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(Created claim: summary (P836): UNION TO RNA PROTEINS (RBPS) REGULATE ALL POST-TRANSCRIPTIONAL STEPS OF GENIC EXPRESSION, FROM WHEN RNA IS BORN IN THE NUCLEUS UNTIL IT DIES IN THE CYTOPLASM. RBPS FORM NETWORKS THAT REGULATE FUNCTIONALLY RELATED TRANSCRIPTS IN A COORDINATED MANNER. THEREFORE, THE ALTERATION OF RBPS CAN HAVE SERIOUS CONSEQUENCES FOR THE CELL. RBPS ARE EMERGING AS CRITICAL REGULATORS OF TUMORIGENESIS, BUT VERY LITTLE IS KNOWN ABOUT THE UNDERLYING MOLECULAR MECHAN...) |
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UNION TO RNA PROTEINS (RBPS) REGULATE ALL POST-TRANSCRIPTIONAL STEPS OF GENIC EXPRESSION, FROM WHEN RNA IS BORN IN THE NUCLEUS UNTIL IT DIES IN THE CYTOPLASM. RBPS FORM NETWORKS THAT REGULATE FUNCTIONALLY RELATED TRANSCRIPTS IN A COORDINATED MANNER. THEREFORE, THE ALTERATION OF RBPS CAN HAVE SERIOUS CONSEQUENCES FOR THE CELL. RBPS ARE EMERGING AS CRITICAL REGULATORS OF TUMORIGENESIS, BUT VERY LITTLE IS KNOWN ABOUT THE UNDERLYING MOLECULAR MECHANISMS AND TARGETS RESPONSIBLE FOR THESE EFFECTS. THE INTEREST OF OUR LABORATORY IS THE STUDY OF THE REGULATION OF TRANSLATION BY RBPS. USING GENETICALLY ESTABLISHED TRANSLATIONAL CONTROL EXAMPLES IN DROSOPHILA, WE HAVE IDENTIFIED PRESERVED REGULATORS THAT, IN HUMANS, FACILITATE TUMOR PROGRESSION. IN THIS PROJECT WE PROPOSE TO DEEPEN THE MOLECULAR MECHANISMS OF TRANSLATIONAL REGULATION BY CONCENTRATING ON SPECIFIC RBPS, AND TO EVALUATE THEIR IMPORTANCE IN TUMORIGENESIS ACCORDING TO THE FOLLOWING OBJECTIVES: _x000D_ 1) STUDY NEW RBPS IMPLICED IN CYTOplasmic POLICYDENIlation, A PROCESS that STIMULES THE TRADE. IN DROSOPHILA THERE ARE AT LEAST TWO MACHINES OF CYTOPLASMIC POLIADENILACION, ONE OF WHICH DEPENDS ON THE FACTOR OF RNAI DICER-2. We want to IDENTIFICATE DICER-2 SUSTRATE, STUDY THE MECHANISMS BY THE DECTION-2 FUNCTION IN POLICYDENILATION AND IDENTIFICATE OTHER RESPONSIBLE FACTORS, TANT OF CANONICAL MAQUINARY AS NON CANONICAL._x000D_ 2) STUDATE TRADUCTIONAL CONTROL MECHANISMS BY SXL, A ESENTIAL EVENT FOR THE VIABILITY OF HEMBRA MOSCAS. SXL RECRUITS OTHER RBPS TO FORM COMPLEXES THAT INTERACT WITH THE EIF3 INITIATION FACTOR. IN ADDITION, SXL PROMOTES THE RECOGNITION OF UORFS. We want to understand as the activity of EIF3 and the recognition of uorphs are regulated by complexes measured by SXL._x000D_ 3) STUDY THE MECHANISMS OF REGULATION BY ONE MAMIFEROS, A PROTEIN THAT PREVIANCE we identify as a SXL CO-FACTOR in DROSOPHILA. OUR DATA INDICATE THAT UNR PROMOTES THE INVASION AND METATASIS OF MELANOMA CELLS THROUGH THE COORDINATION OF A POST-TRANSCRIPTIONAL