IDENTIFICATION OF ROUTES AND TRANSMISSION MECHANISMS OF RESISTANCE TO ANTIBIOTICS THROUGH THE FOOD CHAIN USING CULTURE-DEPENDENT AND INDEPENDENT TECHNIQUES (Q3192266): Difference between revisions
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(Removed claim: summary (P836): ANTIBIOTIC RESISTANCE (ANTIMICROBIAL RESISTANCE AMR) IS ONE OF THE BIGGEST CHALLENGES FACING HUMANITY. THE ACQUIRED RESISTANCE TO CERTAIN ANTIMICROBIAL AGENTS IS ALREADY OF SUCH MAGNITUDE THAT THEIR ABILITY TO TREAT INFECTIONS IS AT STAKE. THE EMERGENCE AND DISSEMINATION OF AMR IS USUALLY ATTRIBUTED TO THE INDISCRIMINATE USE OF ANTIBIOTICS AS THERAPEUTIC AGENTS IN HUMAN OR VETERINARY MEDICINE OR AS GROWTH PROMOTERS IN ANIMAL PRODUCTION. IN ADD...) |
(Created claim: summary (P836): ANTIBIOTIC RESISTANCE (ANTIMICROBIAL RESISTANCE AMR) IS ONE OF THE BIGGEST CHALLENGES FACING HUMANITY. THE ACQUIRED RESISTANCE TO CERTAIN ANTIMICROBIAL AGENTS IS ALREADY OF SUCH MAGNITUDE THAT THEIR ABILITY TO TREAT INFECTIONS IS AT STAKE. THE EMERGENCE AND DISSEMINATION OF AMR IS USUALLY ATTRIBUTED TO THE INDISCRIMINATE USE OF ANTIBIOTICS AS THERAPEUTIC AGENTS IN HUMAN OR VETERINARY MEDICINE OR AS GROWTH PROMOTERS IN ANIMAL PRODUCTION. IN ADDIT...) |
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ANTIBIOTIC RESISTANCE (ANTIMICROBIAL RESISTANCE AMR) IS ONE OF THE BIGGEST CHALLENGES FACING HUMANITY. THE ACQUIRED RESISTANCE TO CERTAIN ANTIMICROBIAL AGENTS IS ALREADY OF SUCH MAGNITUDE THAT THEIR ABILITY TO TREAT INFECTIONS IS AT STAKE. THE EMERGENCE AND DISSEMINATION OF AMR IS USUALLY ATTRIBUTED TO THE INDISCRIMINATE USE OF ANTIBIOTICS AS THERAPEUTIC AGENTS IN HUMAN OR VETERINARY MEDICINE OR AS GROWTH PROMOTERS IN ANIMAL PRODUCTION. IN ADDITION, THE FOOD CHAIN HAS ALSO BEEN IDENTIFIED AS A POSSIBLE TRANSMISSION ROUTE OF AMR. IN FACT, RESEARCH CARRIED OUT IN THE LAST DECADE HAS SUGGESTED THE IMPORTANCE THAT CERTAIN INDUSTRIAL ENVIRONMENTS HAVE AS RESERVOIRS OF RESISTANT MICROORGANISMS AND ANTIBIOTIC RESISTANCE GENES AND HAVE IDENTIFIED THE USE OF BIOCIDES AND MICROBIAL EXPOSURE TO ENVIRONMENTAL STRESS FACTORS AND FOOD PROCESSING TECHNOLOGIES AS POSSIBLE RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT AND DISPERSION OF AMR. HOWEVER, EXISTING STUDIES IN RELATION TO MECHANISMS OF CO-RESISTANCE OR CROSS RESISTANCE TO ANTIBIOTICS MEDIATED BY BACTERIA ARE LIMITED TO A LIMITED NUMBER OF SPECIES. THE STARTING HYPOTHESIS OF THE PROJECT IS THAT CERTAIN CLEANING AND DISINFECTION PRACTICES AND FOOD PROCESSING TECHNOLOGIES USED BOTH IN SLAUGHTERHOUSES AND IN AGRI-FOOD INDUSTRIES ARE EXERTING A SELECTIVE PRESSURE THAT FAVORS THE EMERGENCE AND DISSEMINATION