Role of mitochondrial oxidative stress and changes in lipidoma in obesity-associated fibrosis in acute myocardial infarction. Mechanisms involved (Q3135112)
Jump to navigation
Jump to search
Project Q3135112 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Role of mitochondrial oxidative stress and changes in lipidoma in obesity-associated fibrosis in acute myocardial infarction. Mechanisms involved |
Project Q3135112 in Spain |
Statements
46,000.0 Euro
0 references
92,000.0 Euro
0 references
50.0 percent
0 references
1 January 2016
0 references
16 December 2018
0 references
UNIVERSIDAD COMPLUTENSE DE MADRID
0 references
40°25'0.12"N, 3°42'12.89"W
0 references
28079
0 references
Este estudio se plantea como un proyecto coordinado por el Departamento de Fisiología de la Facultad de Medicina de la UCM en colaboración con el Servicio de Cardiología del Hospital Clínico San Carlos con el objetivo principal de estudiar la fibrosis miocárdica difusa asociada a la obesidad en el infarto de miocardio. Se valorará además los posibles mecanismos implicados especialmente la disfunción mitocondrial que favorece el aumento de estrés oxidativo y el cambio de la composición lipídica del miocardio mediante lipidómica que favorece patrón basal de fibrosis puede presentar características singulares y evolucionar en el seguimiento de forma diferente al de paciente no obeso tras un primer infarto agudo de miocardio. Bajo esta premisa se realizará un estudio clínico que incluirá pacientes obesos y no obesos que sufren su primer infarto de miocardio en los que se realizará una caracterización con imagen cardiaca no invasiva estructural y funcional con cardiorresonancia y ecocardiograma. También se identificará y cuantificará la presencia de fibrosis intersticial difusa y el volumen de matriz extracelular por cardiorresonancia. Se realizará un estudio con un modelo de ratas obesas con infarto de miocardio para identificar los mecanismos moleculares implicados y relacionarlos con cambios funcionales y estructurales cardiacos. Se usarán estudios en cardiofibroblastos y cardiomiocitos para analizar vías de señalización. (Spanish)
0 references
This study is proposed as a project coordinated by the Department of Physiology of the Faculty of Medicine of the UCM in collaboration with the Cardiology Service of the San Carlos Clinical Hospital with the main objective of studying diffuse myocardial fibrosis associated with obesity in myocardial infarction. In addition, the possible mechanisms involved especially mitochondrial dysfunction that favors increased oxidative stress and the change in the lipid composition of the myocardium by lipidomics that favor basal pattern of fibrosis can present unique characteristics and evolve in follow-up differently from the non-obese patient after a first acute myocardial infarction. Under this premise, a clinical study will be conducted that will include obese and non-obese patients who suffer their first myocardial infarction in whom a characterisation with non-invasive structural and functional cardiac image with cardioresonance and echocardiogram will be performed. The presence of diffuse interstitial fibrosis and the volume of extracellular cardioresonance matrix will also be identified and quantified. A study will be conducted with a model of obese rats with myocardial infarction to identify the molecular mechanisms involved and relate them to cardiac functional and structural changes. Studies in cardiofibroblasts and cardiomyocytes will be used to analyse signaling pathways. (English)
12 October 2021
0 references
Madrid
0 references
Identifiers
PI15_01060
0 references