No label defined (Q3205552)

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Revision as of 08:40, 14 October 2021 by DG Regio (talk | contribs) (‎Created claim: summary (P836): NON-SUICIDE AUTOLESION (NSSI) BEHAVIORS ARE A GROWING PUBLIC HEALTH PROBLEM, ESPECIALLY AFFECTING ADOLESCENTS AND YOUNG ADULTS. IN MANY CASES NSSIS ARE USED AS A STRATEGY OF UNADAPTIVE COPING WITH NEGATIVE EMOTIONAL STATES, WITH THE EXPECTATION OF REDUCING SUCH DISCOMFORT. FOR THIS REASON, IT IS NOT SURPRISING THAT NSSIS HAVE BEEN LINKED TO THE PRESENCE OF SOME FORMS OF PSYCHOPATHOLOGY AND, IN PARTICULAR, TO LIMIT PERSONALITY DISORDER (LPD). HOW...)
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Project Q3205552 in Spain
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English
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Project Q3205552 in Spain

    Statements

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    29,040.0 Euro
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    58,080.0 Euro
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    50.0 percent
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    30 December 2016
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    31 December 2020
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    CONSORCI SANITARI DE L'ANOIA
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    41°34'44.47"N, 1°37'2.46"E
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    08102
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    LAS CONDUCTAS DE AUTOLESION NO SUICIDAS (NSSI) SON UN PROBLEMAS CRECIENTE DE SALUD PUBLICA, QUE AFECTA ESPECIALMENTE A ADOLESCENTES Y JOVENES ADULTOS. EN MUCHOS CASOS LAS NSSI SE UTILIZAN COMO UNA ESTRATEGIA DE AFRONTAMIENTO POCO ADAPTATIVA ANTE ESTADOS EMOCIONALES NEGATIVOS, CON LA EXPECTATIVA DE REDUCIR DICHO MALESTAR. POR ESTE MOTIVO, NO ES EXTRAÑO QUE LAS NSSI SE HAYAN RELACIONADO CON LA PRESENCIA DE ALGUNAS FORMAS DE PSICOPATOLOGIA Y, EN ESPECIAL, CON EL TRASTORNO LIMITE DE LA PERSONALIDAD (TLP). SIN EMBARGO, POCO SE SABE HASTA LA FECHA SOBRE LAS BASES NEUROBIOLOGICAS DE LAS NSSI. _x000D_ UNO DE LOS PROCESOS BASICOS QUE HA RECIBIDO MAS ATENCION EN LOS ULTIMOS AÑOS A ESTE RESPECTO, ES EL PROCESAMIENTO DEL CASTIGO Y LA RECOMPENSA. EL SISTEMA DE RECOMPENSA ESTA FORMADO POR UNA AMPLIA RED FRONTO-SUBCORTICAL, Y JUEGA UN PAPEL CRUCIAL EN EL APRENDIZAJE POR REFORZAMIENTO, GUIANDO NUESTRA CONDUCTA PARA CONSEGUIR RECOMPENSAS Y EVITAR CASTIGOS. UNA ALTERACION EN ESTE SISTEMA, PODRIA CONLLEVAR: (A) UNA DIFICULTAD PARA ADAPTAR NUESTRAS EXPECTATIVAS DE RECIBIR UNA RECOMPENSA O UN CASTIGO, EN BASE A LA EXPERIENCIA PREVIA Y, (B) UNA DIFICULTAD PARA AJUSTAR NUESTRO COMPORTAMIENTO EN BASE AL RESULTADO DE ESTE (FEEDBACK). SORPRENDENTEMENTE, A FECHA DE HOY SOLO EXISTE UN ESTUDIO CON PERSONAS CON NSSI QUE HAYA ANALIZADO UNO DE ESTOS ASPECTOS DEL PROCESAMIENTO DE LA RECOMPENSA. EN ESTE, SE SUGIERE UNA ALTERACION EN LA GENERACION DE EXPECTATIVAS DE RECOMPENSA EN ADOLESCENTES CON NSSI, EN RELACION A CONTROLES SANOS. POR OTRA PARTE, ES INTERESANTE DESTACAR QUE ALGUNOS ESTUDIOS EN SUJETOS CON TLP, HAN SUGERIDO UNA ALTERACION DEL PROCESAMIENTO DE LA RECOMPENSA EN ESTOS PACIENTES. EN SUMA, LA ESCASEZ DE ESTUDIOS POR UN LADO Y LA AUSENCIA DE INVESTIGACIONES QUE HAYAN COMPARADO MUESTRAS CLINICAS CON MUESTRAS NO CLINICAS, HACE QUE: (A) NO PODAMOS AFIRMAR ROTUNDAMENTE QUE EL PROCESAMIENTO DE LA RECOMPENSA ESTA IMPLICADO EN LAS NSSI Y, (B) EN CASO AFIRMATIVO, NO PODAMOS DETERMINAR SI ESTA ALTERACION ES LA QUE EXPLICARIA LA ELEVADA CO-OCURRENCIA ENTRE NSSI Y TRASTORNOS MENTALES. ANTE ESTE ESCENARIO, EL OBJETIVO PRINCIPAL DEL PRESENTE PROYECTO DE INVESTIGACION ES DETERMINAR SI LA EXISTENCIA DE NSSI, DESDE UN PUNTO DE VISTA CONDUCTUAL, SE RELACIONA CON ALTERACIONES EN LOS CIRCUITOS CEREBRALES IMPLICADOS EN EL PROCESAMIENTO DE LA RECOMPENSA DE ADULTOS JOVENES CON Y