The Pamplona study of first psychotic episodes: Socio-demographic, genetic, premorbid and clinical predictors of course and evolution at 18 years of follow-up (Q3157567)
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Project Q3157567 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | The Pamplona study of first psychotic episodes: Socio-demographic, genetic, premorbid and clinical predictors of course and evolution at 18 years of follow-up |
Project Q3157567 in Spain |
Statements
44,250.0 Euro
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88,500.0 Euro
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50.0 percent
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1 January 2017
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31 March 2020
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FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE NAVARRA
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42°49'6.42"N, 1°38'39.34"W
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31201
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El objetivo principal es examinar el pronóstico evolutivo y funcional y determinar los predictores sociodemográficos, familiares, premórbidos, clínicos y genéticos en una muestra consecutiva de pacientes con un primer episodio de psicosis. Este es un estudio naturalístico y prospectivo basado en una muestra de de 486 pacientes ingresados consecutivamente en el Complejo Hospitalario de Navarra entre 1990 y 2009 reclutados de un área epidemiológica bien delimitada de 250.000 habitantes que serán evaluados en el periodo del proyecto con una media de seguimiento de 18 años. Las principales medidas de resultado evolutivas incluyen el Comprehensive Assessment of Symptoms and History (CASH) con sus módulos de psicopatología actual y pasada, el diagnóstico DSM-V final, la batería neuropsicológica MATRICS, la evaluación multidimensional de la discapacidad de la OMS (WHODAS 2.0), la escala de funcionamiento global (GAF), el patrón evolutivo incluyendo criterios de remisión, y la calidad de vida. Las principales medidas de predictivas incluyen la carga familiar de psicosis y esquizofrenia, puntuaciones genéticas de riesgo de esquizofrenia, variables premórbidas incluyendo ajuste premórbido y la sintomatología del primer episodio focalizada principalmente las dimensiones psicopatológicas de primer y segundo orden, dimensiones de la experiencia delirante y el diagnóstico DSM V. Se analizará la relación existente entre las variables predictoras y las evolutivas por medio de análisis univariantes y multivariantes de regresión. (Spanish)
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The main objective is to examine the evolutionary and functional prognosis and determine the sociodemographic, family, premorbid, clinical and genetic predictors in a consecutive sample of patients with a first episode of psychosis. This is a natural and prospective study based on a sample of 486 consecutively admitted to the Hospital Complex of Navarre between 1990 and 2009 recruited from a well-defined epidemiological area of 250,000 inhabitants who will be evaluated during the project period with an average follow-up of 18 years. The main evolutionary outcome measures include the Comprehensive Assessment of Symptoms and History (CASH) with its current and past psychopathology modules, the final DSM-V diagnosis, the MATRICS neuropsychological battery, the WHO multidimensional disability assessment (WHODAS 2.0), the global operating scale (GAF), the evolutionary pattern including referral criteria, and quality of life. The main predictive measures include the family burden of psychosis and schizophrenia, genetic scores of risk of schizophrenia, premorbid variables including premorbid adjustment and symptomatology of the first focused episode mainly the first and second order psychopathological dimensions, dimensions of delirant experience and diagnosis DSM V. The relationship between predictive and evolutionary variables will be analysed by means of univariating and multivariate regression analysis. (English)
12 October 2021
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Pamplona/Iruña
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Identifiers
PI16_02148
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