Revision history of "Pathogenesis driven by RNAs with expansion of trinucleotide repeats: mechanisms and therapeutic strategies" (Q84328)

13 October 2024

• curprev 15:4315:43, 13 October 2024‎ DG Regio talk contribs‎ 66,829 bytes −6‎ ‎Changed label, description and/or aliases in pt
• curprev 15:4315:43, 13 October 2024‎ DG Regio talk contribs‎ 66,835 bytes +57‎ ‎Set a claim value: summary (P836): A Distrofia Miotónica (DM) e a Síndrome de Ataxia Tremor-Associada ao X Frágil (FXTAS) são desordens dominantes causadas pelo ganho do RNA da função de repetições expandidas do CUG ou do CGG. Ambos os RNAs podem sequestrar proteínas nucleares, e suas seqüências da repetição submetem-se à tradução atípica em peptides tóxicos do mono-aminoácido. Uma vez que o alvo molecular causal está bem definido, o DM e o FXTAS são altamente suscetíveis ao desenvol...

7 March 2024

• curprev 17:1317:13, 7 March 2024‎ DG Regio talk contribs‎ 66,778 bytes +288‎ ‎Added qualifier: readability score (P590521): 0.1519486704148255

6 July 2023

• curprev 11:3311:33, 6 July 2023‎ DG Regio talk contribs‎ 66,490 bytes 0‎ ‎Changed an Item
• curprev 08:4508:45, 6 July 2023‎ DG Regio talk contribs‎ 66,490 bytes 0‎ ‎Changed an Item

11 June 2023

• curprev 11:1311:13, 11 June 2023‎ Admin talk contribs‎ 66,490 bytes +435‎ BatchIngestion

24 May 2023

• curprev 17:1117:11, 24 May 2023‎ DG Regio talk contribs‎ 66,055 bytes +949‎ ‎Changed an Item

2 March 2023

• curprev 13:1413:14, 2 March 2023‎ DG Regio talk contribs‎ 65,106 bytes +222‎ ‎Changed label, description and/or aliases in fr, it, da, bg, cs, et, fi, el, de, es, mt, nl, hr, lt, sl, hu, sv, lv, ro, and other parts

25 October 2022

• curprev 14:3714:37, 25 October 2022‎ DG Regio talk contribs‎ 64,884 bytes +1,289‎ ‎Changed an Item: Import item from Poland

21 October 2022

• curprev 10:5610:56, 21 October 2022‎ DG Regio talk contribs‎ 63,595 bytes +1,207‎ ‎Changed an Item: Import item from Poland
• curprev 10:5610:56, 21 October 2022‎ DG Regio talk contribs‎ 62,388 bytes −419‎ ‎Removed claim: co-financing rate (P837): 100.0 percentage

27 September 2022

• curprev 09:1309:13, 27 September 2022‎ DG Regio talk contribs‎ 62,807 bytes 0‎ ‎Changed an Item: Change because item Q2513981 was merged with Q2517977

13 August 2022

• curprev 17:1317:13, 13 August 2022‎ DG Regio talk contribs‎ 62,807 bytes +39,698‎ ‎Changed label, description and/or aliases in et, lt, hr, el, sk, fi, hu, cs, lv, ga, sl, bg, mt, pt, da, ro, sv, nl, fr, de, it, es, and other parts: Adding translations: et, lt, hr, el, sk, fi, hu, cs, lv, ga, sl, bg, mt, pt, da, ro, sv,

19 January 2022

• curprev 12:4912:49, 19 January 2022‎ DG Regio talk contribs‎ 23,109 bytes +2,198‎ ‎Changed label, description and/or aliases in es, and other parts: Adding Spanish translations

15 January 2022

• curprev 23:2523:25, 15 January 2022‎ DG Regio talk contribs‎ 20,911 bytes +2,108‎ ‎Changed label, description and/or aliases in it, and other parts: Adding Italian translations

16 December 2021

• curprev 19:5919:59, 16 December 2021‎ DG Regio talk contribs‎ 18,803 bytes +2,151‎ ‎Changed label, description and/or aliases in nl, and other parts: Adding Dutch translations

7 December 2021

• curprev 09:1509:15, 7 December 2021‎ DG Regio talk contribs‎ 16,652 bytes +2,160‎ ‎Changed label, description and/or aliases in de, and other parts: Adding German translations

30 November 2021

• curprev 16:3316:33, 30 November 2021‎ DG Regio talk contribs‎ 14,492 bytes +2,112‎ ‎Created claim: summary (P836): La dystrophie myotonique (DM) et le syndrome de Trémor-Ataxie Fragile associé aux X (FXTAS) sont des troubles dominants causés par le gain d’ARN de la fonction des répétitions CUG ou CGG élargies. Les deux ARN peuvent séquestrer les protéines nucléaires, et leurs séquences répétées subissent une traduction atypique en peptides acides mono-amino toxiques. Étant donné que la cible moléculaire causale est bien définie, les DM et les FXTAS sont très...
• curprev 16:3316:33, 30 November 2021‎ DG Regio talk contribs‎ 12,380 bytes +195‎ ‎Changed label, description and/or aliases in fr: translated_label

