Amount, distribution and dysfunction of body fat as determinants of female gonadal dysfunction: from hypothalamic amenorrhea to polycystic ovary syndrome. (Q3150145): Difference between revisions

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(‎Changed label, description and/or aliases in en: translated_label)
(‎Removed claim: summary (P836): Reproduction requires women’s energy deposits to ensure the nutrition of the developing fetus, so the adipose tissue communicates with the female hypothalamus-hypophyse-gonadal axis. Our hypothesis is that abnormalities in the amount, distribution or function of adipose tissue are associated with functional forms of female gonadal dysfunction in predisposed women, in a broad spectrum ranging from hypothalamic amenorrhea to polycystic ovary syn...)
Property / summary
Reproduction requires women’s energy deposits to ensure the nutrition of the developing fetus, so the adipose tissue communicates with the female hypothalamus-hypophyse-gonadal axis. Our hypothesis is that abnormalities in the amount, distribution or function of adipose tissue are associated with functional forms of female gonadal dysfunction in predisposed women, in a broad spectrum ranging from hypothalamic amenorrhea to polycystic ovary syndrome (PAS). We will study 5 groups of 10 women: women with exercise-associated functional hypothalamic amenorrhea, women without ovulatory dysfunction with similar physical activity, POS patients with and POS patients without hyperandrogenism, and healthy controls for POS groups. The objectives shall be: Primary objective: identify new signaling factors derived from adipose and muscle tissue through the undirected and targeted study of the proteome and gene expression of superficial subcutaneous adipose tissue, deep subcutaneous adipose tissue (visceral adipose equivalent) and skeletal muscle. Secondary objectives: 1) Evaluate the profile of adipokines and intestinal hormones circulating basally and after oral glucose loading, and their relationship with sex steroids and the distribution of adipose tissue. 2) Evaluate the body composition and distribution of body adipose tissue and its relationship with: 2.1. Sex steroids. 2.2. Classic cardiovascular risk factors. 2.3. Subclinical inflammation. 2.4. Oxidative stress. 2.5. Autonomic cardiovascular function. 2.6. Subclinical arteriosclerosis. 2.7. Endocrine disruptors. 2.8. Oral and intestinal microbiome. 2.9 miRNA and lncRNA in blood. The results will increase the knowledge of the mechanisms that link the energy deposits to the female reproductive axis, as well as allow the identification of biomarkers with diagnostic and therapeutic potential for the disorders studied. (English)
 
Property / summary: Reproduction requires women’s energy deposits to ensure the nutrition of the developing fetus, so the adipose tissue communicates with the female hypothalamus-hypophyse-gonadal axis. Our hypothesis is that abnormalities in the amount, distribution or function of adipose tissue are associated with functional forms of female gonadal dysfunction in predisposed women, in a broad spectrum ranging from hypothalamic amenorrhea to polycystic ovary syndrome (PAS). We will study 5 groups of 10 women: women with exercise-associated functional hypothalamic amenorrhea, women without ovulatory dysfunction with similar physical activity, POS patients with and POS patients without hyperandrogenism, and healthy controls for POS groups. The objectives shall be: Primary objective: identify new signaling factors derived from adipose and muscle tissue through the undirected and targeted study of the proteome and gene expression of superficial subcutaneous adipose tissue, deep subcutaneous adipose tissue (visceral adipose equivalent) and skeletal muscle. Secondary objectives: 1) Evaluate the profile of adipokines and intestinal hormones circulating basally and after oral glucose loading, and their relationship with sex steroids and the distribution of adipose tissue. 2) Evaluate the body composition and distribution of body adipose tissue and its relationship with: 2.1. Sex steroids. 2.2. Classic cardiovascular risk factors. 2.3. Subclinical inflammation. 2.4. Oxidative stress. 2.5. Autonomic cardiovascular function. 2.6. Subclinical arteriosclerosis. 2.7. Endocrine disruptors. 2.8. Oral and intestinal microbiome. 2.9 miRNA and lncRNA in blood. The results will increase the knowledge of the mechanisms that link the energy deposits to the female reproductive axis, as well as allow the identification of biomarkers with diagnostic and therapeutic potential for the disorders studied. (English) / rank
Normal rank
 