OF MICROORGANISMS RESISTANT TO ANTIBIOTICS, COMPROMISING THE INTEGRITY AND SAFETY OF THE FOOD CHAIN. THE METARESISTBUGS PROJECT AIMS, IN THE FIRST PLACE, TO INVESTIGATE THE IMPACT THAT THE EXPOSURE OF MICROORGANISMS OF FOOD INTEREST TO BIOCIDES, ENVIRONMENTAL STRESS CONDITIONS AND PROCESSING TECHNOLOGIES HAS ON THE ACQUISITION OF STABLE RESISTANCE TO ANTIBIOTICS, THE EXPRESSION OF ANTIBIOTIC RESISTANCE GENES AND THE HORIZONTAL TRANSFER OF GENETIC DETERMINANTS FROM AMR. A WIDE RANGE OF INDICATOR MICROORGANISMS WILL BE USED, BOTH PATHOGENS, SAFE OR BENEFICIAL MICROORGANISMS, CULTURE MEDIA, FOOD MODELS AND FOOD PROPER. SECONDLY, THE METARESISTBUGS PROJECT PROPOSES THE STUDY USING TECHNIQUES DEPENDENT AND INDEPENDENT OF CULTIVATION OF STRUCTURAL AND FUNCTIONAL CHANGES THAT OCCUR IN MICROBIAL POPULATIONS THAT COLONISE SLAUGHTERHOUSE ENVIRONMENTS AND AGRO-FOOD INDUSTRIES THAT EMPLOY DIFFERENT CLEANING, DISINFECTION AND FOOD PROCESSING STRATEGIES. THESE ANALYSES WILL ALLOW MONITORING THE DISTRIBUTION OF RESISTANT MICROORGANISMS, ANTIBIOTIC RESISTANCE GENES AND MOVABLE GENETIC ELEMENTS IN INDUSTRIAL ENVIRONMENTS PROVIDING THE NECESSARY INFORMATION TO IMPLEMENT QUANTITATIVE RISK ANALYSIS SCHEMES THAT ALLOW THE IDENTIFICATION OF RESERVOIRS AND TRANSMISSION ROUTES OF AMR THROUGH THE FOOD CHAIN. OVERALL, THE RESULTS OBTAINED DURING THE IMPLEMENTATION OF THE PROJECT WILL MAKE IT POSSIBLE TO CLARIFY NEW MECHANISMS FOR THE ACQUISITION AND TRANSFER OF AMR IN INDUSTRIAL ENVIRONMENTS AND FACILITATE THE IDENTIFICATION OF RISK FACTORS ASSOCIATED WITH THE EMERGENCY AND DISPERSION OF AMR FAVORING THE DEVELOPMENT OF PREVENTIVE INTERVENTIONS AND GUIDELINES OF RECOMMENDATIONS AIMED AT GUARANTEEING FOOD SECURITY. (English) | |||||||||||||||
| Property / summary: ANTIBIOTIC RESISTANCE (ANTIMICROBIAL RESISTANCE AMR) IS ONE OF THE BIGGEST CHALLENGES FACING HUMANITY. THE ACQUIRED RESISTANCE TO CERTAIN ANTIMICROBIAL AGENTS IS ALREADY OF SUCH MAGNITUDE THAT THEIR ABILITY TO TREAT INFECTIONS IS AT STAKE. THE EMERGENCE AND DISSEMINATION OF AMR IS USUALLY ATTRIBUTED TO THE INDISCRIMINATE USE OF ANTIBIOTICS AS THERAPEUTIC AGENTS IN HUMAN OR VETERINARY MEDICINE OR AS GROWTH PROMOTERS IN ANIMAL PRODUCTION. IN ADDITION, THE FOOD CHAIN HAS ALSO BEEN IDENTIFIED AS A POSSIBLE TRANSMISSION ROUTE OF AMR. IN FACT, RESEARCH CARRIED OUT IN THE LAST DECADE HAS SUGGESTED THE IMPORTANCE THAT CERTAIN INDUSTRIAL ENVIRONMENTS HAVE AS RESERVOIRS OF RESISTANT MICROORGANISMS AND ANTIBIOTIC RESISTANCE GENES AND HAVE IDENTIFIED THE USE OF BIOCIDES AND MICROBIAL EXPOSURE TO ENVIRONMENTAL STRESS FACTORS AND FOOD PROCESSING TECHNOLOGIES AS POSSIBLE RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT AND DISPERSION OF AMR. HOWEVER, EXISTING STUDIES IN RELATION TO MECHANISMS OF CO-RESISTANCE OR CROSS RESISTANCE TO ANTIBIOTICS MEDIATED BY BACTERIA ARE LIMITED TO A LIMITED NUMBER OF SPECIES. THE STARTING HYPOTHESIS OF THE PROJECT IS THAT CERTAIN CLEANING AND DISINFECTION PRACTICES AND FOOD PROCESSING TECHNOLOGIES USED BOTH IN SLAUGHTERHOUSES AND IN AGRI-FOOD INDUSTRIES ARE EXERTING A SELECTIVE PRESSURE THAT FAVORS THE EMERGENCE AND DISSEMINATION OF MICROORGANISMS RESISTANT TO ANTIBIOTICS, COMPROMISING THE INTEGRITY AND SAFETY OF THE FOOD CHAIN. THE METARESISTBUGS PROJECT AIMS, IN THE FIRST PLACE, TO INVESTIGATE THE IMPACT THAT THE EXPOSURE OF MICROORGANISMS OF FOOD INTEREST TO BIOCIDES, ENVIRONMENTAL STRESS CONDITIONS AND PROCESSING TECHNOLOGIES HAS ON THE ACQUISITION OF STABLE RESISTANCE TO ANTIBIOTICS, THE EXPRESSION OF ANTIBIOTIC RESISTANCE GENES AND THE HORIZONTAL TRANSFER OF GENETIC DETERMINANTS FROM AMR. A WIDE RANGE OF INDICATOR MICROORGANISMS WILL BE USED, BOTH PATHOGENS, SAFE OR BENEFICIAL MICROORGANISMS, CULTURE MEDIA, FOOD MODELS AND FOOD PROPER. SECONDLY, THE METARESISTBUGS PROJECT PROPOSES THE STUDY USING TECHNIQUES DEPENDENT AND INDEPENDENT OF CULTIVATION OF STRUCTURAL AND FUNCTIONAL CHANGES THAT OCCUR IN MICROBIAL POPULATIONS THAT COLONISE SLAUGHTERHOUSE ENVIRONMENTS AND AGRO-FOOD INDUSTRIES THAT EMPLOY DIFFERENT CLEANING, DISINFECTION AND FOOD PROCESSING STRATEGIES. THESE ANALYSES WILL ALLOW MONITORING THE DISTRIBUTION OF RESISTANT MICROORGANISMS, ANTIBIOTIC RESISTANCE GENES AND MOVABLE GENETIC ELEMENTS IN INDUSTRIAL ENVIRONMENTS PROVIDING THE NECESSARY INFORMATION TO IMPLEMENT QUANTITATIVE RISK ANALYSIS SCHEMES THAT ALLOW THE IDENTIFICATION OF RESERVOIRS AND TRANSMISSION ROUTES OF AMR THROUGH THE FOOD CHAIN. OVERALL, THE RESULTS OBTAINED DURING THE IMPLEMENTATION OF THE PROJECT WILL MAKE IT POSSIBLE TO CLARIFY NEW MECHANISMS FOR THE ACQUISITION AND TRANSFER OF AMR IN INDUSTRIAL ENVIRONMENTS AND FACILITATE THE IDENTIFICATION OF RISK FACTORS ASSOCIATED WITH THE EMERGENCY AND DISPERSION OF AMR FAVORING THE DEVELOPMENT OF PREVENTIVE INTERVENTIONS AND GUIDELINES OF RECOMMENDATIONS AIMED AT GUARANTEEING FOOD SECURITY. (English) / rank | |||||||||||||||
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| Property / summary: ANTIBIOTIC RESISTANCE (ANTIMICROBIAL RESISTANCE AMR) IS ONE OF THE BIGGEST CHALLENGES FACING HUMANITY. THE ACQUIRED RESISTANCE TO CERTAIN ANTIMICROBIAL AGENTS IS ALREADY OF SUCH MAGNITUDE THAT THEIR ABILITY TO TREAT INFECTIONS IS AT STAKE. THE EMERGENCE AND DISSEMINATION OF AMR IS USUALLY ATTRIBUTED TO THE INDISCRIMINATE USE OF