Examination of the delayed release of the influenza vaccine using biodegradable microneeds (Q3988875): Difference between revisions
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The current influenza vaccine usually consists of proteins from pathogenic agents of the virus and is administered by injection into the muscle. However, single injection into the muscle often leads to incomplete protection. In addition, administration by injection is annoying and impractical, which hinders a high degree of vaccination. When it is technically possible to expose the immune system to the vaccine over a period of weeks, a qualitative and quantitatively high-quality immune response can be built up. In this project, research is being carried out on the development of biodegradable microneeds that allow (flu) vaccine to be administered painlessly and slowly released into the skin.Micron needles are tiny needles of less than one millimetre long that penetrate only into the upper layers of skin. The microneeds are applied to a surface (array), creating a microneeldle patch (MNP), which can be applied as a patch to the skin. With this, unlike ‘normal’ hypodermic needles, the administration of drugs is painless because it does not touch the nerve endings. The consortium wants to develop a technology in which the flu vaccine is slowly released from the microneeds. Compared to existing microneeds that, after being inserted into the skin, dissolve almost immediately, this is completely new. The aim is to produce the microneeds from biodegradable synthetic polymers that slowly break down (and eventually dissolve) over a period of several weeks to months. The necessary knowledge will be gathered during this project. The objective of this knowledge development project is to develop the necessary medical, scientific and technical knowledge to develop an MNP, based on biodegradable PEOZ multi-block co-polymers, in a follow-up project, with which flu vaccines can be administered.The project is in line with the challenge of health, demography and well-being set out in the RIS3 because the consortium is working towards a new technique that allows for a more effective vaccination. The project is also in line with specific objective B of the Operational Programme 2014-2020 Northern Netherlands because the knowledge position of SMEs based in the North Netherlands is improved through collaboration with two knowledge institutions, also located in the North Netherlands, and with Cardiff University School of Pharmacy and Pharmaceutical Sciences.The consortium consists of three parties:1. InnoCore Tehnologies B.V.: SME party, based in Groningen. Specialised in the development of injectable pharmaceutical forms of administration with controlled drug release based on biodegradable polymers. In this project focuses on the development of knowledge about: new biodegradable polymers with the required mechanical strength and release kinetics; MNP production technology; drafting development and commercialisation roadmap.2. University of Groningen (Group of Pharmaceutical Technology and Biopharmaceutical): Specialised in the development, analysis and validation of pharmaceutical forms of administration. Focus vision in this project on: stabilising subunit influenza vaccine; analysis of release kinetics and bioactivity of the vaccine; MNP production technology.3. University Medical Center Groningen (Faculty of Medical Sciences, Department of Vaccinology): Specialised in immunology and flu vaccination. In this project focuses on manufacturing and supplying subunit influenza virus vaccine and conducting animal experiments in vivo studies. (English) | |||||||||||||||
| Property / summary: The current influenza vaccine usually consists of proteins from pathogenic agents of the virus and is administered by injection into the muscle. However, single injection into the muscle often leads to incomplete protection. In addition, administration by injection is annoying and impractical, which hinders a high degree of vaccination. When it is technically possible to expose the immune system to the vaccine over a period of weeks, a qualitative and quantitatively high-quality immune response can be built up. In this project, research is being carried out on the development of biodegradable microneeds that allow (flu) vaccine to be administered painlessly and slowly released into the skin.Micron needles are tiny needles of less than one millimetre long that penetrate only into the upper layers of skin. The microneeds are applied to a surface (array), creating a microneeldle patch (MNP), which can be applied as a patch to the skin. With this, unlike ‘normal’ hypodermic needles, the administration of drugs is painless because it does not touch the nerve endings. The