Cancer Research on Therapy Resistance: From Basic Mechanisms to Novel Targets (Q3367341)

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Project Q3367341 in Portugal
Language Label Description Also known as
English
Cancer Research on Therapy Resistance: From Basic Mechanisms to Novel Targets
Project Q3367341 in Portugal

    Statements

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    500,000.0 Euro
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    588,235.0 Euro
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    85.0 percent
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    1 March 2021
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    29 May 2023
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    IPATIMUP-INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO
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    O projeto visa identificar novos mecanismos moleculares envolvidos na resistência à terapia do cancro e identificar novos alvos terapêuticos, usando modelos pré-clínicos.Os objetivos assentam em três linhas de investigação:1. Papel da regulação do RNA na resistência à terapia de cancro.2. Caracterização e função de proteínas como alvos terapêuticos.3. Instabilidade cromossómica na heterogenidade tumoral e na resposta terapêutica. (Portuguese)
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    The project aims to identify new molecular mechanisms involved in cancer therapy resistance and identify new therapeutic targets, using pro-clinical models. The objectives are based on three lines of research:1. Role of RNA regulation in resistance to cancer therapy.2. Characterisation and function of proteins as therapeutic targets.3. Chromosomal instability in tumor heterogenity and therapeutic response. (English)
    29 November 2021
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    Le projet vise à identifier de nouveaux mécanismes moléculaires impliqués dans la résistance au traitement du cancer et à identifier de nouvelles cibles thérapeutiques à l’aide de modèles procliniques. Rôle de la régulation de l’ARN dans la résistance au traitement du cancer.2. Caractérisation et fonction des protéines en tant que cibles thérapeutiques.3. Instabilité chromosomique dans l’hétérogénicité tumorale et la réponse thérapeutique. (French)
    7 December 2021
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    Das Projekt zielt darauf ab, neue molekulare Mechanismen zu identifizieren, die an der Krebstherapieresistenz beteiligt sind, und neue therapeutische Ziele anhand von proklinischen Modellen zu identifizieren. Die Ziele basieren auf drei Forschungslinien:1. Rolle der RNA-Regulierung in der Resistenz gegen Krebstherapie.2. Charakterisierung und Funktion von Proteinen als therapeutische Ziele.3. Chromosomale Instabilität bei Tumorheterogenität und therapeutischem Ansprechen. (German)
    16 December 2021
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    Het project is gericht op het identificeren van nieuwe moleculaire mechanismen die betrokken zijn bij kankertherapieresistentie en het identificeren van nieuwe therapeutische doelen, met behulp van proklinische modellen. De doelstellingen zijn gebaseerd op drie onderzoekslijnen:1. Rol van RNA-regelgeving bij resistentie tegen kankertherapie.2. Karakterisering en functie van eiwitten als therapeutische doelen.3. Chromosomale instabiliteit in tumor heterogeniteit en therapeutische respons. (Dutch)
    20 December 2021
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    Porto, Área Metropolitana do Porto, Norte
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    Identifiers

    NORTE-01-0145-FEDER-000051
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