ANTIBIOTICS AS THERAPEUTIC AGENTS IN HUMAN OR VETERINARY MEDICINE OR AS GROWTH PROMOTERS IN ANIMAL PRODUCTION. IN ADDITION, THE FOOD CHAIN HAS ALSO BEEN IDENTIFIED AS A POSSIBLE TRANSMISSION ROUTE OF AMR. IN FACT, RESEARCH CARRIED OUT IN THE LAST DECADE HAS SUGGESTED THE IMPORTANCE THAT CERTAIN INDUSTRIAL ENVIRONMENTS HAVE AS RESERVOIRS OF RESISTANT MICROORGANISMS AND ANTIBIOTIC RESISTANCE GENES AND HAVE IDENTIFIED THE USE OF BIOCIDES AND MICROBIAL EXPOSURE TO ENVIRONMENTAL STRESS FACTORS AND FOOD PROCESSING TECHNOLOGIES AS POSSIBLE RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT AND DISPERSION OF AMR. HOWEVER, EXISTING STUDIES IN RELATION TO MECHANISMS OF CO-RESISTANCE OR CROSS RESISTANCE TO ANTIBIOTICS MEDIATED BY BACTERIA ARE LIMITED TO A LIMITED NUMBER OF SPECIES. THE STARTING HYPOTHESIS OF THE PROJECT IS THAT CERTAIN CLEANING AND DISINFECTION PRACTICES AND FOOD PROCESSING TECHNOLOGIES USED BOTH IN SLAUGHTERHOUSES AND IN AGRI-FOOD INDUSTRIES ARE EXERTING A SELECTIVE PRESSURE THAT FAVORS THE EMERGENCE AND DISSEMINATION OF MICROORGANISMS RESISTANT TO ANTIBIOTICS, COMPROMISING THE INTEGRITY AND SAFETY OF THE FOOD CHAIN. THE METARESISTBUGS PROJECT AIMS, IN THE FIRST PLACE, TO INVESTIGATE THE IMPACT THAT THE EXPOSURE OF MICROORGANISMS OF FOOD INTEREST TO BIOCIDES, ENVIRONMENTAL STRESS CONDITIONS AND PROCESSING TECHNOLOGIES HAS ON THE ACQUISITION OF STABLE RESISTANCE TO ANTIBIOTICS, THE EXPRESSION OF ANTIBIOTIC RESISTANCE GENES AND THE HORIZONTAL TRANSFER OF GENETIC DETERMINANTS FROM AMR. A WIDE RANGE OF INDICATOR MICROORGANISMS WILL BE USED, BOTH PATHOGENS, SAFE OR BENEFICIAL MICROORGANISMS, CULTURE MEDIA, FOOD MODELS AND FOOD PROPER. SECONDLY, THE METARESISTBUGS PROJECT PROPOSES THE STUDY USING TECHNIQUES DEPENDENT AND INDEPENDENT OF CULTIVATION OF STRUCTURAL AND FUNCTIONAL CHANGES THAT OCCUR IN MICROBIAL POPULATIONS THAT COLONISE SLAUGHTERHOUSE ENVIRONMENTS AND AGRO-FOOD INDUSTRIES THAT EMPLOY DIFFERENT CLEANING, DISINFECTION AND FOOD PROCESSING STRATEGIES. THESE ANALYSES WILL ALLOW MONITORING THE DISTRIBUTION OF RESISTANT MICROORGANISMS, ANTIBIOTIC RESISTANCE GENES AND MOVABLE GENETIC ELEMENTS IN INDUSTRIAL ENVIRONMENTS PROVIDING THE NECESSARY INFORMATION TO IMPLEMENT QUANTITATIVE RISK ANALYSIS SCHEMES THAT ALLOW THE IDENTIFICATION OF RESERVOIRS AND TRANSMISSION ROUTES OF AMR THROUGH THE FOOD CHAIN. OVERALL, THE RESULTS OBTAINED DURING THE IMPLEMENTATION OF THE PROJECT WILL MAKE IT POSSIBLE TO CLARIFY NEW MECHANISMS FOR THE ACQUISITION AND TRANSFER OF AMR IN INDUSTRIAL ENVIRONMENTS AND FACILITATE THE IDENTIFICATION OF RISK FACTORS ASSOCIATED WITH THE EMERGENCY AND DISPERSION OF AMR FAVORING THE DEVELOPMENT OF PREVENTIVE INTERVENTIONS AND GUIDELINES OF RECOMMENDATIONS AIMED AT GUARANTEEING FOOD SECURITY. (English) / qualifier | |||||||||||||||