29 October 2020

• curprev 05:1905:19, 29 October 2020‎ DG Regio talk contribs‎ 12,185 bytes −406‎ ‎Removed claim: financed by (P890): Directorate-General for Regional and Urban Policy (Q8361), Removing unnecessary financed by statement
• curprev 05:1905:19, 29 October 2020‎ DG Regio talk contribs‎ 12,591 bytes −34‎ ‎Changed label, description and/or aliases in 2 languages: Changing unique label-description pair

14 October 2020

• curprev 12:3612:36, 14 October 2020‎ DG Regio talk contribs‎ 12,625 bytes +166‎ ‎Changed label, description and/or aliases in 1 language: translated_label
• curprev 12:3612:36, 14 October 2020‎ DG Regio talk contribs‎ 12,459 bytes −170‎ ‎Changed label, description and/or aliases in 1 language: remove_english_label
• curprev 12:3612:36, 14 October 2020‎ DG Regio talk contribs‎ 12,629 bytes +1,819‎ ‎Created claim: summary (P836): Myotonic Dystrophy (DM) and Fragile X-associated tremor-Ataxia Syndrome (FXTAS) are dominant disorders caused by RNA gain of function of expanded CUG or CGG repeats. Both RNAs may sequester nuclear proteins, and their repeat sequences Undergo untypical translation into toxic mono-amino acid peptides. Since the causative molecular target is well defined, DM and FXTAS are highly amenable to the development of RNA targeting therapy. We and others d...
• curprev 12:3612:36, 14 October 2020‎ DG Regio talk contribs‎ 10,810 bytes −942‎ ‎Removed claim: summary (P836): Myotoic Dystrophy (DM) and Fragile X-associated tremora-taxia Syndrome (FXTAS)Boh RNAS mat sequeaster nuclear protein, and their thereof.Since the cause of molecular target is well defined, DM and FXTAS are duly amending to the development of the development of RNA.And other, with a view to producing results, in animal models of DM;they are a new tool to reduce the effect of FAS to reduce its translation rate.Iim to achieve the gene that shall...

25 September 2020

• curprev 00:3000:30, 25 September 2020‎ DG Regio talk contribs‎ 11,752 bytes +1,159‎ ‎Changed an Item: Fixing rounding issue
• curprev 00:3000:30, 25 September 2020‎ DG Regio talk contribs‎ 10,593 bytes −1,167‎ ‎Removed claim: budget (P474): 839,813.2799999999 euro

23 September 2020

• curprev 06:2106:21, 23 September 2020‎ DG Regio talk contribs‎ 11,760 bytes +1,159‎ ‎Changed an Item: Fixing rounding issue
• curprev 06:2106:21, 23 September 2020‎ DG Regio talk contribs‎ 10,601 bytes −1,167‎ ‎Removed claim: EU contribution (P835): 839,813.2799999999 euro

9 June 2020

• curprev 18:5918:59, 9 June 2020‎ DG Regio talk contribs‎ 11,768 bytes +429‎ ‎Changed an Item

7 June 2020

• curprev 10:1610:16, 7 June 2020‎ DG Regio talk contribs‎ 11,339 bytes +431‎ ‎Changed an Item

26 March 2020

• curprev 13:4813:48, 26 March 2020‎ DG Regio talk contribs‎ 10,908 bytes +431‎ ‎Changed an Item

4 March 2020

• curprev 10:0710:07, 4 March 2020‎ DG Regio talk contribs‎ 10,477 bytes +942‎ ‎Created claim: summary (P836): Myotoic Dystrophy (DM) and Fragile X-associated tremora-taxia Syndrome (FXTAS)Boh RNAS mat sequeaster nuclear protein, and their thereof.Since the cause of molecular target is well defined, DM and FXTAS are duly amending to the development of the development of RNA.And other, with a view to producing results, in animal models of DM;they are a new tool to reduce the effect of FAS to reduce its translation rate.Iim to achieve the gene that shall b...

18 February 2020

• curprev 07:4707:47, 18 February 2020‎ DG Regio talk contribs‎ 9,535 bytes +170‎ ‎Changed an Item: Label in wikidata changed

8 February 2020

• curprev 18:4418:44, 8 February 2020‎ DG Regio talk contribs‎ 9,365 bytes +823‎ ‎Changed an Item
• curprev 18:4418:44, 8 February 2020‎ DG Regio talk contribs‎ 8,542 bytes −417‎ ‎Removed claim: financed by (P890): European Union (Q1)

31 January 2020

• curprev 10:5110:51, 31 January 2020‎ DG Regio talk contribs‎ 8,959 bytes +844‎ ‎Changed an Item

14 January 2020

• curprev 10:2910:29, 14 January 2020‎ DG Regio talk contribs‎ 8,115 bytes +8,115‎ ‎Created a new Item