ACQUISITION, DESIGN, CHARACTERISATION, MODELLING AND 3D PRINTING OF 3D MODELS, IN THE MACRO/MICROSCALE, OF BONE TISSUES AND BIOMIMETIC SCAFFOLDING FOR TISSUE ENGINEERING (Q3171273)
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Project Q3171273 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | ACQUISITION, DESIGN, CHARACTERISATION, MODELLING AND 3D PRINTING OF 3D MODELS, IN THE MACRO/MICROSCALE, OF BONE TISSUES AND BIOMIMETIC SCAFFOLDING FOR TISSUE ENGINEERING |
Project Q3171273 in Spain |
Statements
38,115.0 Euro
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76,230.0 Euro
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50.0 percent
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30 December 2016
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29 December 2019
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UNIVERSIDAD POLITECNICA DE CATALUÑA
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41°22'58.40"N, 2°10'38.75"E
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08019
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EL OBJETIVO PRINCIPAL DE ESTE PROYECTO ES OBTENER, DISEÑAR Y CARACTERIZAR MODELOS COMPUTACIONALES PARAMETRICOS DE ESTRUCTURAS MATERIALES BIOMIMETICAS POROSAS PARA INGENIERIA DE TEJIDO OSEO, Y APLICAR ESTE CONOCIMIENTO A LA RESOLUCION DE PROBLEMAS CLINICOS DE GRAN IMPORTANCIA Y AFECTACION SOCIAL. EL PROYECTO SE CENTRA EN LA RESOLUCION DE PROBLEMAS CLINICOS EN EL AMBITO DE:_x000D_ _x000D_ 1. LA CIRUGIA VERTEBRAL DE MINIMA INVASION (VERTEBROPLASTIA Y CIFOPLASTIA). EN ESTE CAMPO ES IMPORTANTE COMPRENDER LAS DIFERENCIAS MICROESTRUCTURALES DE LAS DISTINTAS VERTEBRAS (SACRA, LUMBAR, ETC.) PARA OPTIMIZAR EL ABORDAJE CLINICO (TANTO INSTRUMENTAL COMO QUIRURGICO) Y APORTAR SOLUCIONES ESPECIFICAS AL ESTADO REAL DE LAS VERTEBRAS OSTEOPOROTICAS INFILTRADAS CON BIOCEMENTO._x000D_ _x000D_ 2. EL ESTUDIO DE LAS ALTERACIONES PARCIALES (HIPOSMIA) O TOTALES (ANOSMIA) DEL SISTEMA OLFATIVO RELACIONADAS CON LA EDAD (ENVEJECIMIENTO), TRAUMATISMO CEREBRAL AGUDO (ACCIDENTES), ENFERMEDADES INFLAMATORIAS (RINOSINUSITIS), VIRICAS (RESFRIADO COMUN) Y NEURODEGENERATIVAS (PARKINSON, ALZHEIMER). EN ESTE CAMPO ES CLAVE ENTENDER EL PAPEL QUE JUEGA EL HUESO ETMOIDES Y SU LAMINA CRIBOSA EN LA MUCOSA OLFATIVA (NEUROEPITELIO) COMO PUERTA DE COMUNICACION O ENTRADA AL SISTEMA NERVIOSO CENTRAL (SNC; BULBOS OLFATORIOS) MEDIANTE EL DESARROLLO DE MODELOS OSEOS TRIDIMENSIONALES (3D-SCAFFOLDS) PARA EL DESARROLLO POSTERIOR DE MODELOS DE ESTAS ENFERMEDADES PARA ESTUDIAR SU FISIOPATOLOGIA Y DESARROLLAR NUEVAS DIANAS TERAPEUTICAS Y FARMACOS DE LIBERACION CONTROLADA IN SITU._x000D_ _x000D_ 3. LA ODONTOLOGIA (TRATAMIENTOS DE PROCESOS