Targeted depression of anti-apotitic proteins belonging to the Bl-2 phase in neutrons as as a potential that against periodontal disease. In vitro and in vivo analysis. (Q84300)
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Project in Poland financed by DG Regio
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Targeted depression of anti-apotitic proteins belonging to the Bl-2 phase in neutrons as as a potential that against periodontal disease. In vitro and in vivo analysis. |
Project in Poland financed by DG Regio |
Statements
2,000,000.0 zloty
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2,000,000.0 zloty
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100.0 percent
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1 April 2019
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31 March 2022
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UNIWERSYTET JAGIELLOŃSKI
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Chronic periodontal disease(PD) is one of the most frequent inflammatory diseases affecting 11.2% of the world’s population and representing a prominent public health burden. Risk factors for developing PD are cigarette smoking, diabetes, osteoporosis, and infections with periodontal pathogens(i.e. Porphyromonas gingivalis). The pathogenesis of PD is associated with an over-reactive host inflammatory response to P.gingivalis. Current literature implicates hyper-reactive neutrophils as the main immune cell type responsible for the tissue damage and the disease progression. Neutrophils have very short lifespan, controlled by the Bcl-2 family proteins, but it can be significantly prolonged during the infection. Therefore, I hypothesize that hyper-activity and prolonged survival of neutrophils induced by P.gingivalis through the increased expression of pro-survival members of the Bcl-2 family proteins is a novel, yet uncharacterized mechanism strongly contributing to the development of PD. (Polish)
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Protect period is of the most of the world’s population and representing a prominent public health burden.C. Porphymononas gingievalis risk factors for developing PD are.The pathogenesis of PD is associated with an abuse.Current literature on the notional amount of damage and the control progression.Neutrophils have heave very short Lifesspan, controlled by the Bll-2 readily Proteins, but it can be created during the entry.They shall be replaced by the following: (English)
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Identifiers
POIR.04.04.00-00-42FE/17
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