OF THE MILK CHARACTERS IN THE MURCIA-GRENADINE BREED WITH THE AIM OF EVALUATING THEIR POSSIBLE INCORPORATION, AS A SOURCE OF INFORMATION, IN THE PROGRAM OF GENETIC IMPROVEMENT OF THIS BREED. FIRST, AN EXPERIMENT BASED ON RNA-SEQ TECHNOLOGY WILL BE CARRIED OUT IN WHICH THE BREAST EXPRESSION OF GENES ENCODING MESSENGER RNA AND RNA REGULATORS WERE COMPARED IN FOUR PRODUCTIVE STAGES (BEFORE LACTATION, AND ONSET, HALF AND END OF IT). THIS EXPERIMENT WILL IDENTIFY GENES WHOSE EXPRESSION, IN THE MAMMARY GLAND, IS ACTIVATED AS A RESULT OF THE ESTABLISHMENT AND MAINTENANCE OF LACTATION. IN PARALLEL, THE GENOTYPING OF 1200 GOATS WILL BE CARRIED OUT WITH PRODUCTIVE RECORDS FOR THE PRODUCTION AND COMPOSITION OF MILK AND THE CHARACTERISTICS OF BODY AND UDDER FORMATION. GENOTYPING WILL BE CARRIED OUT WITH A 50K SNPS CHIP, SO THAT VARIATION CAN BE CHARACTERISED ON A GENOMIC SCALE. BY COMBINING THE GWAS AND RNASEQ APPROACHES, THE GENOMIC REGIONS ASSOCIATED SIGNIFICANTLY WITH THE DAIRY AND BODY-FORMING CHARACTERS WILL BE IDENTIFIED. ON THE OTHER HAND, CHARACTERS RELATED TO THE VIABILITY OF THE INDIVIDUAL WILL BE ANALYSED THROUGH A DUAL STRATEGY. FIRST, A BAYESIAN METHOD WILL BE USED TO DETECT REGIONS OF THE CAPRINE GENOME IN WHICH THERE IS A DISTORTION IN THE TRANSMISSION OF ALLELES TO THE OFFSPRING (I.E., THAT THEY DIVIDE INTO NON-MENDELIAN PROPORTIONS). IN ADDITION, GENOMIC CONSANGUINITY COEFFICIENTS WILL BE ESTIMATED AND GENOMIC REGIONS IDENTIFIED WHERE THERE IS CONSANGUINOUS DEPRESSION FOR SOME OF THE CHARACTERS UNDER STUDY. THE INFORMATION GENERATED IN THE PROJECT MAY BE USED TO IDENTIFY MUTATIONS WITH CAUSAL EFFECTS ON THE STUDIED CHARACTERS THAT CAN BE USED AS GENE-ASSISTED SELECTION CRITERIA. LIKEWISE, THE USEFULNESS OF THE GENOMIC INFORMATION IN PREDICTING THE GENETIC POTENTIAL OF THE CANDIDATES FOR BREEDING WILL BE EVALUATED. (English) / rank | |||||||||||||||
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| Property / summary: SPAIN IS THE SECOND EUROPEAN COUNTRY (AFTER GREECE) WITH THE HIGHEST CAPRINE CENSUS, BEING MAINLY SPECIALISED IN THE PRODUCTION OF MILK AND CHEESE. THE MURCIANO-GRENADINE BREED IS UNDOUBTEDLY THE MAIN SPANISH DAIRY GOAT BREED, PRESENTING AVERAGE PRODUCTIONS OF 530 KG OF MILK PER LACTATION AND BEING EXPORTED TO VARIOUS COUNTRIES SUCH AS MEXICO, ROMANIA AND MOROCCO. IN THIS PROJECT IT IS PROPOSED TO ADDRESS THE STUDY OF THE GENOMIC ARCHITECTURE OF THE MILK CHARACTERS IN THE MURCIA-GRENADINE BREED WITH THE AIM OF EVALUATING THEIR POSSIBLE INCORPORATION, AS A SOURCE OF INFORMATION, IN THE PROGRAM OF GENETIC IMPROVEMENT OF THIS BREED. FIRST, AN EXPERIMENT BASED ON RNA-SEQ TECHNOLOGY WILL BE CARRIED OUT IN WHICH THE BREAST EXPRESSION OF GENES ENCODING MESSENGER RNA AND RNA REGULATORS WERE COMPARED IN FOUR PRODUCTIVE STAGES (BEFORE LACTATION, AND ONSET, HALF AND END OF IT). THIS EXPERIMENT WILL IDENTIFY GENES WHOSE EXPRESSION, IN THE MAMMARY GLAND, IS ACTIVATED AS A RESULT OF THE ESTABLISHMENT AND MAINTENANCE OF LACTATION. IN PARALLEL, THE GENOTYPING OF 1200 GOATS WILL BE CARRIED OUT WITH PRODUCTIVE RECORDS FOR THE PRODUCTION AND COMPOSITION OF MILK AND THE CHARACTERISTICS OF BODY AND UDDER FORMATION. GENOTYPING WILL BE CARRIED OUT WITH A 50K SNPS CHIP, SO THAT VARIATION CAN BE CHARACTERISED ON A GENOMIC SCALE. BY COMBINING THE GWAS AND RNASEQ APPROACHES, THE GENOMIC REGIONS ASSOCIATED