Minimally invasive administration of surfactant (Lisa, Insure, nebulisation). Effect on hemodynamics, oxygenation and brain function in experimental model of surfactant deficit. (Q3171424): Difference between revisions
Jump to navigation
Jump to search
(Created claim: summary (P836): OBJECTIVE: To evaluate, compare and determine which of the forms of non-invasive ventilation most used in the NICU (NCPAP or NIPPV) without or with the administration of surfactant (using Insure, Lisa or nebulisation techniques) presents improvements at the pulmonary and hemodynamic level with fewer effects at the brain level, in a well-established model of newborn pigs with SF deficiency that breathe spontaneously. METHODOLOGY: Design and s...) |
(Changed label, description and/or aliases in en: translated_label) |
||
| label / en | label / en | ||
Minimally invasive administration of surfactant (Lisa, Insure, nebulisation). Effect on hemodynamics, oxygenation and brain function in experimental model of surfactant deficit. | |||
Revision as of 17:15, 12 October 2021
Project Q3171424 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Minimally invasive administration of surfactant (Lisa, Insure, nebulisation). Effect on hemodynamics, oxygenation and brain function in experimental model of surfactant deficit. |
Project Q3171424 in Spain |
Statements
43,500.0 Euro
0 references
87,000.0 Euro
0 references
50.0 percent
0 references
1 January 2019
0 references
31 March 2022
0 references
ASOCIACION INSTITUTO DE INVESTIGACION SANITARIA BIOCRUCES
0 references
43°17'43.73"N, 2°59'24.32"W
0 references
48013
0 references
OBJETIVO: Evaluar, comparar y determinar cual de las formas de ventilación no invasiva mas usadas en la UCIN (NCPAP o NIPPV) sin o con la administración de surfactante (empleando técnicas Insure, Lisa o nebulización) presenta mejoras a nivel pulmonar y hemodinámico con menos efectos a nivel cerebral, en un modelo bien establecido de cerdos recién nacidos con deficiencia de SF que respiran espontáneamente. METODOLOGIA: Diseño y sujetos de estudio: 8 grupos de cerdos neonatales (2-4 días de edad) con déficit de surfactante (n=6/grupo). De forma randomizada recibirán tratamiento NCPAP o NIPPV, sin y con una de las diferentes formas de administración de surfactante (Insure, Lisa o nebulizado). Cirugía: Los animales serán cateterizados (arteria femoral y vena yugular) y se aislara una carótida para la medición de flujo de forma continua a través de una sonda ultrasónica de flujo. Se realizaran lavados broncoalveolares para conseguir la depleción del SF y posteriormente los animales serán randomizados al tratamiento correspondiente. Determinaciones: Se medirán parámetros cardiovasculares, intercambio gaseoso y función pulmonar. Del mismo modo, se medirá la hemodinámica, metabolismo y función cerebral. Se determinara la perfusión y oxigenación cerebral mediante NIRS, se evaluara los cambios en el electroencefalograma y se determinara la existencia de lesión mediante ultrasonografía. Después de la extracción de muestras se estudiara el daño histológico, el estrés oxidativo y la inflamación mediante diferentes técnicas bioquímicas e inmunoensayos. (Spanish)
0 references
OBJECTIVE: To evaluate, compare and determine which of the forms of non-invasive ventilation most used in the NICU (NCPAP or NIPPV) without or with the administration of surfactant (using Insure, Lisa or nebulisation techniques) presents improvements at the pulmonary and hemodynamic level with fewer effects at the brain level, in a well-established model of newborn pigs with SF deficiency that breathe spontaneously. METHODOLOGY: Design and study subjects: 8 groups of neonatal pigs (2-4 days old) with surfactant deficit (n=6/group). Randomly, they will receive NCPAP or NIPPV treatment, without and with one of the different forms of surfactant administration (Insure, Lisa or nebulised). Surgery: The animals will be catheterised (femoral artery and jugular vein) and a carotid is isolated for continuous flow measurement through an ultrasonic flow probe. Bronchoalveolar washes will be carried out to achieve SF depletion and subsequently the animals will be randomised to the corresponding treatment. Determinations: Cardiovascular parameters, gas exchange and lung function shall be measured. Similarly, hemodynamics, metabolism and brain function will be measured. Brain infusion and oxygenation shall be determined by NIRS, changes in the electroencephalogram shall be evaluated and lesions determined by ultrasound. After sampling, histological damage, oxidative stress and inflammation will be studied using different biochemical and immunoassay techniques. (English)
12 October 2021
0 references
Barakaldo
0 references
Identifiers
PI18_00166
0 references