ANALYSIS AND CONTROL OF CONSANGUINITY AND GENOMIC KINSHIP IN THE MANAGEMENT OF GENETIC RESOURCES IN ANIMAL CONSERVATION AND IMPROVEMENT (Q3136385)
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Project Q3136385 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | ANALYSIS AND CONTROL OF CONSANGUINITY AND GENOMIC KINSHIP IN THE MANAGEMENT OF GENETIC RESOURCES IN ANIMAL CONSERVATION AND IMPROVEMENT |
Project Q3136385 in Spain |
Statements
126,808.0 Euro
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158,510.0 Euro
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80.0 percent
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30 December 2016
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31 December 2020
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UNIVERSIDAD DE VIGO
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42°14'15.58"N, 8°43'28.99"W
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36057
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EL AVANCE METODOLOGICO EN LA GENERACION DE DATOS GENOMICOS MEDIANTE LAS TECNICAS DE GENOTIPADO MASIVO Y SECUENCIACION SUPONE UN ANALISIS DETALLADO DE LA DIVERSIDAD CON MULTIPLES APLICACIONES EN LA CONSERVACION DE RECURSOS GENETICOS TANTO EN PROGRAMAS DE CONSERVACION COMO EN PROGRAMAS DE MEJORA GENETICA ANIMAL. LA DISPONIBILIDAD DE ESTOS DATOS PERMITE OBTENER ESTIMAS PRECISAS DE LA CONSANGUINIDAD Y EL PARENTESCO MOLECULARES, LAS CUALES REQUIEREN EL DESARROLLO Y REFINAMIENTO DE NUEVAS TECNICAS DE ANALISIS, SU INCORPORACION EN LA SIMULACION DE MODELOS BIOLOGICOS Y LA REEVALUACION DE LAS ESTRATEGIAS DE GESTION DE LOS RECURSOS GENETICOS. EL PRESENTE PROYECTO TIENE COMO OBJETIVO RESPONDER A DIFERENTES CUESTIONES GENERADAS POR LA OBTENCION DE ESTIMAS MOLECULARES DEL PARENTESCO Y LA CONSANGUINIDAD. EN EL PRIMER BLOQUE DE OBJETIVOS SE ANALIZARAN Y DESARROLLARAN APLICACIONES DEL PARENTESCO GENOMICO EN LA ESTIMACION Y CONTROL DE LA DIVERSIDAD GENETICA Y EN LA DETECCION DE LA HUELLA DE LA SELECCION, Y SE DESARROLLARAN ECUACIONES PREDICTIVAS DEL CENSO EFECTIVO DE POBLACION EN UN MODELO GENOMICO DE MUTACIONES DELETEREAS. EN EL SEGUNDO BLOQUE SE EVALUARAN LAS CONSECUENCIAS DE USAR INFORMACION GENOMICA EN LA GESTION DE POBLACIONES CONSERVADAS, EN ASPECTOS TALES COMO EL MANEJO DE POBLACIONES SUBDIVIDIDAS, LA CREACION DE POBLACIONES SINTETICAS (PARA PROGRAMAS EX-SITU O COMO BASE PARA UN PROGRAMA DE MEJORA GENETICA) O EN LA OPTIMIZACION DE PROGRAMAS DE REFUERZO POBLACIONAL (SUPPORTIVE BREEDING).TAMBIEN SE GENERARAN DATOS GENOMICOS EMPIRICOS SOBRE DEPRESION CONSANGUINEA Y PURGACION EN PROGRAMAS DE CONSERVACION. (Spanish)
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THE METHODOLOGICAL ADVANCE IN THE GENERATION OF GENOMIC DATA THROUGH MASS GENOTYPING AND SEQUENCING TECHNIQUES IMPLIES A DETAILED ANALYSIS OF DIVERSITY WITH MULTIPLE APPLICATIONS IN THE CONSERVATION OF GENETIC RESOURCES IN BOTH CONSERVATION PROGRAMS AND ANIMAL GENETIC IMPROVEMENT PROGRAMS. THE AVAILABILITY OF THESE DATA ALLOWS OBTAINING PRECISE ESTIMATES OF MOLECULAR CONSANGUINITY AND KINSHIP, WHICH REQUIRE THE DEVELOPMENT AND REFINEMENT OF NEW TECHNIQUES OF ANALYSIS, THEIR INCORPORATION IN THE SIMULATION OF BIOLOGICAL MODELS AND THE RE-EVALUATION OF THE STRATEGIES FOR THE MANAGEMENT OF GENETIC RESOURCES. THIS PROJECT AIMS TO ANSWER DIFFERENT QUESTIONS GENERATED BY THE OBTAINING OF MOLECULAR ESTIMATES OF KINSHIP AND CONSANGUINITY. IN THE FIRST BLOCK OF OBJECTIVES, APPLICATIONS OF THE GENOMIC KINSHIP WILL BE ANALYSED AND DEVELOPED IN THE ESTIMATION AND CONTROL OF GENETIC DIVERSITY AND IN THE DETECTION OF THE FOOTPRINT OF THE SELECTION, AND PREDICTIVE EQUATIONS OF THE EFFECTIVE POPULATION CENSUS WILL BE DEVELOPED IN A GENOMIC MODEL OF DELETERIOUS MUTATIONS. THE SECOND BLOCK WILL EVALUATE THE CONSEQUENCES OF USING GENOMIC INFORMATION IN THE MANAGEMENT OF CONSERVED POPULATIONS, IN ASPECTS SUCH AS THE MANAGEMENT OF SUBDIVIDED POPULATIONS, THE CREATION OF SYNTHETIC POPULATIONS (FOR EX-SITU PROGRAMS OR AS A BASIS FOR A GENETIC IMPROVEMENT PROGRAM) OR IN THE OPTIMISATION OF POPULATION REINFORCEMENT PROGRAMS (SUPPORTIVE BREEDING).TAMBIEN WILL GENERATE EMPIRICAL GENOMIC DATA ON BLOOD DEPRESSION AND PURGATION IN CONSERVATION PROGRAMS. (English)
12 October 2021
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Vigo
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Identifiers
CGL2016-75904-C2-1-P
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