PROGRAM AT THE LEVEL OF TRANSLATION AND STABILITY OF THE MRNA. AS FOR TRANSLATION, UNR NOT ONLY WORKS IN ITS ESTABLISHED ROLE AS ITAF (IRES TRANS-ACTING FACTOR), BUT ALSO REGULATES ELONGATION. WE WANT TO INVESTIGATE THESE TWO FUNCTIONS OF UNR IN TRANSCRIPTS IMPORTANT FOR TUMOR PROGRESSION. IN ADDITION, WE WANT TO IDENTIFY THE INTERACTION OF UNR, AND EVALUATE THE CONSEQUENCES OF TRANSLATIONAL REGULATION BY UNR ON SENESCENCE, CELL STRESS AND METATASIS IN RATON. For ULTIMO, we are interested in correlating the EXPRESSION of one and a grid group with the MELANOMA PROGRESS IN PATIENTS._x000D_ 4) IDENTIFICATE OTHER RBPS IMPLICATE IN THE TUMORAL PROGRESS IN THE CONTEXT OF MELANOMA, USING THE TECHNOLOGY “interactome-CAPTURE”. (English) | |||||||||||||||
| Property / summary: UNION TO RNA PROTEINS (RBPS) REGULATE ALL POST-TRANSCRIPTIONAL STEPS OF GENIC EXPRESSION, FROM WHEN RNA IS BORN IN THE NUCLEUS UNTIL IT DIES IN THE CYTOPLASM. RBPS FORM NETWORKS THAT REGULATE FUNCTIONALLY RELATED TRANSCRIPTS IN A COORDINATED MANNER. THEREFORE, THE ALTERATION OF RBPS CAN HAVE SERIOUS CONSEQUENCES FOR THE CELL. RBPS ARE EMERGING AS CRITICAL REGULATORS OF TUMORIGENESIS, BUT VERY LITTLE IS KNOWN ABOUT THE UNDERLYING MOLECULAR MECHANISMS AND TARGETS RESPONSIBLE FOR THESE EFFECTS. THE INTEREST OF OUR LABORATORY IS THE STUDY OF THE REGULATION OF TRANSLATION BY RBPS. USING GENETICALLY ESTABLISHED TRANSLATIONAL CONTROL EXAMPLES IN DROSOPHILA, WE HAVE IDENTIFIED PRESERVED REGULATORS THAT, IN HUMANS, FACILITATE TUMOR PROGRESSION. IN THIS PROJECT WE PROPOSE TO DEEPEN THE MOLECULAR MECHANISMS OF TRANSLATIONAL REGULATION BY CONCENTRATING ON SPECIFIC RBPS, AND TO EVALUATE THEIR IMPORTANCE IN TUMORIGENESIS ACCORDING TO THE FOLLOWING OBJECTIVES: _x000D_ 1) STUDY NEW RBPS IMPLICED IN CYTOplasmic POLICYDENIlation, A PROCESS that STIMULES THE TRADE. IN DROSOPHILA THERE ARE AT LEAST TWO MACHINES OF CYTOPLASMIC POLIADENILACION, ONE OF WHICH DEPENDS ON THE FACTOR OF RNAI DICER-2. We want to IDENTIFICATE DICER-2 SUSTRATE, STUDY THE MECHANISMS BY THE DECTION-2 FUNCTION IN POLICYDENILATION AND IDENTIFICATE OTHER RESPONSIBLE FACTORS, TANT OF CANONICAL MAQUINARY AS NON CANONICAL._x000D_ 2) STUDATE TRADUCTIONAL CONTROL MECHANISMS BY SXL, A ESENTIAL EVENT FOR THE VIABILITY OF HEMBRA MOSCAS. SXL RECRUITS OTHER RBPS TO FORM COMPLEXES THAT INTERACT WITH THE EIF3 INITIATION FACTOR. IN ADDITION, SXL PROMOTES THE RECOGNITION OF UORFS. We want to understand as the activity of EIF3 and the recognition of uorphs are regulated by complexes measured by SXL._x000D_ 3) STUDY THE MECHANISMS OF REGULATION BY ONE MAMIFEROS, A PROTEIN THAT