BIOMEDICAL APPLICATIONS OF ARTIFICIAL TISSUE MODELS IN TOXICITY AND PERMEABILITY TESTING OF TOPICAS PREPARATIONS. BIO-TEAR PROJECT (Q3214929): Difference between revisions
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BIOMEDICAL APPLICATIONS OF ARTIFICIAL TISSUE MODELS IN TOXICITY AND PERMEABILITY TESTING OF TOPICAS PREPARATIONS. BIO-TEAR PROJECT | |||
Revision as of 08:27, 12 October 2021
Project Q3214929 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | BIOMEDICAL APPLICATIONS OF ARTIFICIAL TISSUE MODELS IN TOXICITY AND PERMEABILITY TESTING OF TOPICAS PREPARATIONS. BIO-TEAR PROJECT |
Project Q3214929 in Spain |
Statements
626,350.4 Euro
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782,938.0 Euro
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80.0 percent
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14 July 2016
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16 July 2018
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DROPSENS, SL
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43°27'16.45"N, 5°51'2.30"W
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33035
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El proyecto Bio-Tear consiste en el desarrollo de pruebas de toxicidad y permeabilidad de preparaciones tópicas utilizando modelos de tejido artificial, abaratando costes y evitando el uso de animales vivos. En concreto se trata de investigar la obtención de modelos de cornea u otras estructuras anatómicas como mucosas (conjuntiva, alveolar, gástrica,?), piel u otros epitelios partiendo de cultivos celulares humanos, que pueden ser monitorizados permanentemente y que permitan realizar estudios preclínicos de toxicidad y permeabilidad en fármacos. Dentro del proyecto se investigará también sobre nuevos sistemas de monitorización permanente basados en sensores electroquímicos y sistemas novedosos de vehiculación de medicamentos._x000D_ Para entender el proyecto hay que tener en cuenta que el único test actualmente reconocido por la OCDE para la evaluación de la irritabilidad de fármacos en corneas y piel es el Test Draize, que consiste en test in vivo realizado en conejo. Este test tiene un coste muy elevado y problemas éticos asociados por el uso de animales vivos._x000D_ A más, el proyecto abordará la preparación de fórmulas magistrales para patologías oculares no resueltas por vías comerciales que serán sometidas a evaluación de toxicidad y permeabilidad según estos sistemas, lo que permitirá acelerar el traslado de éstas a la práctica clínica en un corto periodo de tiempo. (Spanish)
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The Bio-Tear project consists in developing toxicity and permeability tests for topical preparations, using artificial tissue models to reduce costs and prevent testing on live animals. More specifically, research is carried out to obtain models of cornea or other anatomical structures such as mucous membranes (conjunctive, alveolar, gastric), skin or other epitheliums based on human cell cultures, that can be monitored permanently and enable pre-clinical toxicity and permeability studies to be made in pharmaceuticals. The project will also research into new permanent monitoring systems based on electro-chemical sensors and innovative systems for carrying medicaments._x000D_ In order to understand the project, it must be remembered that the only test currently recognised by the OECD to evaluate the irritability of pharmaceuticals on corneas and skin is the Draize Test, which is tested on live rabbits. The test entails very high costs and ethical problems due to the use of live animals._x000D_ Furthermore, the project will tackle the preparation of magistral formulas for eye disease not treatable by commercial products, which will undergo evaluation of toxicity and permeability according to these systems, and will speed up their transfer to clinical practices in a short space of time. (English)
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Llanera
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Identifiers
IDE/2016/000216
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