New tools and strategies to control TB (Q3167758)

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Project Q3167758 in Spain
Language Label Description Also known as
English
New tools and strategies to control TB
Project Q3167758 in Spain

    Statements

    country
    Spain
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    EU contribution
    31,000.0 Euro
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    budget
    62,000.0 Euro
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    co-financing rate
    50.0 percent
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    start time
    1 January 2019
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    end time
    31 March 2022
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    beneficiary name (string)
    INSTITUTO ARAGONES DE CIENCIAS DE LA SALUD
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    coordinate location

    41°39'7.67"N, 0°52'51.38"W
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    postal code
    50297
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    summary
    Con el objetivo de ampliar el conocimiento del genoma del complejo tuberculosis que facilite una estrategia óptima para el control de la TB, nos planteamos: 1.- Diseñar un método de diagnóstico rápido de resistencia a fármacos que proporcione información sobre linaje evolutivo. 2.- Contrastar las resistencias genotípicas y fenotípicas en aislamientos clínicos de tuberculosis MDR circulantes en nuestro país desde 1998. 3.- Analizar regiones diferenciales en el genoma de tuberculosis mediante secuenciación genómica y valorar su significado en la patogenia y evolución. 4.- Estudiar la microevolución de los aislamientos debidos a una reactivación de tuberculosis en Aragón e identificar los factores de riesgo que se puedan asociar. 5.- Geolocalizar, visualizar y analizar espacialmente la prevalencia de tuberculosis. (Spanish)
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    With the aim of broadening the knowledge of the tuberculosis complex genome that facilitates an optimal strategy for TB control, we propose: 1.- Design a rapid diagnostic method of drug resistance that provides information on evolutionary lineage. 2.- Contrast genotypic and phenotypic resistances in clinical isolations of circulating MDR tuberculosis in our country since 1998. 3.- Analyse differential regions in the tuberculosis genome by genomic sequencing and assess its significance in pathogenesis and evolution. 4.- Study the microevolution of isolation due to a reactivation of tuberculosis in Aragon and identify the risk factors that may be associated. 5.- Geolocalise, visualise and spatially analyse the prevalence of tuberculosis. (English)
    point in time
    12 October 2021
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    location (string)
    Zaragoza
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    Identifiers

    Spanish Kohesio ID
    PI18_00336
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