consortium wants to develop a technology in which the flu vaccine is slowly released from the microneeds. Compared to existing microneeds that, after being inserted into the skin, dissolve almost immediately, this is completely new. The aim is to produce the microneeds from biodegradable synthetic polymers that slowly break down (and eventually dissolve) over a period of several weeks to months. The necessary knowledge will be gathered during this project. The objective of this knowledge development project is to develop the necessary medical, scientific and technical knowledge to develop an MNP, based on biodegradable PEOZ multi-block co-polymers, in a follow-up project, with which flu vaccines can be administered.The project is in line with the challenge of health, demography and well-being set out in the RIS3 because the consortium is working towards a new technique that allows for a more effective vaccination. The project is also in line with specific objective B of the Operational Programme 2014-2020 Northern Netherlands because the knowledge position of SMEs based in the North Netherlands is improved through collaboration with two knowledge institutions, also located in the North Netherlands, and with Cardiff University School of Pharmacy and Pharmaceutical Sciences.The consortium consists of three parties:1. InnoCore Tehnologies B.V.: SME party, based in Groningen. Specialised in the development of injectable pharmaceutical forms of administration with controlled drug release based on biodegradable polymers. In this project focuses on the development of knowledge about: new biodegradable polymers with the required mechanical strength and release kinetics; MNP production technology; drafting development and commercialisation roadmap.2. University of Groningen (Group of Pharmaceutical Technology and Biopharmaceutical): Specialised in the development, analysis and validation of pharmaceutical forms of administration. Focus vision in this project on: stabilising subunit influenza vaccine; analysis of release kinetics and bioactivity of the vaccine; MNP production technology.3. University Medical Center Groningen (Faculty of Medical Sciences, Department of Vaccinology): Specialised in immunology and flu vaccination. In this project focuses on manufacturing and supplying subunit influenza virus vaccine and conducting animal experiments in vivo studies. (English) / rank | |||||||||||||||
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| Property / summary: The current influenza vaccine usually consists of proteins from pathogenic agents of the virus and is administered by injection into the muscle. However, single injection into the muscle often leads to incomplete protection. In addition, administration by injection is annoying and impractical, which hinders a high degree of vaccination. When it is technically possible to expose the immune system to the vaccine over a period of weeks, a qualitative and quantitatively high-quality immune response can be built up. In this project, research is being carried out on the development of biodegradable microneeds that allow (flu) vaccine to be administered painlessly and slowly released into the skin.Micron needles are tiny needles of less than one millimetre long that penetrate only into the upper layers of skin. The microneeds are applied to a surface (array), creating a microneeldle patch (MNP), which can be applied as a patch to the skin. With this, unlike ‘normal’ hypodermic needles, the administration of drugs is painless because it does not touch the nerve endings. The consortium wants to develop a technology in which the flu vaccine is slowly released from the microneeds. Compared to existing microneeds that, after being inserted into the skin, dissolve almost immediately, this is completely new. The aim is to produce the microneeds from biodegradable synthetic polymers that slowly break down (and eventually dissolve) over a period of several weeks to months. The necessary knowledge will be gathered during this project. The objective of this knowledge development project is to develop the necessary medical, scientific and technical knowledge to develop an MNP, based on biodegradable PEOZ multi-block co-polymers, in a follow-up project, with which flu vaccines can be administered.The project is in line with the challenge of health, demography and well-being set out in the RIS3 because the consortium is working towards a new technique that allows for a more effective vaccination. The project is also in line with specific objective B of the Operational Programme 2014-2020 Northern Netherlands because the knowledge position of SMEs based in the North Netherlands is improved through collaboration with two knowledge institutions, also located in the North Netherlands, and