SIGNIFICANTLY WITH THE DAIRY AND BODY-FORMING CHARACTERS WILL BE IDENTIFIED. ON THE OTHER HAND, CHARACTERS RELATED TO THE VIABILITY OF THE INDIVIDUAL WILL BE ANALYSED THROUGH A DUAL STRATEGY. FIRST, A BAYESIAN METHOD WILL BE USED TO DETECT REGIONS OF THE CAPRINE GENOME IN WHICH THERE IS A DISTORTION IN THE TRANSMISSION OF ALLELES TO THE OFFSPRING (I.E., THAT THEY DIVIDE INTO NON-MENDELIAN PROPORTIONS). IN ADDITION, GENOMIC CONSANGUINITY COEFFICIENTS WILL BE ESTIMATED AND GENOMIC REGIONS IDENTIFIED WHERE THERE IS CONSANGUINOUS DEPRESSION FOR SOME OF THE CHARACTERS UNDER STUDY. THE INFORMATION GENERATED IN THE PROJECT MAY BE USED TO IDENTIFY MUTATIONS WITH CAUSAL EFFECTS ON THE STUDIED CHARACTERS THAT CAN BE USED AS GENE-ASSISTED SELECTION CRITERIA. LIKEWISE, THE USEFULNESS OF THE GENOMIC INFORMATION IN PREDICTING THE GENETIC POTENTIAL OF THE CANDIDATES FOR BREEDING WILL BE EVALUATED. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 12:34, 12 October 2021
Project Q3137408 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3137408 in Spain |
Statements
105,875.0 Euro
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211,750.0 Euro
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50.0 percent
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30 December 2016
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31 December 2020
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CENTRO DE INVESTIGACION EN AGRIGENOMICA
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41°29'27.71"N, 2°8'15.00"E
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08266
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ESPAÑA ES EL SEGUNDO PAIS EUROPEO (DESPUES DE GRECIA) CON UN MAYOR CENSO CAPRINO, ESTANDO ESPECIALIZADO FUNDAMENTALMENTE EN LA PRODUCCION DE LECHE Y QUESO. LA RAZA MURCIANO-GRANADINA ES, SIN LUGAR A DUDAS, LA PRINCIPAL RAZA CAPRINA LECHERA ESPAÑOLA, PRESENTANDO PRODUCCIONES MEDIAS DE 530 KG DE LECHE POR LACTACION Y SIENDO EXPORTADA A DIVERSOS PAISES COMO POR EJEMPLO MEXICO, RUMANIA Y MARRUECOS. EN EL PRESENTE PROYECTO SE PLANTEA ABORDAR EL ESTUDIO DE LA ARQUITECTURA GENOMICA DE LOS CARACTERES LECHEROS EN LA RAZA MURCIANO-GRANADINA CON LA FINALIDAD DE EVALUAR SU EVENTUAL INCORPORACION, COMO FUENTE DE INFORMACION, EN EL PROGRAMA DE MEJORA GENETICA DE DICHA RAZA. EN PRIMER LUGAR, SE LLEVARA A CABO UN EXPERIMENTO BASADO EN LA TECNOLOGIA RNA-SEQ EN EL QUE SE COMPARARA LA EXPRESION MAMARIA DE GENES QUE CODIFICAN RNA MENSAJEROS Y RNA REGULADORES EN CUATRO ETAPAS PRODUCTIVAS (ANTES DE LA LACTACION, E INICIO, MITAD Y FINAL DE LA MISMA). ESTE EXPERIMENTO PERMITIRA IDENTIFICAR LOS GENES CUYA EXPRESION, EN LA GLANDULA MAMARIA, SE ACTIVA COMO CONSECUENCIA DEL ESTABLECIMIENTO Y MANTENIMIENTO DE LA LACTACION. EN PARALELO, SE LLEVARA A CABO EL GENOTIPADO DE 1200 CABRAS CON REGISTROS PRODUCTIVOS PARA LA PRODUCCION Y LA COMPOSICION DE LA LECHE Y LOS CARACTERES DE CONFORMACION CORPORAL Y DE LA UBRE. EL GENOTIPADO SE LLEVARA A CABO CON UN CHIP DE SNPS 50K, DE MODO QUE PUEDA CARACTERIZARSE LA VARIACION A UNA ESCALA GENOMICA. MEDIANTE LA COMBINACION DE LAS APROXIMACIONES GWAS Y RNASEQ, SE IDENTIFICARAN LAS REGIONES GENOMICAS ASOCIADAS SIGNIFICATIVAMENTE A LOS CARACTERES LECHEROS Y DE CONFORMACION CORPORAL. POR OTRA PARTE, SE ANALIZARAN CARACTERES RELACIONADOS CON LA VIABILIDAD DEL INDIVIDUO MEDIANTE UNA DOBLE