Identification of genes associated with the development of Combined Familar Hyperlipemia. (Q3153986)
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Project Q3153986 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Identification of genes associated with the development of Combined Familar Hyperlipemia. |
Project Q3153986 in Spain |
Statements
28,750.0 Euro
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57,500.0 Euro
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50.0 percent
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1 January 2014
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30 March 2018
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INSTITUTO ARAGONES DE CIENCIAS DE LA SALUD
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41°39'7.67"N, 0°52'51.38"W
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50297
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El objetivo general del presente proyecto es identificar los genes/SNPs que se asocian con Hiperlipemia Familiar Combinada para poder definir un score genético con utilidad diagnóstica o predictiva. Para ello, como objetivos secundarios, se pretende identificar los genes/SNPs específicos de los factores de riesgo cardiovascular que son muy característicos de esta entidad: hipercolesterolemia, hipertrigliceridemia, hipertensión y obesidad, e identificar los genes/SNPs específicos, y las potenciales interacciones entre los mismos que se asocien con la presencia de Hiperlipemia Familiar Combinada. La metodología propuesta es determinar mediante la tecnología de OpenArray diferentes SNPs que se ha demostrado en diferentes estudios GWA que se asocian con los siguientes factores de riesgo cardiovascular: hiperlipemia, hipertensión arterial y obesidad, en 5 grupos de sujetos: 1000 sujetos con Hiperlipemia Familiar Combinada, 1000 sujetos con hipertensión arterial, 1000 sujetos con obesidad, 1000 sujetos controles sanos y 1000 sujetos de la población general. Con los resultados obtenidos se realizará el análisis estadístico para analizar asociación, interacción, y capacidad predictiva y así definir un score genético de Hiperlipemia Familiar Combinada que mejore el diagnóstico de esta hiperlipemia. (Spanish)
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The general objective of this project is to identify genes/NPS that are associated with Combined Family Hyperlipidemia in order to define a genetic score with diagnostic or predictive utility. For this purpose, as secondary objectives, the aim is to identify the genes/NPS specific to the cardiovascular risk factors that are very characteristic of this entity: hypercholesterolemia, hypertriglyceridaemia, hypertension and obesity, and identify the specific genes/NPSs, and the potential interactions between them that are associated with the presence of Combined Family Hyperlipemia. The proposed methodology is to determine using OpenArray technology different SNPs that have been demonstrated in different GWA studies that are associated with the following cardiovascular risk factors: hyperlipemia, hypertension and obesity, in 5 groups of subjects: 1000 subjects with combined family hyperlipidemia, 1000 subjects with high blood pressure, 1000 subjects with obesity, 1000 healthy control subjects and 1000 subjects from the general population. With the results obtained, the statistical analysis will be performed to analyse association, interaction, and predictive capacity and thus define a genetic score of Combined Family Hyperlipemia that improves the diagnosis of this hyperlipemia. (English)
12 October 2021
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Zaragoza
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Identifiers
PI13_02507
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