with Cardiff University School of Pharmacy and Pharmaceutical Sciences.The consortium consists of three parties:1. InnoCore Tehnologies B.V.: SME party, based in Groningen. Specialised in the development of injectable pharmaceutical forms of administration with controlled drug release based on biodegradable polymers. In this project focuses on the development of knowledge about: new biodegradable polymers with the required mechanical strength and release kinetics; MNP production technology; drafting development and commercialisation roadmap.2. University of Groningen (Group of Pharmaceutical Technology and Biopharmaceutical): Specialised in the development, analysis and validation of pharmaceutical forms of administration. Focus vision in this project on: stabilising subunit influenza vaccine; analysis of release kinetics and bioactivity of the vaccine; MNP production technology.3. University Medical Center Groningen (Faculty of Medical Sciences, Department of Vaccinology): Specialised in immunology and flu vaccination. In this project focuses on manufacturing and supplying subunit influenza virus vaccine and conducting animal experiments in vivo studies. (English) / qualifier | |||||||||||||||
point in time: 15 December 2021
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Revision as of 06:20, 15 December 2021
Project Q3988875 in Netherlands
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Examination of the delayed release of the influenza vaccine using biodegradable microneeds |
Project Q3988875 in Netherlands |
Statements
2,122,966.33 Euro
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5,608,893.871 Euro
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37.85 percent
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1 July 2020
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31 December 2022
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Innocore Technologies
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53°13'11.21"N, 6°34'39.68"E
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9713 GX
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9700AB
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9700RB
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De huidige griepvaccin bestaan meestal uit eiwitten van ziekteverwekkers van het virus en worden middels een injectie in de spier toegediend. Eenmalige injectie in de spier leidt echter vaak tot een onvolledige bescherming. Daarnaast is toediening via injectie vervelend en onpraktisch, wat een hoge vaccinatiegraad belemmert. Wanneer het technisch mogelijk is om het immuunsysteem over een periode van weken bloot te stellen aan het vaccin dan kan een kwalitatief en kwantitatief hoogwaardig immuunrespons worden opgebouwd. In dit project wordt onderzoek gedaan naar de ontwikkeling van bio-afbreekbare micronaalden waarmee (griep-)vaccin pijnloos kan worden toegediend en langzaam in de huid wordt afgegeven.Micronaalden zijn piepkleine naaldjes van minder dan een millimeter lang die alleen in de bovenste huidlagen doordringen. De micronaalden worden aangebracht op een vlak (array), waarmee een microneeldle patch (MNP) ontstaat, die als een pleister op de huid kan worden aangebracht. Hiermee is, in tegenstelling tot ‘gewone’ hypoderme naalden, de toediening van medicijnen pijnloos omdat hierbij de zenuwuiteinden niet geraakt worden. Het consortium wil een technologie ontwikkelen waarbij het griepvaccin langzaam vrijkomt uit de micronaalden. In vergelijking met bestaande micronaalden die, nadat ze in de huid zijn ingebracht, vrijwel direct oplossen, is dit compleet nieuw. Het doel is om de micronaalden te vervaardigen uit biodegradeerbare synthetische polymeren die langzaam afbreken (en uiteindelijk oplossen) over een periode van enkele weken tot maanden. De benodigde kennis zal gedurende dit project worden vergaard. De doelstelling van dit kennisontwikkelingsproject is om de noodzakelijke medische, wetenschappelijke en technische kennis te ontwikkelen om in een vervolgproject een MNP, op basis van bio-afbreekbare PEOZ multi-block co-polymeren, te ontwikkelen waarmee vaccins tegen griep kunnen worden toegediend.Het project sluit aan bij de in de RIS3 geformuleerd uitdaging rond gezondheid, demografie en welzijn omdat het consortium toewerkt naar een nieuwe techniek waarmee een effectievere vaccinatie mogelijk wordt. Ook sluit het project aan bij specifieke doelstelling B van het Operationeel Programma 2014-2020 Noord-Nederland omdat de kennispositie van een in Noord-Nederland gevestigd MKB wordt verbeterd door samenwerking met twee, tevens in Noord-Nederland gevestigde, kennisinstellingen en met School of Pharmacy and Pharmaceutical Sciences van Cardiff University.Het consortium bestaat uit drie partijen:1. InnoCore