SIN TLP. NUESTRA HIPOTESIS DE PARTIDA ES QUE LA ACTIVIDAD CEREBRAL EN LA RED DE RECOMPENSA DURANTE LAS FASES DE ANTICIPACION Y PROCESAMIENTO DEL FEEDBACK ESTARA ALTERADA EN PRESENCIA DE NSSI. ADEMAS, TAMBIEN SE POSTULA QUE DICHA ALTERACION SERA MAYOR CUANDO EXISTA UNA CO-OCURRENCIA ENTRE NSSI Y TLP, SUGIRIENDO UNA RELACION POSITIVA ENTRE LA ALTERACION EN EL PROCESAMIENTO DE LA RECOMPENSA Y LA GRAVEDAD CLINICA_x000D_ PARA CONSEGUIR LOS OBJETIVOS PROPUESTOS, REALIZAREMOS DOS EXPERIMENTOS CON RESONANCIA MAGNETICA FUNCIONAL, EN LOS QUE SE REGISTRARA LA ACTIVIDAD CEREBRAL DE LOS PARTICIPANTES MIENTRAS REALIZAN UNAS TAREAS DE RECOMPENSA. EL PROYECTO PUEDE SUPONER UN AVANCE EN EL CONOCIMIENTO DE LAS NSSI Y SOBRE SU POSIBLE RELACION CON LA PSICOPATOLOGIA. (Spanish)
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    NON-SUICIDE AUTOLESION (NSSI) BEHAVIORS ARE A GROWING PUBLIC HEALTH PROBLEM, ESPECIALLY AFFECTING ADOLESCENTS AND YOUNG ADULTS. IN MANY CASES NSSIS ARE USED AS A STRATEGY OF UNADAPTIVE COPING WITH NEGATIVE EMOTIONAL STATES, WITH THE EXPECTATION OF REDUCING SUCH DISCOMFORT. FOR THIS REASON, IT IS NOT SURPRISING THAT NSSIS HAVE BEEN LINKED TO THE PRESENCE OF SOME FORMS OF PSYCHOPATHOLOGY AND, IN PARTICULAR, TO LIMIT PERSONALITY DISORDER (LPD). HOWEVER, LITTLE IS KNOWN TO DATE ON THE NSSI NEUROBIOLOGICAL BASES. _x000D_ one of the basic processes that have received the most attention in the last years to this reservation, is the process of CASTIGO and RECOMPENSE. THE REWARD SYSTEM IS MADE UP OF AN EXTENSIVE FRONTO-SUBCORTICAL NETWORK, AND PLAYS A CRUCIAL ROLE IN STRENGTHENING LEARNING, GUIDING OUR BEHAVIOR TO GET REWARDS AND AVOID PUNISHMENT. AN ALTERATION IN THIS SYSTEM COULD LEAD TO: (A) A DIFFICULTY IN ADAPTING OUR EXPECTATIONS OF RECEIVING A REWARD OR PUNISHMENT, BASED ON PREVIOUS EXPERIENCE AND, (B) A DIFFICULTY IN ADJUSTING OUR BEHAVIOR BASED ON THE OUTCOME OF THIS (FEEDBACK). SURPRISINGLY, TODAY THERE IS ONLY ONE STUDY WITH PEOPLE WITH NSSI THAT HAS ANALYSED ONE OF THESE ASPECTS OF REWARD PROCESSING. IN THIS, AN ALTERATION IS SUGGESTED IN THE GENERATION OF REWARD EXPECTATIONS IN ADOLESCENTS WITH NSSI, IN RELATION TO HEALTHY CONTROLS. ON THE OTHER HAND, IT IS INTERESTING TO NOTE THAT SOME STUDIES IN SUBJECTS WITH PLT HAVE SUGGESTED AN ALTERATION IN THE PROCESSING OF REWARD IN THESE PATIENTS. IN SHORT, THE SCARCITY OF STUDIES ON THE ONE HAND AND THE ABSENCE OF RESEARCH THAT COMPARED CLINICAL SAMPLES WITH NON-CLINICAL SAMPLES, MEANS THAT: (A) WE CANNOT STATE EMPHATICALLY THAT THE PROCESSING OF THE REWARD IS INVOLVED IN THE NSSI AND (B) IF SO, WE CANNOT DETERMINE WHETHER THIS ALTERATION WOULD EXPLAIN THE HIGH CO-OCCURRENCE BETWEEN NSSI AND MENTAL DISORDERS. IN VIEW OF THIS SCENARIO, THE MAIN OBJECTIVE OF THIS RESEARCH PROJECT IS TO DETERMINE WHETHER THE EXISTENCE OF NSSI, FROM A BEHAVIORAL POINT OF VIEW, IS RELATED TO ALTERATIONS IN THE BRAIN CIRCUITS INVOLVED IN THE PROCESSING OF THE REWARD OF YOUNG ADULTS WITH AND WITHOUT TLP. OUR STARTING HYPOTHESIS IS THAT BRAIN ACTIVITY IN THE REWARD NETWORK DURING THE FEEDBACK ANTICIPATION AND PROCESSING PHASES WILL BE ALTERED IN THE PRESENCE OF NSSI. In addition, they are also postulated to say high quality when there is a co-occurrence between NSSI and TLP, suggesting a POSITIVE RELATION BETWEEN THE ALTERATION IN THE PROCESSING OF THE RECOMPENSE AND CLINICAL GRAVEDAY_x000D_ TO CONCERN PROPERTY OBJECTIVES, we will carry out two experiences with functional MAGNETIC RESONANCE, in which the CEREBRAL ACTIVITY of the parties involved is registered. THE PROJECT CAN BE AN ADVANCE IN THE KNOWLEDGE OF NSSI AND ITS POSSIBLE RELATIONSHIP WITH PSYCHOPATHOLOGY. (English)
    14 October 2021
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    Igualada
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    Identifiers

    PSI2016-79980-P
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