BIO3DBRAIN: 3D PRINTED BIOLOGICAL MODELS FOR THE STUDY OF THE BRAIN AND ITS PATHOLOGIES (Q4138546)
Jump to navigation
Jump to search
Project Q4138546 in Italy
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | BIO3DBRAIN: 3D PRINTED BIOLOGICAL MODELS FOR THE STUDY OF THE BRAIN AND ITS PATHOLOGIES |
Project Q4138546 in Italy |
Statements
36,288.0 Euro
0 references
72,576.0 Euro
0 references
50.0 percent
0 references
UNIVERSITÃ DEGLI STUDI DI ROMA LA SAPIENZA
0 references
LA MANCANZA DI APPROPRIATI MODELLI IN VITRO DEL SISTEMA NERVOSO UMANO OSTACOLA LA COMPRENSIONE DEI MECCANISMI PATOLOGICI E LO SVILUPPO DI FARMACI. QUESTO PROGETTO MIRA A GENERARE, MEDIANTE METODI INNOVATIVI DI GENERAZIONE GUIDATA DI ORGANOIDI E DI 3D BIOPRINTING, NUOVI MODELLI 3D DEL SISTEMA NERVOSO UMANO BASATI SU CELLULE CEREBRALI DERIVATE DA CELLULE STAMINALI PLURIPOTENTI INDOTTE (IPSC). LE IPSC POSSONO ESSERE DERIVATE DA QUALSIASI INDIVIDUO RIPROGRAMMANDO LE CELLULE DEL CORPO, E POI CONVERTITE IN QUALSIASI TIPO DI CELLULA DI INTERESSE. PRODURREMO MODELLI 3D DI PATOLOGIE DEL NEUROSVILUPPO, NEURODEGENERATIVE, E DI TUMORI CEREBRALI. ANALIZZEREMO QUESTI MODELLI DI MALATTIE PER STUDIARNE I MECCANISMI, E PER VALUTARE SE POSSONO ESSERE UTILIZZATI PER TEST FARMACOLOGICI E PER LO SVILUPPO DI STRUMENTI DIAGNOSTICI. FINE ULTIMO DEL PROGETTO Ê CHE TALI MODELLI 3D CARATTERIZZATI DAL POTER ESSERE PAZIENTE SPECIFICI, DIVENTINO PIATTAFORME AFFIDABILI PER LO SCREENING FARMACOLOGICO PER LA MEDICI (Italian)
0 references
LA FALTA DE MODELOS IN VITRO APROPIADOS DEL SISTEMA NERVIOSO HUMANO DIFICULTA LA COMPRENSIÓN DE LOS MECANISMOS PATOLÓGICOS Y EL DESARROLLO DE FÁRMACOS. ESTE PROYECTO TIENE COMO OBJETIVO GENERAR, A TRAVÉS DE MÉTODOS INNOVADORES DE GENERACIÓN GUIADA DE ORGANOIDES Y BIOIMPRESIÓN 3D, NUEVOS MODELOS 3D DEL SISTEMA NERVIOSO HUMANO BASADOS EN CÉLULAS CEREBRALES DERIVADAS DE CÉLULAS MADRE PLURIPOTENTES INDUCIDAS (IPSC). IPSCS SE PUEDEN DERIVAR DE CUALQUIER INDIVIDUO MEDIANTE LA REPROGRAMACIÓN DE LAS CÉLULAS DEL CUERPO, Y LUEGO CONVERTIDO EN CUALQUIER TIPO DE CÉLULA DE INTERÉS. PRODUCIREMOS MODELOS 3D DE PATOLOGÍAS DE NEURODESARROLLO, NEURODEGENERATIVAS Y TUMORES CEREBRALES. ANALIZAREMOS ESTOS MODELOS DE ENFERMEDADES PARA ESTUDIAR SUS MECANISMOS Y EVALUAR SI PUEDEN UTILIZARSE PARA PRUEBAS FARMACOLÓGICAS Y PARA EL DESARROLLO DE HERRAMIENTAS DIAGNÓSTICAS. EL OBJETIVO FINAL DEL PROYECTO ES QUE ESTOS MODELOS 3D, CARACTERIZADOS POR SER ESPECÍFICOS PARA EL PACIENTE, SE CONVIERTAN EN PLATAFORMAS CONFIABLES PARA EL CRIBADO FARMACOLÓGICO PARA LOS MÉDICOS (Spanish)
30 January 2022
0 references
THE LACK OF APPROPRIATE IN VITRO MODELS OF THE HUMAN NERVOUS SYSTEM HINDERS THE UNDERSTANDING OF PATHOLOGICAL MECHANISMS AND THE DEVELOPMENT OF DRUGS. THIS PROJECT AIMS TO GENERATE, THROUGH INNOVATIVE METHODS OF GUIDED GENERATION OF ORGANOIDS AND 3D BIOPRINTING, NEW 3D MODELS OF THE HUMAN NERVOUS SYSTEM BASED ON BRAIN CELLS DERIVED FROM INDUCED PLURIPOTENT STEM CELLS (IPSC). IPSCS CAN BE DERIVED FROM ANY INDIVIDUAL BY REPROGRAMMING THE CELLS OF THE BODY, AND THEN CONVERTED INTO ANY TYPE OF CELL OF INTEREST. WE WILL PRODUCE 3D MODELS OF NEURODEVELOPMENTAL PATHOLOGIES, NEURODEGENERATIVES, AND BRAIN TUMORS. WE WILL ANALYSE THESE DISEASE MODELS TO STUDY THEIR MECHANISMS, AND TO ASSESS WHETHER THEY CAN BE USED FOR PHARMACOLOGICAL TESTING AND FOR THE DEVELOPMENT OF DIAGNOSTIC TOOLS. THE ULTIMATE GOAL OF THE PROJECT IS THAT THESE 3D MODELS CHARACTERISED BY BEING PATIENT-SPECIFIC, BECOME RELIABLE PLATFORMS FOR PHARMACOLOGICAL SCREENING FOR DOCTORS (English)
31 January 2022
0 references
ROMA
0 references