No label defined (Q3137987)

From EU Knowledge Graph
Revision as of 12:32, 12 October 2021 by DG Regio (talk | contribs) (‎Created claim: summary (P836): Current soft tissue repair treatments use synthetic biomaterials as an integral part of medical devices designed to replace lost natural functions (BM-TB). The design of new BM-TB capable of guiding and stimulating specific responses to the molecular level, coupled with a detailed study of cell-material interactions, can open a new chapter in personalised medicine where BM-TBs prepare to match each type of tissue and pathology. SCENARIO: alterat...)
Jump to navigation Jump to search
Project Q3137987 in Spain
Language Label Description Also known as
English
No label defined
Project Q3137987 in Spain

    Statements

    country
    Spain
    0 references
    EU contribution
    48,250.0 Euro
    0 references
    budget
    96,500.0 Euro
    0 references
    co-financing rate
    50.0 percent
    0 references
    start time
    1 January 2018
    0 references
    end time
    31 March 2021
    0 references
    beneficiary name (string)
    FUNDACION INSTITUTO DE INVESTIGACION DEL HOSPITAL UNIVERSITARIO VALL D'HEBRON (VHIR)
    0 references
    beneficiary
    Q3134470
    0 references
    coordinate location

    41°22'58.40"N, 2°10'38.75"E
    0 references
    postal code
    08019
    0 references
    summary
    Los tratamientos actuales para la reparación de tejidos blandos utilizan biomateriales sintéticos como parte integral de dispositivos médicos diseñados para reemplazar funciones naturales perdidas (BM-TB). El diseño de nuevos BM-TB capaces de guiar y estimular respuestas específicas al nivel molecular, acoplado a un estudio detallado de las interacciones célula-material, puede abrir un nuevo capítulo en la medicina personalizada dónde los BM-TB se preparen para concordar con cada tipo de tejido y patología. HIPÓTESIS: alteraciones en la estructura y función de fibroblastos derivados de tejidos blandos comprometidos (hernia abdominal y prolapso de órganos pélvicos), crearán interfaces específicas, susceptibles de ser modelizadas y manipuladas “in vitro” (en contacto con polímeros modificados) a un nivel mecanicista. OBJETIVOS: 1) Obtener, propagar y caracterizar fibroblastos de biopsias peroperatorias; 2) Evaluar una selección de tratamientos en las superficies de 2 materiales escogidos por su uso común cómo BM-TB. METODOLOGÍA: A) Tipo de estudio: Experimental in vitro; B) Sujetos: Fibroblastos primarios de pacientes con hernia incisional, prolapso de órganos pélvicos, y control (n=20/grupo); Materiales: Polipropileno y PVDF; C) Metodología: Cultivo y caracterización (morfológica, funcional, expresión génica), de los fibroblastos primarios en placa y en sustratos con/sin modificación de superficies; Fabricación de nanotopografias superficiales y caracterización físico-química (interferometria luz blanca, ángulo de contacto, microscopia electrónica (SEM), potencial Z) de los materiales; Biofuncionalización superficial para inducir una respuesta celular/tisular específica (péptidos y/o fragmentos de proteínas) y caracterización: Espectroscopia de fotoelectrones (XPS), técnicas de inmunofluorescencia. Espectroscopia de RAMAN; D: Análisis estadístico e integración de resultados. (Spanish)
    0 references
    Current soft tissue repair treatments use synthetic biomaterials as an integral part of medical devices designed to replace lost natural functions (BM-TB). The design of new BM-TB capable of guiding and stimulating specific responses to the molecular level, coupled with a detailed study of cell-material interactions, can open a new chapter in personalised medicine where BM-TBs prepare to match each type of tissue and pathology. SCENARIO: alterations in the structure and function of fibroblasts derived from compromised soft tissues (abdominal hernia and pelvic organ prolapse), will create specific interfaces, capable of being modelled and manipulated “in vitro” (in contact with modified polymers) at a mechanistic level. OBJECTIVES: 1) Obtain, propagate and characterise fibroblasts from peroperative biopsies; 2) Evaluate a selection of treatments on surfaces of 2 materials chosen for their common use as BM-TB. METHODOLOGY: Type of study: In vitro experimental; B) Subjects: Primary fibroblasts in patients with incisional hernia, pelvic organ prolapse, and control (n=20/group); Materials: Polypropylene and PVDF; Methodology: Culture and characterisation (morphological, functional, gene expression), of primary fibroblasts on plate and on substrates with/without surface modification; Manufacture of surface nanotopographies and physicochemical characterisation (white light interferometry, contact angle, electron microscopy (SEM), potential Z) of materials; Surface biofunctionalisation to induce a specific cell/tisular response (peptides or protein fragments) and characterisation: Photoelectron spectroscopy (XPS), immunofluorescence techniques. RAMAN spectroscopy; D: Statistical analysis and integration of results. (English)
    point in time
    12 October 2021
    0 references
    location (string)
    Barcelona
    0 references

    Identifiers

    Spanish Kohesio ID
    PI17_01236
    0 references
     
    Retrieved from "https://linkedopendata.eu/w/index.php?title=Item:Q3137987&oldid=12771256"