Property / summary: Reproduction requires women’s energy deposits to ensure the nutrition of the developing fetus, so the adipose tissue communicates with the female hypothalamus-hypophyse-gonadal axis. Our hypothesis is that abnormalities in the amount, distribution or function of adipose tissue are associated with functional forms of female gonadal dysfunction in predisposed women, in a broad spectrum ranging from hypothalamic amenorrhea to polycystic ovary syndrome (PAS). We will study 5 groups of 10 women: women with exercise-associated functional hypothalamic amenorrhea, women without ovulatory dysfunction with similar physical activity, POS patients with and POS patients without hyperandrogenism, and healthy controls for POS groups. The objectives shall be: Primary objective: identify new signaling factors derived from adipose and muscle tissue through the undirected and targeted study of the proteome and gene expression of superficial subcutaneous adipose tissue, deep subcutaneous adipose tissue (visceral adipose equivalent) and skeletal muscle. Secondary objectives: 1) Evaluate the profile of adipokines and intestinal hormones circulating basally and after oral glucose loading, and their relationship with sex steroids and the distribution of adipose tissue. 2) Evaluate the body composition and distribution of body adipose tissue and its relationship with: 2.1. Sex steroids. 2.2. Classic cardiovascular risk factors. 2.3. Subclinical inflammation. 2.4. Oxidative stress. 2.5. Autonomic cardiovascular function. 2.6. Subclinical arteriosclerosis. 2.7. Endocrine disruptors. 2.8. Oral and intestinal microbiome. 2.9 miRNA and lncRNA in blood. The results will increase the knowledge of the mechanisms that link the energy deposits to the female reproductive axis, as well as allow the identification of biomarkers with diagnostic and therapeutic potential for the disorders studied. (English) / qualifier
point in time: 12 October 2021
Timestamp+2021-10-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0
 

Revision as of 15:15, 12 October 2021

Project Q3150145 in Spain
Language Label Description Also known as
English
Amount, distribution and dysfunction of body fat as determinants of female gonadal dysfunction: from hypothalamic amenorrhea to polycystic ovary syndrome.
Project Q3150145 in Spain

    Statements

    contained in NUTS
    Madrid
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    country
    Spain
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    EU contribution
    86,000.0 Euro
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    budget
    172,000.0 Euro
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    co-financing rate
    50.0 percent
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    start time
    1 January 2019
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    end time
    31 March 2022
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    beneficiary name (string)
    FUNDACION INVESTIGACION BIOMEDICA HOSPITAL RAMON Y CAJAL
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    beneficiary
    Q3135016
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    coordinate location

    40°25'0.12"N, 3°42'12.89"W
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    postal code
    28079
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    summary
    La reproducción requiere de la mujer unos depósitos de energía que garanticen la nutrición del feto en desarrollo, por lo que el tejido adiposo se comunica con el eje hipotálamo-hipófiso-gonadal femenino. Nuestra hipótesis es que las anomalías en la cantidad, la distribución y/o la función del tejido adiposo se asocian a formas funcionales de disfunción gonadal femenina en mujeres predispuestas, en un espectro amplio que va desde la amenorrea hipotalámica hasta el síndrome de ovario poliquístico (SOP). Estudiaremos 5 grupos de 10 mujeres: mujeres con amenorrea hipotalámica funcional asociada al ejercicio, mujeres sin disfunción ovulatoria con actividad física similar, pacientes SOP con y pacientes SOP sin hiperandrogenismo, y controles sanas para los grupos con SOP. Los objetivos serán: Objetivo primario: identificar nuevos factores de señalización derivados del tejido adiposo y muscular mediante el estudio no dirigido y dirigido del proteoma y de la expresión génica del tejido adiposo subcutáneo superficial, tejido adiposo subcutáneo profundo (equivalente tejido adiposo visceral) y del musculo esquelético. Objetivos secundarios: 1) Evaluar el perfil de adipoquinas y hormonas intestinales circulantes basalmente y tras carga oral de glucosa, y su relación con los esteroides sexuales y la distribución de tejido adiposo. 2) Evaluar la composición corporal y distribución del tejido adiposo corporal y su relación con: 2.1. Esteroides sexuales. 2.2. Factores de riesgo cardiovascular clásicos. 2.3. Inflamación subclínica. 2.4. Estrés oxidativo. 2.5. Función autonómica cardiovascular. 2.6. Arteriosclerosis subclínica. 2.7. Disruptores endocrinos. 2.8. Microbioma oral e intestinal. 2.9 miRNA y lncRNA en sangre. Los resultados aumentarán el conocimiento de los mecanismos que vinculan los depósitos energéticos con el eje reproductivo femenino, así como permitirán la identificación de biomarcadores con potencial diagnóstico y terapéutico para los trastornos estudiados. (Spanish)
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    location (string)
    Madrid
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    Identifiers

    Spanish Kohesio ID
    PI18_01122
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