point in time: 13 October 2021
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Revision as of 00:00, 13 October 2021
Project Q3192266 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | IDENTIFICATION OF ROUTES AND TRANSMISSION MECHANISMS OF RESISTANCE TO ANTIBIOTICS THROUGH THE FOOD CHAIN USING CULTURE-DEPENDENT AND INDEPENDENT TECHNIQUES |
Project Q3192266 in Spain |
Statements
114,950.0 Euro
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229,900.0 Euro
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50.0 percent
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30 December 2016
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30 June 2021
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UNIVERSIDAD DE LEON
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42°38'2.94"N, 5°58'17.11"W
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24089
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LA RESISTENCIA BACTERIANA A LOS ANTIBIOTICOS (ANTIMICROBIAL RESISTANCE ¿ AMR) ES UNO DE LOS RETOS DE MAYOR ENVERGADURA A LOS QUE SE ENFRENTA LA HUMANIDAD. LAS RESISTENCIAS ADQUIRIDAS FRENTE A DETERMINADOS AGENTES ANTIMICROBIANOS SON YA DE TAL MAGNITUD QUE SU APTITUD PARA EL TRATAMIENTO DE INFECCIONES SE ENCUENTRA EN ENTREDICHO. LA EMERGENCIA Y DISEMINACION DE AMR SE ATRIBUYE HABITUALMENTE AL USO INDISCRIMINADO DE ANTIBIOTICOS COMO AGENTES TERAPEUTICOS EN MEDICINA HUMANA O VETERINARIA O COMO PROMOTORES DE CRECIMIENTO EN PRODUCCION ANIMAL. ADEMAS, LA CADENA ALIMENTARIA TAMBIEN HA SIDO IDENTIFICADA COMO UNA POSIBLE RUTA DE TRANSMISION DE AMR. DE HECHO, INVESTIGACIONES LLEVADAS A CABO EN LA ULTIMA DECADA HAN SUGERIDO LA IMPORTANCIA QUE DETERMINADOS AMBIENTES INDUSTRIALES TIENEN COMO RESERVORIOS DE MICROORGANISMOS RESISTENTES Y GENES DE RESISTENCIA A ANTIBIOTICOS Y HAN IDENTIFICADO LA UTILIZACION DE BIOCIDAS Y LA EXPOSICION MICROBIANA A FACTORES DE ESTRES AMBIENTAL Y TECNOLOGIAS DE PROCESADO DE ALIMENTOS COMO POSIBLES FACTORES DE RIESGO ASOCIADOS CON EL DESARROLLO Y DISPERSION DE AMR. SIN EMBARGO, LOS ESTUDIOS EXISTENTES EN RELACION A MECANISMOS DE CO-RESISTENCIA O RESISTENCIA CRUZADA A LOS ANTIBIOTICOS MEDIADA POR EXPOSICION A CONDICIONES DE ESTRES SON ESCASOS Y SE CENTRAN EN UN NUMERO LIMITADO DE CEPAS DE UNAS POCAS ESPECIES BACTERIANAS. LA HIPOTESIS DE PARTIDA DEL PROYECTO ES QUE DETERMINADAS PRACTICAS DE LIMPIEZA Y DESINFECCION Y TECNOLOGIAS DE PROCESADO DE ALIMENTOS UTILIZADAS TANTO EN MATADEROS COMO EN INDUSTRIAS AGROALIMENTARIAS ESTAN