Hypersensitivity to Platinums and Taxans: description of immunological phenotypes and search for biomarkers that optimise diagnosis and treatment. (Q3166536): Difference between revisions
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(Created claim: summary (P836): Hypersensitivity reactions to antineoplastic agents have increased, and without an adequate allergological approach patients who present them may be deprived of first-line treatments. The main objectives of this study are to evaluate the validity of the Basophil Activation Technique (BAT) as a useful test in the diagnosis of Allergy to Platinums and Taxans against clinical diagnosis and to evaluate immunological changes (activation of basophils...) |
(Changed label, description and/or aliases in en: translated_label) |
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Hypersensitivity to Platinums and Taxans: description of immunological phenotypes and search for biomarkers that optimise diagnosis and treatment. | |||
Revision as of 16:50, 12 October 2021
Project Q3166536 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Hypersensitivity to Platinums and Taxans: description of immunological phenotypes and search for biomarkers that optimise diagnosis and treatment. |
Project Q3166536 in Spain |
Statements
43,500.0 Euro
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87,000.0 Euro
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50.0 percent
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1 January 2019
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31 March 2022
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FUNDACION INVESTIGACION BIOMEDICA HOSPITAL RAMON Y CAJAL
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40°25'0.12"N, 3°42'12.89"W
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28079
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Las reacciones de hipersensibilidad frente a agentes antineoplásicos se han incrementado, y sin un adecuado abordaje alergológico los pacientes que las presentan se pueden ver privados de tratamientos de primera línea. Los objetivos principales de este estudio consisten evaluar la validez de la Técnica de Activación de Basófilos (TAB) como prueba de utilidad en el diagnóstico de Alergia a Platinos y Taxanos frente al diagnóstico clínico y en evaluar los cambios inmunológicos (activación de basófilos y proliferación linfocitos T y liberación de citoquinas) del proceso de desensibilización en pacientes Alérgicos a Platinos y Taxanos. Metodología: se realizará un estudio transversal prospectivo se realizará un estudio transversal prospectivo evaluar la validez de la técnica de activación de basófilos (TAB). Se realizará una comparación de forma ciega e independiente del TAB, con el resultado de la prueba cutánea y la prueba de exposición controlada con lo Platinos o Taxanos. Y además se realizará un estudio longitudinal prospectivo, que incluya una cohorte de pacientes alérgicos a Platinos o Taxanos que se sometan a un proceso de desensibilización frente a dichos agentes antineoplásicos. El grupo control serán aquellos pacientes con estudio alergológico negativo que continúan con su esquema terapéutico habitual de administración de Platinos/Taxanos. (Spanish)
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Hypersensitivity reactions to antineoplastic agents have increased, and without an adequate allergological approach patients who present them may be deprived of first-line treatments. The main objectives of this study are to evaluate the validity of the Basophil Activation Technique (BAT) as a useful test in the diagnosis of Allergy to Platinums and Taxans against clinical diagnosis and to evaluate immunological changes (activation of basophils and T lymphocyte proliferation and release of cytokines) of the desensitisation process in patients allergic to Platinums and Taxans. Methodology: a prospective cross-sectional study will be conducted to evaluate the validity of the Basophil activation (BAT) technique. A blind and independent comparison of the TAB shall be performed with the result of the skin test and the controlled exposure test with the Platinums or Taxans. In addition, a prospective longitudinal study will be carried out, including a cohort of patients allergic to Platinums or Taxans who undergo a process of desensitisation against these antineoplastic agents. The control group will be those patients with negative allergological study who continue with their usual therapeutic regimen of platinum/Taxan administration. (English)
12 October 2021
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Madrid
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Identifiers
PI18_00962
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