COMPLEJOS COMO DEFORMIDADES DENTOFACIALES, QUISTES MANDIBULARES O CANCER ORAL Y MAXILOFACIAL). EN ESTE CAMPO LOS MODELOS VIRTUALES E IMPRESOS A ESCALA FACILITAN CLARAMENTE LAS ESTRATEGIAS DE ABORDAJE CLINICO EN QUIROFANO Y MEJORAN LA TRANSMISION DE CONOCIMIENTOS EN EL PLANO DOCENTE Y ASISTENCIAL._x000D_ _x000D_ EN LOS TRES CASOS CLINICOS QUE SE VAN A ANALIZAR LA METODOLOGIA A SEGUIR SERA LA MISMA. SE OBTENDRAN IMAGENES MEDICAS DE TOMOGRAFIA COMPUTERIZADA (TC), MICRO-CT Y DE RESONANCIA MAGNETICA NUCLEAR (RMN). LAS IMAGENES SERAN RECONSTRUIDAS CON SOFTWARE ADECUADO PARA OBTENER REPRESENTACIONES O MODELOS 3D IDENTICOS DE LAS UNIDADES ANALIZADAS (VERTEBRA, HUESO ETMOIDE, MANDIBULA, ETC.) TANTO A NIVEL MACRO (FORMA GEOMETRICA EXTERNA) COMO MICROESTRUCTURAL (CARACTERIZACION HISTOMORFOMETRICA DE LAS DISTINTAS ESTRUCTURAS OSEAS). LOS MODELOS VIRTUALES 3D SERAN EXPORTADOS A PROGRAMAS DE COMPUTACION MULTIFISICA Y SERAN CARACTERIZADOS TANTO DESDE EL PUNTO DE VISTA MECANICO COMO FLUIDICO. LOS MODELOS VIRTUALES SE IMPRIMIRAN EN 3D CON MATERIALES BIOCOMPATIBLES. TAMBIEN SE HARAN ESTUDIOS CELULARES IN VITRO E IN VIVO. UNA VEZ ANALIZADA TODA ESTA INFORMACION SE OBTENDRAN RECOMENDACIONES CLARAS QUE PERMITIRAN REDEFINIR: A) LAS TECNICAS QUIRURGICAS (ABORDAJE E INSTRUMENTAL QUIRURGICO EN VERTEBRA SACRA, MANDIBULA, CRANEO, ETC., POR EJEMPLO); Y B) LA MICROESTRUCTURA Y LAS CARACTERISTICAS HISTOMORFOMETRICAS OPTIMAS DE UN IMPLANTE BIOMIMETICO DE LAMINA CRIBOSA QUE SIENTE LAS BASES PARA FUTUROS DESARROLLOS DE INGENIERIA DE TEJIDOS DEL TEJIDO NEUROEPITELIAL DEL SISTEMA OLFATIVO (NOSE-ON-A-CHIP)._x000D_ _x000D_ POR ULTIMO, EN UN PLANO MAS GENERAL, EL DESARROLLO, LA CARACTERIZACION Y LA COMPUTACION DE MODELOS TEORICOS PARAMETRICOS DE ESTRUCTURAS BIOMIMETICAS OSEAS PERMITIRA AMPLIAR EL CONOCIMIENTO GENERAL Y LA CAPACIDAD DE MANIPULACION DE MODELOS MATERIALES POROSOS CON APLICACION A MUCHOS OTROS CAMPOS DE LA INGENIERIA. (Spanish)
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THE MAIN OBJECTIVE OF THIS PROJECT IS TO OBTAIN, DESIGN AND CHARACTERISE PARAMETRIC COMPUTATIONAL MODELS OF POROUS BIOMIMETIC MATERIAL STRUCTURES FOR BONE TISSUE ENGINEERING, AND APPLY THIS KNOWLEDGE TO THE RESOLUTION OF CLINICAL PROBLEMS OF GREAT IMPORTANCE AND SOCIAL IMPACT. The PROJECT CENTRE IN THE RESOLUTION OF CLINIC PROBLEMS IN THE ENVIRONMENT OF:_x000D_ _x000D_ 1. SPINAL SURGERY OF MINIMAL INVASION (VERTEBROPLASTY AND CYFOPLASTY). The microstructural differences of the vertebrates (SACRA, LUMBAR, ETC.) TO OPTIMICE CLINICAL ABORDAJE (INSTRUMENTAL AS AQUIRURGIC) AND REPORT SPECIFIC SOLUTIONS TO THE REAL STATE OF THE REAL STATE OF INFILTRATED Osteporotic Vertebrates WITH BIOCEMENT._x000D_ _x000D_ 2. THE STUDY OF PARTIAL ALTERATIONS (HYPOSMIA) OR TOTAL (ANESMIA) OF THE OLFACTORY SYSTEM RELATED TO AGE (AGEING), ACUTE BRAIN TRAUMA (ACCIDENTS), INFLAMMATORY DISEASES (RINOSINUSITIS), VIRICAS (COMMON COLD) AND NEURODEGENERATIVE (PARKINSON, ALZHEIMER’S). IN THIS FIELD IT IS KEY TO UNDERSTAND THE ROLE OF THE ETHMOID BONE AND ITS CRIBOSE LAMINA IN THE OLFACTORY MUCOSA (NEUROEPITELIUM) AS A GATEWAY TO THE CENTRAL NERVOUS SYSTEM (CNS; Olfactory bulbs) MEASURE THE DEVELOPMENT OF TRIDIMENSIONAL BODIES (3D-scaffolds) FOR THE POSTERIOR DEVELOPMENT OF THIS DISEASES FOR STUDING YOUR pathophysiology AND DEVELOPING NEW TERAPEUTIC DAYS AND FARMACYS OF LIBERATION CONTROL IN SITU._x000D_ _x000D_ 3. DENTISTRY (TREATMENT OF COMPLEX PROCESSES SUCH AS DENTOFACIAL DEFORMITIES, JAW CYSTS OR ORAL AND MAXILLOFACIAL CANCER). At this level, the VIRTUAL and IMPRESSED models make the CLINICAL ABORDAJE STRATEGIES in QUIROPHAN and improve the process of knowledge in the client and assistance platform._x000D_ _x000D_ in the three clinical cases that are intended to analyse the methodology to follow the same. MEDICAL IMAGES OF COMPUTERISED TOMOGRAPH (CT), MICRO-CT AND NUCLEAR MAGNETIC RESONANCE (RMN) WILL BE OBTAINED. THE IMAGES WILL BE RECONSTRUCTED WITH APPROPRIATE SOFTWARE TO OBTAIN IDENTICAL 3D REPRESENTATIONS OR MODELS OF THE ANALYSED UNITS (VERTEBRA, ETHMOID BONE, JAW, ETC.) BOTH AT MACRO LEVEL (EXTERNAL GEOMETRIC SHAPE) AND MICROSTRUCTURAL (HISTOMORFOMETRICA CHARACTERISATION OF THE DIFFERENT HOSE STRUCTURES). THE 3D VIRTUAL MODELS WILL BE EXPORTED TO MULTIFISICA COMPUTER PROGRAMS AND WILL BE CHARACTERISED BOTH MECHANICALLY AND FLUIDLY. VIRTUAL MODELS WILL BE PRINTED IN 3D WITH BIOCOMPATIBLE MATERIALS. CELL STUDIES WILL ALSO BE IN VITRO AND IN VIVO. ONCE ALL THIS INFORMATION HAS BEEN ANALYSED, CLEAR RECOMMENDATIONS WILL BE OBTAINED THAT WILL ALLOW TO REDEFINE: SURGICAL TECHNIQUES (E.G. HANDLING AND SURGICAL INSTRUMENTS IN SACRA VERTEBRA, JAW, CRANIO, ETC.); And (B) the microstructure AND OPTIMAL HYSTOMOR PHOMETRIAL CHARACTERISTICS OF A BIOMIMETIC IMPLEMENTATION OF THE OLFATIVO SYSTEM neuroepithelial TYSTEM (NOSE-ON-A-CHIP) databases._x000D_ _x000D_ _x000D_ _x000D_ in a more general scenario, the development, the CHARACTERISATION AND COMPUTATION of parametric models of biomimetic structures will allow to expand the general knowledge and capacity of the manipullation of porous MATERIAL MODELS with application to many other changes in the region. (English)
12 October 2021
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Barcelona
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Identifiers
DPI2016-77768-R
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