Immediate hypersensitivity reactions to arylpropionic acid-derived NSAIDs. Role of the native drug and its metabolites. Study of mechanisms involved. (Q3208688): Difference between revisions
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(Created claim: summary (P836): Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in hypersensitivity reactions. Within this broad group of drugs, arylpropionic derivatives are the drugs that most often induce this type of reaction. These include cross-intolerance, responding to several chemically unrelated drugs, and selective reactions, with response to only one chemical group or individual structure. The clinical characteristics of these e...) |
(Changed label, description and/or aliases in en: translated_label) |
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Immediate hypersensitivity reactions to arylpropionic acid-derived NSAIDs. Role of the native drug and its metabolites. Study of mechanisms involved. | |||
Revision as of 08:52, 14 October 2021
Project Q3208688 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Immediate hypersensitivity reactions to arylpropionic acid-derived NSAIDs. Role of the native drug and its metabolites. Study of mechanisms involved. |
Project Q3208688 in Spain |
Statements
40,750.0 Euro
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81,500.0 Euro
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50.0 percent
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1 January 2016
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31 March 2020
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HOSPITAL UNIVERSITARIO INFANTA LEONOR
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40°25'0.12"N, 3°42'12.89"W
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28079
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Los antiinflamatorios no esteroides (AINEs) son los fármacos mas frecuentemente implicados en reacciones de hipersensibilidad. Dentro de este amplio grupo de medicamentos, los derivados arilpropiónicos son los fármacos que con más frecuencia inducen este tipo de reacciones. Se incluyen las de intolerancia cruzada, con respuesta a varios fármacos químicamente no relacionados, y las reacciones selectivas, con respuesta solo a un grupo químico o estructura individual. Las características clínicas de estas entidades sugieren que varios mecanismos pueden estar implicados en las reacciones selectivas. Debido a que los arilpropiónicos se metabolizan rápidamente y de forma extensa, se considera que además del fármaco nativo los metabolitos generados pueden estar implicados en el desarrollo de este tipo de reacciones. Se pretende estudiar el mecanismo implicado que incluye una respuesta IgE específica, con liberación de histamina y otros mediadores vasoactivos, así como la generación de mediadores inflamatorios por otros mecanismos. Para ello se estudiaran la activación de basófilos, el reconocimiento por anticuerpos IgE de prototipos de conjugados de arilpropiónico con moléculas espaciadores y la cuantificación de mediadores inflamatorios, incluidos metabolitos de leucotrienos, y la generación de péptidos de quininas. Los estudios de transcriptómica ayudarán a establecer patrones diferenciales de expresión génica en las lesiones de piel entre las distintas entidades que se consideran dentro de las reacciones de hipersensibilidad inmediata a AINEs. Se pretende con ello conocer los mecanismos implicados así como sentar las bases para desarrollar en un futuro métodos in vitro para el diagnóstico de estas entidades. (Spanish)
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Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in hypersensitivity reactions. Within this broad group of drugs, arylpropionic derivatives are the drugs that most often induce this type of reaction. These include cross-intolerance, responding to several chemically unrelated drugs, and selective reactions, with response to only one chemical group or individual structure. The clinical characteristics of these entities suggest that several mechanisms may be involved in selective reactions. Because arylpropionics are rapidly and extensively metabolised, it is considered that in addition to the native drug the generated metabolites may be involved in the development of this type of reaction. The aim is to study the involved mechanism that includes a specific IgE response, with release of histamine and other vasoactive mediators, as well as the generation of inflammatory mediators by other mechanisms. To this end, the activation of basophils, the recognition by IgE antibodies of prototypes of arylpropionic conjugates with spacer molecules and the quantification of inflammatory mediators, including leucotriene metabolites, and the generation of quinine peptides were studied. Transcriptomic studies will help establish differential patterns of gene expression in skin lesions between the different entities considered within the immediate hypersensitivity reactions to NSAIDs. The aim is to know the mechanisms involved and to lay the basis for developing in vitro methods for the diagnosis of these entities in the future. (English)
14 October 2021
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Madrid
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Identifiers
PI15_00726
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