PREVIANCE we identify as a SXL CO-FACTOR in DROSOPHILA. OUR DATA INDICATE THAT UNR PROMOTES THE INVASION AND METATASIS OF MELANOMA CELLS THROUGH THE COORDINATION OF A POST-TRANSCRIPTIONAL PROGRAM AT THE LEVEL OF TRANSLATION AND STABILITY OF THE MRNA. AS FOR TRANSLATION, UNR NOT ONLY WORKS IN ITS ESTABLISHED ROLE AS ITAF (IRES TRANS-ACTING FACTOR), BUT ALSO REGULATES ELONGATION. WE WANT TO INVESTIGATE THESE TWO FUNCTIONS OF UNR IN TRANSCRIPTS IMPORTANT FOR TUMOR PROGRESSION. IN ADDITION, WE WANT TO IDENTIFY THE INTERACTION OF UNR, AND EVALUATE THE CONSEQUENCES OF TRANSLATIONAL REGULATION BY UNR ON SENESCENCE, CELL STRESS AND METATASIS IN RATON. For ULTIMO, we are interested in correlating the EXPRESSION of one and a grid group with the MELANOMA PROGRESS IN PATIENTS._x000D_ 4) IDENTIFICATE OTHER RBPS IMPLICATE IN THE TUMORAL PROGRESS IN THE CONTEXT OF MELANOMA, USING THE TECHNOLOGY “interactome-CAPTURE”. (English) / rank | |||||||||||||||
Normal rank | |||||||||||||||
| Property / summary: UNION TO RNA PROTEINS (RBPS) REGULATE ALL POST-TRANSCRIPTIONAL STEPS OF GENIC EXPRESSION, FROM WHEN RNA IS BORN IN THE NUCLEUS UNTIL IT DIES IN THE CYTOPLASM. RBPS FORM NETWORKS THAT REGULATE FUNCTIONALLY RELATED TRANSCRIPTS IN A COORDINATED MANNER. THEREFORE, THE ALTERATION OF RBPS CAN HAVE SERIOUS CONSEQUENCES FOR THE CELL. RBPS ARE EMERGING AS CRITICAL REGULATORS OF TUMORIGENESIS, BUT VERY LITTLE IS KNOWN ABOUT THE UNDERLYING MOLECULAR MECHANISMS AND TARGETS RESPONSIBLE FOR THESE EFFECTS. THE INTEREST OF OUR LABORATORY IS THE STUDY OF THE REGULATION OF TRANSLATION BY RBPS. USING GENETICALLY ESTABLISHED TRANSLATIONAL CONTROL EXAMPLES IN DROSOPHILA, WE HAVE IDENTIFIED PRESERVED REGULATORS THAT, IN HUMANS, FACILITATE TUMOR PROGRESSION. IN THIS PROJECT WE PROPOSE TO DEEPEN THE MOLECULAR MECHANISMS OF TRANSLATIONAL REGULATION BY CONCENTRATING ON SPECIFIC RBPS, AND TO EVALUATE THEIR IMPORTANCE IN TUMORIGENESIS ACCORDING TO THE FOLLOWING OBJECTIVES: _x000D_ 1) STUDY NEW RBPS IMPLICED IN CYTOplasmic POLICYDENIlation, A PROCESS that STIMULES THE TRADE. IN DROSOPHILA THERE ARE AT LEAST TWO MACHINES OF CYTOPLASMIC POLIADENILACION, ONE OF WHICH DEPENDS ON THE FACTOR OF RNAI DICER-2. We want to IDENTIFICATE DICER-2 SUSTRATE, STUDY THE MECHANISMS BY THE DECTION-2 FUNCTION IN POLICYDENILATION AND IDENTIFICATE OTHER RESPONSIBLE FACTORS, TANT OF CANONICAL MAQUINARY AS NON CANONICAL._x000D_ 2) STUDATE TRADUCTIONAL CONTROL MECHANISMS BY SXL, A ESENTIAL EVENT FOR THE VIABILITY OF HEMBRA MOSCAS. SXL RECRUITS OTHER RBPS TO FORM COMPLEXES THAT INTERACT WITH THE EIF3 INITIATION FACTOR. IN ADDITION, SXL PROMOTES