Nanoantibodies based on conexin and panexin as new hemicanal inhibitors for the therapy of inflammatory diseases COPACABANA (Q3252312)
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Project Q3252312 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Nanoantibodies based on conexin and panexin as new hemicanal inhibitors for the therapy of inflammatory diseases COPACABANA |
Project Q3252312 in Spain |
Statements
6,250.0 Euro
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12,500.0 Euro
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50.0 percent
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1 January 2018
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31 December 2018
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PROTOQSAR 2000 SL
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39°28'10.96"N, 0°22'34.82"W
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46250
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El proyecto COPACABANA pretende introducir nano-anticuerpos elegibles para fines terapéuticos dirigidos contra Cx43, Cx32, Cx26 y Panx1, utilizando protocolos novedosos, incluida la inmunización con ADN de llamas combinada con tecnología de nano-discos. COPACABANA probará estos nano-anticuerpos por su potencial para inhibir los hemicanales y para aliviar las características patológicas en modelos en roedores de una variedad de enfermedades inflamatorias. (Spanish)
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The COPACABANA eligible project aims to introduce nano-antibodies for therapeutic purposes directed against Cx43, Cx32, Cx26 and Panx1, using novel protocols including DNA immunization with combined flames nano-discs. COPACABANA test these nano-antibodies for their potential to inhibit hemichannels and to alleviate the pathological features in rodent models of a variety of inflammatory diseases. (English)
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Le projet COPACABANA vise à introduire des nano-anticorps éligibles à des fins thérapeutiques ciblant les Cx43, Cx32, Cx26 et Panx1, en utilisant de nouveaux protocoles, y compris l’immunisation de l’ADN de flamme combinée à la technologie nanodisque. Copacabana testera ces nano-anticorps afin de déterminer leur potentiel d’inhibition des hémicanaux et d’atténuer les caractéristiques pathologiques dans les modèles de rongeurs de diverses maladies inflammatoires. (French)
5 December 2021
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Das COPACABANA-Projekt zielt darauf ab, Nanoantikörper einzuführen, die für therapeutische Zwecke in Frage kommen, die auf Cx43, Cx32, Cx26 und Panx1 abzielen, wobei neuartige Protokolle verwendet werden, einschließlich der Flammen-DNA-Immunisierung in Kombination mit Nanodisc-Technologie. Copacabana wird diese Nanoantikörper auf ihr Potenzial zur Hemmung von Hemikalien und zur Linderung pathologischer Eigenschaften in Nagetiermodellen verschiedener entzündlicher Erkrankungen testen. (German)
10 December 2021
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Het COPACABANA-project heeft tot doel nano-antilichamen te introduceren die in aanmerking komen voor therapeutische doeleinden gericht op Cx43, Cx32, Cx26 en Panx1, met behulp van nieuwe protocollen, waaronder vlam-DNA-immunisatie gecombineerd met nanodisc-technologie. Copacabana zal deze nano-antilichamen testen op hun potentieel om hemicanalen te remmen en pathologische kenmerken in knaagdiermodellen van een verscheidenheid van ontstekingsziekten te verlichten. (Dutch)
18 December 2021
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Il progetto COPACABANA mira a introdurre nano-anticorpi idonei a scopi terapeutici mirati a Cx43, Cx32, Cx26 e Panx1, utilizzando nuovi protocolli, tra cui l'immunizzazione del DNA a fiamma combinata con la tecnologia nanodisc. Copacabana testerà questi nano-anticorpi per il loro potenziale di inibire gli emicanali e di alleviare le caratteristiche patologiche nei modelli di roditori di una varietà di malattie infiammatorie. (Italian)
17 January 2022
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Valencia
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Identifiers
20F01020101U_IVCI00000APEA8025
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