Termotic fluorescent dyes in the labelling of nucleic acids. (Q77578): Difference between revisions
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(Removed claim: summary (P836): Reference_reference_programme_aids:SA.41471 (2015/X) _public:Article 25 of Commission Regulation (EC) No 651/2014 of 17 June 2014 declaring certain categories of aid compatible with the internal market in the application of Article 107 and 108 of the Treaty (OJ(OJ LEU L 187/1, 26.06.2014).The object of the project is the synthesis of thermoapparent fluorescent dyes, with extensive use in molecular biology in particular in the labelling of biop...) |
(Created claim: summary (P836): Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014). The subject of the project is the synthesis of thermosensitive fluorescence dyes, with a wide use in molecular biology, especially in the labelli...) |
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Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014). The subject of the project is the synthesis of thermosensitive fluorescence dyes, with a wide use in molecular biology, especially in the labelling of biopolymeres such as nucleic acids. Thermosensitivity of fluorescent dyes will allow the development of new diagnostic methods based on correlation of fluorescence with temperature change, which will enlarge the detection spectrum. Thermo-sensitivity is achieved through thermocycling, a process used in bioorganic chemistry to protect functional groups, and which, in extreme cases, can lead to permanent removal of fluorescent dye. The removal of the dye causes a change in fluorescence light emissions, a factor allowing the traceability of synthetic nucleic acids in living organisms. The synthesis of thermosensitive dyes uses new condensed 2-pyridinyl systems, whose chemical modification changes the fluorescence of the entire dye. Chemical synthesis of precursors will be achieved with microwave support, thus increasing the efficiency of the process. As a result, in the project we are going to get some new fluorescent dyes differing in abortion and radiation emission. The applicant Polish biotechnology company synthesising nucleic acids on behalf of customers has the appropriate know-how and resources to implement the project. The objective of implementing new dyes on the market in direct sales or in the form of a processed product (diagnostic kits) will be preceded by industrial research and development work. (English) | |||||||||||||||
| Property / summary: Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014). The subject of the project is the synthesis of thermosensitive fluorescence dyes, with a wide use in molecular biology, especially in the labelling of biopolymeres such as nucleic acids. Thermosensitivity of fluorescent dyes will allow the development of new diagnostic methods based on correlation of fluorescence with temperature change, which will enlarge the detection spectrum. Thermo-sensitivity is achieved through thermocycling, a process used in bioorganic chemistry to protect functional groups, and which, in extreme cases, can lead to permanent removal of fluorescent dye. The removal of the dye causes a change in fluorescence light emissions, a factor allowing the traceability of synthetic nucleic acids in living organisms. The synthesis of thermosensitive dyes uses new condensed 2-pyridinyl systems, whose chemical modification changes the fluorescence of the entire dye. Chemical synthesis of precursors will be achieved with microwave support, thus increasing the efficiency of the process. As a result, in the project we are going to get some new fluorescent dyes differing in abortion and radiation emission. The applicant Polish biotechnology company synthesising nucleic acids on behalf of customers has the appropriate know-how and resources to implement the project. The objective of implementing new dyes on the market in direct sales or in the form of a processed product (diagnostic kits) will be preceded by industrial research and development work. (English) / rank | |||||||||||||||
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| Property / summary: Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014). The subject of the project is the synthesis of thermosensitive fluorescence dyes, with a wide use in molecular biology, especially in the labelling of biopolymeres such as nucleic acids. Thermosensitivity of fluorescent dyes will allow the development of new diagnostic methods based on correlation of fluorescence with temperature change, which will enlarge the detection spectrum. Thermo-sensitivity is achieved through thermocycling, a process used in bioorganic chemistry to protect functional groups, and which, in extreme cases, can lead to permanent removal of fluorescent dye. The removal of the dye causes a change in fluorescence light emissions, a factor allowing the traceability of synthetic nucleic acids in living organisms. The synthesis of thermosensitive dyes uses new condensed 2-pyridinyl systems, whose chemical modification changes the fluorescence of the entire dye. Chemical synthesis of precursors will be achieved with microwave support, thus increasing the efficiency of the process. As a result, in the project we are going to get some new fluorescent dyes differing in abortion and radiation emission. The applicant Polish biotechnology company synthesising nucleic acids on behalf of customers has the appropriate know-how and resources to implement the project. The objective of implementing new dyes on the market in direct sales or in the form of a processed product (diagnostic kits) will be preceded by industrial research and development work. (English) / qualifier | |||||||||||||||
