Effect of antibiotic treatment on progression of capsular contracture of a breast implant in a murine model (Q3165318): Difference between revisions
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(Created claim: summary (P836): Capsular contracture (CC) is the most frequent complication and the first cause of reintervention in patients with breast implants. There are several studies that propose that the pathogenic factor underlying a CC is a subclinical infection associated with the formation of bacterial biofilms (mainly Propionibacterium acnes and negative coagulase staphylococci) on the implant. The fundamental objective of this Project is to analyse whether the an...) |
(Changed label, description and/or aliases in en: translated_label) |
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Effect of antibiotic treatment on progression of capsular contracture of a breast implant in a murine model | |||
Revision as of 16:57, 12 October 2021
Project Q3165318 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Effect of antibiotic treatment on progression of capsular contracture of a breast implant in a murine model |
Project Q3165318 in Spain |
Statements
46,000.0 Euro
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92,000.0 Euro
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50.0 percent
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1 January 2018
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31 March 2021
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FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE NAVARRA
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42°49'6.42"N, 1°38'39.34"W
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31201
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La contractura capsular (CC) es la complicación más frecuente y la primera causa de reintervención en pacientes portadoras de implantes mamarios. Hay varios trabajos que proponen que el factor patogénico que subyace a una CC es una infección subclínica asociada a la formación de biofilms bacterianos (fundamentalmente por Propionibacterium acnes y estafilococos coagulasa negativos) sobre el implante. El objetivo fundamental de este Proyecto es analizar si el tratamiento antibiótico de la CC precoz es capaz de detener su progresión en un modelo experimental de infección asociada a implantes. Los objetivos secundarios son: 1) Comparar la capacidad de P. acnes y S. epidermidis para originar una CC en un modelo experimental murino, evaluando la estructura macro y microscópica de la cápsula desarrollada en respuesta a cada microorganismo. 2) Comparar el cultivo y la PCR universal sobre una biopsia de tejido peri-implante con el cultivo tras sonicación de los implantes retirados para el diagnóstico de una CC (infección subclínica) en un modelo experimental de infección asociada a implante. 3) Comparar la eficacia de diferentes antimicrobianos (vancomicina, daptomicina, tedizolid, ceftarolina, dalbavancina y tigeciclina) para erradicar los biofilms de S. epidermidis formados sobre el implante y en la cápsula peri-implante en un modelo animal de infección. 4) Comparar la eficacia de la amoxicilina para erradicar los biofilms de P. acnes formadas sobre un implante y sobre la cápsula peri-implante en un modelo animal de infección. Para completar estos objetivos se utilizará un modelo experimental previamente descrito y ya estandarizado por nuestro grupo con ratas hembras tipo Wistar (n=110). Si se demuestra que el tratamiento antibiótico frena la progresión de la CC se dispondrá de una evidencia científica para realizar un ensayo clínico en humanos con la intención final de cambiar la práctica clínica en el diagnóstico y tratamiento de esta entidad. (Spanish)
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Capsular contracture (CC) is the most frequent complication and the first cause of reintervention in patients with breast implants. There are several studies that propose that the pathogenic factor underlying a CC is a subclinical infection associated with the formation of bacterial biofilms (mainly Propionibacterium acnes and negative coagulase staphylococci) on the implant. The fundamental objective of this Project is to analyse whether the antibiotic treatment of early CC is able to stop its progression in an experimental model of infection associated with implants. The secondary objectives are: 1) Compare the ability of P. acnes and S. epidermidis to originate a CC in a murine experimental model, evaluating the macro and microscopic structure of the capsule developed in response to each microorganism. 2) Compare the culture and universal PCR on a peri-implant tissue biopsy with the culture after sonication of the implants removed for the diagnosis of a CC (subclinical infection) in an experimental model of infection associated with implantation. 3) Compare the efficacy of different antimicrobials (vancomycin, daptomycin, tedizolid, ceftaroline, dalbavancin and tigecycline) in eradicating the biofilms of S. epidermidis formed on the implant and in the peri-implant capsule in an animal model of infection. 4) Compare the efficacy of amoxicillin in eradicating P. acnes biofilms formed on an implant and on the peri-implant capsule in an animal model of infection. An experimental model previously described and standardised by our group with Wistar female rats (n=110) will be used to complete these objectives. If antibiotic therapy is shown to slow the progression of CC, scientific evidence will be available to conduct a clinical trial in humans with the ultimate intention to change clinical practice in the diagnosis and treatment of this entity. (English)
12 October 2021
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Pamplona/Iruña
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Identifiers
PI17_00974
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