THE RECOGNITION OF UORFS. We want to understand as the activity of EIF3 and the recognition of uorphs are regulated by complexes measured by SXL._x000D_ 3) STUDY THE MECHANISMS OF REGULATION BY ONE MAMIFEROS, A PROTEIN THAT PREVIANCE we identify as a SXL CO-FACTOR in DROSOPHILA. OUR DATA INDICATE THAT UNR PROMOTES THE INVASION AND METATASIS OF MELANOMA CELLS THROUGH THE COORDINATION OF A POST-TRANSCRIPTIONAL PROGRAM AT THE LEVEL OF TRANSLATION AND STABILITY OF THE MRNA. AS FOR TRANSLATION, UNR NOT ONLY WORKS IN ITS ESTABLISHED ROLE AS ITAF (IRES TRANS-ACTING FACTOR), BUT ALSO REGULATES ELONGATION. WE WANT TO INVESTIGATE THESE TWO FUNCTIONS OF UNR IN TRANSCRIPTS IMPORTANT FOR TUMOR PROGRESSION. IN ADDITION, WE WANT TO IDENTIFY THE INTERACTION OF UNR, AND EVALUATE THE CONSEQUENCES OF TRANSLATIONAL REGULATION BY UNR ON SENESCENCE, CELL STRESS AND METATASIS IN RATON. For ULTIMO, we are interested in correlating the EXPRESSION of one and a grid group with the MELANOMA PROGRESS IN PATIENTS._x000D_ 4) IDENTIFICATE OTHER RBPS IMPLICATE IN THE TUMORAL PROGRESS IN THE CONTEXT OF MELANOMA, USING THE TECHNOLOGY “interactome-CAPTURE”. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 12:27, 12 October 2021
Project Q3135078 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3135078 in Spain |
Statements
207,515.0 Euro
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415,030.0 Euro
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50.0 percent
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1 January 2016
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30 June 2019
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FUNDACION CENTRO DE REGULACION GENOMICA
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41°22'58.40"N, 2°10'38.75"E
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08019
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LAS PROTEINAS DE UNION A RNA (RBPS) REGULAN TODOS LOS PASOS POST-TRANSCRIPCIONALES DE LA EXPRESION GENICA, DESDE QUE EL RNA NACE EN EL NUCLEO HASTA QUE MUERE EN EL CITOPLASMA. LAS RBPS FORMAN REDES QUE REGULAN TRANSCRITOS FUNCIONALMENTE RELACIONADOS DE MANERA COORDINADA. POR ELLO, LA ALTERACION DE RBPS PUEDE TENER GRAVES CONSECUENCIAS PARA LA CELULA. LAS RBPS ESTAN EMERGIENDO COMO REGULADORES CRITICOS DE LA TUMORIGENESIS, PERO SE SABE MUY POCO SOBRE LOS MECANISMOS MOLECULARES SUBYACENTES Y LAS DIANAS RESPONSABLES DE ESTOS EFECTOS. EL INTERES DE NUESTRO LABORATORIO ES EL ESTUDIO DE LA REGULACION DE LA TRADUCCION POR RBPS. USANDO EJEMPLOS DE CONTROL TRADUCCIONAL ESTABLECIDOS GENETICAMENTE EN DROSOPHILA, HEMOS IDENTIFICADO