point in time: 14 October 2020
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Revision as of 10:11, 14 October 2020
Project in Poland financed by DG Regio
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Termotic fluorescent dyes in the labelling of nucleic acids. |
Project in Poland financed by DG Regio |
Statements
1,981,604.35 zloty
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2,521,068.49 zloty
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78.6 percent
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1 October 2017
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30 September 2020
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FUTURESYNTHESIS SPÓŁKA Z OGRANICZONĄ ODPOWIEDZIALNOŚCIĄ
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52°24'2.2"N, 16°55'11.3"E
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Numer_referencyjny_programu_pomocowego: SA.41471(2015/X) Przeznaczenie_pomocy_publicznej: art. 25 rozporządzenia KE nr 651/2014 z dnia 17 czerwca 2014 r. uznające niektóre rodzaje pomocy za zgodne z rynkiem wewnętrznym w stosowaniu art. 107 i 108 Traktatu (Dz. Urz. UE L 187/1 z 26.06.2014). Przedmiotem projektu jest synteza termowrażliwych barwników fluorescencyjych, o szerokim zastosowaniu w biologii molekularnej szczególnie w znakowaniu biopolimerów takich jak kwasy nukleinowe. Termowrażliwość barwników fluorescencyjnych pozwoli na opracowanie nowych metod diagnostycznych opartych o korelację fluorescencji ze zmianą temperatury co w konsekwencji powiększy spektrum detekcji. Termowrażliwość jest realizowana poprzez termocyklizację, proces stosowany w chemii bioorganicznej w ochronie grup funkcyjnych, i która w skrajnym przypadku może prowadzić do trwałego usunięcia barwnika fluorescencyjnego. Usunięcie barwnika powoduje zmianę emisji światła fluorescencynego, czynnik pozwalający na śledzenie funkcji syntetycznych kwasów nukleinowych w organizmach żywych. Synteza termowrażliwych barwników wykorzystuje nowe skondensowane układy 2-pirydynylowe, których modyfikacja chemiczna zmienia fluorescencję całego barwnika. Syntezy chemiczne prekursorów zrealizowane zostaną przy pomocy wspomagania mikrofalowego, powodując w ten sposób wzrost wydajności procesu. Dzięki temu w projekcie zamierzamy otrzymać kilka nowych barwników fluorescencyjnych różniących się aborcją i emisja promieniowania. Wnioskodawca polska firma biotechnologiczna syntetyzująca kwasy nukleinowe na zlecenie klientów posiada odpowiednie know-how oraz zasoby do realizacji przedmiotowego projektu. Osiągniecie celu czyli wdrożenie do produkcji i sprzedaż na rynku nowych barwników w bezpośredniej sprzedaży lub w postaci produktu przetworzonego (zestawy diagnostyczne) zostanie poprzedzone badaniami przemysłowymi i pracami rozwojo (Polish)
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Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014). The subject of the project is the synthesis of thermosensitive fluorescence dyes, with a wide use in molecular biology, especially in the labelling of biopolymeres such as nucleic acids. Thermosensitivity of fluorescent dyes will allow the development of new diagnostic methods based on correlation of fluorescence with temperature change, which will enlarge the detection spectrum. Thermo-sensitivity is achieved through thermocycling, a process used in bioorganic chemistry to protect functional groups, and which, in extreme cases, can lead to permanent removal of fluorescent dye. The removal of the dye causes a change in fluorescence light emissions, a factor allowing the traceability of synthetic nucleic acids in living organisms. The synthesis of thermosensitive dyes uses new condensed 2-pyridinyl systems, whose chemical modification changes the fluorescence of the entire dye. Chemical synthesis of precursors will be achieved with microwave support, thus increasing the efficiency of the process. As a result, in the project we are going to get some new fluorescent dyes differing in abortion and radiation emission. The applicant Polish biotechnology company synthesising nucleic acids on behalf of customers has the appropriate know-how and resources to implement the project. The objective of implementing new dyes on the market in direct sales or in the form of a processed product (diagnostic kits) will be preceded by industrial research and development work. (English)
14 October 2020
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Identifiers
POIR.01.01.01-00-0027/17
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