Q3166707 (Q3166707): Difference between revisions
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(Created claim: summary (P836): THE RISING AGE OF THE WORLD’S POPULATION AND MODERN LIVING CONDITIONS SEEM TO HAVE AN EFFECT ON BRAIN-RELATED DISEASES. CONDITIONS SUCH AS ALZHEIMER’S, PARKINSON’S, DEPRESSION AND MANY OTHERS ARE BEING CONTINUOUSLY INVESTIGATED ALL OVER THE WORLD. As a result, INTERNATIONAL INICIATIVE VARIES HAVE REFERRED IN THE IMPORTANCE OF THE COMPRENSION OF NEURONAL ACTIVITY IN THE BREBRO._x000D_ _x000D__x000D__x000D_ _x000D__x000D__x000D__x000D__x000D__x000...) |
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THE RISING AGE OF THE WORLD’S POPULATION AND MODERN LIVING CONDITIONS SEEM TO HAVE AN EFFECT ON BRAIN-RELATED DISEASES. CONDITIONS SUCH AS ALZHEIMER’S, PARKINSON’S, DEPRESSION AND MANY OTHERS ARE BEING CONTINUOUSLY INVESTIGATED ALL OVER THE WORLD. As a result, INTERNATIONAL INICIATIVE VARIES HAVE REFERRED IN THE IMPORTANCE OF THE COMPRENSION OF NEURONAL ACTIVITY IN THE BREBRO._x000D_ _x000D__x000D__x000D_ _x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D__x000D___x we will study NEURONAL NEURONAL RED CONECTIVITY PROCESSING PROCESSES IN 3D that Happen in DIFFERENT ORGANISMUS MODEL CEREBRIES. TO DO THIS, A NOVEL TECHNIQUE WILL BE USED WHICH IS BASED ON BREAKING AN OLD PARADIGM IN MICROSCOPY: DECOUPLING THE OPTIC ILLUMINATION OF THE DETECTION OPTIC. THIS IS ACHIEVED BY INCORPORATING WAVEFRONT CODING INTO A LIGHT SHEET MICROSCOPE. THIS RESULTS IN THE ABILITY TO OBTAIN OPTICAL SECTIONING OF IMAGE PLANES THAT ARE OUTSIDE THE FOCAL POSITION. THIS SYSTEM ADDS A NEW DEGREE OF FREEDOM IN MICROSCOPY AND, AS SUCH, HAS ENORMOUS RELEVANCE AND GREAT POTENTIAL FOR NEW IMAGINATIVE APPLICATIONS. IN PARTICULAR, WE HAVE PREVIOUSLY DEMONSTRATED THAT THIS NEW DEGREE OF FREEDOM CAN BE USED TO OBTAIN HIGH RESOLUTION VOLUMETRIC IMAGES AT UNPRECEDENTED SPEEDS. Even where we know, our team is the first at_x000D_ RESENT THIS APPROXIMATION._x000D_ _x000D_ ASI, THE PROJECT THAT IS HERE IS THE next NATURAL PASE OF OUR INICIAL RESULTS AND will be applied NOW on the web of neurobiology. IN THIS PROJECT, THE CAPABILITIES OF OUR NEW IMAGING SYSTEM WILL BE USED, TOGETHER WITH OUR NEUROSCIENCE COLLABORATORS, TO VISUALISE, IN 3D, THE CALCIUM WAVE PATTERNS THAT ORIGINATE DURING THE PROCESS OF NEURONAL ACTIVITY IN THE BRAIN OF SEVERAL MODEL ORGANISMS (SUCH AS NEMATODES, ZEBRA FISH AND TADPOLES). ONCE THIS COMMUNICATION PATTERN HAS BEEN RECORDED, DIFFERENT TOOLS OF OPTIMAL MANIPULATION AT THE CELLULAR LEVEL WILL BE USED, SUCH AS NEURONAL PHOTO-STIMULATION OR CONTROLLED PHOTO-ABLATION, BOTH AT THE LEVEL OF A SINGLE NEURONAL CELL. ONCE THE PHOTO-STIMULATION OR PHOTO-ABLATION HAS BEEN APPLIED, THE CALCIUM DYNAMICS WILL BE VISUALISED AGAIN. THIS WILL ALLOW THE DETERMINATION OF CHANGES IN THE BEHAVIOR OF THE BRAIN, THUS HAVING A BETTER UNDERSTANDING OF THE NEURAL NETWORK, AS WELL AS A BETTER VISION OF THE FUNCTION OF THE DIFFERENT PARTS OF IT. All THIS INFORMATION REPRESENT, FOR SAME, A ADELING PASS FOR THE COMMUNITY OF Neurobiology,_x000D_ PROPOTIONING A IMPORTANT BASE FOR FUTURES INVESTIGATIONS WITH A GREAT IMPACT FOR_x000D_ THE SOCIETY IN GENERAL. (English) | |||||||||||||||
