Regional support for genetic research (Q4301573)
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Project Q4301573 in Austria, Czechia
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Regional support for genetic research |
Project Q4301573 in Austria, Czechia |
Statements
664,231.62 Euro
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781,448.97 Euro
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85.0 percent
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1 December 2019
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30 November 2022
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Biology Centre CAS
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48°58'41.38"N, 14°26'45.02"E
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48°18'20.12"N, 14°17'58.70"E
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Almost 20 years have passed since the first draft of the human genome was published, but we are still a long way from understanding the relationships between the DNA sequence of genes and their actual function. Due to the clinical heterogeneity of the patients as well as the complex genetic architecture and the different frequency with which human diseases occur, it is usually very difficult to assign the individual gene mutations to the clinical phenotypes. Answering such complex questions requires a comprehensive and coordinated effort between individual competence centers. The main goal of the project applied for is to set up a regional genetic center (REGGEN) to use the synergies of two experienced laboratories, the CAS Biological Center (BC CAS) in České Budějovice and the Johannes Kepler University (JKU) in Linz. REGGEN will mainly focus on research into rare genetic diseases. This newly developing research center will combine the best complementary expertise of both laboratories and, through the efficient coordination of know-how and research funding, will acquire the most modern equipment and technologies, which will then contribute to the research of rare and often little-known diseases. In connection with this project, for example, research is being carried out into the increasing number of harmful changes in the genome of the male germline with advancing age and its connection with the increased risk of disease (paternal age effect) using the model organism Drosophila. It will also be tested whether changes in selected evolutionarily conserved signaling pathways, which are being tested in Drosophila, are also associated with an increased risk of disease in humans. The development of REGGEN represents the opportunity for top-class genetic research by pooling the synergies of two cross-border institutes, and thereby also strengthening the two research locations Upper Austria and České Budějovice. The data obtained from REGGEN will contribute to the current state of knowledge in researching the mechanisms of certain rare diseases. Student participation will contribute to a higher quality of education and to the job market for young researchers from the program area and beyond. The project thus strengthens the position of the entire program region and is in line with the South Bohemian regional innovation strategy RIS3 and the strategy program "Innovative Upper Austria 2020". (English)
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