Long-term impact of healing of chronic HCV infection with direct antivirals on inflammatory mediators and liver and extrahepatic manifestations of the virus (Q3167157): Difference between revisions
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(Created claim: summary (P836): Since 2015 we have had direct-acting antiviral treatments that do not require joint use of interferon and that provide high cure rate of infection. Patients with chronic hepatitis C virus (HCV) infection have immunological changes that influence the altered balance of soluble inflammation mediators, some of which have been linked to specific manifestations secondary to HCV. Once the sustained viral response to HCV treatment has been achieved, th...) |
(Changed label, description and/or aliases in en: translated_label) |
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Long-term impact of healing of chronic HCV infection with direct antivirals on inflammatory mediators and liver and extrahepatic manifestations of the virus | |||
Revision as of 16:55, 12 October 2021
Project Q3167157 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Long-term impact of healing of chronic HCV infection with direct antivirals on inflammatory mediators and liver and extrahepatic manifestations of the virus |
Project Q3167157 in Spain |
Statements
31,000.0 Euro
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62,000.0 Euro
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50.0 percent
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1 January 2019
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31 March 2022
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FUNDACION INVESTIGACION BIOMEDICA HOSPITAL PUERTA DE HIERRO
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40°28'23.02"N, 3°52'20.68"W
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28080
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Desde 2015 disponemos de tratamientos antivirales de acción directa que no precisan el uso conjunto de interferon y que proporcionan elevadas tasa de curación de la infección. Los pacientes con infección crónica por virus de la hepatitis C (VHC) presentan alteraciones inmunológicas que confluyen en el balance alterado de mediadores solubles de inflamación, algunos de los cuales se han relacionado con manifestaciones concretas secundarias al VHC. Una vez alcanzada la respuesta viral sostenida al tratamiento frente al VHC, existe un cierto grado de recuperación inmunológica, pero esta recuperación no es completa y aún no se conoce si se mantiene o normaliza a largo plazo. El objetivo de este estudio es analizar la evolución de mediadores solubles de inflamación antes de recibir tratamiento antiviral directo, a las 12 semanas del fin del tratamiento y a los cuatro años del mismo. Además se analizarán las manifestaciones clínicas secundarias a la infección por el VHC en los mismos puntos del estudio. Se incluirán 250 pacientes (100 monoinfectados por VHC, 100 coinfectados por VIH/VHC y 50 trasplantados hepáticos con infección crónica por el VHC) que hayan recibido antivirales de acción directa desde 2015 hasta 2017. Se analizaran 14 marcadores séricos mediante técnicas de ELISA y de análisis múltiplex por citometría de flujo. Se evaluará la asociación de la modulación de los marcadores solubles con la incidencia y evolución de las manifestaciones asociadas a VHC a corto y largo plazo. (Spanish)
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Since 2015 we have had direct-acting antiviral treatments that do not require joint use of interferon and that provide high cure rate of infection. Patients with chronic hepatitis C virus (HCV) infection have immunological changes that influence the altered balance of soluble inflammation mediators, some of which have been linked to specific manifestations secondary to HCV. Once the sustained viral response to HCV treatment has been achieved, there is a certain degree of immune recovery, but this recovery is not complete and it is not yet known whether it is maintained or normalised in the long term. The objective of this study is to analyse the evolution of soluble inflammation mediators before receiving direct antiviral treatment, 12 weeks after the end of treatment and four years after treatment. In addition, clinical manifestations secondary to HCV infection will be analysed at the same points of the study. This will include 250 patients (100 HCV monoinfected, 100 HIV/HCV co-infected and 50 liver transplants with chronic HCV infection) who received direct-acting antivirals from 2015 to 2017. 14 serum markers will be analysed using ELISA techniques and multiplex analysis by flow cytometry. The association of soluble marker modulation with the incidence and evolution of HCV-associated manifestations in the short and long term shall be evaluated. (English)
12 October 2021
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Majadahonda
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Identifiers
PI18_00846
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