REGULADORES CONSERVADOS QUE, EN HUMANOS, FACILITAN LA PROGRESION TUMORAL. EN ESTE PROYECTO PROPONEMOS AHONDAR EN LOS MECANISMOS MOLECULARES DE REGULACION TRADUCCIONAL CONCENTRANDONOS EN RBPS CONCRETAS, Y EVALUAR SU IMPORTANCIA EN TUMORIGENESIS DE ACUERDO A LOS SIGUIENTES OBJETIVOS: _x000D_ 1) ESTUDIAR NUEVAS RBPS IMPLICADAS EN POLIADENILACION CITOPLASMATICA, UN PROCESO QUE ESTIMULA LA TRADUCCION. EN DROSOPHILA EXISTEN AL MENOS DOS MAQUINARIAS DE POLIADENILACION CITOPLASMATICA, UNA DE LAS CUALES DEPENDE DEL FACTOR DE RNAI DICER-2. QUEREMOS IDENTIFICAR LOS SUSTRATOS DE DICER-2, ESTUDIAR LOS MECANISMOS POR LOS QUE DICER-2 FUNCIONA EN POLIADENILACION E IDENTIFICAR OTROS FACTORES RESPONSABLES, TANTO DE LA MAQUINARIA CANONICA COMO NO CANONICA._x000D_ 2) ESTUDIAR LOS MECANISMOS DE CONTROL TRADUCCIONAL POR SXL, UN EVENTO ESENCIAL PARA LA VIABILIDAD DE MOSCAS HEMBRA. SXL RECLUTA A OTRAS RBPS PARA FORMAR COMPLEJOS QUE INTERACCIONAN CON EL FACTOR DE INICIACION EIF3. ADEMAS, SXL PROMUEVE EL RECONOCIMIENTO DE UORFS. QUEREMOS ENTENDER COMO LA ACTIVIDAD DE EIF3 Y EL RECONOCIMIENTO DE UORFS SE REGULAN POR COMPLEJOS MEDIADOS POR SXL._x000D_ 3) ESTUDIAR LOS MECANISMOS DE REGULACION POR UNR EN MAMIFEROS, UNA PROTEINA QUE PREVIAMENTE IDENTIFICAMOS COMO UN CO-FACTOR DE SXL EN DROSOPHILA. NUESTROS DATOS INDICAN QUE UNR PROMUEVE LA INVASION Y METASTASIS DE CELULAS DE MELANOMA A TRAVES DE LA COORDINACION DE UN PROGRAMA POST-TRANSCRIPCIONAL A NIVEL DE TRADUCCION Y ESTABILIDAD DEL MRNA. EN CUANTO A TRADUCCION, UNR NO SOLO FUNCIONA EN SU PAPEL ESTABLECIDO COMO ITAF (IRES TRANS-ACTING FACTOR), SINO QUE TAMBIEN REGULA LA ELONGACION. QUEREMOS INVESTIGAR ESTAS DOS FUNCIONES DE UNR EN TRANSCRITOS IMPORTANTES PARA LA PROGRESION TUMORAL. ADEMAS, QUEREMOS IDENTIFICAR EL INTERACTOMA DE UNR, Y EVALUAR LAS CONSECUENCIAS DE LA REGULACION TRADUCCIONAL POR UNR EN LA SENESCENCIA, EL ESTRES CELULAR Y LA METASTASIS EN RATON. POR ULTIMO, NOS INTERESA CORRELACIONAR LA EXPRESION DE UNR Y UN REDUCIDO GRUPO DE TARGETS CON LA PROGRESION DE MELANOMA EN MUESTRAS DE PACIENTES._x000D_ 4) IDENTIFICAR OTRAS RBPS IMPLICADAS EN LA PROGRESION TUMORAL EN EL CONTEXTO DE MELANOMA, USANDO LA TECNOLOGIA "INTERACTOME-CAPTURE". (Spanish)
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UNION TO RNA PROTEINS (RBPS) REGULATE ALL POST-TRANSCRIPTIONAL STEPS OF GENIC EXPRESSION, FROM WHEN RNA IS BORN IN THE NUCLEUS UNTIL IT DIES IN THE CYTOPLASM. RBPS FORM NETWORKS THAT REGULATE FUNCTIONALLY RELATED TRANSCRIPTS IN A COORDINATED MANNER. THEREFORE, THE ALTERATION OF RBPS CAN HAVE SERIOUS CONSEQUENCES FOR THE CELL. RBPS ARE EMERGING AS CRITICAL