EJERCIENDO UNA PRESION SELECTIVA QUE FAVORECE LA EMERGENCIA Y DISEMINACION DE MICROORGANISMOS RESISTENTES A ANTIBIOTICOS COMPROMETIENDO LA INTEGRIDAD Y SEGURIDAD DE LA CADENA ALIMENTARIA. EL PROYECTO METARESISTBUGS PRETENDE, EN PRIMER LUGAR, INVESTIGAR EL IMPACTO QUE LA EXPOSICION DE MICROORGANISMOS DE INTERES ALIMENTARIO A BIOCIDAS, CONDICIONES DE ESTRES AMBIENTAL Y TECNOLOGIAS DE PROCESADO TIENE SOBRE LA ADQUISICION DE RESISTENCIA ESTABLE A ANTIBIOTICOS, LA EXPRESION DE GENES DE RESISTENCIA A ANTIBIOTICOS Y LA TRANSFERENCIA HORIZONTAL DE DETERMINANTES GENETICOS DE AMR. PARA ELLO SE EMPLEARAN UN AMPLIO ABANICO DE MICROORGANISMOS INDICADORES, TANTO PATOGENOS COMO INOCUOS O BENEFICIOSOS, MEDIOS DE CULTIVO, MODELOS DE ALIMENTOS Y ALIMENTOS PROPIAMENTE DICHOS. EN SEGUNDO LUGAR, EL PROYECTO METARESISTBUGS PROPONE EL ESTUDIO MEDIANTE TECNICAS DEPENDIENTES E INDEPENDIENTES DE CULTIVO DE LOS CAMBIOS ESTRUCTURALES Y FUNCIONALES QUE OCURREN EN LAS POBLACIONES MICROBIANAS QUE COLONIZAN AMBIENTES DE MATADEROS E INDUSTRIAS AGROALIMENTARIAS QUE EMPLEAN DIFERENTES ESTRATEGIAS DE LIMPIEZA, DESINFECCION Y PROCESADO DE ALIMENTOS. ESTOS ANALISIS PERMITIRAN MONITORIZAR LA DISTRIBUCION DE MICROORGANISMOS RESISTENTES, GENES DE RESISTENCIA A ANTIBIOTICOS Y ELEMENTOS GENETICOS MOVILES EN AMBIENTES INDUSTRIALES APORTANDO LA INFORMACION NECESARIA PARA IMPLEMENTAR ESQUEMAS CUANTITATIVOS DE ANALISIS DE RIESGOS QUE PERMITAN LA IDENTIFICACION DE RESERVORIOS Y RUTAS DE TRANSMISION DE AMR A TRAVES DE LA CADENA ALIMENTARIA. GLOBALMENTE, LOS RESULTADOS OBTENIDOS DURANTE LA EJECUCION DEL PROYECTO PERMITIRAN ESCLARECER NUEVOS MECANISMOS DE ADQUISICION Y TRANSMISION DE AMR EN AMBIENTES INDUSTRIALES Y FACILITARAN LA IDENTIFICACION DE FACTORES DE RIESGO ASOCIADOS A LA EMERGENCIA Y DISPERSION DE AMR FAVORECIENDO EL DESARROLLO DE INTERVENCIONES PREVENTIVAS Y GUIAS DE RECOMENDACIONES ENCAMINADAS A GARANTIZAR LA SEGURIDAD ALIMENTARIA. (Spanish)
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ANTIBIOTIC RESISTANCE (ANTIMICROBIAL RESISTANCE AMR) IS ONE OF THE BIGGEST CHALLENGES FACING HUMANITY. THE ACQUIRED RESISTANCE TO CERTAIN ANTIMICROBIAL AGENTS IS ALREADY OF SUCH MAGNITUDE THAT THEIR ABILITY TO TREAT INFECTIONS IS AT STAKE. THE EMERGENCE AND DISSEMINATION OF AMR IS USUALLY ATTRIBUTED TO THE INDISCRIMINATE USE OF ANTIBIOTICS AS THERAPEUTIC AGENTS IN HUMAN OR VETERINARY MEDICINE OR AS GROWTH PROMOTERS IN ANIMAL PRODUCTION. IN ADDITION, THE FOOD CHAIN HAS ALSO BEEN IDENTIFIED AS A POSSIBLE TRANSMISSION ROUTE OF AMR. IN FACT, RESEARCH CARRIED OUT IN THE LAST DECADE HAS SUGGESTED THE IMPORTANCE THAT CERTAIN INDUSTRIAL ENVIRONMENTS HAVE AS