| Property / summary: THE RISING AGE OF THE WORLD’S POPULATION AND MODERN LIVING CONDITIONS SEEM TO HAVE AN EFFECT ON BRAIN-RELATED DISEASES. CONDITIONS SUCH AS ALZHEIMER’S, PARKINSON’S, DEPRESSION AND MANY OTHERS ARE BEING CONTINUOUSLY INVESTIGATED ALL OVER THE WORLD. As a result, INTERNATIONAL INICIATIVE VARIES HAVE REFERRED IN THE IMPORTANCE OF THE COMPRENSION OF NEURONAL ACTIVITY IN THE BREBRO._x000D_ _x000D__x000D__x000D_ _x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D__x000D___x we will study NEURONAL NEURONAL RED CONECTIVITY PROCESSING PROCESSES IN 3D that Happen in DIFFERENT ORGANISMUS MODEL CEREBRIES. TO DO THIS, A NOVEL TECHNIQUE WILL BE USED WHICH IS BASED ON BREAKING AN OLD PARADIGM IN MICROSCOPY: DECOUPLING THE OPTIC ILLUMINATION OF THE DETECTION OPTIC. THIS IS ACHIEVED BY INCORPORATING WAVEFRONT CODING INTO A LIGHT SHEET MICROSCOPE. THIS RESULTS IN THE ABILITY TO OBTAIN OPTICAL SECTIONING OF IMAGE PLANES THAT ARE OUTSIDE THE FOCAL POSITION. THIS SYSTEM ADDS A NEW DEGREE OF FREEDOM IN MICROSCOPY AND, AS SUCH, HAS ENORMOUS RELEVANCE AND GREAT POTENTIAL FOR NEW IMAGINATIVE APPLICATIONS. IN PARTICULAR, WE HAVE PREVIOUSLY DEMONSTRATED THAT THIS NEW DEGREE OF FREEDOM CAN BE USED TO OBTAIN HIGH RESOLUTION VOLUMETRIC IMAGES AT UNPRECEDENTED SPEEDS. Even where we know, our team is the first at_x000D_ RESENT THIS APPROXIMATION._x000D_ _x000D_ ASI, THE PROJECT THAT IS HERE IS THE next NATURAL PASE OF OUR INICIAL RESULTS AND will be applied NOW on the web of neurobiology. IN THIS PROJECT, THE CAPABILITIES OF OUR NEW IMAGING SYSTEM WILL BE USED, TOGETHER WITH OUR NEUROSCIENCE COLLABORATORS, TO VISUALISE, IN 3D, THE CALCIUM WAVE PATTERNS THAT ORIGINATE DURING THE PROCESS OF NEURONAL ACTIVITY IN THE BRAIN OF SEVERAL MODEL ORGANISMS (SUCH AS NEMATODES, ZEBRA FISH AND TADPOLES). ONCE THIS COMMUNICATION PATTERN HAS BEEN RECORDED, DIFFERENT TOOLS OF OPTIMAL MANIPULATION AT THE CELLULAR LEVEL WILL BE USED, SUCH AS NEURONAL PHOTO-STIMULATION OR CONTROLLED PHOTO-ABLATION, BOTH AT THE LEVEL OF A SINGLE NEURONAL CELL. ONCE THE PHOTO-STIMULATION OR PHOTO-ABLATION HAS BEEN APPLIED, THE CALCIUM DYNAMICS WILL BE VISUALISED AGAIN. THIS WILL ALLOW THE DETERMINATION OF CHANGES IN THE BEHAVIOR OF THE BRAIN, THUS HAVING A BETTER UNDERSTANDING OF THE NEURAL NETWORK, AS WELL AS A BETTER VISION OF THE FUNCTION OF THE DIFFERENT PARTS OF IT. All THIS INFORMATION REPRESENT, FOR SAME, A ADELING PASS FOR THE COMMUNITY OF Neurobiology,_x000D_ PROPOTIONING A IMPORTANT BASE FOR FUTURES INVESTIGATIONS WITH A GREAT IMPACT FOR_x000D_ THE SOCIETY IN GENERAL. (English) / rank | |||||||||||||||
