Selective express tumor diagnostic with narrow band nanophotonic structures (Q3128691)

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Project Q3128691 in Greece
Language Label Description Also known as
English
Selective express tumor diagnostic with narrow band nanophotonic structures
Project Q3128691 in Greece

    Statements

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    92,000.0 Euro
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    10 October 2017
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    9 October 2019
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    ΝΑΝΟΤΥΠΟΣ ΟΕ
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    40°54'2.41"N, 22°57'19.80"E
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    35°11'2.58"N, 24°58'5.63"E
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    his EXODIAGNOS project proposal addresses the development of novel approach for tumor diagnostics. A new selective, early-stage, non-invasive, express cancer diagnostic procedure utilizing exosomal vesiclesand their content recognition by specially designed narrow bandwidth active/passive nano- andmicrophotonic sensors will be proposed for clinical trials.Our approach is based on three recently suggested novelties.(i) Recognition of exosomal biomarkers – surface and intravesicular proteins and mRNA and DNA nucleic acids – as tumor markers.(ii) Amplitude and phase detection methods using narrow band localized plasmonic resonances and resonances in microcavities, to make a breakthrough in the sensitivity and selectivity of the respective bioand environmental sensors.(iii) Ultra-sensitive detection promised by Active Plasmonic Platform (quantum emitters coupled with the plasmonic nanoresonators and/or microresonators). (Greek)
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    his EXODIAGNOS project proposal addresses the development of novel approach for tumor diagnostics. A new selective, early-stage, non-invasive, express cancer diagnostic procedure utilising exosomal vesiclesand their content recognition by specially designed narrow bandwidth active/passive nano- andmicrophotonic sensors will be proposed for clinical trials.Our approach is based on three recently suggested Novelties.(i) Recognition of exosomal biomarkers surface and intravesicular proteins and mRNA and DNA nucleic acids as tumor markers.(ii) amplitude and phase detection methods using narrow band localised plasmonic resonances and resonances in microcavities, to make a breakthrough in the sensitivity and selectivity of the respective bioand environmental sensors.(iii) Ultra-sensitive detection promised by Active plasmonic Platform (quantum emitters coupled with the plasmonic nanoresonators and/or microresonators). (English)
    30 September 2021
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    sa proposition de projet EXODIAGNOS porte sur le développement d’une nouvelle approche pour le diagnostic tumoral. Une nouvelle procédure sélective, précoce et non invasive, de diagnostic express du cancer utilisant des vésicules exosomiques et leur reconnaissance de leur contenu par des capteurs nano- et microphotoniques actifs/passifs à bande étroite spécialement conçus seront proposées pour les essais cliniques. Notre approche est basée sur trois nouveautés récemment suggérées.(i) Reconnaissance des biomarqueurs exosomiques de surface et des protéines intravesiculaires et des acides nucléiques mRNA et ADN comme marqueurs tumoraux.(ii) Méthodes de détection d’amplitude et de phase utilisant des résonances plasmiques localisées à bande étroite et des résonances dans les microcavités, afin de faire une percée dans la sensibilité et la sélection des micro-émetteurs de l’environnement. (French)
    30 November 2021
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    sein Projektvorschlag EXODIAGNOS befasst sich mit der Entwicklung eines neuartigen Ansatzes für die Tumordiagnostik. Für klinische Studien wird ein neues selektives, frühes, nicht-invasives, Express-Krebsdiagnostikverfahren unter Verwendung exosomaler Vesikel und deren inhaltlicher Erkennung durch speziell entwickelte, aktive/passive Nano- und Mikrophotonische Sensoren vorgeschlagen. Unser Ansatz basiert auf drei kürzlich vorgeschlagenen Neuheiten. i) Anerkennung exosomaler Biomarkeroberflächen und Intravesikproteine sowie mRNA- und DNA-Nukleinsäuren als Tumormarker.ii) Amplitude und Phasendetektionsmethoden mit engbandigen lokalisierten Plasmaresonanzen und Resonanzen in Mikrokavitäten, um einen Durchbruch in den jeweiligen Mikroplasmen zu ermöglichen. (German)
    7 December 2021
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    zijn EXODIAGNOS projectvoorstel richt zich op de ontwikkeling van een nieuwe aanpak voor tumordiagnostiek. Een nieuwe selectieve, vroege, niet-invasieve, express kanker diagnostische procedure met behulp van exosomale vesicles en hun inhoud herkenning door speciaal ontworpen smalle bandbreedte actieve/passieve nano- en microfotonische sensoren zal worden voorgesteld voor klinische proeven.Onze aanpak is gebaseerd op drie onlangs voorgestelde Novelties.i) Erkenning van exosomale biomarkers oppervlakte en intravesiculaire eiwitten en mRNA en DNA nucleic zuren als tumor markers.ii) amplitude en fase detectie methoden met behulp van smalle band gelokaliseerde plasonanties en resonanties in microcaviteiten, om een doorbraak te maken in de gevoeligheid en selectiviteit van de respectieve omgevingsgevoelige sensoren. (Dutch)
    17 December 2021
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    la sua proposta di progetto EXODIAGNOS affronta lo sviluppo di un nuovo approccio per la diagnostica tumorale. Per le sperimentazioni cliniche verrà proposta una nuova procedura diagnostica selettiva, precoce, non invasiva, con vescicole esosomiche e il loro riconoscimento del contenuto mediante sensori nano- emicrofotonici attivi/passivi appositamente progettati a banda stretta.Il nostro approccio si basa su tre novità recentemente suggerite.(i) Riconoscimento della superficie dei biomarcatori esosomiali e delle proteine intravesicolari e degli acidi nucleici mRNA e DNA come marcatori tumorali. (Italian)
    15 January 2022
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    Identifiers

    5.017.617
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