ROLE OF ADIPOKINES IN INTERVERTEBRAL DISC DEGENERATION (DDIV): A NEW PHSIOPATOLOGICAL APPROACH. (Q3161061)

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Revision as of 16:35, 12 October 2021 by DG Regio (talk | contribs) (‎Created claim: summary (P836): The fundamental objective of this project is to deepen the knowledge of the molecular, biochemical and cellular mechanisms involved in the etiopathogeny of the degenerative disease of the intervertebral disc. In particular, those potentially exercised by adipokinas and neuroendocrine factors that regulate both energetic and metabolic homeostasis and modulation of the inflammatory and immunological response. The study will focus on clarifying the...)
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Project Q3161061 in Spain
Language Label Description Also known as
English
ROLE OF ADIPOKINES IN INTERVERTEBRAL DISC DEGENERATION (DDIV): A NEW PHSIOPATOLOGICAL APPROACH.
Project Q3161061 in Spain

    Statements

    country
    Spain
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    EU contribution
    105,600.0 Euro
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    budget
    132,000.0 Euro
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    co-financing rate
    80.0 percent
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    start time
    1 January 2018
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    end time
    31 March 2021
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    beneficiary name (string)
    FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA
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    beneficiary
    Q3136853
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    coordinate location

    42°52'49.51"N, 8°32'45.10"W
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    postal code
    15078
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    summary
    El objetivo fundamental de este proyecto consiste en profundizar en el conocimiento de los mecanismos moleculares, bioquímicos y celulares implicados en la etiopatogenia de la enfermedad degenerativa del disco intervertebral. En particular, aquellos potencialmente ejercidos por las adipokinas y factores neuroendocrinos que regulan tanto la homeostasis energética y metabólica como la modulación de la respuesta inflamatoria e inmunológica. El estudio estará enfocado a esclarecer las bases moleculares de la degeneración discal ejercidas por la lipocalina-2 (LCN2/NGAL), la visfatina, la nesfatina-1 (NUCB2), la progranulina, la serpina-2, la chemerina y el ghrelin en las células del disco intervertebral humano. (Spanish)
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    The fundamental objective of this project is to deepen the knowledge of the molecular, biochemical and cellular mechanisms involved in the etiopathogeny of the degenerative disease of the intervertebral disc. In particular, those potentially exercised by adipokinas and neuroendocrine factors that regulate both energetic and metabolic homeostasis and modulation of the inflammatory and immunological response. The study will focus on clarifying the molecular bases of disc degeneration exerted by lipocaline-2 (LCN2/NGAL), visfatin, nesfatin-1 (NUCB2), progranulin, serpine-2, chemerin and ghrelin in human intervertebral disc cells. (English)
    point in time
    12 October 2021
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    location (string)
    Santiago de Compostela
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    Identifiers

    Spanish Kohesio ID
    PI17_00409
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