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| Property / summary: THE RISING AGE OF THE WORLD’S POPULATION AND MODERN LIVING CONDITIONS SEEM TO HAVE AN EFFECT ON BRAIN-RELATED DISEASES. CONDITIONS SUCH AS ALZHEIMER’S, PARKINSON’S, DEPRESSION AND MANY OTHERS ARE BEING CONTINUOUSLY INVESTIGATED ALL OVER THE WORLD. As a result, INTERNATIONAL INICIATIVE VARIES HAVE REFERRED IN THE IMPORTANCE OF THE COMPRENSION OF NEURONAL ACTIVITY IN THE BREBRO._x000D_ _x000D__x000D__x000D_ _x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D__x000D___x we will study NEURONAL NEURONAL RED CONECTIVITY PROCESSING PROCESSES IN 3D that Happen in DIFFERENT ORGANISMUS MODEL CEREBRIES. TO DO THIS, A NOVEL TECHNIQUE WILL BE USED WHICH IS BASED ON BREAKING AN OLD PARADIGM IN MICROSCOPY: DECOUPLING THE OPTIC ILLUMINATION OF THE DETECTION OPTIC. THIS IS ACHIEVED BY INCORPORATING WAVEFRONT CODING INTO A LIGHT SHEET MICROSCOPE. THIS RESULTS IN THE ABILITY TO OBTAIN OPTICAL SECTIONING OF IMAGE PLANES THAT ARE OUTSIDE THE FOCAL POSITION. THIS SYSTEM ADDS A NEW DEGREE OF FREEDOM IN MICROSCOPY AND, AS SUCH, HAS ENORMOUS RELEVANCE AND GREAT POTENTIAL FOR NEW IMAGINATIVE APPLICATIONS. IN PARTICULAR, WE HAVE PREVIOUSLY DEMONSTRATED THAT THIS NEW DEGREE OF FREEDOM CAN BE USED TO OBTAIN HIGH RESOLUTION VOLUMETRIC IMAGES AT UNPRECEDENTED SPEEDS. Even where we know, our team is the first at_x000D_ RESENT THIS APPROXIMATION._x000D_ _x000D_ ASI, THE PROJECT THAT IS HERE IS THE next NATURAL PASE OF OUR INICIAL RESULTS AND will be applied NOW on the web of neurobiology. IN THIS PROJECT, THE CAPABILITIES OF OUR NEW IMAGING SYSTEM WILL BE USED, TOGETHER WITH OUR NEUROSCIENCE COLLABORATORS, TO VISUALISE, IN 3D, THE CALCIUM WAVE PATTERNS THAT ORIGINATE DURING THE PROCESS OF NEURONAL ACTIVITY IN THE BRAIN OF SEVERAL MODEL ORGANISMS (SUCH AS NEMATODES, ZEBRA FISH AND TADPOLES). ONCE THIS COMMUNICATION PATTERN HAS BEEN RECORDED, DIFFERENT TOOLS OF OPTIMAL MANIPULATION AT THE CELLULAR LEVEL WILL BE USED, SUCH AS NEURONAL PHOTO-STIMULATION OR CONTROLLED PHOTO-ABLATION, BOTH AT THE LEVEL OF A SINGLE NEURONAL CELL. ONCE THE PHOTO-STIMULATION OR PHOTO-ABLATION HAS BEEN APPLIED, THE CALCIUM DYNAMICS WILL BE VISUALISED AGAIN. THIS WILL ALLOW THE DETERMINATION OF CHANGES IN THE BEHAVIOR OF THE BRAIN, THUS HAVING A BETTER UNDERSTANDING OF THE NEURAL NETWORK, AS WELL AS A BETTER VISION OF THE FUNCTION OF THE DIFFERENT PARTS OF IT. All THIS INFORMATION REPRESENT, FOR SAME, A ADELING PASS FOR THE COMMUNITY OF Neurobiology,_x000D_ PROPOTIONING A IMPORTANT BASE FOR FUTURES INVESTIGATIONS WITH A GREAT IMPACT FOR_x000D_ THE SOCIETY IN GENERAL. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 17:05, 12 October 2021
Project Q3166707 in Spain
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| English | No label defined |
Project Q3166707 in Spain |
Statements
66,550.0 Euro
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133,100.0 Euro
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50.0 percent
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30 December 2016
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29 December 2019