ESTRATEGIA. EN PRIMER LUGAR SE USARA UN METODO BAYESIANO PARA DETECTAR REGIONES DEL GENOMA CAPRINO EN LAS QUE EXISTA UNA DISTORSION EN LA TRANSMISION DE ALELOS A LA DESCENDENCIA (ES DECIR, QUE SEGREGUEN EN PROPORCIONES NO-MENDELIANAS). ASIMISMO, SE ESTIMARAN COEFICIENTES DE CONSANGUINIDAD GENOMICOS Y SE IDENTIFICARAN REGIONES GENOMICAS EN LAS QUE EXISTA DEPRESION CONSANGUINEA PARA ALGUNOS DE LOS CARACTERES BAJO ESTUDIO. LA INFORMACION GENERADA EN EL PROYECTO PODRA UTILIZARSE PARA IDENTIFICAR MUTACIONES CON EFECTOS CAUSALES SOBRE LOS CARACTERES ESTUDIADOS QUE PUEDAN SER EMPLEADAS COMO CRITERIOS DE SELECCION ASISTIDA POR GENES. ASIMISMO, SE VALORARA LA UTILIDAD DE LA INFORMACION GENOMICA PARA PREDECIR EL POTENCIAL GENETICO DE LOS CANDIDATOS A REPRODUCTORES. (Spanish)
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SPAIN IS THE SECOND EUROPEAN COUNTRY (AFTER GREECE) WITH THE HIGHEST CAPRINE CENSUS, BEING MAINLY SPECIALISED IN THE PRODUCTION OF MILK AND CHEESE. THE MURCIANO-GRENADINE BREED IS UNDOUBTEDLY THE MAIN SPANISH DAIRY GOAT BREED, PRESENTING AVERAGE PRODUCTIONS OF 530 KG OF MILK PER LACTATION AND BEING EXPORTED TO VARIOUS COUNTRIES SUCH AS MEXICO, ROMANIA AND MOROCCO. IN THIS PROJECT IT IS PROPOSED TO ADDRESS THE STUDY OF THE GENOMIC ARCHITECTURE OF THE MILK CHARACTERS IN THE MURCIA-GRENADINE BREED WITH THE AIM OF EVALUATING THEIR POSSIBLE INCORPORATION, AS A SOURCE OF INFORMATION, IN THE PROGRAM OF GENETIC IMPROVEMENT OF THIS BREED. FIRST, AN EXPERIMENT BASED ON RNA-SEQ TECHNOLOGY WILL BE CARRIED OUT IN WHICH THE BREAST EXPRESSION OF GENES ENCODING MESSENGER RNA AND RNA REGULATORS WERE COMPARED IN FOUR PRODUCTIVE STAGES (BEFORE LACTATION, AND ONSET, HALF AND END OF IT). THIS EXPERIMENT WILL IDENTIFY GENES WHOSE EXPRESSION, IN THE MAMMARY GLAND, IS ACTIVATED AS A RESULT OF THE ESTABLISHMENT AND MAINTENANCE OF LACTATION. IN PARALLEL, THE GENOTYPING OF 1200 GOATS WILL BE CARRIED OUT WITH PRODUCTIVE RECORDS FOR THE PRODUCTION AND COMPOSITION OF MILK AND THE CHARACTERISTICS OF BODY AND UDDER FORMATION. GENOTYPING WILL BE CARRIED OUT WITH A 50K SNPS CHIP, SO THAT VARIATION CAN BE CHARACTERISED ON A GENOMIC SCALE. BY COMBINING THE GWAS AND RNASEQ APPROACHES, THE GENOMIC REGIONS ASSOCIATED SIGNIFICANTLY WITH THE DAIRY AND BODY-FORMING CHARACTERS WILL BE IDENTIFIED. ON THE OTHER HAND, CHARACTERS RELATED TO THE VIABILITY OF THE INDIVIDUAL WILL BE ANALYSED THROUGH A DUAL STRATEGY. FIRST, A BAYESIAN METHOD WILL BE USED TO DETECT REGIONS OF THE CAPRINE GENOME IN WHICH THERE IS A DISTORTION IN THE TRANSMISSION OF ALLELES TO THE OFFSPRING (I.E., THAT THEY DIVIDE INTO NON-MENDELIAN PROPORTIONS). IN ADDITION, GENOMIC CONSANGUINITY COEFFICIENTS WILL BE ESTIMATED AND GENOMIC REGIONS IDENTIFIED WHERE THERE IS CONSANGUINOUS DEPRESSION FOR SOME OF THE CHARACTERS UNDER STUDY. THE INFORMATION GENERATED IN THE PROJECT MAY BE USED TO IDENTIFY MUTATIONS WITH CAUSAL EFFECTS ON THE STUDIED CHARACTERS THAT CAN BE USED AS GENE-ASSISTED SELECTION CRITERIA. LIKEWISE, THE USEFULNESS OF THE GENOMIC INFORMATION IN PREDICTING THE GENETIC POTENTIAL OF THE CANDIDATES FOR BREEDING WILL BE EVALUATED. (English)
12 October 2021
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Cerdanyola del Vallès
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Identifiers
AGL2016-76108-R
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