RESERVOIRS OF RESISTANT MICROORGANISMS AND ANTIBIOTIC RESISTANCE GENES AND HAVE IDENTIFIED THE USE OF BIOCIDES AND MICROBIAL EXPOSURE TO ENVIRONMENTAL STRESS FACTORS AND FOOD PROCESSING TECHNOLOGIES AS POSSIBLE RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT AND DISPERSION OF AMR. HOWEVER, EXISTING STUDIES IN RELATION TO MECHANISMS OF CO-RESISTANCE OR CROSS RESISTANCE TO ANTIBIOTICS MEDIATED BY BACTERIA ARE LIMITED TO A LIMITED NUMBER OF SPECIES. THE STARTING HYPOTHESIS OF THE PROJECT IS THAT CERTAIN CLEANING AND DISINFECTION PRACTICES AND FOOD PROCESSING TECHNOLOGIES USED BOTH IN SLAUGHTERHOUSES AND IN AGRI-FOOD INDUSTRIES ARE EXERTING A SELECTIVE PRESSURE THAT FAVORS THE EMERGENCE AND DISSEMINATION OF MICROORGANISMS RESISTANT TO ANTIBIOTICS, COMPROMISING THE INTEGRITY AND SAFETY OF THE FOOD CHAIN. THE METARESISTBUGS PROJECT AIMS, IN THE FIRST PLACE, TO INVESTIGATE THE IMPACT THAT THE EXPOSURE OF MICROORGANISMS OF FOOD INTEREST TO BIOCIDES, ENVIRONMENTAL STRESS CONDITIONS AND PROCESSING TECHNOLOGIES HAS ON THE ACQUISITION OF STABLE RESISTANCE TO ANTIBIOTICS, THE EXPRESSION OF ANTIBIOTIC RESISTANCE GENES AND THE HORIZONTAL TRANSFER OF GENETIC DETERMINANTS FROM AMR. A WIDE RANGE OF INDICATOR MICROORGANISMS WILL BE USED, BOTH PATHOGENS, SAFE OR BENEFICIAL MICROORGANISMS, CULTURE MEDIA, FOOD MODELS AND FOOD PROPER. SECONDLY, THE METARESISTBUGS PROJECT PROPOSES THE STUDY USING TECHNIQUES DEPENDENT AND INDEPENDENT OF CULTIVATION OF STRUCTURAL AND FUNCTIONAL CHANGES THAT OCCUR IN MICROBIAL POPULATIONS THAT COLONISE SLAUGHTERHOUSE ENVIRONMENTS AND AGRO-FOOD INDUSTRIES THAT EMPLOY DIFFERENT CLEANING, DISINFECTION AND FOOD PROCESSING STRATEGIES. THESE ANALYSES WILL ALLOW MONITORING THE DISTRIBUTION OF RESISTANT MICROORGANISMS, ANTIBIOTIC RESISTANCE GENES AND MOVABLE GENETIC ELEMENTS IN INDUSTRIAL ENVIRONMENTS PROVIDING THE NECESSARY INFORMATION TO IMPLEMENT QUANTITATIVE RISK ANALYSIS SCHEMES THAT ALLOW THE IDENTIFICATION OF RESERVOIRS AND TRANSMISSION ROUTES OF AMR THROUGH THE FOOD CHAIN. OVERALL, THE RESULTS OBTAINED DURING THE IMPLEMENTATION OF THE PROJECT WILL MAKE IT POSSIBLE TO CLARIFY NEW MECHANISMS FOR THE ACQUISITION AND TRANSFER OF AMR IN INDUSTRIAL ENVIRONMENTS AND FACILITATE THE IDENTIFICATION OF RISK FACTORS ASSOCIATED WITH THE EMERGENCY AND DISPERSION OF AMR FAVORING THE DEVELOPMENT OF PREVENTIVE INTERVENTIONS AND GUIDELINES OF RECOMMENDATIONS AIMED AT GUARANTEEING FOOD SECURITY. (English)
13 October 2021
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León
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Identifiers
AGL2016-78085-P
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