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INSTITUTO DE CIENCIAS FOTONICAS
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41°17'9.96"N, 1°58'56.71"E
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08056
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EL AUMENTO DE LA EDAD DE LA POBLACION DEL MUNDO Y LAS CONDICIONES DE VIDA MODERNA PARECEN TENER UN EFECTO SOBRE LAS ENFERMEDADES RELACIONADAS CON EL CEREBRO. AFECCIONES COMO EL ALZHEIMER, EL PARKINSON, LA DEPRESION Y MUCHOS OTROS ESTAN SIENDO CONTINUAMENTE INVESTIGADOS EN TODO EL MUNDO. COMO RESULTADO, VARIAS INICIATIVAS INTERNACIONALES HAN RECALCADO EN LA IMPORTANCIA DE LA COMPRENSION DE LA ACTIVIDAD NEURONAL EN EL CEREBRO PARA PODER ASI ENTENDER MEJOR LOS SECRETOS DE LAS DIFERENTES ENFERMEDADES RELACIONADAS CON EL CEREBRO._x000D_ _x000D_ EN ESTE PROYECTO ESTUDIAREMOS LOS RAPIDOS PROCESOS DE CONECTIVIDAD DE RED NEURONAL EN 3D QUE SUCEDEN EN CEREBROS DE DIFERENTES ORGANISMOS MODELO. PARA ELLO, SE UTILIZARA UNA NOVEDOSA TECNICA LA CUAL SE BASA EN ROMPER UN VIEJO PARADIGMA EN AL MICROSCOPIA: DESACOPLAR LA OPTICA DE ILUMINACION DE LA OPTICA DE DETECCION. ESTO SE LOGRA MEDIANTE LA INCORPORACION DE CODIFICACION DE FRENTE DE ONDA EN UN MICROSCOPIO DE HOJA DE LUZ. ESTO RESULTA EN LA CAPACIDAD DE OBTENER SECCIONADO OPTICO DE PLANOS DE IMAGEN QUE ESTAN FUERA DE LA POSICION FOCAL. ESTE SISTEMA AÑADE UN NUEVO GRADO DE LIBERTAD EN LA MICROSCOPIA Y, COMO TAL, POSEE UNA ENORME RELEVANCIA Y UN GRAN POTENCIAL PARA NUEVAS E IMAGINATIVAS APLICACIONES. EN PARTICULAR, HEMOS PREVIAMENTE DEMOSTRADO QUE ESTE NUEVO GRADO DE LIBERTAD PUEDE SER UTILIZADO PARA OBTENER IMAGENES VOLUMETRICAS DE ALTA RESOLUCION A VELOCIDADES SIN PRECEDENTES. HASTA DONDE SABEMOS, NUESTRO EQUIPO ES EL PRIMERO EN_x000D_ PRESENTAR ESTA APROXIMACION._x000D_ _x000D_ ASI, EL PROYECTO QUE AQUI SE PRESENTA ES EL SIGUIENTE PASO NATURAL DE NUESTROS RESULTADOS INICIALES Y SE APLICARA AHORA EN EL CAMPO DE LA NEUROBIOLOGIA. EN ESTE PROYECTO, LAS CAPACIDADES DE NUESTRO NUEVO SISTEMA DE IMAGEN SE UTILIZARAN, JUNTO CON NUESTROS COLABORADORES EXPERTOS EN NEUROCIENCIAS, PARA VISUALIZAR, EN 3D, LOS PATRONES DE ONDAS DE CALCIO QUE SE ORIGINAN DURANTE EL PROCESO DE LA ACTIVIDAD NEURONAL EN EL CEREBRO DE VARIOS ORGANISMOS MODELO (TALES COMO NEMATODOS, PECES ZEBRA Y RENACUAJOS). UNA VEZ QUE DICHO PATRON DE COMUNICACION HAYA SIDO REGISTRADO, SE UTILIZARAN DISTINTAS HERRAMIENTAS DE MANIPULACION OPTICA A NIVEL CELULAR, TALES COMO LA FOTO-ESTIMULACION NEURONAL O LA REALIZACION DE FOTO-ABLACION CONTROLADA, AMBOS A NIVEL DE UNA SOLA CELULA NEURONAL. UNA VEZ APLICADA LA FOTO-ESTIMULACION O LA FOTO-ABLACION, SE VISUALIZARA NUEVAMENTE EL PATRON LAS DINAMICAS DE CALCIO. ESTO PERMITIRA LA DETERMINACION DE LOS CAMBIOS EN EL COMPORTAMIENTO DEL CEREBRO, TENIENDO DE ESTA MANERA UNA MEJOR COMPRENSION DE LA RED NEURONAL, ASI COMO UNA MEJOR VISION DE LA FUNCION DE LAS DIFERENTES PARTES DE LA MISMA. TODA ESTA INFORMACION REPRESENTA, POR SI MISMA, UN PASO ADELANTE PARA LA COMUNIDAD DE NEUROBIOLOGIA,_x000D_ PROPORCIONANDO UNA IMPORTANTE BASE PARA FUTURAS INVESTIGACIONES CON UN GRAN IMPACTO PARA_x000D_ LA SOCIEDAD EN GENERAL. (Spanish)
