EPIGENETIC THERAPY FOR THE TREATMENT OF CORONAVIRUS INFECTIONS (Q4201949)
Jump to navigation
Jump to search
Project Q4201949 in Italy
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | EPIGENETIC THERAPY FOR THE TREATMENT OF CORONAVIRUS INFECTIONS |
Project Q4201949 in Italy |
Statements
210,299.02 Euro
0 references
420,598.04 Euro
0 references
50.0 percent
0 references
ISTITUTO EUROPEO DI ONCOLOGIA SRL
0 references
ITALFARMACO S.P.A.
0 references
ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLA LOMBARDIA E DELL'EMILIA ROMAGNA "BRUNO UBERTINI"
0 references
ISTITUTO SUPERIORE DI SANITÃ
0 references
BACKGROUND. IL VIRUS SARS-COV-2 POSSIEDE UN GENOMA A RNA A SINGOLO FILAMENTO. DOPO LÂ INGRESSO NELLA CELLULA BERSAGLIO, IL VIRUS INIZIA LE FASI DI REPLICAZIONE DEL SUO GENOMA E DI SINTESI DELLE PROTEINE NECESSARIE. LE CELLULE EPITELIALI DELLE VIE AEREE E LE CELLULE DELLA IMMUNITÃ INNATA (MACROFAGI) SONO I PRINCIPALI BERSAGLI DEL VIRUS. DURANTE LA REPLICAZIONE DEL VIRUS SARS-COV-2, VIENE GENERATO RNA A DOPPIA ELICA (DOUBLE-STRANDED RNA, DSRNA) CHE PORTA ALLÂ ATTIVAZIONE DI VARI MECCANISMI DI DSRNA-SENSING. LA RISPOSTA GENERATA INDUCE LA SINTESI DI INTERFERONI, CHEMOCHINE, CITOCHINE E LA MIGRAZIONE IN LOCO DI CELLULE DEL SISTEMA IMMUNITARIO CHE AMPLIFICANO E PERFEZIONANO LA RISPOSTA INIZIALE. I CORONAVIRUS ESPRIMONO PROTEINE CHE SONO IN GRADO DI INATTIVARE I MECCANISMI DI DSRNA-SENSING, INNESCANDO LA DEREGOLAZIONE COMPLESSIVA DELLA RISPOSTA ALLÂ INFEZIONE VIRALE CHE PORTA AD UN ULTERIORE DANNO CHE DERIVA DALLÂ ECCESSIVA INFIAMMAZIONE DEI TESSUTI E DALLA INEFFICACE RISPOSTA DI ALCUNE POP (Italian)
0 references
BACKGROUND. SARS-COV-2 HAS A SINGLE FILAMENT RNA GENOME. AFTER ENTERING THE TARGET CELL, THE VIRUS BEGINS THE PHASES OF REPLICATION OF ITS GENOME AND SYNTHESIS OF THE NECESSARY PROTEINS. THE EPITHELIAL CELLS OF THE AIRWAY AND THE CELLS OF THE INNATE IMMUNITY (MACROPHAGES) ARE THE MAIN TARGETS OF THE VIRUS. DURING THE REPLICATION OF THE SARS-COV-2 VIRUS, DOUBLE-STRANDED RNA (DSRNA) IS GENERATED, LEADING TO THE ACTIVATION OF VARIOUS DSRNA-SENSING MECHANISMS. THE RESPONSE GENERATED INDUCES THE SYNTHESIS OF INTERFERONS, CHEMOKINES, CYTOKINES AND ON-SITE MIGRATION OF IMMUNE SYSTEM CELLS THAT AMPLIFY AND REFINE THE INITIAL RESPONSE. CORONAVIRUSES EXPRESS PROTEINS THAT ARE ABLE TO INACTIVATE DSRNA-SENSING MECHANISMS, TRIGGERING THE OVERALL DEREGULATION OF THE RESPONSE TO VIRAL INFECTION LEADING TO FURTHER DAMAGE RESULTING FROM EXCESSIVE TISSUE INFLAMMATION AND INEFFECTIVE RESPONSE OF SOME POPS (English)
1 February 2022
0 references
CONTEXTE. LE SARS-COV-2 A UN GÉNOME D’ARN À FILAMENT UNIQUE. APRÈS ÊTRE ENTRÉ DANS LA CELLULE CIBLE, LE VIRUS COMMENCE LES PHASES DE RÉPLICATION DE SON GÉNOME ET DE LA SYNTHÈSE DES PROTÉINES NÉCESSAIRES. LES CELLULES ÉPITHÉLIALES DES VOIES RESPIRATOIRES ET LES CELLULES DE L’IMMUNITÉ INNÉE (MACROPHAGES) SONT LES PRINCIPALES CIBLES DU VIRUS. LORS DE LA RÉPLICATION DU VIRUS SARS-COV-2, L’ARN À DOUBLE BRIN (ARNDS) EST GÉNÉRÉ, CE QUI ENTRAÎNE L’ACTIVATION DE DIVERS MÉCANISMES DE DÉTECTION DE L’ARNS DS. LA RÉPONSE GÉNÉRÉE INDUIT LA SYNTHÈSE DES INTERFÉRONS, DES CHIMOKINES, DES CYTOKINES ET DE LA MIGRATION SUR PLACE DES CELLULES DU SYSTÈME IMMUNITAIRE QUI AMPLIFIENT ET RAFFINENT LA RÉPONSE INITIALE. LES CORONAVIRUS EXPRIMENT DES PROTÉINES CAPABLES D’INACTIVER LES MÉCANISMES DE DÉTECTION DE L’ARNS DS, CE QUI DÉCLENCHE LA DÉRÉGULATION GLOBALE DE LA RÉPONSE À L’INFECTION VIRALE, CE QUI ENTRAÎNE D’AUTRES DOMMAGES RÉSULTANT D’UNE INFLAMMATION EXCESSIVE DES TISSUS ET D’UNE RÉPONSE INEFFICACE DE CERTAINES POPS. (French)
2 February 2022
0 references
CINISELLO BALSAMO
0 references
MILANO
0 references
BRESCIA
0 references