STUDY OF THE RELATIONSHIP BETWEEN INFLAMMATION, MALNUTRICION AND INTESTINAL MICROBIOTA IN THE DEVELOPMENT AND PROGRESSION OF HEART FAILURE (Q3181433): Difference between revisions
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(Created claim: summary (P836): Literature data demonstrate an interrelationship between pathogenic mechanisms of congestive heart failure (CI), inflammation, nutrition and the composition of intestinal flora. Patients with HF have a low-medium-grade inflammatory status that is evident in both obese and malnourished patients, although the prognosis of the former is much better than that of undernourished patients. The origin of inflammation in HF patients is not known for cert...) |
(Changed label, description and/or aliases in en: translated_label) |
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STUDY OF THE RELATIONSHIP BETWEEN INFLAMMATION, MALNUTRICION AND INTESTINAL MICROBIOTA IN THE DEVELOPMENT AND PROGRESSION OF HEART FAILURE | |||
Revision as of 20:36, 12 October 2021
Project Q3181433 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | STUDY OF THE RELATIONSHIP BETWEEN INFLAMMATION, MALNUTRICION AND INTESTINAL MICROBIOTA IN THE DEVELOPMENT AND PROGRESSION OF HEART FAILURE |
Project Q3181433 in Spain |
Statements
58,250.0 Euro
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116,500.0 Euro
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50.0 percent
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1 January 2015
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31 March 2019
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FUNDACION INVESTIGACION BIOMEDICA HOSPITAL CLINICO SAN CARLOS
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40°25'0.12"N, 3°42'12.89"W
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28079
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Los datos de literatura demuestran una interrelación entre los mecanismos patogénicos de la insuficiencia cardiaca congestiva (IC) , la inflamación, la nutrición y la composición de la flora intestinal. Los pacientes con IC presentan un estado inflamatorio de grado bajo-medio que es evidente tanto en pacientes obesos como en estado de malnutrición, aunque el pronóstico de los primeros es mucho mejor que el de los pacientes desnutridos. El origen de la inflamación en los pacientes con IC no se sabe con certeza, pero recientemente se ha sugerido que el intestino puede tener un papel muy importante; los pacientes con IC sufren alteraciones funcionales y morfológicas que pueden traducirse en un fracaso de la “función barrera” de la mucosa intestinal, aumentando su permeabilidad y la invasión microbiana. Nuestra hipótesis es que la inflamación y la composición de la flora intestinal de los pacientes con IC es distinta en función de su estado nutricional y, por tanto, la administración de una dieta inmunomoduladora a pacientes con IC con malnutrición permitirá restaurar el equilibrio de la flora intestinal disminuyendo la inflamación, lo cual ejercerá un efecto beneficioso sobre la morbimortalidad de estos pacientes. El estudio de un modelo experimental de IC nos permitirá establecer la causalidad de estos cambios en el desarrollo de la IC y nos proporcionará tejidos que no se pueden obtener de los pacientes. El análisis sinérgico de estos parámetros podría proporcionar nuevos conocimientos en el tratamiento de la IC que harían posible el «manejo personalizado» de los pacientes con IC. (Spanish)
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Literature data demonstrate an interrelationship between pathogenic mechanisms of congestive heart failure (CI), inflammation, nutrition and the composition of intestinal flora. Patients with HF have a low-medium-grade inflammatory status that is evident in both obese and malnourished patients, although the prognosis of the former is much better than that of undernourished patients. The origin of inflammation in HF patients is not known for certain, but it has recently been suggested that the bowel may play a very important role; patients with HF suffer from functional and morphological alterations that can result in a failure of the “barrier function” of the intestinal mucosa, increasing their permeability and microbial invasion. Our hypothesis is that the inflammation and composition of the intestinal flora of patients with HF is different depending on their nutritional status and, therefore, the administration of an immunomodulatory diet to patients with HF with malnutrition will restore the balance of the intestinal flora by decreasing inflammation, which will have a beneficial effect on the morbidity and mortality of these patients. The study of an experimental HF model will allow us to establish the causality of these changes in the development of HF and will provide tissues that cannot be obtained from patients. Synergistic analysis of these parameters could provide new knowledge in the treatment of HF that would make possible the “customised management” of HF patients. (English)
12 October 2021
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Madrid
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Identifiers
PI14_01856
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