Tehnologies B.V.: MKB partij, gevestigd in Groningen. Gespecialiseerd in de ontwikkeling van injecteerbare farmaceutische toedieningsvormen met gereguleerde medicijn afgifte op basis van biodegradeerbare polymeren. Richt zich in dit project op de ontwikkeling van kennis over: nieuwe biodegradeerbare polymeren met de vereiste mechanische sterkte en afgiftekinetiek; MNP productietechniek; opstellen ontwikkel- en commercialisatie roadmap.2. Rijksuniversiteit Groningen (Vakgroep Farmaceutische Technologie en Biofarmacie): Gespecialiseerd in de ontwikkeling, analyse en validatie van farmaceutische toedieningsvormen. Richt zicht in dit project op: het stabiliseren van subunit influenza vaccin; analyseren van afgifte kinetiek en bio-activiteit van het vaccin; MNP productietechniek.3. Universitair Medisch Centrum Groningen (Faculteit Medische Wetenschappen, vakgroep Vaccinologie): Gespecialiseerd in immunologie en griepvaccinatie. Richt zich in dit project op het vervaardigen en aanleveren van subunit influenza virus vaccin en uitvoeren van dierexperimenten in vivo studies. (Dutch)
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The current influenza vaccine usually consists of proteins from pathogenic agents of the virus and is administered by injection into the muscle. However, single injection into the muscle often leads to incomplete protection. In addition, administration by injection is annoying and impractical, which hinders a high degree of vaccination. When it is technically possible to expose the immune system to the vaccine over a period of weeks, a qualitative and quantitatively high-quality immune response can be built up. In this project, research is being carried out on the development of biodegradable microneeds that allow (flu) vaccine to be administered painlessly and slowly released into the skin.Micron needles are tiny needles of less than one millimetre long that penetrate only into the upper layers of skin. The microneeds are applied to a surface (array), creating a microneeldle patch (MNP), which can be applied as a patch to the skin. With this, unlike ‘normal’ hypodermic needles, the administration of drugs is painless because it does not touch the nerve endings. The consortium wants to develop a technology in which the flu vaccine is slowly released from the microneeds. Compared to existing microneeds that, after being inserted into the skin, dissolve almost immediately, this is completely new. The aim is to produce the microneeds from biodegradable synthetic polymers that slowly break down (and eventually dissolve) over a period of several weeks to months. The necessary knowledge will be gathered during this project. The objective of this knowledge development project is to develop the necessary medical, scientific and technical knowledge to develop an MNP, based on biodegradable PEOZ multi-block co-polymers, in a follow-up project, with which flu vaccines can be administered.The project is in line with the challenge of health, demography and well-being set out in the RIS3 because the consortium is working towards a new technique that allows for a more effective vaccination. The project is also in line with specific objective B of the Operational Programme 2014-2020 Northern Netherlands because the knowledge position of SMEs based in the North Netherlands is improved through collaboration with two knowledge institutions, also located in the North Netherlands, and with Cardiff University School of Pharmacy and Pharmaceutical Sciences.The consortium consists of three parties:1. InnoCore Tehnologies B.V.: SME party, based in Groningen. Specialised in the development of injectable pharmaceutical forms of administration with controlled drug release based on biodegradable polymers. In this project focuses on the development of knowledge about: new biodegradable polymers with the required mechanical strength and release kinetics; MNP production technology; drafting development and commercialisation roadmap.2. University of Groningen (Group of Pharmaceutical Technology and Biopharmaceutical): Specialised in the development, analysis and validation of pharmaceutical forms of administration. Focus vision in this project on: stabilising subunit influenza vaccine; analysis of release kinetics and bioactivity of the vaccine; MNP production technology.3. University Medical Center Groningen (Faculty of Medical Sciences, Department of Vaccinology): Specialised in immunology and flu vaccination. In this project focuses on manufacturing and supplying subunit influenza virus vaccine and conducting animal experiments in vivo studies. (English)
15 December 2021
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Identifiers
OP-2014-2023-Noord-OPSNN0325
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