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THE RISING AGE OF THE WORLD’S POPULATION AND MODERN LIVING CONDITIONS SEEM TO HAVE AN EFFECT ON BRAIN-RELATED DISEASES. CONDITIONS SUCH AS ALZHEIMER’S, PARKINSON’S, DEPRESSION AND MANY OTHERS ARE BEING CONTINUOUSLY INVESTIGATED ALL OVER THE WORLD. As a result, INTERNATIONAL INICIATIVE VARIES HAVE REFERRED IN THE IMPORTANCE OF THE COMPRENSION OF NEURONAL ACTIVITY IN THE BREBRO._x000D_ _x000D__x000D__x000D_ _x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D__x000D___x we will study NEURONAL NEURONAL RED CONECTIVITY PROCESSING PROCESSES IN 3D that Happen in DIFFERENT ORGANISMUS MODEL CEREBRIES. TO DO THIS, A NOVEL TECHNIQUE WILL BE USED WHICH IS BASED ON BREAKING AN OLD PARADIGM IN MICROSCOPY: DECOUPLING THE OPTIC ILLUMINATION OF THE DETECTION OPTIC. THIS IS ACHIEVED BY INCORPORATING WAVEFRONT CODING INTO A LIGHT SHEET MICROSCOPE. THIS RESULTS IN THE ABILITY TO OBTAIN OPTICAL SECTIONING OF IMAGE PLANES THAT ARE OUTSIDE THE FOCAL POSITION. THIS SYSTEM ADDS A NEW DEGREE OF FREEDOM IN MICROSCOPY AND, AS SUCH, HAS ENORMOUS RELEVANCE AND GREAT POTENTIAL FOR NEW IMAGINATIVE APPLICATIONS. IN PARTICULAR, WE HAVE PREVIOUSLY DEMONSTRATED THAT THIS NEW DEGREE OF FREEDOM CAN BE USED TO OBTAIN HIGH RESOLUTION VOLUMETRIC IMAGES AT UNPRECEDENTED SPEEDS. Even where we know, our team is the first at_x000D_ RESENT THIS APPROXIMATION._x000D_ _x000D_ ASI, THE PROJECT THAT IS HERE IS THE next NATURAL PASE OF OUR INICIAL RESULTS AND will be applied NOW on the web of neurobiology. IN THIS PROJECT, THE CAPABILITIES OF OUR NEW IMAGING SYSTEM WILL BE USED, TOGETHER WITH OUR NEUROSCIENCE COLLABORATORS, TO VISUALISE, IN 3D, THE CALCIUM WAVE PATTERNS THAT ORIGINATE DURING THE PROCESS OF NEURONAL ACTIVITY IN THE BRAIN OF SEVERAL MODEL ORGANISMS (SUCH AS NEMATODES, ZEBRA FISH AND TADPOLES). ONCE THIS COMMUNICATION PATTERN HAS BEEN RECORDED, DIFFERENT TOOLS OF OPTIMAL MANIPULATION AT THE CELLULAR LEVEL WILL BE USED, SUCH AS NEURONAL PHOTO-STIMULATION OR CONTROLLED PHOTO-ABLATION, BOTH AT THE LEVEL OF A SINGLE NEURONAL CELL. ONCE THE PHOTO-STIMULATION OR PHOTO-ABLATION HAS BEEN APPLIED, THE CALCIUM DYNAMICS WILL BE VISUALISED AGAIN. THIS WILL ALLOW THE DETERMINATION OF CHANGES IN THE BEHAVIOR OF THE BRAIN, THUS HAVING A BETTER UNDERSTANDING OF THE NEURAL NETWORK, AS WELL AS A BETTER VISION OF THE FUNCTION OF THE DIFFERENT PARTS OF IT. All THIS INFORMATION REPRESENT, FOR SAME, A ADELING PASS FOR THE COMMUNITY OF Neurobiology,_x000D_ PROPOTIONING A IMPORTANT BASE FOR FUTURES INVESTIGATIONS WITH A GREAT IMPACT FOR_x000D_ THE SOCIETY IN GENERAL. (English)
12 October 2021
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Castelldefels
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Identifiers
FIS2016-80455-R
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