REGULATORS OF TUMORIGENESIS, BUT VERY LITTLE IS KNOWN ABOUT THE UNDERLYING MOLECULAR MECHANISMS AND TARGETS RESPONSIBLE FOR THESE EFFECTS. THE INTEREST OF OUR LABORATORY IS THE STUDY OF THE REGULATION OF TRANSLATION BY RBPS. USING GENETICALLY ESTABLISHED TRANSLATIONAL CONTROL EXAMPLES IN DROSOPHILA, WE HAVE IDENTIFIED PRESERVED REGULATORS THAT, IN HUMANS, FACILITATE TUMOR PROGRESSION. IN THIS PROJECT WE PROPOSE TO DEEPEN THE MOLECULAR MECHANISMS OF TRANSLATIONAL REGULATION BY CONCENTRATING ON SPECIFIC RBPS, AND TO EVALUATE THEIR IMPORTANCE IN TUMORIGENESIS ACCORDING TO THE FOLLOWING OBJECTIVES: _x000D_ 1) STUDY NEW RBPS IMPLICED IN CYTOplasmic POLICYDENIlation, A PROCESS that STIMULES THE TRADE. IN DROSOPHILA THERE ARE AT LEAST TWO MACHINES OF CYTOPLASMIC POLIADENILACION, ONE OF WHICH DEPENDS ON THE FACTOR OF RNAI DICER-2. We want to IDENTIFICATE DICER-2 SUSTRATE, STUDY THE MECHANISMS BY THE DECTION-2 FUNCTION IN POLICYDENILATION AND IDENTIFICATE OTHER RESPONSIBLE FACTORS, TANT OF CANONICAL MAQUINARY AS NON CANONICAL._x000D_ 2) STUDATE TRADUCTIONAL CONTROL MECHANISMS BY SXL, A ESENTIAL EVENT FOR THE VIABILITY OF HEMBRA MOSCAS. SXL RECRUITS OTHER RBPS TO FORM COMPLEXES THAT INTERACT WITH THE EIF3 INITIATION FACTOR. IN ADDITION, SXL PROMOTES THE RECOGNITION OF UORFS. We want to understand as the activity of EIF3 and the recognition of uorphs are regulated by complexes measured by SXL._x000D_ 3) STUDY THE MECHANISMS OF REGULATION BY ONE MAMIFEROS, A PROTEIN THAT PREVIANCE we identify as a SXL CO-FACTOR in DROSOPHILA. OUR DATA INDICATE THAT UNR PROMOTES THE INVASION AND METATASIS OF MELANOMA CELLS THROUGH THE COORDINATION OF A POST-TRANSCRIPTIONAL PROGRAM AT THE LEVEL OF TRANSLATION AND STABILITY OF THE MRNA. AS FOR TRANSLATION, UNR NOT ONLY WORKS IN ITS ESTABLISHED ROLE AS ITAF (IRES TRANS-ACTING FACTOR), BUT ALSO REGULATES ELONGATION. WE WANT TO INVESTIGATE THESE TWO FUNCTIONS OF UNR IN TRANSCRIPTS IMPORTANT FOR TUMOR PROGRESSION. IN ADDITION, WE WANT TO IDENTIFY THE INTERACTION OF UNR, AND EVALUATE THE CONSEQUENCES OF TRANSLATIONAL REGULATION BY UNR ON SENESCENCE, CELL STRESS AND METATASIS IN RATON. For ULTIMO, we are interested in correlating the EXPRESSION of one and a grid group with the MELANOMA PROGRESS IN PATIENTS._x000D_ 4) IDENTIFICATE OTHER RBPS IMPLICATE IN THE TUMORAL PROGRESS IN THE CONTEXT OF MELANOMA, USING THE TECHNOLOGY “interactome-CAPTURE”. (English)
12 October 2021
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Barcelona
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Identifiers
BFU2015-68741-P
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