MOLECULAR CHARACTERISATION OF CANINE BREAST CARCINOMA AT THE TISSUE AND PLASMATIC LEVEL (Q3135597): Difference between revisions
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CARACTÉRISATION MOLÉCULAIRE DU CARCINOME DU SEIN CANIN AU NIVEAU TISSULAIRE ET PLASMATIQUE | |||
Revision as of 08:08, 2 December 2021
Project Q3135597 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | MOLECULAR CHARACTERISATION OF CANINE BREAST CARCINOMA AT THE TISSUE AND PLASMATIC LEVEL |
Project Q3135597 in Spain |
Statements
70,760.8 Euro
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88,451.0 Euro
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80.0 percent
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1 January 2016
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11 July 2016
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UNIVERSIDAD DE CORDOBA
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37°53'4.49"N, 4°46'33.64"W
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14021
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CON ESTUDIOS ANTERIORES SOBRE TUMORES DE MAMA CANINOS (PM98-0164, AGL03-6289, AGL2006-09016, CVI-P07-02559, AGL2011-025553) HEMOS DEMOSTRADO QUE: I) LOS TUMORES CON RECEPTORES DE ESTROGENOS (RE) Y RECEPTORES DE PROGESTERONA (RP) PRESENTAN MENOR TASA DE RECIDIVAS Y MENOR EXPRESION DE HER-2 Y QUE RESPONDEN AL TRATAMIENTO ENDOCRINO CON UN DESCENSO DE LA PROLIFERACION CELULAR TANTO IN VIVO COMO IN VITRO; Y II) QUE LA POBLACION CELULAR MAS HETEROGENEA EN CUANTO A MORFOLOGIA E INMUNOFENOTIPO ES LA DE CELULAS MIOEPITELIALES (ME), QUE COMPARTE CON LA POBLACION DE CELULAS BASALES LA EXPRESION DE CITOQUERATINAS DE TIPO BASAL. EN LA ESPECIE HUMANA SE HA DEMOSTRADO LA EXISTENCIA DE VARIOS TIPOS DE CANCER DE MAMA EN FUNCION DE SU FENOTIPO MOLECULAR Y EL TIPO BASAL ES EL DE MAYOR AGRESIVIDAD BIOLOGICA. EN LA ESPECIE CANINA SE HAN DEFINIDO SUBTIPOS EQUIVALENTES UTILIZANDO TECNICAS INMUNOHISTOQUIMICAS Y SE HA SUGERIDO QUE EL NIVEL DE (DES)DIFERENCIACION DE LAS CELULAS ME PODRIA SER EL RESPONSABLE DE SU MAYOR AGRESIVIDAD BIOLOGICA. CON ESTE PROYECTO PRETENDEMOS ANALIZAR EL FENOTIPO MOLECULAR DEL CANCER DE MAMA CANINO MEDIANTE ESTUDIOS DE EXPRESION GENICA TANTO A NIVEL TISULAR COMO PLASMATICO (BIOPSIA LIQUIDA) PARA SU APLICACION EN LA EVALUACION CLINICA PRONOSTICA Y TERAPEUTICA DE LOS ANIMALES CON TUMORES MALIGNOS DE MAMA. (Spanish)
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WITH PREVIOUS STUDIES ON CANINE BREAST TUMORS (PM98-0164, AGL03-6289, AGL2006-09016, CVI-P07-02559, AGL2011-025553) WE HAVE SHOWN THAT: ESTROGEN RECEPTOR (RE) AND PROGESTERONE (RP) RECEPTOR TUMORS HAVE LOWER RECURRENCE RATES AND LOWER HER-2 EXPRESSION AND RESPOND TO ENDOCRINE TREATMENT WITH A DECREASE IN CELL PROLIFERATION IN VIVO AND IN VITRO; AND II) THAT THE MOST HETEROGENEOUS CELL POPULATION IN TERMS OF MORPHOLOGY AND IMMUNOPHENOTYPE IS THAT OF MYOEPITHELIAL CELLS (ME), WHICH SHARES WITH THE POPULATION OF BASAL CELLS THE EXPRESSION OF BASAL-TYPE CYTOKERATINS. SEVERAL TYPES OF BREAST CANCER HAVE BEEN SHOWN TO EXIST IN THE HUMAN SPECIES BASED ON THEIR MOLECULAR PHENOTYPE AND THE BASAL TYPE IS THE MOST BIOLOGICALLY AGGRESSIVE. IN THE CANINE SPECIES EQUIVALENT SUBTYPES HAVE BEEN DEFINED USING INMUNOHISTOQUIMICAS TECHNIQUES AND IT HAS BEEN SUGGESTED THAT THE LEVEL OF (DE)DIFFERENTIATING THE CELLS COULD BE RESPONSIBLE FOR THEIR GREATER BIOLOGICAL AGGRESSIVENESS. WITH THIS PROJECT WE AIM TO ANALYSE THE MOLECULAR PHENOTYPE OF CANINE BREAST CANCER BY MEANS OF GENIC EXPRESSION STUDIES AT BOTH TISSUE AND PLASMATIC LEVEL (LIQUID BIOPSY) FOR ITS APPLICATION IN CLINICAL PROGNOSTIC AND THERAPEUTIC EVALUATION OF ANIMALS WITH MALIGNANT BREAST TUMORS. (English)
12 October 2021
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Córdoba
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Identifiers
AGL2015-64316-R
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