Severe childhood obesity of early onset: Metabolic, hormonal, genetic, genomic and metabolomic foundations. (Q3161241): Difference between revisions
Jump to navigation
Jump to search
(Changed label, description and/or aliases in en: translated_label) |
(Removed claim: summary (P836): Obesity is the most prevalent chronic disease in childhood and adolescence in our environment and throughout the Western world, and is therefore one of the most common reasons for consultation in general pediatric clinical practice and, in particular, in pediatric endocrinology. There are also a large number of comorbidities secondary to obesity, which can be observed more and more often in childhood and adolescence. It is accepted that this i...) |
||||||||||||||
| Property / summary | |||||||||||||||
| Property / summary: Obesity is the most prevalent chronic disease in childhood and adolescence in our environment and throughout the Western world, and is therefore one of the most common reasons for consultation in general pediatric clinical practice and, in particular, in pediatric endocrinology. There are also a large number of comorbidities secondary to obesity, which can be observed more and more often in childhood and adolescence. It is accepted that this increase in prevalence is due to the imbalance between intake and energy expenditure. However, the influence of individual and family genetic burden on the risk of developing obesity is increasingly evident. Gradually, the pathophysiological bases of appetite control and energy expenditure are discovered, based on the study of the increasing number of cases derived from the existence of underlying genetic, endocrinological or syndromic alterations, so it is not possible to talk about obesity in a generic way, but rather it would be more appropriate to refer to obesity, because their pathophysiological basis is different and, therefore, they differ tangentially in the methodology of study and therapeutic approach. This project, continuation of the previous PI10/00747 aims to continue developing the auxological, metabolic, biochemical and hormonal bases of children with severe early-onset obesity (OSIP), deepen the study of monogenic alterations and CNVs detected, increase the genetic and genomic study of new patients with OSIP and develop metabolomic studies in children and experimental animals. (English) / rank | |||||||||||||||
| Property / summary: Obesity is the most prevalent chronic disease in childhood and adolescence in our environment and throughout the Western world, and is therefore one of the most common reasons for consultation in general pediatric clinical practice and, in particular, in pediatric endocrinology. There are also a large number of comorbidities secondary to obesity, which can be observed more and more often in childhood and adolescence. It is accepted that this increase in prevalence is due to the imbalance between intake and energy expenditure. However, the influence of individual and family genetic burden on the risk of developing obesity is increasingly evident. Gradually, the pathophysiological bases of appetite control and energy expenditure are discovered, based on the study of the increasing number of cases derived from the existence of underlying genetic, endocrinological or syndromic alterations, so it is not possible to talk about obesity in a generic way, but rather it would be more appropriate to refer to obesity, because their pathophysiological basis is different and, therefore, they differ tangentially in the methodology of study and therapeutic approach. This project, continuation of the previous PI10/00747 aims to continue developing the auxological, metabolic, biochemical and hormonal bases of children with severe early-onset obesity (OSIP), deepen the study of monogenic alterations and CNVs detected, increase the genetic and genomic study of new patients with OSIP and develop metabolomic studies in children and experimental animals. (English) / qualifier | |||||||||||||||
| |||||||||||||||
Revision as of 17:21, 12 October 2021
Project Q3161241 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Severe childhood obesity of early onset: Metabolic, hormonal, genetic, genomic and metabolomic foundations. |
Project Q3161241 in Spain |
Statements
85,250.0 Euro
0 references
170,500.0 Euro
0 references
50.0 percent
0 references
1 January 2014
0 references
31 March 2017
0 references
FUNDACION INVESTIGACION BIOMEDICA DEL HOSPITAL NIÑO JESUS
0 references
40°25'0.12"N, 3°42'12.89"W
0 references
28079
0 references
La obesidad constituye la enfermedad crónica más prevalente en la infancia y la adolescencia en nuestro medio y en todo el mundo occidental, siendo, por tanto, uno de los motivos de consulta más frecuentes en la práctica clínica pediátrica general y, particularmente, en endocrinología pediátrica. Asimismo, existe un gran número de comorbilidades secundarias a la obesidad que, cada vez con mayor frecuencia, se pueden observar ya en la infancia y en la adolescencia. Se acepta que este incremento de prevalencia es debido, al desequilibrio entre la ingesta y el gasto energético. Sin embargo, cada vez es más evidente la influencia de la carga genética individual y familiar en el riesgo de desarrollar obesidad. Paulatinamente, se van descubriendo las bases fisiopatológicas del control del apetito y del gasto energético, a partir del estudio del creciente número de casos derivados de la existencia de alteraciones genéticas,endocrinológicas o sindrómicas subyacentes, por lo que no se puede hablar de obesidad de forma genérica, sino que sería más adecuado referirse a obesidades , pues su base fisiopatológica es diferente y, por tanto, difieren tangencialmente en la metodología de estudio y abordaje terapéutico. Este proyecto, continuación del anterior PI10/00747 persigue continuar desarrollando las bases auxológicas, metabólicas, bioquímicas y hormonales del niño con obesidad severa de inicio precoz (OSIP), profundizar en el estudio de las alteraciones monogénicas y CNVs detectadas, incrementar el estudio genético y genómico de nuevos pacientes con OSIP y desarrollar estudios de metabolómica en niños y en animales de experimentación. (Spanish)
0 references
Madrid
0 references
Identifiers
PI13_02195
0 references